AU2003240743A1 - Deoxyhypusine-synthase inhibitors, pharmaceuticals comprising said inhibitors and uses thereof - Google Patents

Deoxyhypusine-synthase inhibitors, pharmaceuticals comprising said inhibitors and uses thereof

Info

Publication number
AU2003240743A1
AU2003240743A1 AU2003240743A AU2003240743A AU2003240743A1 AU 2003240743 A1 AU2003240743 A1 AU 2003240743A1 AU 2003240743 A AU2003240743 A AU 2003240743A AU 2003240743 A AU2003240743 A AU 2003240743A AU 2003240743 A1 AU2003240743 A1 AU 2003240743A1
Authority
AU
Australia
Prior art keywords
inhibitors
deoxyhypusine
pharmaceuticals
synthase
synthase inhibitors
Prior art date
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Abandoned
Application number
AU2003240743A
Inventor
Joachim Hauber
Andreas Hirsch
Alexander Steinkasserer
Current Assignee (The listed assignees may be inaccurate. Google has not performed a legal analysis and makes no representation or warranty as to the accuracy of the list.)
VIAXXEL BIOTECH GmbH
Original Assignee
VIAXXEL BIOTECH GmbH
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by VIAXXEL BIOTECH GmbH filed Critical VIAXXEL BIOTECH GmbH
Publication of AU2003240743A1 publication Critical patent/AU2003240743A1/en
Abandoned legal-status Critical Current

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D239/00—Heterocyclic compounds containing 1,3-diazine or hydrogenated 1,3-diazine rings
    • C07D239/02—Heterocyclic compounds containing 1,3-diazine or hydrogenated 1,3-diazine rings not condensed with other rings
    • C07D239/06—Heterocyclic compounds containing 1,3-diazine or hydrogenated 1,3-diazine rings not condensed with other rings having one double bond between ring members or between a ring member and a non-ring member
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P31/00—Antiinfectives, i.e. antibiotics, antiseptics, chemotherapeutics
    • A61P31/12—Antivirals
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P31/00—Antiinfectives, i.e. antibiotics, antiseptics, chemotherapeutics
    • A61P31/12—Antivirals
    • A61P31/14—Antivirals for RNA viruses
    • A61P31/18—Antivirals for RNA viruses for HIV
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P35/00—Antineoplastic agents
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P37/00—Drugs for immunological or allergic disorders
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D239/00—Heterocyclic compounds containing 1,3-diazine or hydrogenated 1,3-diazine rings
    • C07D239/02—Heterocyclic compounds containing 1,3-diazine or hydrogenated 1,3-diazine rings not condensed with other rings
    • C07D239/04—Heterocyclic compounds containing 1,3-diazine or hydrogenated 1,3-diazine rings not condensed with other rings having no double bonds between ring members or between ring members and non-ring members
    • Y—GENERAL TAGGING OF NEW TECHNOLOGICAL DEVELOPMENTS; GENERAL TAGGING OF CROSS-SECTIONAL TECHNOLOGIES SPANNING OVER SEVERAL SECTIONS OF THE IPC; TECHNICAL SUBJECTS COVERED BY FORMER USPC CROSS-REFERENCE ART COLLECTIONS [XRACs] AND DIGESTS
    • Y02—TECHNOLOGIES OR APPLICATIONS FOR MITIGATION OR ADAPTATION AGAINST CLIMATE CHANGE
    • Y02P—CLIMATE CHANGE MITIGATION TECHNOLOGIES IN THE PRODUCTION OR PROCESSING OF GOODS
    • Y02P20/00—Technologies relating to chemical industry
    • Y02P20/50—Improvements relating to the production of bulk chemicals
    • Y02P20/55—Design of synthesis routes, e.g. reducing the use of auxiliary or protecting groups

Landscapes

  • Health & Medical Sciences (AREA)
  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Public Health (AREA)
  • General Chemical & Material Sciences (AREA)
  • Medicinal Chemistry (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Veterinary Medicine (AREA)
  • Animal Behavior & Ethology (AREA)
  • General Health & Medical Sciences (AREA)
  • Virology (AREA)
  • Communicable Diseases (AREA)
  • Oncology (AREA)
  • Engineering & Computer Science (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Immunology (AREA)
  • AIDS & HIV (AREA)
  • Tropical Medicine & Parasitology (AREA)
  • Molecular Biology (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
AU2003240743A 2002-06-12 2003-06-04 Deoxyhypusine-synthase inhibitors, pharmaceuticals comprising said inhibitors and uses thereof Abandoned AU2003240743A1 (en)

Applications Claiming Priority (3)

Application Number Priority Date Filing Date Title
GB0213498A GB2389581A (en) 2002-06-12 2002-06-12 Hydrogenated pyrimidines and their use as inhibitors of deoxyhypusine-synthase or hypusination of eIF-5A
GB0213498.9 2002-06-12
PCT/EP2003/005854 WO2003106433A1 (en) 2002-06-12 2003-06-04 Deoxyhypusine-synthase inhibitors, pharmaceuticals comprising said inhibitors and uses thereof

Publications (1)

Publication Number Publication Date
AU2003240743A1 true AU2003240743A1 (en) 2003-12-31

Family

ID=9938447

Family Applications (1)

Application Number Title Priority Date Filing Date
AU2003240743A Abandoned AU2003240743A1 (en) 2002-06-12 2003-06-04 Deoxyhypusine-synthase inhibitors, pharmaceuticals comprising said inhibitors and uses thereof

Country Status (3)

Country Link
AU (1) AU2003240743A1 (en)
GB (1) GB2389581A (en)
WO (1) WO2003106433A1 (en)

Families Citing this family (1)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
FR2962906A1 (en) * 2010-07-20 2012-01-27 Univ Nice Sophia Antipolis USE OF INHIBITORS OF HYPUSINYLATION OF eIF5A TO TREAT ISCHEMIC AND HYPOXIC DISEASES

Family Cites Families (7)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US4138563A (en) * 1978-01-05 1979-02-06 American Cyanamid Company 2-Acylamidoethyl-2-tetrahydropyrimidines
US4427802A (en) * 1981-07-27 1984-01-24 Hexcel Corporation Heterocyclic multifunctional amine adducts and curable compositions containing the same
US5091576A (en) * 1986-12-02 1992-02-25 University Of Florida Anti-neoplastic, anti-viral or anti-retroviral spermine derivatives
AU8769291A (en) * 1990-09-17 1992-04-15 Children's Medical Center Corporation Deoxyhypusyl hydroxylase inhibitors
US5849587A (en) * 1995-06-09 1998-12-15 Cornell Research Foundation, Inc. Method of inhibiting viral replication in eukaryotic cells and of inducing apoptosis of virally-infected cells
CA2244139C (en) * 1996-02-02 2005-06-07 Pharmacia & Upjohn S.P.A. Distamycin derivatives, process for preparing them, and their use as antitumor and antiviral agents
BR0012984A (en) * 1999-08-04 2002-07-16 Millennium Pharm Inc Method for treating a condition associated with mc4-r in a mammal, compound binding to mc4-r, and pharmaceutical composition

Also Published As

Publication number Publication date
GB2389581A (en) 2003-12-17
WO2003106433A1 (en) 2003-12-24
GB0213498D0 (en) 2002-07-24

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Legal Events

Date Code Title Description
MK6 Application lapsed section 142(2)(f)/reg. 8.3(3) - pct applic. not entering national phase