AU2002235071A1 - Injection syringe having dosage device - Google Patents

Injection syringe having dosage device

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Publication number
AU2002235071A1
AU2002235071A1 AU2002235071A AU2002235071A AU2002235071A1 AU 2002235071 A1 AU2002235071 A1 AU 2002235071A1 AU 2002235071 A AU2002235071 A AU 2002235071A AU 2002235071 A AU2002235071 A AU 2002235071A AU 2002235071 A1 AU2002235071 A1 AU 2002235071A1
Authority
AU
Australia
Prior art keywords
ampoule
connection
syringe
injection device
outer syringe
Prior art date
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Granted
Application number
AU2002235071A
Other versions
AU2002235071B2 (en
Inventor
Mats Bonnier
Current Assignee (The listed assignees may be inaccurate. Google has not performed a legal analysis and makes no representation or warranty as to the accuracy of the list.)
MATS BONNIER SJUKVARD OCH UTVECKLING AB
Original Assignee
MATS BONNIER SJUKVARD OCH UTVECKLING AB
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Priority claimed from SE0100709A external-priority patent/SE518708C2/en
Application filed by MATS BONNIER SJUKVARD OCH UTVECKLING AB filed Critical MATS BONNIER SJUKVARD OCH UTVECKLING AB
Publication of AU2002235071A1 publication Critical patent/AU2002235071A1/en
Application granted granted Critical
Publication of AU2002235071B2 publication Critical patent/AU2002235071B2/en
Anticipated expiration legal-status Critical
Ceased legal-status Critical Current

Links

Description

Injection syringe having dosage device
DESCRIPTION
TECHNICAL AREA A hypodermic syringe comprising an outer syringe being arranged in connection with an ampoule for medical agent. The ampoule is mutually displaceable inside the outer syringe, whereby an indication device is arranged to the ampoule and applied to be uncovered at the mutual displacement, whereby a dosage is adjustable and readable.
BACKGROUND OF THE INVENTION Diabetes is a chronic metabolic disease, which is characterised in the lack of the hormone insulin. There is different types of diabetes, whereof the type 1 diabetes exists when the ability of the pancreas to produce insulin successively decrease or cease, leading to lack of insulin. At the type 1 diabetes the treatment, except for cost treatment, also consists of supplying insulin, which is given via injection under the skin four to eight times a day.
Diabetes is a disease, which in worst case, particularly at the type 1 diabetes, may cause death if not treated in a correct way. In other cases complications may appear such as kidney injuries, lack of circulation, particularly the extremities, eye damages leading to blindness, to early death, etcetera.
Technical means exist such as syringe pencils and insulin pumps, considerably facilitating the supply of insulin. The syringe pencil contains insulin and a hypodermic needle in one unit, which, for instance, can be carried in the breast pocket. Insulin pumps are battery operated and carried outside the body, and then the insulin is introduced via a plastic catheter and a hypodermic needle being mounted under the skin.
In the present-day situation it is very common that the diabetic patient him or herself injects the insulin by means of a syringe pencil according to the construction mentioned above. When a syringe pencil is carried in the daily life it is desirable that it is easy to use, reliable, as accurate as possible in dosing. Another desired object is that one and the same syringe pencil can be used several times, even having the same medicine ampoule left therein.
The state of the art shows a number of syringe pencils.
In EP 0 688 571 and EP 0 702 970 a medicine pencil with an injection and dosage construction is shown, having a very complex construction with a large number of parts. In EP 0 388 806 a syringe exists, which comprises a.o. a helical spring with a rotary casing for dosage. Additional syringe pencils are shown in WO 89/07463 and DE 40 13 769, which, however, exhibit very complex constructions.
US-A-5,454,793 shows an injection syringe having a rotating, piston rod-receiving unit, in which unit an ampoule can be inserted and rotated into position in the syringe before administrating. There is not any possibility to predetermine the dose size in this device.
Altogether, the documents above indicates that improvements of syringe pencils are desirable in the aspect of achieving syringe pencils having a simple construction, being inexpensive to produce, and which are also appropriate for use several times having the same ampoule or cartridge containing medical agent, or reusable with the exchange of the medical ampoule or cartridge.
SUMMARY OF THE INVENTION The main object of the present invention is to provide an injection device comprising an outer syringe, which is arranged in connection with an ampoule for medical agent. The ampoule is mutually movable or displaceable inside the outer syringe, whereby an indication device is arranged in connection with the ampoule, which is applied to be uncovered at the mutual displacement, whereby a dosage can be adjustable and readable.
This object is obtained by means of a device according to claim 1. The preferred embodiments are evident by the appended claims.
SHORT DESCRIPTION OF THE DRAWINGS In the following, the invention will be described in more detail and in a non-limiting way with reference to the accompanying drawings, in which:
Fig. la schematically shows a side-view of a piston to an injection pencil;
Fig. lb schematically shows a side-view of an ampoule or cartridge containing medical agent to an injection pencil;
Fig. lc schematically shows a side-view of an outer syringe according to a first and a second preferred embodiment of the invention;
Fig. Id schematically shows a side-view of an outer front part of an outer syringe according to a second preferred embodiment of the invention;
Fig. le schematically shows a side-view and a front-view of a supporting washer to an injection pencil of a preferred embodiment of the invention ;
Fig. If schematically shows a side-view of a safety casing for the hypodermic needle of an injection pencil;
Fig. lg schematically shows a side-view of a safety plug for the piston to an injection pencil;
Fig. 2 schematically shows a side-view of the hypodermic needle and the piston arranged in connection with a medical ampoule or cartridge containing medical agent; Fig.3 schematically shows a side-view of the hypodermic needle, the piston and the medical ampoule or cartridge containing the medical agent arranged in an outer syringe according to a first embodiment of the invention; and Fig. 4 schematically shows a side-view of the hypodermic needle, the piston and the medical ampoule or cartridge containing the medical agent arranged in an outer syringe according to a second embodiment of the invention.
DETAILED DESCRIPTION OF EMBODIMENTS
An injection device with a dosage device comprises a piston 1, an ampoule 2, a hypodermic syringe 3, a first preferred embodiment of an outer syringe 5, or an outer front member of a second preferred injection device 4 'and a second preferred embodiment of an outer syringe 5 ' , a support washer 6, a protecting cover 7 and a safety plug 8, see Figs, la -g.
The injection device such as a syringe pencil is in a first preferred embodiment particularly preferred for use one or several times, see Fig. 3. A second preferred embodiment of the syringe pencil is particularly preferred for use several times and reuse, see Fig. 4. With reuse meansthat it is intended for one or a number of exchanges of the ampoule 2 of the syringe pencil to new ampoules 2 containing medical.
In a preferred embodiment of the invention said ampoule 2 is preferably a container such as an ampoule or a cartridge containing a medical agent in multiple production in the present-day-situation. A hypodermic needle 3 is fixedly arranged to the ampoule 2, see Fig. lb. Moreover, a piston 1 is arranged in connection with the ampoule 2.
In greater detail, said piston 1 comprises a rod piston 11, a tube or the like, preferably with a substantially circular cross section. The piston 1 is in one of its ends provided with a washer 12, see Fig. la, which is used as a pressure surface at injection, e.g. by a thumb of a patient. The piston 1 is in its other end provided with a sealing device 13. The sealing device 13 is preferably a sealing body of an elastic material, e.g. a polymer, a rubber or the like, which closes tightly at contact and abutment to a surface. Such sealing and sealing materials are known at prevalent syringes.
In a preferred embodiment of the invention the piston 1 is provided with an indication device 14, preferably in the form of a graduated longitudinal scale, which is divided into units, which preferably correspond to volume units of medical agent.
Further the ampoule 2 is shaped as an elongated hollow tube 21, being closed at both ends, and closes a medical agent in liquid form, see Fig. lb. The ampoule 2 preferably shows a substantially circular cross section. The ampoule 2 is provided with a stopping device 22 in one of its ends, e.g. a lip, wedge, collar or the like, which for instance shows a stop position for the piston 1 at the injection by the ampoule 2. The ampoule 2 is provided with a fixedly arranged hypodermic needle 3 in its other end.
In a first particularly preferred embodiment of the invention according to above, the ampoule 2 is provided with a connection device 23 for connecting the ampoule 2 with the outer syringe 5, see Figs lb-c. The connection device 23 is preferably arranged in the same end of the ampoule 2 as the stopping device 22. The connection device 23 consists preferably of external threads, splines or the like.
In a second particularly preferred embodiment of the invention according to above the ampoule is provided with a second connection device 24 for connecting the ampoule 2 to a second embodiment of the injection device 5 ' . The connection device 24 is preferably arranged in connection with the hypodermic needle 3, and consists preferably of external threads, splines or the like.
Finally, the ampoule 2 is provided with an indication device 24 or reading device on its surrounding surface or envelope surface, preferably in the form of a graduated longitudinal scale. The indication device 25 is divided into units corresponding to volume unit's medical agent in the ampoule 2.
Altogether, concerning the medicine ampoule 2 in its entirety, said ampoule 2 is mutually arranged with the hypodermic needle 3 and the piston 1 according to the following. The sealing device 13 and a part of the piston rod 11 is applied inside the ampoule 2 in such a way that the sealing device 13 fits tightly against the interior enveloping surface of the ampoule 2, see Fig.2. The sealing device 13 provides that leakage of the medical agent does not occur of the ampoule 2, and particularly not in connection with the sealing device 13. Further, the sealing device 13 can slide along the interior enveloping surface of the ampoule 2 with the movement of the piston 1 inside the ampoule 2, preferably in the direction toward the hypodermic needle 3, whereby the sealing device 13 fits tightly against the interior enveloping surface without leakage of the medical agent occuring from the ampoule 2.
In a first preferred embodiment of the invention, the ampoule 2, the hypodermic needle 3 and the piston 1, which are mutually arranged according the description above, are arranged in said outer syringe 5, see Fig. 3.
The outer syringe 5 comprises a part, such as a tube 52, housing or the like, see Fig. lc. The outer syringe 5 shows a substantially circular cross section and an inside diameter being substantially larger than the outer diameter of the ampoule 2. Further, the outer syringe 5 is provided with a connection device 51 for connection with the ampoule 2.The connection device 51 is preferably arranged along the interior surrounding surface or the enveloping surface of the outer syringe 5, and preferably comprises internal threads, splines or the like, corresponding and co-operating with the connection device 23 of the ampoule 2. At the connection of the ampoule, comprising the hypodermic needle 3 and the piston 1, with the outer syringe 5, the ampoule is fastened into the outer syringe 5 by means of the connection devices 23 and 51. In this way, the ampoule 2 is also moveable or displaceable inside the outer syringe 5, whereby the outer syringe is moveable along the outer envelope surface of the ampoule 2 in a corresponding way, see Fig.3.
The outer syringe 5 is provided with a supporting washer 6 for achieving an improved axial operation of the movement of the piston 1 inside the ampoule 2. The supporting washer 6 comprises a spline 61, such as a hole, recess or the like, in which spline 61 the piston rod 11 of the piston 1 is arranged, see Fig. le. Consequently, the supporting washer 6 achieves an improved accuracy and reliability, and decreases the risk for leakage of the injection pencil as well.
The injection pencil according a first improved embodiment is used in the following way.
A dosage is performed by means of the relative displacement of the outer syringe 5 along the ampoule 2 in the direction toward the hypodermic needle 3 before the injection, which is applicable both for use of a new ampoule 2 and the succeeding injections. Thus, an adjustment of the specific medicine dose is carried out by means of the required number of units or scale shares according to the indication device 25.
In a preferred embodiment of the invention, a reading of the position of the outer syringe 5 relative to the ampoule 2 occurs, for instance in the uncovered point 26 between the outer syringe 5 and the ampoule 2 of the indication device 25, see Fig. 3.
At the injection the outer syringe 5 is screwed, in the direction towards the hypodermic needle 3, the number of scale units of medical agent corresponding to the medicine dose needed according to the indication device 25. Then the piston 1 is pushed into the ampoule 2 by pressing the washer 12. At the movement of the piston 1 into the ampoule 2 the medical agent is pressed out of the ampoule 2 via the hypodermic needle 3. The piston 1 is stopped in its movement by the supporting washer 6, whereby the injection according to the adjusted dose of medical agent is executed.
According to the description mentioned above dosage and injection can be repeated until the piston 1 substantially reaches the bottom or the end position of the ampoule 2, whereby the ampoule 2 has been emptied of medical agent.
The remaining amount of medical agent of the ampoule 2 substantially corresponds to the absolute position of the outer syringe 5 along the ampoule 2, specified in units or scale shares of the indication device 25, which is applicable after the previous injection, but on the other hand before dosage. When there is an emptied medicine ampoule 2 in the injection pencil an exchange to a new ampoule 2 is performed by demounting the supporting washer 6 before the empty ampoule 2 is screwed out of the outer syringe 5, preferably in the opposite direction than at dosage, by means of the connection devices 51 and 23. A new ampoule 2 containing medical agent is arranged to the outer pencil 5 according to above.
Finally, the injection pencil is provided with a protecting cover 7 for protecting the patient against the needlepoint of the hypodermic needle 3 at bringing the injection pencil, but also for giving a substantially sterile needlepoint of the hypodermic needle 3, see Fig. If. Moreover, the injection pencil is provided with a safety plug for avoiding that the piston is exposed for unnecessary pushs or impacts, see Fig. lg.
A second particulariy preferred embodiment of the invention comprises an outer syringe 5 'and an outer front part 4 'for the outer syringe 5 ', except the included parts of the injection device mentioned above, see Fig. 4.
According to a second particulariy preferred embodiment of the invention, the outer syringe 5 'has substantially the same construction as in the said first preferred embodiment, except regarding dimensions, etc.
The said outer front part of the outer syringe 4 'is a tube, a casing or the like having a substantially circularly cross section and a diameter substantially larger than the diameter of said ampoule 2, see Fig. Id. Further, the member 4 ' s provided with an connection device 41 for the ampoule 2is in one of its internal end, preferably in form of internal threads, splines or the like, and provided with an connection device 42 for the outer syringe 5 ' on its outer surrounding surface or envelope surface, preferably in the form of external threads, splines or the like.
Moreover, the outer front part 4 'to the outer syringe 5 ' is provided with an indication device 43 on its surrounding outer surface or enveloping surface, preferably in the form of a longitudinal readable scale, in the corresponding way as the ampoule 2 is provided with an indication device 23 according to the first particularly preferred embodiment of the invention.
The outer syringe 5 'exhibits a diameter being substantially larger than the diameter of the outer front part 4 'of the outer syringe 5 'and an inside diameter adjusted to the outer diameter of the front part. The connection device 51 of the outer syringe 5 'corresponds to and co-operates with the outer connection device 42 of the outer front part 4 'of the outer syringe 5 'in the same way as the connection devices 51 and 23 are corresponding and co- operating between the outer syringe 5 and the ampoule 2 according to the first particularly preferred embodiment of the invention.
In a second particularly preferred embodiment of the invention, the ampoule 2 is brought inside the outer front part of the outer syringe 4 'by inserting and screwing the ampoule 2 into the outer front part 4 ', whereby this is brought to an end position, preferably to a locking by means of the connection devices 41 and 24. Then the outer front part 4 ' is brought to the outer syringe 5 'comprising the ampoule 2, preferably by insertion and displacement by means of the connection devices 51 and 42, respectively, see Fig. 4.
Thus, the outer syringe 5 'is displaceable along the outer front part 4 ' in a direction toward the hypodermic needle 3, whereby the outer pencil 5 'is displaceable along the indication device 42 in the corresponding way as the outer syringe 5 according to the first preferred embodiment is displaceable or telescopeable along the indications device 23.
Dosage and injection with a hypodermic syringe, according the second particulariy preferred embodiment of the invention, is carried out in a corresponding way as with the injection pencil according to the first preferred embodiment of the invention.
The outer syringe 5, 5 'is also provided with an indication device 53 according to other embodiments of the invention.
In a particulariy preferred embodiment said injection pencil is an insulin pencil, and said medical agent is consequently insulin.
The invention is not limited to the shown embodiments but can be varied in a number of different ways, for instance by combination of two or more of the embodiments shown, without depart from the scope of the appended claims, and the arrangement and the method can be implemented in a number of ways depending on application, functional units, needs and requirements and so on.

Claims (13)

  1. CLAIMS l.An injection device comprising an outer syringe (5, 5 '), which is arranged in connection with an ampoule (2) for medical agent comprising a piston inserted therein, characterised in that the ampoule (2) is axially displaceable inside the outer syringe (5, 5 ') relatively to this, whereby an indication device (14, 25, 43) is arranged in connection with the ampoule (2), which is established to be uncovered at the mutual displacement, whereby a dosage is adjustable and readable by the displacement of the ampoule relatively to the outer syringe (5, 5 '), and whereby the piston rod is arranged to cooperate with the outer syringe (5, 5 ') for giving said dose.
  2. 2. An injection device as claimed in claim 1, characterised in that the outer syringe (5) is provided with a connection device (51) in form of threads, splines or the like, and that the ampoule (2) is provided with a connection device (23) in form of threads, splines or the like, whereby these connection devices (51, 23) cooperate with each other.
  3. 3. An injection device as claimed in claim 2, characterised in that the ampoule (2) is mutually displaceable inside the outer syringe (5) by means of said connection devices (51, 23).
  4. 4. An injection device as claimed in any of the proceeding claims, characterised in that the ampoule (2) is preferably an ampoule or cartridge, containing a medical agent, existing in multiple production in the present-day-situation.
  5. 5. An injection device as claimed in any of the proceeding claims, characterised in that a piston (1) and a hypodermic needle (3) are arranged in connection with said ampoule (2).
  6. 6. An injection device as claimed in any of the proceeding claims, characterised in that a indication device (25) is arranged on the enveloping surface of the ampoule (2), preferably in the form of a graduated longitudinal scale, which is divided into units corresponding to volume units of medical agent.
  7. 7. An injection device as claimed in claim 1, characterised in that the outer syringe (5 ' ) is provided with a connection device (51) in the form of threads, splines or the like, and a front part arranged to the outer syringe (4 ') is provided with a connection device (42) in the form of threads, splines or the like, whereby these connection devices (51, 42) cooperate with each other.
  8. 8. An injection device as claimed in claim 7, 5 characterised in that the outer front part (4 ') comprising the ampoule (2) is mutually displaceable inside the outer syringe (5 ') by means of said connection devices (51, 42).
  9. 9. An injection device as claimed in any of the claims 7 to 8, 10 characterised in that the ampoule (2) is provided with a connection device (24) in the form of threads, splines or the like, and the front forward part (4 ' ) is provided with a connection device (41) of an outer front part (4 '), whereby these cooperate with each other.
  10. 15 10. An injection device as claimed in any of the claims 7 to 9, characterised in that the ampoule (2) is fixedly arranged to the outer front part (4 ') by means of the connection devices (24, 41).
  11. 20 11. An injection device as claimed in any of the claims 7 to 10, characterised in that a indication device (43) is arranged on the surrounding or enveloping surface of the outer front part (4 '), preferably in the form of a graduated longitudinal scale, which is divided into units corresponding to volume units of medical agent.
    25
  12. 12. An injection device according to any of the proceeding claims, characterised in that the injection device preferably shows a protecting cover for the hypodermic needle, and a safety plug for the piston.
    30
  13. 13. Method for adjustment of the dosage in connection with injection with an outer syringe (5, 5 ' ), which is arranged in connection with an ampoule (2) for medical agent, characterised in displacing the ampoule (2) inside the outer syringe (5, 5 ') for uncovering an indication 35 device (25, 43) in connection with the ampoule (2) at the mutual displacement, whereby a dosage is adjusted and read.
AU2002235071A 2001-02-28 2002-02-28 Injection syringe having dosage device Ceased AU2002235071B2 (en)

Applications Claiming Priority (3)

Application Number Priority Date Filing Date Title
SE0100709A SE518708C2 (en) 2001-02-28 2001-02-28 Syringe with metering device
SE0100709-5 2001-02-28
PCT/SE2002/000353 WO2002070050A1 (en) 2001-02-28 2002-02-28 Injection syringe having dosage device

Publications (2)

Publication Number Publication Date
AU2002235071A1 true AU2002235071A1 (en) 2003-03-13
AU2002235071B2 AU2002235071B2 (en) 2006-03-30

Family

ID=20283184

Family Applications (1)

Application Number Title Priority Date Filing Date
AU2002235071A Ceased AU2002235071B2 (en) 2001-02-28 2002-02-28 Injection syringe having dosage device

Country Status (9)

Country Link
US (1) US20040024365A1 (en)
EP (1) EP1363689B1 (en)
AT (1) ATE343405T1 (en)
AU (1) AU2002235071B2 (en)
CA (1) CA2438665A1 (en)
DE (1) DE60215617T2 (en)
NZ (1) NZ528119A (en)
SE (1) SE518708C2 (en)
WO (1) WO2002070050A1 (en)

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US20050215957A1 (en) * 2004-03-26 2005-09-29 Mallinckrodt Inc. Calibrated pushrod for injection volume control in prefilled syringes
US20070214692A1 (en) 2006-03-16 2007-09-20 Ferrara Kenneth D System for facilitating preparation of medication doses
US9345639B2 (en) 2006-03-16 2016-05-24 Kenneth D. Ferrara System for facilitating preparation of medication doses
EP2201973A1 (en) * 2008-12-23 2010-06-30 Sanofi-Aventis Deutschland GmbH Drug delivery device with piston rod carrying dose markings
US10207056B2 (en) * 2010-03-31 2019-02-19 Sanofi-Aventis Deutschland Gmbh Set of members for a drug delivery device, drug delivery device and set of drug delivery devices
CA3042909C (en) * 2010-06-18 2021-04-13 Becton, Dickinson And Company Adjustable dose setting plunger for syringe
WO2015156183A1 (en) * 2014-04-07 2015-10-15 ニプロ株式会社 Syringe
JP6945967B2 (en) * 2016-03-31 2021-10-06 ニプロ株式会社 Dosage regulator and syringe with it
CN113304377B (en) * 2021-04-25 2023-07-04 山东大学齐鲁医院 Injector for anesthesia

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US405100A (en) * 1889-06-11 Otto kloppe
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US778879A (en) * 1904-07-27 1905-01-03 Anton Molinari Syringe.
DE3715258C2 (en) * 1987-05-08 1996-10-31 Haselmeier Wilhelm Fa Injection device
US5374256A (en) * 1989-06-16 1994-12-20 Science Incorporated Fluid container for use with a fluid delivery apparatus
US5226896A (en) * 1990-04-04 1993-07-13 Eli Lilly And Company Dose indicating injection pen
US5112307A (en) * 1990-04-24 1992-05-12 Habley Medical Technology Corp. Dental syringe having a medication filled carpule and an automatically-detaching piston stem
JPH0531190A (en) * 1991-07-26 1993-02-09 Seikagaku Kogyo Co Ltd Injector
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US5279585A (en) * 1992-02-04 1994-01-18 Becton, Dickinson And Company Medication delivery pen having improved dose delivery features
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