AU2002336085B2 - C2-substituted Indane-1-ones and their derivatives, method for their production and their use as medicaments - Google Patents
C2-substituted Indane-1-ones and their derivatives, method for their production and their use as medicaments Download PDFInfo
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- AU2002336085B2 AU2002336085B2 AU2002336085A AU2002336085A AU2002336085B2 AU 2002336085 B2 AU2002336085 B2 AU 2002336085B2 AU 2002336085 A AU2002336085 A AU 2002336085A AU 2002336085 A AU2002336085 A AU 2002336085A AU 2002336085 B2 AU2002336085 B2 AU 2002336085B2
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- -1 C2-substituted Indane-1-ones Chemical class 0.000 title claims description 34
- 238000000034 method Methods 0.000 title claims description 18
- 239000003814 drug Substances 0.000 title claims description 9
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- 150000001875 compounds Chemical class 0.000 claims description 131
- 150000003839 salts Chemical class 0.000 claims description 18
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- 229910052731 fluorine Inorganic materials 0.000 claims description 10
- 238000011282 treatment Methods 0.000 claims description 10
- 230000003647 oxidation Effects 0.000 claims description 9
- 238000007254 oxidation reaction Methods 0.000 claims description 9
- 238000011321 prophylaxis Methods 0.000 claims description 9
- 229910052739 hydrogen Inorganic materials 0.000 claims description 8
- 241000124008 Mammalia Species 0.000 claims description 7
- 125000000217 alkyl group Chemical group 0.000 claims description 7
- 125000000896 monocarboxylic acid group Chemical group 0.000 claims description 7
- 125000004178 (C1-C4) alkyl group Chemical group 0.000 claims description 6
- PXGOKWXKJXAPGV-UHFFFAOYSA-N Fluorine Chemical compound FF PXGOKWXKJXAPGV-UHFFFAOYSA-N 0.000 claims description 6
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- 125000004435 hydrogen atom Chemical group [H]* 0.000 claims description 6
- 208000008589 Obesity Diseases 0.000 claims description 5
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- 229910052799 carbon Inorganic materials 0.000 claims description 3
- 125000006297 carbonyl amino group Chemical group [H]N([*:2])C([*:1])=O 0.000 claims description 3
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- 125000004940 pyridazin-4-yl group Chemical group N1=NC=C(C=C1)* 0.000 description 1
- 125000000246 pyrimidin-2-yl group Chemical group [H]C1=NC(*)=NC([H])=C1[H] 0.000 description 1
- 125000000714 pyrimidinyl group Chemical group 0.000 description 1
- 229960001455 quinapril Drugs 0.000 description 1
- JSDRRTOADPPCHY-HSQYWUDLSA-N quinapril Chemical compound C([C@@H](C(=O)OCC)N[C@@H](C)C(=O)N1[C@@H](CC2=CC=CC=C2C1)C(O)=O)CC1=CC=CC=C1 JSDRRTOADPPCHY-HSQYWUDLSA-N 0.000 description 1
- 150000003254 radicals Chemical class 0.000 description 1
- 230000009103 reabsorption Effects 0.000 description 1
- 238000010992 reflux Methods 0.000 description 1
- 238000009877 rendering Methods 0.000 description 1
- 150000008223 ribosides Chemical class 0.000 description 1
- 229960004586 rosiglitazone Drugs 0.000 description 1
- 229960004889 salicylic acid Drugs 0.000 description 1
- 229940076279 serotonin Drugs 0.000 description 1
- 230000000697 serotonin reuptake Effects 0.000 description 1
- 239000003772 serotonin uptake inhibitor Substances 0.000 description 1
- 229960004425 sibutramine Drugs 0.000 description 1
- 229960002855 simvastatin Drugs 0.000 description 1
- RYMZZMVNJRMUDD-HGQWONQESA-N simvastatin Chemical compound C([C@H]1[C@@H](C)C=CC2=C[C@H](C)C[C@@H]([C@H]12)OC(=O)C(C)(C)CC)C[C@@H]1C[C@@H](O)CC(=O)O1 RYMZZMVNJRMUDD-HGQWONQESA-N 0.000 description 1
- 210000003491 skin Anatomy 0.000 description 1
- 239000011734 sodium Substances 0.000 description 1
- RMBAVIFYHOYIFM-UHFFFAOYSA-M sodium methanethiolate Chemical compound [Na+].[S-]C RMBAVIFYHOYIFM-UHFFFAOYSA-M 0.000 description 1
- RZWQDAUIUBVCDD-UHFFFAOYSA-M sodium;benzenethiolate Chemical compound [Na+].[S-]C1=CC=CC=C1 RZWQDAUIUBVCDD-UHFFFAOYSA-M 0.000 description 1
- 239000012453 solvate Substances 0.000 description 1
- 239000007921 spray Substances 0.000 description 1
- 238000007920 subcutaneous administration Methods 0.000 description 1
- 125000001424 substituent group Chemical group 0.000 description 1
- IIACRCGMVDHOTQ-UHFFFAOYSA-N sulfamic acid Chemical compound NS(O)(=O)=O IIACRCGMVDHOTQ-UHFFFAOYSA-N 0.000 description 1
- 150000003462 sulfoxides Chemical class 0.000 description 1
- FWMUJAIKEJWSSY-UHFFFAOYSA-N sulfur dichloride Chemical compound ClSCl FWMUJAIKEJWSSY-UHFFFAOYSA-N 0.000 description 1
- 239000000829 suppository Substances 0.000 description 1
- 239000004094 surface-active agent Substances 0.000 description 1
- 239000000725 suspension Substances 0.000 description 1
- 229960001367 tartaric acid Drugs 0.000 description 1
- 229960001693 terazosin Drugs 0.000 description 1
- VCKUSRYTPJJLNI-UHFFFAOYSA-N terazosin Chemical compound N=1C(N)=C2C=C(OC)C(OC)=CC2=NC=1N(CC1)CCN1C(=O)C1CCCO1 VCKUSRYTPJJLNI-UHFFFAOYSA-N 0.000 description 1
- 238000012360 testing method Methods 0.000 description 1
- 238000002560 therapeutic procedure Methods 0.000 description 1
- 150000001467 thiazolidinediones Chemical class 0.000 description 1
- 150000003568 thioethers Chemical class 0.000 description 1
- 125000003396 thiol group Chemical group [H]S* 0.000 description 1
- 229960004605 timolol Drugs 0.000 description 1
- 239000000196 tragacanth Substances 0.000 description 1
- 235000010487 tragacanth Nutrition 0.000 description 1
- 229940116362 tragacanth Drugs 0.000 description 1
- ITMCEJHCFYSIIV-UHFFFAOYSA-N triflic acid Chemical compound OS(=O)(=O)C(F)(F)F ITMCEJHCFYSIIV-UHFFFAOYSA-N 0.000 description 1
- 230000007306 turnover Effects 0.000 description 1
- 229960001130 urapidil Drugs 0.000 description 1
- 239000000777 urocortin Substances 0.000 description 1
- 229960001722 verapamil Drugs 0.000 description 1
- 239000007762 w/o emulsion Substances 0.000 description 1
- 229940124024 weight reducing agent Drugs 0.000 description 1
Classifications
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
- C07C317/00—Sulfones; Sulfoxides
- C07C317/24—Sulfones; Sulfoxides having sulfone or sulfoxide groups and doubly-bound oxygen atoms bound to the same carbon skeleton
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P3/00—Drugs for disorders of the metabolism
- A61P3/04—Anorexiants; Antiobesity agents
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P3/00—Drugs for disorders of the metabolism
- A61P3/08—Drugs for disorders of the metabolism for glucose homeostasis
- A61P3/10—Drugs for disorders of the metabolism for glucose homeostasis for hyperglycaemia, e.g. antidiabetics
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
- C07C323/00—Thiols, sulfides, hydropolysulfides or polysulfides substituted by halogen, oxygen or nitrogen atoms, or by sulfur atoms not being part of thio groups
- C07C323/22—Thiols, sulfides, hydropolysulfides or polysulfides substituted by halogen, oxygen or nitrogen atoms, or by sulfur atoms not being part of thio groups containing thio groups and doubly-bound oxygen atoms bound to the same carbon skeleton
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
- C07C2602/00—Systems containing two condensed rings
- C07C2602/02—Systems containing two condensed rings the rings having only two atoms in common
- C07C2602/04—One of the condensed rings being a six-membered aromatic ring
- C07C2602/08—One of the condensed rings being a six-membered aromatic ring the other ring being five-membered, e.g. indane
Landscapes
- Chemical & Material Sciences (AREA)
- Organic Chemistry (AREA)
- Health & Medical Sciences (AREA)
- Diabetes (AREA)
- Pharmacology & Pharmacy (AREA)
- Life Sciences & Earth Sciences (AREA)
- Hematology (AREA)
- Obesity (AREA)
- Engineering & Computer Science (AREA)
- Chemical Kinetics & Catalysis (AREA)
- General Chemical & Material Sciences (AREA)
- Medicinal Chemistry (AREA)
- Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
- Veterinary Medicine (AREA)
- Public Health (AREA)
- Bioinformatics & Cheminformatics (AREA)
- Animal Behavior & Ethology (AREA)
- General Health & Medical Sciences (AREA)
- Emergency Medicine (AREA)
- Endocrinology (AREA)
- Child & Adolescent Psychology (AREA)
- Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
- Acyclic And Carbocyclic Compounds In Medicinal Compositions (AREA)
- Organic Low-Molecular-Weight Compounds And Preparation Thereof (AREA)
- Pyridine Compounds (AREA)
- Heterocyclic Carbon Compounds Containing A Hetero Ring Having Nitrogen And Oxygen As The Only Ring Hetero Atoms (AREA)
- Indole Compounds (AREA)
- Heterocyclic Compounds Containing Sulfur Atoms (AREA)
Applications Claiming Priority (3)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| DE10142722.0 | 2001-08-31 | ||
| DE10142722A DE10142722A1 (de) | 2001-08-31 | 2001-08-31 | C2-substituierte Indan-1-one und ihre Derivate, Verfahren zu ihrer Herstellung und ihre Verwendung als Arzneimittel |
| PCT/EP2002/009207 WO2003020677A2 (de) | 2001-08-31 | 2002-08-17 | C2-substituierte indan-1-one und ihre derivate, verfahren zu ihrer herstellung und ihre verwendung als arzneimittel |
Publications (2)
| Publication Number | Publication Date |
|---|---|
| AU2002336085A1 AU2002336085A1 (en) | 2003-06-05 |
| AU2002336085B2 true AU2002336085B2 (en) | 2007-10-11 |
Family
ID=7697277
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| AU2002336085A Ceased AU2002336085B2 (en) | 2001-08-31 | 2002-08-17 | C2-substituted Indane-1-ones and their derivatives, method for their production and their use as medicaments |
Country Status (12)
| Country | Link |
|---|---|
| US (1) | US6762326B2 (https=) |
| EP (1) | EP1425267B1 (https=) |
| JP (1) | JP4280164B2 (https=) |
| AR (1) | AR036675A1 (https=) |
| AT (1) | ATE472525T1 (https=) |
| AU (1) | AU2002336085B2 (https=) |
| CA (1) | CA2458528C (https=) |
| DE (2) | DE10142722A1 (https=) |
| IL (1) | IL160608A0 (https=) |
| MX (1) | MXPA04001846A (https=) |
| PE (1) | PE20030360A1 (https=) |
| WO (1) | WO2003020677A2 (https=) |
Families Citing this family (2)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| GB9920393D0 (en) | 1999-08-27 | 1999-11-03 | Medix Scient Uk Limited | Plant extract mixtures and their uses |
| US7659313B2 (en) | 2007-09-13 | 2010-02-09 | Gateway Health Alliances, Inc. | Methods and related compositions using specific indanes to reduce weight and inhibit lipase, α-amylase and α-glucosidase activity in mammals |
Citations (2)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| US4129656A (en) * | 1976-01-20 | 1978-12-12 | Hoechst Aktiengesellschaft | Thiazolidine derivatives, salidiuretic compositions and methods of effecting salidiuresis employing them |
| WO2001002373A1 (fr) * | 1999-07-06 | 2001-01-11 | Merck Patent Gmbh | Dihydrobenzodiazepines et leur utilisation dans le traitement de dyslipidemies |
Family Cites Families (13)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| DE2640358A1 (de) * | 1976-09-08 | 1978-03-16 | Hoechst Ag | Thiazolidinderivate und verfahren zu ihrer herstellung |
| EP0009554B1 (de) * | 1978-07-27 | 1983-04-27 | Schering Aktiengesellschaft | Indanyl-Derivate, Verfahren zu ihrer Herstellung und diese Verbindungen enthaltende pharmazeutische Präparate |
| WO1989003681A1 (en) * | 1987-10-19 | 1989-05-05 | Pfizer Inc. | Substituted tetralins, chromans and related compounds in the treatment of asthma |
| SG47557A1 (en) * | 1993-01-29 | 1998-04-17 | American Cyanamid Co | Aminocycloalkanobenzodioxoles as beta-3 selective adrenergic agents |
| WO1997020802A1 (en) * | 1995-12-06 | 1997-06-12 | Venantius Limited | Indane dimer compounds and their pharmaceutical use |
| AU727775B2 (en) | 1996-01-17 | 2000-12-21 | Novo Nordisk A/S | Fused 1,2,4-thiadiazine and fused 1,4-thiazine derivatives, their preparation and use |
| IL128332A0 (en) | 1996-08-30 | 2000-01-31 | Novo Nordisk As | GLP-1 derivatives |
| IL127296A (en) | 1996-12-31 | 2003-01-12 | Reddy Research Foundation | Heterocyclic compounds, process for their preparation and pharmaceutical compositions containing them |
| PL338013A1 (en) | 1997-07-16 | 2000-09-25 | Novo Nordisk As | Derivatives of condensed 1,2,4-thiadiazine, their production and application |
| DE19831878C2 (de) * | 1998-07-17 | 2001-05-17 | Aventis Pharma Gmbh | Polycyclische Thiazolidin-2-yliden Amine, Verfahren zu ihrer Herstellung und ihre Verwendung als Arzneimittel |
| DE19844547C2 (de) * | 1998-09-29 | 2002-11-07 | Aventis Pharma Gmbh | Polycyclische Dihydrothiazole, Verfahren zu ihrer Herstellung und ihre Verwendung als Arzneimittel |
| DE19908539A1 (de) * | 1999-02-26 | 2000-08-31 | Aventis Pharma Gmbh | Polycyclische 2-Amino-Dihydrothiazolsysteme, Verfahren zu ihrer Herstellung und ihre Verwendung als Arzneimittel |
| EP1078632A1 (en) | 1999-08-16 | 2001-02-28 | Sanofi-Synthelabo | Use of monoamine oxydase inhibitors for the manufacture of drugs intended for the treatment of obesity |
-
2001
- 2001-08-31 DE DE10142722A patent/DE10142722A1/de not_active Withdrawn
-
2002
- 2002-08-17 JP JP2003524950A patent/JP4280164B2/ja not_active Expired - Fee Related
- 2002-08-17 AT AT02769973T patent/ATE472525T1/de active
- 2002-08-17 WO PCT/EP2002/009207 patent/WO2003020677A2/de not_active Ceased
- 2002-08-17 CA CA2458528A patent/CA2458528C/en not_active Expired - Fee Related
- 2002-08-17 IL IL16060802A patent/IL160608A0/xx unknown
- 2002-08-17 EP EP02769973A patent/EP1425267B1/de not_active Expired - Lifetime
- 2002-08-17 AU AU2002336085A patent/AU2002336085B2/en not_active Ceased
- 2002-08-17 DE DE50214511T patent/DE50214511D1/de not_active Expired - Lifetime
- 2002-08-17 MX MXPA04001846A patent/MXPA04001846A/es active IP Right Grant
- 2002-08-22 PE PE2002000806A patent/PE20030360A1/es not_active Application Discontinuation
- 2002-08-29 AR ARP020103245A patent/AR036675A1/es unknown
- 2002-08-30 US US10/231,326 patent/US6762326B2/en not_active Expired - Lifetime
Patent Citations (2)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| US4129656A (en) * | 1976-01-20 | 1978-12-12 | Hoechst Aktiengesellschaft | Thiazolidine derivatives, salidiuretic compositions and methods of effecting salidiuresis employing them |
| WO2001002373A1 (fr) * | 1999-07-06 | 2001-01-11 | Merck Patent Gmbh | Dihydrobenzodiazepines et leur utilisation dans le traitement de dyslipidemies |
Also Published As
| Publication number | Publication date |
|---|---|
| DE10142722A1 (de) | 2003-03-27 |
| CA2458528A1 (en) | 2003-03-13 |
| AR036675A1 (es) | 2004-09-29 |
| EP1425267B1 (de) | 2010-06-30 |
| IL160608A0 (en) | 2004-07-25 |
| US20030130345A1 (en) | 2003-07-10 |
| MXPA04001846A (es) | 2004-06-15 |
| CA2458528C (en) | 2011-01-25 |
| WO2003020677A2 (de) | 2003-03-13 |
| ATE472525T1 (de) | 2010-07-15 |
| WO2003020677A3 (de) | 2003-07-31 |
| US6762326B2 (en) | 2004-07-13 |
| EP1425267A2 (de) | 2004-06-09 |
| PE20030360A1 (es) | 2003-05-16 |
| JP4280164B2 (ja) | 2009-06-17 |
| DE50214511D1 (de) | 2010-08-12 |
| JP2005525295A (ja) | 2005-08-25 |
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Legal Events
| Date | Code | Title | Description |
|---|---|---|---|
| PC1 | Assignment before grant (sect. 113) |
Owner name: SANOFI-AVENTIS DEUTSCHLAND GMBH Free format text: FORMER APPLICANT(S): AVENTIS PHARMA DEUTSCHLAND GMBH |
|
| FGA | Letters patent sealed or granted (standard patent) | ||
| MK14 | Patent ceased section 143(a) (annual fees not paid) or expired |