AU2003210137A8 - Method for producing recombinant proteins in micro-organisms - Google Patents

Method for producing recombinant proteins in micro-organisms

Info

Publication number
AU2003210137A8
AU2003210137A8 AU2003210137A AU2003210137A AU2003210137A8 AU 2003210137 A8 AU2003210137 A8 AU 2003210137A8 AU 2003210137 A AU2003210137 A AU 2003210137A AU 2003210137 A AU2003210137 A AU 2003210137A AU 2003210137 A8 AU2003210137 A8 AU 2003210137A8
Authority
AU
Australia
Prior art keywords
organisms
micro
recombinant proteins
producing recombinant
producing
Prior art date
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Abandoned
Application number
AU2003210137A
Other versions
AU2003210137A1 (en
Inventor
Martin Hils
Rudy Susilo
Hans Gunther Gassen
Ralf Pasternack
Hans Christian Korting
Current Assignee (The listed assignees may be inaccurate. Google has not performed a legal analysis and makes no representation or warranty as to the accuracy of the list.)
N Zyme Biotec GmbH
Original Assignee
N Zyme Biotec GmbH
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by N Zyme Biotec GmbH filed Critical N Zyme Biotec GmbH
Publication of AU2003210137A8 publication Critical patent/AU2003210137A8/en
Publication of AU2003210137A1 publication Critical patent/AU2003210137A1/en
Abandoned legal-status Critical Current

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
    • C12N9/00—Enzymes; Proenzymes; Compositions thereof; Processes for preparing, activating, inhibiting, separating or purifying enzymes
    • C12N9/14—Hydrolases (3)
    • C12N9/48—Hydrolases (3) acting on peptide bonds (3.4)
    • C12N9/50—Proteinases, e.g. Endopeptidases (3.4.21-3.4.25)
    • C12N9/64—Proteinases, e.g. Endopeptidases (3.4.21-3.4.25) derived from animal tissue
    • C12N9/6421—Proteinases, e.g. Endopeptidases (3.4.21-3.4.25) derived from animal tissue from mammals
    • C12N9/6424—Serine endopeptidases (3.4.21)
    • C12N9/6435—Plasmin (3.4.21.7), i.e. fibrinolysin
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P17/00—Drugs for dermatological disorders
    • A61P17/02—Drugs for dermatological disorders for treating wounds, ulcers, burns, scars, keloids, or the like
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P27/00—Drugs for disorders of the senses
    • A61P27/02—Ophthalmic agents
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P7/00—Drugs for disorders of the blood or the extracellular fluid
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P7/00—Drugs for disorders of the blood or the extracellular fluid
    • A61P7/02—Antithrombotic agents; Anticoagulants; Platelet aggregation inhibitors
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P9/00—Drugs for disorders of the cardiovascular system
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P9/00—Drugs for disorders of the cardiovascular system
    • A61P9/10—Drugs for disorders of the cardiovascular system for treating ischaemic or atherosclerotic diseases, e.g. antianginal drugs, coronary vasodilators, drugs for myocardial infarction, retinopathy, cerebrovascula insufficiency, renal arteriosclerosis
    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
    • C12N15/00—Mutation or genetic engineering; DNA or RNA concerning genetic engineering, vectors, e.g. plasmids, or their isolation, preparation or purification; Use of hosts therefor
    • C12N15/09—Recombinant DNA-technology
    • C12N15/11—DNA or RNA fragments; Modified forms thereof; Non-coding nucleic acids having a biological activity
    • C12N15/62—DNA sequences coding for fusion proteins
    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12Y—ENZYMES
    • C12Y304/00—Hydrolases acting on peptide bonds, i.e. peptidases (3.4)
    • C12Y304/21—Serine endopeptidases (3.4.21)
    • C12Y304/21007—Plasmin (3.4.21.7), i.e. fibrinolysin
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K2319/00—Fusion polypeptide
    • C07K2319/01—Fusion polypeptide containing a localisation/targetting motif
    • C07K2319/02—Fusion polypeptide containing a localisation/targetting motif containing a signal sequence

Landscapes

  • Health & Medical Sciences (AREA)
  • Engineering & Computer Science (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • General Health & Medical Sciences (AREA)
  • Genetics & Genomics (AREA)
  • Medicinal Chemistry (AREA)
  • Animal Behavior & Ethology (AREA)
  • Veterinary Medicine (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • General Chemical & Material Sciences (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Public Health (AREA)
  • Zoology (AREA)
  • Wood Science & Technology (AREA)
  • Biomedical Technology (AREA)
  • General Engineering & Computer Science (AREA)
  • Biotechnology (AREA)
  • Molecular Biology (AREA)
  • Biochemistry (AREA)
  • Heart & Thoracic Surgery (AREA)
  • Microbiology (AREA)
  • Diabetes (AREA)
  • Hematology (AREA)
  • Cardiology (AREA)
  • Vascular Medicine (AREA)
  • Ophthalmology & Optometry (AREA)
  • Urology & Nephrology (AREA)
  • Biophysics (AREA)
  • Physics & Mathematics (AREA)
  • Dermatology (AREA)
  • Plant Pathology (AREA)
  • Enzymes And Modification Thereof (AREA)
  • Micro-Organisms Or Cultivation Processes Thereof (AREA)
  • Measuring Or Testing Involving Enzymes Or Micro-Organisms (AREA)
  • Medicinal Preparation (AREA)
  • Polysaccharides And Polysaccharide Derivatives (AREA)
AU2003210137A 2002-02-06 2003-02-06 Method for producing recombinant proteins in micro-organisms Abandoned AU2003210137A1 (en)

Applications Claiming Priority (5)

Application Number Priority Date Filing Date Title
EP02002716.5 2002-02-06
EP02002716 2002-02-06
US35780902P 2002-02-21 2002-02-21
US60/357,809 2002-02-21
PCT/DE2003/000341 WO2003066842A2 (en) 2002-02-06 2003-02-06 Method for producing recombinant proteins in micro-organisms

Publications (2)

Publication Number Publication Date
AU2003210137A8 true AU2003210137A8 (en) 2003-09-02
AU2003210137A1 AU2003210137A1 (en) 2003-09-02

Family

ID=36743321

Family Applications (1)

Application Number Title Priority Date Filing Date
AU2003210137A Abandoned AU2003210137A1 (en) 2002-02-06 2003-02-06 Method for producing recombinant proteins in micro-organisms

Country Status (7)

Country Link
EP (1) EP1472346A2 (en)
JP (1) JP2005525798A (en)
CN (1) CN1768138A (en)
AU (1) AU2003210137A1 (en)
CA (1) CA2475277A1 (en)
MX (1) MXPA04007585A (en)
WO (1) WO2003066842A2 (en)

Families Citing this family (31)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
DK2056864T3 (en) 2006-08-28 2014-03-10 Omnio Healer Ab CANDIDATES AGAINST INFECTION
ES2453496T3 (en) 2006-08-28 2014-04-08 Omnio Healer Ab Novel pharmacological diane of prevention and treatment of periodontal disease, improvement of the healing of periodontal wounds and promotion of oral health
CA2767612A1 (en) * 2009-07-10 2011-01-13 Thrombogenics Nv Variants of plasminogen and plasmin
JP2013509181A (en) * 2009-10-30 2013-03-14 メルク・シャープ・エンド・ドーム・コーポレイション Process for producing therapeutic proteins in Pichia pastoris lacking dipeptidylaminopeptidase activity
WO2012093132A1 (en) 2011-01-05 2012-07-12 Thrombogenics Nv Plasminogen and plasmin variants
CN103764163A (en) 2011-08-12 2014-04-30 斯路姆基因公司 Plasminogen and plasmin variants
TWI653981B (en) 2015-12-18 2019-03-21 深圳瑞健生命科學硏究院有限公司 Use of plasminogen for the preparation of a medicament for preventing or treating a condition associated with diabetic nerve injury
US10709771B2 (en) 2015-12-18 2020-07-14 Talengen International Limited Method for preventing or treating diabetic retinopathy
CN108463235A (en) 2015-12-18 2018-08-28 泰伦基国际有限公司 A method of for preventing and treating cervical erosion
CA3008475C (en) * 2015-12-18 2024-06-04 Talengen International Limited Method for preventing and treating hepatic tissue injury and related disorders thereof
DK3391902T3 (en) 2015-12-18 2023-11-20 Talengen Int Ltd PLASMINOGEN FOR USE IN THE TREATMENT OF DIABETIC ANGIOCARDIOPATHY
CN106890319A (en) * 2015-12-18 2017-06-27 深圳瑞健生命科学研究院有限公司 A kind of method prevented or treat BDR
WO2017101866A1 (en) * 2015-12-18 2017-06-22 深圳瑞健生命科学研究院有限公司 Method for preventing or treating acute thrombosis and chronic thrombosis
CN108778307A (en) 2015-12-18 2018-11-09 泰伦基国际有限公司 A method of prevention and treatment diabetic nephropathy
WO2017101873A1 (en) 2015-12-18 2017-06-22 深圳瑞健生命科学研究院有限公司 Method for preventing or treating radiation and chemical damage
CN106890320A (en) * 2015-12-18 2017-06-27 深圳瑞健生命科学研究院有限公司 It is a kind of for preventing or treating acute and Chronic Thrombotic method
CN106890323A (en) * 2015-12-18 2017-06-27 深圳瑞健生命科学研究院有限公司 A kind of method for preventing and treating liver tissue injury and its associated conditions
CN110191718A (en) * 2016-12-15 2019-08-30 泰伦基国际有限公司 A method of preventing and treating histoorgan fibrosis
WO2018107701A1 (en) 2016-12-15 2018-06-21 深圳瑞健生命科学研究院有限公司 Novel drug for reducing blood glucose and improving glucose tolerance
CN108210915A (en) * 2016-12-15 2018-06-29 深圳瑞健生命科学研究院有限公司 Improve drug of heart disease and application thereof
CN108210901A (en) * 2016-12-15 2018-06-29 深圳瑞健生命科学研究院有限公司 A kind of new drug that is hypoglycemic and improving sugar tolerance
TW202123962A (en) * 2016-12-15 2021-07-01 大陸商深圳瑞健生命科學研究院有限公司 Method for preventing and treating kidney fibrosis
CN110114079A (en) 2016-12-15 2019-08-09 泰伦基国际有限公司 A kind of method and drug preventing and treating obesity
CA3047167A1 (en) 2016-12-15 2018-06-21 Talengen International Limited Method for treating and preventing atherosclerosis and complications thereof
CN108210904A (en) * 2016-12-15 2018-06-29 深圳瑞健生命科学研究院有限公司 Treat drug of atherosclerosis and its complication and application thereof
TWI677348B (en) 2016-12-15 2019-11-21 大陸商深圳瑞健生命科學研究院有限公司 A way to improve heart disease
US11938172B2 (en) 2017-06-19 2024-03-26 Talengen International Limited Method for regulating and controlling GLP-1/GLP-1R and drug
CN109971736B (en) * 2017-12-27 2021-07-23 中科院大连化物所盘锦产业技术研究院有限公司 Aminohexosidase related to strawberry softening, coding gene, preparation and application
CN110358780A (en) * 2018-04-10 2019-10-22 东莞泛亚太生物科技有限公司 A kind of gene encoding 'beta '-mannase, and the recombinant plasmid containing the gene and recombinant bacterium and its construction method
CN109456989B (en) * 2018-10-31 2022-03-29 陕西慧康生物科技有限责任公司 Construction method of vector for improving secretion expression of pichia pastoris
CN116854792A (en) * 2023-04-28 2023-10-10 优睿赛思(武汉)生物科技有限公司 Mutant alpha-factor signal peptide, coding gene, expression vector and application thereof

Family Cites Families (3)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US5190756A (en) * 1989-12-01 1993-03-02 Genentech, Inc. Methods and materials for expression of human plasminogen variant
GB9222758D0 (en) * 1992-10-29 1992-12-09 British Bio Technology Proteins and nucleic acids
JP4047170B2 (en) * 2000-12-21 2008-02-13 トロム−イクス・ナムローゼ・フエンノートシャップ Yeast expression vector and method for producing recombinant protein by expression in yeast cells

Also Published As

Publication number Publication date
MXPA04007585A (en) 2005-09-20
CA2475277A1 (en) 2003-08-14
EP1472346A2 (en) 2004-11-03
AU2003210137A1 (en) 2003-09-02
WO2003066842A3 (en) 2004-06-10
CN1768138A (en) 2006-05-03
WO2003066842A2 (en) 2003-08-14
JP2005525798A (en) 2005-09-02

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Legal Events

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MK6 Application lapsed section 142(2)(f)/reg. 8.3(3) - pct applic. not entering national phase