AU2002231342A1 - Mitral valve constricting device, system and method - Google Patents
Mitral valve constricting device, system and methodInfo
- Publication number
- AU2002231342A1 AU2002231342A1 AU2002231342A AU2002231342A AU2002231342A1 AU 2002231342 A1 AU2002231342 A1 AU 2002231342A1 AU 2002231342 A AU2002231342 A AU 2002231342A AU 2002231342 A AU2002231342 A AU 2002231342A AU 2002231342 A1 AU2002231342 A1 AU 2002231342A1
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- Australia
- Prior art keywords
- resilient member
- mitral valve
- introducer
- coronary sinus
- heart
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Description
MITRAL VALVE CONSTRICTING DEVICE, SYSTEM AND METHOD
Field of the Invention:
The present invention generally relates to a device, system and method for treating a deformed heart valve. The present invention more particularly relates to a device, system and method for constricting a mitral valve annulus to correct mitral valve dilation.
Background of the Invention: The human heart generally includes four valves. Of these valves, a most critical one is known as the mitral valve. The mitral valve is located in the left atrial ventricular opening between the left atrium and left ventricle. The mitral valve is intended to prevent regurgitation of blood from the left ventricle into the left atrium when the left ventricle contracts. In preventing blood regurgitation the mitral valve must be able to withstand considerable back pressure as the left ventricle contracts. The valve cusps of the mitral valve are anchored to muscular wall of the heart by delicate but strong fibrous cords in order to support the cusps during left ventricular contraction. In a healthy mitral valve, the geometry of the mitral valve ensures that the cusps overlie each other to preclude regurgitation of the blood during left ventricular contraction.
The normal functioning of the mitral valve in preventing regurgitation can be impaired by dilated cardiomyopathy caused by disease or certain natural defects. For example, certain diseases may cause dilation of the mitral valve annulus. This can result in deformation of the mitral valve geometry to cause ineffective closure of the mitral valve during left ventricular contraction. Such ineffective closure results in leakage through the mitral valve and regurgitation. Diseases such as bacterial inflammations of the heart or heart failure can cause the aforementioned distortion or dilation of the mitral valve annulus. Needless to say, mitral valve regurgitation must not go uncorrected. One method of repairing a mitral valve having impaired function is to completely replace the valve. This method has been found to be particularly suitable for replacing a mitral valve when one of the cusps has been severely damaged or deformed. While the replacement of the entire valve eliminates the immediate
problem associated with a dilated mitral valve annulus, presently available prosthetic heart valves do not possess the same durability as natural heart valves.
Various other surgical procedures have been developed to correct the deformation of the mitral valve annulus and thus retain the intact natural heart valve function. These surgical techniques involve repairing the shape of the dilated or deformed valve annulus. Such techniques, generally known as annuloplasty, require surgically restricting the valve annulus to minimize dilation. Here, a prosthesis is typically sutured about the base of the valve leaflets to reshape the valve annulus and restrict the movement of the valve annulus during the opening and closing of the mitral valve.
Many different types of prostheses have been developed for use in such surgery. In general, prostheses are annular or partially annular shaped members which fit about the base of the valve annulus. The annular or partially annular shaped members may be formed from a rigid material, such as a metal, or from a flexible material.
While the prior art methods mentioned above have been able to achieve some success in treating mitral regurgitation, they have not been without problems and potential adverse consequences. For example, these procedures require open heart surgery. Such procedures are expensive, are extremely invasive requiring considerable recovery time, and pose the concomitant mortality risks associated with such procedures. Given these factors, such procedures are often reserved as a last resort and hence are employed late in the mitral regurgitation progression. Further, the effectiveness of such procedures is difficult to assess during the procedure and may not be known until a much later time. Hence, the ability to make adjustments to or changes in the prostheses to obtain optimum effectiveness is extremely limited. Later corrections, if made at all, require still another open heart surgery.
SUMMARY OF THE INVENTION
The present invention provides an improved device, system, and method to treat mitral regurgitation. Of particular importance, and in accordance with a salient aspect of the present invention, mitral regurgitation may be treated without resorting to open heart surgery. This is rendered possible by the realization that the coronary sinus of a heart is near to and at least partially encircles the mitral valve annulus.
Hence, the device of the present invention may be employed through introduction into the coronary sinus to advantageously effect the geometry of the mitral valve annulus.
The device for effecting the condition of a mitral valve annulus of a heart, in accordance with the broader aspects of the present invention, includes a resilient member having a cross sectional dimension for being received within the coronary sinus of the heart. The device has a longitudinal dimension having an arched configuration for partially encircling the mitral valve and exerting an inward pressure on the mitral valve when placed within the coronary sinus. The inward pressure constricts the mitral valve annulus. This serves to essentially restore the mitral valve geometry to promote effective valve sealing action and to eliminate mitral regurgitation.
The device may be implanted in the coronary sinus using only percutaneous techniques similar to the techniques used to implant cardiac leads such as pacemaker leads. Hence, the present invention also provides a system and method for treating dilated cardiomyopathy which causes mitral regurgitation. The system includes the resilient member and an elongated introducer configured for being releasably coupled to the resilient member. The introducer is preferably flexible to permit it to advance the resilient member into the heart and into the coronary sinus through the coronary sinus ostium. To promote guidance, the system may -further include an elongated sheath which straightens the resilient member and which is first advanced into the coronary sinus. Then, the resilient member and introducer are moved through the sheath until the resilient member is in position within the coronary sinus. The sheath may be partially retracted to permit the resilient member to assume its preformed arched configuration. Once the resilient member is properly positioned, the introducer is then decoupled from the resilient member and retracted through the sheath. The procedure is then completed by the retraction of the sheath. As a result, the resilient member is left within the coronary sinus to exert the inward pressure on the mitral valve to restore mitral valve geometry. In accordance with a particular aspect of the present invention, the resilient member takes the form of a generally C-shaped clip. The clip is resilient to permit straightening during implant. Once implanted in the coronary sinus, the clip is
permitted to assume its C-shaped configuration. This enables the clip to exert a substantially radially inward compressive force on the mitral valve annulus.
Since the device, system and method may be employed in a comparatively noninvasive procedure, mitral valve regurgitation may be treated with the device, system and method at an early stage in the mitral regurgitation progression. The device may be placed with relative ease by any noninvasive cardiologist. Since the heart remains completely intact throughout the procedure, the effectiveness of the procedure may be readily determined. Should adjustments be deemed desirable, such adjustments may be made before the patient is sent to recovery.
BRIEF DESCRIPTION OF THE DRAWINGS
The features of the present invention which are believed to be novel are set forth with particularity in the appended claims. The invention, together with further aspects and advantages thereof, may best be understood by making reference to the following description taken in conjunction with the accompanying drawings, and the several figures of which like reference numerals identify identical elements, and wherein:
FIG. 1 is a superior view of a human heart with the atria removed; FIG. 2 is another superior view of a human heart with the atria removed and illustrating a mitral valve therapy device embodying the present invention within the coronary sinus and partially extending into the right atrium of the heart;
FIG. 3 is a simplified perspective view of a human heart illustrating an intermediate stage in implanting a mitral valve therapy device in accordance with a preferred embodiment of the present invention; FIG. 4 is a simplified perspective view of a human heart illustrating a further stage in implanting a mitral valve therapy device in accordance with a preferred embodiment of the present invention;
FIG. 5 is a partial cross sectional view, to an enlarged scale, illustrating a releasable coupling arrangement of the mitral valve therapy device and an introducer in accordance with a preferred embodiment of the present invention; FIG. 6 is a cross sectional view taken along lines 6-6 of FIG. 5;
FIG. 7 is a plan view illustrating a mitral valve therapy device embodying the present invention shown in a stressed state and an unstressed relative configuration shown in dashed lines;
FIG. 8 is a superior view similar to that of FIGS. 1 and 2 illustrating the relative relation between the mitral valve and an implanted mitral valve therapy device embodying the present invention;
FIG. 9 is a partial plan view, to an enlarged scale, of a fixation arrangement provided on a mitral valve therapy device embodying the present invention; and
FIG. 10 is a partial plan view, to an enlarged scale, illustrating an alternative fixation arrangement embodying the present invention.
DETAILED DESCRIPTION OF THE INVENTION
Referring now to FIG. 1, it is a superior view of a human heart 10 with the atria removed to expose the mitral valve 12 and coronary sinus 14 of the heart 10 to lend a better understanding of the present invention. Also generally shown in FIG. 1 are the pulmonary valve 22, the aortic valve 24, and the tricuspid valve 26 of the heart 10.
More specifically, the mitral valve 12 includes an anterior cusp 16, a posterior cusp 18 and an annulus 20. The annulus encircles the cusps 16 and 18 and maintains their spacing to provide a complete closure during a left ventricular contraction. As is well known, the coronary sinus 14 partially encircles the mitral valve 12 adjacent to the mitral valve annulus 20. As is also known, the coronary sinus is part of the venus system of the heart and extends along the AV groove between the left atrium and the left ventricle. This places the coronary sinus essentially within the same plane as the mitral valve annulus making the coronary sinus available for placement of the mitral valve therapy device of the present invention therein.
FIG. 2 shows a mitral valve therapy device 30 embodying the present invention in position within the coronary sinus 14 of the heart 10. As may be noted in FIG. 2, the device is elongated and has an arched configuration. The device also at least partially encircles the mitral valve 12 adjacent to the mitral valve annulus 20. The device 30, by virtue of having an unstressed preformed arched radius smaller than the radius of the dilated mitral valve annulus 20, imparts an inward, generally
radial force designated by arrows 32, on the mitral valve annulus 20. This force returns the mitral valve annulus 20 to its original or substantially original geometry to permit the cusps 16 and 18 to more fully come together for sealing the left atrium during left ventricular contraction. The device 30 has a cross section dimension to be received by the coronary sinus. It is preferably formed of a resilient material to permit the device to be straightened and/or bent for being advanced into the coronary sinus. After being positioned as illustrated, the device is permitted to assume its preformed arched configuration to act upon the mitral valve annulus as previously described. To that end, the device may be formed of, for example, Nitinol, a nickel titanium alloy, well known in the art. This material, as is well known, is capable of being preformed but manipulated to be straight or partially bent while having sufficient memory to return to its preformed configuration. In order to be received within the coronary sinus, the device may have a cross sectional dimension of, for example, on the order of four or five french.
FIGS. 3-6 illustrate a manner in which the mitral valve therapy device may be implanted within the coronary sinus 14 in accordance with a preferred embodiment of the present invention. Referring initially to FIG. 3, an elongated flexible sheath 32 is first introduced into the heart 10 through the superior vena cava 11 into the right atrium 13, and to and through the coronary sinus ostium 15. The sheath 32 is then further advanced into the coronary sinus 14. Advancement of the sheath 32 continues until the distal end 34 of the sheath 32 reaches or slightly enters the great cardiac vein 17. The sheath 32 preferably takes the form of a double-wound polyester catheter. The sheath is dimensioned for receiving the mitral valve therapy device 30 and the introducer 36. To that end, the sheath may have an inner diameter dimension of six french or greater.
The distal end of the introducer 36 and the proximal end of the therapy device 30 each include coupling mechanisms forming a releasable coupling arrangement 38. The coupling arrangement 38 will be described in greater detail subsequently with reference to FIGS. 5 and 6.
The introducer 36 as will be noted in FIG. 3 is elongated and has a diameter dimension similar to the cross sectional dimension of the device 30. The introducer is also flexible. It may be formed of, for example, stainless steel.
Once the sheath 32 is positioned within the heart 10 as illustrated in FIG. 3, the proximal end of the device 30 is coupled to the distal end of the introducer 36. The device 30 and introducer 36 are then fed into the sheath 32. As the device 30 is advanced through the sheath 32 by moving the introducer 36 relative to the sheath 32, the device 30 and introducer 36 follow the path defined by the sheath 32. When the distal end of the device 30 reaches or is near the distal end 34 of the sheath 32, the advancement of the introducer 36 and device 30 is terminated.
The next step is the partial retraction of the sheath 32. This may be best seen in FIG. 4. The sheath 32 is pulled back while the introducer 36 is held stationary. This continues until the distal end 34 of the sheath 32 is proximal to the coupling arrangement of the device 30 and the introducer 36.
Referring to FIGS. 5 and 6, the coupling arrangement 38 includes a coupling interlock mechanism 40 at the proximal end of the mitral valve therapy device 30 and a complimentary interlock mechanism 42 at the distal end of the introducer 36. After the sheath 32 is retracted where the distal end 34 of the sheath 32 is proximal to the coupling arrangement 38 as seen in FIG. 4, rotation of the sheath and introducer relative to the device 30 releases the introducer 36 from the device 30. The sheath 32 and introducer 36 may now be completely retracted from the patient's heart 10. This leaves the mitral valve therapy device 30 in place within the coronary sinus to act upon the mitral valve annulus to return the mitral valve to a proper sealing function during left ventricular contraction.
FIG. 7 shows the mitral valve therapy device 10 in a stressed condition. The dashed line 44 illustrates the degree of arcuate shifting of the device 30 towards its preformed unstressed state. When first implanted, the device 30 will have a radius of curvature which is greater than its preformed radius of curvature by virtue of the resistance to the device imposed by the heart anatomy. The device, in seeking to migrate to its preformed unstressed state indicated by the dashed line 44, exerts the aforementioned radially inward force on the mitral valve annulus.
FIG. 8 is another view of the heart 10 illustrating the mitral valve therapy device 30 in position within the coronary sinus 14. Here, it may be seen that the device 30 includes a proximal end 46 and a distal end 48. The length of the device 30 is selected so that the included angle theta (θ), defined by the proximal end 46 and distal end 48 together with the center 50 of the mitral valve 12, is preferably
greater than 180°. Selecting such a length for the device 30 will assist in the device 30 being held in place and promote a uniform radial force on the mitral valve.
The mitral valve therapy device 30 illustrated in FIGS. 2-8 has sufficient length to project through the coronary sinus ostium into the right atrium so that the proximal end 46 of the device 30 is proximal to the coronary sinus ostium. The device 30 may include additional fixation to hold the device 30 in place. To this end, FIG. 9 shows a fixation element 52 at the proximal end of the mitral valve therapy device 30. The fixation element 52, in accordance with this preferred embodiment, takes the form of a polyester mesh 54 bound to the inner surface of the device 30. This serves to grip heart tissue, such as the right atrial or coronary sinus wall, to maintain the device 30 in its implanted desired position. Alternatively, as shown in FIG. 10, the fixation may be provided by a plurality of teeth 56 formed in the inner surface of the device 30. This alternative arrangement will also provide a gripping action to maintain the device in its proper position. As can thus be seen from the foregoing, the present invention provides a new an improved device, system and method for treating mitral regurgitation. The device may be employed with only percutaneous techniques. This allows the patient to receive therapy much sooner in the mitral regurgitation progression than previously available with prior art techniques. The cost of the therapy will also be comparatively low making the therapy more generally available. Further, the mitral valve therapy device may be implanted by any noninvasive cardiologist, again lending to the general availability of the therapy. Still further, the device may be readily removed in the event that the therapy is unsuccessful or adjustment is necessary. Lastly, since the heart remains intact and fully functional throughout the procedure, the effectiveness of the therapy may be immediately deduced for optimized adjustment. While particular embodiments of the present invention have been shown and described, modifications may be made, and it is therefore intended in the appended claims to cover all such changes and modifications which fall within the true spirit and scope of the invention.
Claims (31)
1. A device for effecting the condition of a mitral valve annulus of a heart comprising a resilient member having a cross sectional dimension for being received within the coronary sinus of the heart and having a longitudinal dimension having an arched configuration for partially encircling the mitral valve and exerting an inward pressure on the mitral valve when within the coronary sinus adjacent the mitral valve for constricting the mitral valve annulus.
2. The device of claim 1 wherein the resilient member has a distal end and a proximal end, and wherein the distal end and proximal end define an included angle of at least 180°.
3. The device of claim 1 wherein the resilient member has a. distal end and a proximal end and wherein the resilient member longitudinal dimension is of a length to cause the proximal end of the resilient member to be proximal to the ostium of the coronary sinus.
4. The device of claim 1 wherein the resilient member includes at least one fixation element.
5. The device of claim 4 wherein the at least one fixation element is at a proximal end of the resilient member.
6. The device of claim 4 wherein the at least one fixation element is a plurality of teeth formed in the resilient member.
7. The device of claim 4 wherein the at least one fixation element is material mesh.
8. The device of claim 7 wherein the material mesh is a polyester mesh.
9. The device of claim 1 wherein the resilient member is formed of an alloy including at least nickel and titanium.
10. A mitral valve annulus constricting device comprising a generally C- shaped clip member formed of resilient material for exerting a substantially radially inward force on the mitral valve annulus when placed in the coronary sinus of a heart about and adjacent to the mitral valve.
11. A mitral valve therapy system comprising: a resilient member having a cross sectional dimension for being received within the coronary sinus of a heart and having a longitudinal dimension having an arched configuration for partially encircling the mitral valve of the heart and exerting a substantially radially inward compressive force on the mitral valve annulus of the heart when placed within the coronary sinus adjacent the mitral valve, the resilient member having a proximal end including a coupling mechanism; and, an elongated introducer formed of flexible material and having a distal end including a coupling mechanism for being releasably coupled to the resilient member coupling member for guiding the resilient member into the coronary sinus of the heart and being detached from the resilient member once the resilient member is placed within the coronary sinus to permit the introducer to be removed from the heart while leaving the resilient member positioned within the coronary sinus.
12. The system of claim 11 wherein the resilient member has a distal end opposite the proximal end, and wherein the distal end and proximal end define an included angle of at least 180°.
13. The system of claim 11 wherein the resilient member longitudinal dimension is of a length to cause the proximal end of the resilient member to be proximal to the ostium of the coronary sinus.
14. The system of claim 11 wherein the resilient member includes at least one fixation element.
15. The system of claim 14 wherein the at least one fixation element is at the proximal end of the resilient member.
16. The system of claim 14 wherein the at least one fixation element is a plurality of teeth formed in the resilient member.
17. The system of claim 14 wherein the at least one fixation element is material mesh.
18. The system of claim 17 wherein the material mesh is a polyester mesh.
19. The system of claim 11 wherein the resilient member is formed of an alloy including at least nickel and titanium.
20. The system of claim 11 wherein the introducer is formed of stainless steel.
21. The system of claim 11 further including an elongated cylindrical sheath dimension for receiving the resilient member and the introducer, the sheath being flexible for advancement into the coronary sinus and guiding the resilient member into the coronary sinus.
22. The system of claim 21 wherein the sheath has a distal end and wherein the resilient member coupling mechanism and introducer coupling mechanism are releasable when the distal end of the sheath is proximal to the introducer coupling mechanism.
23. The system of claim 22 wherein the sheath is formed of polyester.
24. The system of claim 11 wherein the resilient member and introducer are rotatable relative to one another for causing the introducer coupling mechanism and resilient member coupling mechanism to release.
25. A method of treating dilated cardiomyopathy of a heart of a patient, the method including the steps of: providing a constriction device formed of resilient material having an unstressed C-shape configuration with an effective radius less than a dilated mitral valve annulus radius and a cross sectional dimension for being received within the coronary sinus of the heart; and advancing the constriction device into the coronary sinus of the heart until the constriction device at least partially encircles the mitral value of the heart.
26. The method of claim 25 wherein the advancing step includes releasably coupling the constriction device to an elongated flexible introducer and moving the constriction device into the coronary sinus with the introducer.
27. The method of claim 26 including the further steps of releasing the introducer from the constriction device when the constriction device at least partially encircles the mitral valve and removing the introducer from the patient.
28. The method of claim 26 including the further step of placing a cylindrical sheath within the coronary sinus of the heart of the patient, the sheath having a cross sectional dimension for receiving the introducer and constriction device, and wherein the advancing step includes the step of guiding the introducer and constriction device into the coronary sinus within the sheath.
29. The method of claim 28 including the further steps of releasing the introducer from the constriction device when the constriction device at least partially encircles the mitral valve and removing the introducer and sheath from the patient.
30. The method of claim 29 including the further step of retracting the sheath until the sheath is proximal to the constriction device prior to releasing the introducer from the constriction device.
31. A mitral valve annulus constricting device comprising a generally C- shaped clip member formed of resilient material for exerting a substantially radially compressive force on the mitral valve annulus when placed adjacent to the mitral valve.
Applications Claiming Priority (3)
Application Number | Priority Date | Filing Date | Title |
---|---|---|---|
US09/751,271 US7591826B2 (en) | 2000-12-28 | 2000-12-28 | Device implantable in the coronary sinus to provide mitral valve therapy |
US09/751,271 | 2000-12-28 | ||
PCT/US2001/050860 WO2002053206A2 (en) | 2000-12-28 | 2001-12-27 | Mitral valve constricting device, system and method |
Publications (2)
Publication Number | Publication Date |
---|---|
AU2002231342A1 true AU2002231342A1 (en) | 2003-01-23 |
AU2002231342B2 AU2002231342B2 (en) | 2005-10-13 |
Family
ID=25021249
Family Applications (1)
Application Number | Title | Priority Date | Filing Date |
---|---|---|---|
AU2002231342A Expired AU2002231342B2 (en) | 2000-12-28 | 2001-12-27 | Mitral valve constricting device, system and method |
Country Status (9)
Country | Link |
---|---|
US (1) | US7591826B2 (en) |
EP (1) | EP1395182B1 (en) |
JP (1) | JP4113431B2 (en) |
AT (1) | ATE422863T1 (en) |
AU (1) | AU2002231342B2 (en) |
CA (1) | CA2433672C (en) |
DE (1) | DE60137724D1 (en) |
ES (1) | ES2322552T3 (en) |
WO (1) | WO2002053206A2 (en) |
Families Citing this family (236)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
US20030045771A1 (en) * | 1997-01-02 | 2003-03-06 | Schweich Cyril J. | Heart wall tension reduction devices and methods |
US6050936A (en) | 1997-01-02 | 2000-04-18 | Myocor, Inc. | Heart wall tension reduction apparatus |
US7883539B2 (en) | 1997-01-02 | 2011-02-08 | Edwards Lifesciences Llc | Heart wall tension reduction apparatus and method |
FR2768324B1 (en) | 1997-09-12 | 1999-12-10 | Jacques Seguin | SURGICAL INSTRUMENT FOR PERCUTANEOUSLY FIXING TWO AREAS OF SOFT TISSUE, NORMALLY MUTUALLY REMOTE, TO ONE ANOTHER |
US6332893B1 (en) | 1997-12-17 | 2001-12-25 | Myocor, Inc. | Valve to myocardium tension members device and method |
US6260552B1 (en) | 1998-07-29 | 2001-07-17 | Myocor, Inc. | Transventricular implant tools and devices |
US20040044350A1 (en) | 1999-04-09 | 2004-03-04 | Evalve, Inc. | Steerable access sheath and methods of use |
US6629534B1 (en) | 1999-04-09 | 2003-10-07 | Evalve, Inc. | Methods and apparatus for cardiac valve repair |
US6752813B2 (en) | 1999-04-09 | 2004-06-22 | Evalve, Inc. | Methods and devices for capturing and fixing leaflets in valve repair |
US7811296B2 (en) | 1999-04-09 | 2010-10-12 | Evalve, Inc. | Fixation devices for variation in engagement of tissue |
US7666204B2 (en) | 1999-04-09 | 2010-02-23 | Evalve, Inc. | Multi-catheter steerable guiding system and methods of use |
US8216256B2 (en) | 1999-04-09 | 2012-07-10 | Evalve, Inc. | Detachment mechanism for implantable fixation devices |
SE514718C2 (en) * | 1999-06-29 | 2001-04-09 | Jan Otto Solem | Apparatus for treating defective closure of the mitral valve apparatus |
US7192442B2 (en) * | 1999-06-30 | 2007-03-20 | Edwards Lifesciences Ag | Method and device for treatment of mitral insufficiency |
US6997951B2 (en) * | 1999-06-30 | 2006-02-14 | Edwards Lifesciences Ag | Method and device for treatment of mitral insufficiency |
US6989028B2 (en) * | 2000-01-31 | 2006-01-24 | Edwards Lifesciences Ag | Medical system and method for remodeling an extravascular tissue structure |
US6402781B1 (en) * | 2000-01-31 | 2002-06-11 | Mitralife | Percutaneous mitral annuloplasty and cardiac reinforcement |
US7507252B2 (en) * | 2000-01-31 | 2009-03-24 | Edwards Lifesciences Ag | Adjustable transluminal annuloplasty system |
US6723038B1 (en) | 2000-10-06 | 2004-04-20 | Myocor, Inc. | Methods and devices for improving mitral valve function |
US7591826B2 (en) | 2000-12-28 | 2009-09-22 | Cardiac Dimensions, Inc. | Device implantable in the coronary sinus to provide mitral valve therapy |
US7510576B2 (en) * | 2001-01-30 | 2009-03-31 | Edwards Lifesciences Ag | Transluminal mitral annuloplasty |
JP4184794B2 (en) | 2001-02-05 | 2008-11-19 | ビアカー・インコーポレーテッド | Method and apparatus for improving mitral valve function |
EP1363559A4 (en) | 2001-02-05 | 2008-10-01 | Viacor Inc | Apparatus and method for reducing mitral regurgitation |
US6890353B2 (en) | 2001-03-23 | 2005-05-10 | Viacor, Inc. | Method and apparatus for reducing mitral regurgitation |
US7186264B2 (en) | 2001-03-29 | 2007-03-06 | Viacor, Inc. | Method and apparatus for improving mitral valve function |
US8202315B2 (en) | 2001-04-24 | 2012-06-19 | Mitralign, Inc. | Catheter-based annuloplasty using ventricularly positioned catheter |
US7037334B1 (en) | 2001-04-24 | 2006-05-02 | Mitralign, Inc. | Method and apparatus for catheter-based annuloplasty using local plications |
US6800090B2 (en) * | 2001-05-14 | 2004-10-05 | Cardiac Dimensions, Inc. | Mitral valve therapy device, system and method |
US6676702B2 (en) * | 2001-05-14 | 2004-01-13 | Cardiac Dimensions, Inc. | Mitral valve therapy assembly and method |
US7144363B2 (en) * | 2001-10-16 | 2006-12-05 | Extensia Medical, Inc. | Systems for heart treatment |
US7052487B2 (en) * | 2001-10-26 | 2006-05-30 | Cohn William E | Method and apparatus for reducing mitral regurgitation |
US6949122B2 (en) * | 2001-11-01 | 2005-09-27 | Cardiac Dimensions, Inc. | Focused compression mitral valve device and method |
US6824562B2 (en) * | 2002-05-08 | 2004-11-30 | Cardiac Dimensions, Inc. | Body lumen device anchor, device and assembly |
US7635387B2 (en) | 2001-11-01 | 2009-12-22 | Cardiac Dimensions, Inc. | Adjustable height focal tissue deflector |
US7311729B2 (en) | 2002-01-30 | 2007-12-25 | Cardiac Dimensions, Inc. | Device and method for modifying the shape of a body organ |
US6908478B2 (en) | 2001-12-05 | 2005-06-21 | Cardiac Dimensions, Inc. | Anchor and pull mitral valve device and method |
US6976995B2 (en) | 2002-01-30 | 2005-12-20 | Cardiac Dimensions, Inc. | Fixed length anchor and pull mitral valve device and method |
US6793673B2 (en) | 2002-12-26 | 2004-09-21 | Cardiac Dimensions, Inc. | System and method to effect mitral valve annulus of a heart |
US7179282B2 (en) | 2001-12-05 | 2007-02-20 | Cardiac Dimensions, Inc. | Device and method for modifying the shape of a body organ |
SE524709C2 (en) | 2002-01-11 | 2004-09-21 | Edwards Lifesciences Ag | Device for delayed reshaping of a heart vessel and a heart valve |
US6764510B2 (en) | 2002-01-09 | 2004-07-20 | Myocor, Inc. | Devices and methods for heart valve treatment |
CA2688796A1 (en) * | 2002-01-11 | 2003-07-10 | Edwards Lifesciences Ag. | Delayed memory device |
US6960229B2 (en) | 2002-01-30 | 2005-11-01 | Cardiac Dimensions, Inc. | Device and method for modifying the shape of a body organ |
US20050209690A1 (en) * | 2002-01-30 | 2005-09-22 | Mathis Mark L | Body lumen shaping device with cardiac leads |
US7125420B2 (en) * | 2002-02-05 | 2006-10-24 | Viacor, Inc. | Method and apparatus for improving mitral valve function |
US7048754B2 (en) | 2002-03-01 | 2006-05-23 | Evalve, Inc. | Suture fasteners and methods of use |
US7004958B2 (en) * | 2002-03-06 | 2006-02-28 | Cardiac Dimensions, Inc. | Transvenous staples, assembly and method for mitral valve repair |
US6797001B2 (en) * | 2002-03-11 | 2004-09-28 | Cardiac Dimensions, Inc. | Device, assembly and method for mitral valve repair |
AU2003228865B2 (en) * | 2002-05-08 | 2009-01-15 | Cardiac Dimensions Pty. Ltd. | Device and method for modifying the shape of a body organ |
CA2494758C (en) | 2002-08-01 | 2013-03-19 | The General Hospital Corporation | Cardiac devices and methods for minimally invasive repair of ischemic mitral regurgitation |
US20040133062A1 (en) * | 2002-10-11 | 2004-07-08 | Suresh Pai | Minimally invasive cardiac force transfer structures |
US7087064B1 (en) | 2002-10-15 | 2006-08-08 | Advanced Cardiovascular Systems, Inc. | Apparatuses and methods for heart valve repair |
WO2004037317A2 (en) | 2002-10-21 | 2004-05-06 | Mitralign Incorporated | Method and apparatus for performing catheter-based annuloplasty using local plications |
US20050119735A1 (en) | 2002-10-21 | 2005-06-02 | Spence Paul A. | Tissue fastening systems and methods utilizing magnetic guidance |
US7112219B2 (en) | 2002-11-12 | 2006-09-26 | Myocor, Inc. | Devices and methods for heart valve treatment |
US8187324B2 (en) * | 2002-11-15 | 2012-05-29 | Advanced Cardiovascular Systems, Inc. | Telescoping apparatus for delivering and adjusting a medical device in a vessel |
US20040098116A1 (en) | 2002-11-15 | 2004-05-20 | Callas Peter L. | Valve annulus constriction apparatus and method |
US9149602B2 (en) | 2005-04-22 | 2015-10-06 | Advanced Cardiovascular Systems, Inc. | Dual needle delivery system |
US7404824B1 (en) | 2002-11-15 | 2008-07-29 | Advanced Cardiovascular Systems, Inc. | Valve aptation assist device |
US6945978B1 (en) | 2002-11-15 | 2005-09-20 | Advanced Cardiovascular Systems, Inc. | Heart valve catheter |
US7335213B1 (en) | 2002-11-15 | 2008-02-26 | Abbott Cardiovascular Systems Inc. | Apparatus and methods for heart valve repair |
US7981152B1 (en) | 2004-12-10 | 2011-07-19 | Advanced Cardiovascular Systems, Inc. | Vascular delivery system for accessing and delivering devices into coronary sinus and other vascular sites |
US7485143B2 (en) * | 2002-11-15 | 2009-02-03 | Abbott Cardiovascular Systems Inc. | Apparatuses and methods for heart valve repair |
US7837729B2 (en) * | 2002-12-05 | 2010-11-23 | Cardiac Dimensions, Inc. | Percutaneous mitral valve annuloplasty delivery system |
US7316708B2 (en) * | 2002-12-05 | 2008-01-08 | Cardiac Dimensions, Inc. | Medical device delivery system |
US20040133240A1 (en) * | 2003-01-07 | 2004-07-08 | Cardiac Dimensions, Inc. | Electrotherapy system, device, and method for treatment of cardiac valve dysfunction |
US7314485B2 (en) | 2003-02-03 | 2008-01-01 | Cardiac Dimensions, Inc. | Mitral valve device using conditioned shape memory alloy |
US20040158321A1 (en) * | 2003-02-12 | 2004-08-12 | Cardiac Dimensions, Inc. | Method of implanting a mitral valve therapy device |
US20040254600A1 (en) * | 2003-02-26 | 2004-12-16 | David Zarbatany | Methods and devices for endovascular mitral valve correction from the left coronary sinus |
US20040220654A1 (en) * | 2003-05-02 | 2004-11-04 | Cardiac Dimensions, Inc. | Device and method for modifying the shape of a body organ |
US20060161169A1 (en) * | 2003-05-02 | 2006-07-20 | Cardiac Dimensions, Inc., A Delaware Corporation | Device and method for modifying the shape of a body organ |
US10667823B2 (en) | 2003-05-19 | 2020-06-02 | Evalve, Inc. | Fixation devices, systems and methods for engaging tissue |
US20060136053A1 (en) * | 2003-05-27 | 2006-06-22 | Rourke Jonathan M | Method and apparatus for improving mitral valve function |
US7887582B2 (en) | 2003-06-05 | 2011-02-15 | Cardiac Dimensions, Inc. | Device and method for modifying the shape of a body organ |
US7351259B2 (en) * | 2003-06-05 | 2008-04-01 | Cardiac Dimensions, Inc. | Device, system and method to affect the mitral valve annulus of a heart |
WO2005018507A2 (en) | 2003-07-18 | 2005-03-03 | Ev3 Santa Rosa, Inc. | Remotely activated mitral annuloplasty system and methods |
WO2005009286A2 (en) * | 2003-07-23 | 2005-02-03 | Viacor, Inc. | Method and apparatus for improving mitral valve function |
US7998112B2 (en) | 2003-09-30 | 2011-08-16 | Abbott Cardiovascular Systems Inc. | Deflectable catheter assembly and method of making same |
US7004176B2 (en) * | 2003-10-17 | 2006-02-28 | Edwards Lifesciences Ag | Heart valve leaflet locator |
US20060184242A1 (en) * | 2003-10-20 | 2006-08-17 | Samuel Lichtenstein | Method and apparatus for percutaneous reduction of anterior-posterior diameter of mitral valve |
US20050177228A1 (en) * | 2003-12-16 | 2005-08-11 | Solem Jan O. | Device for changing the shape of the mitral annulus |
US9526616B2 (en) | 2003-12-19 | 2016-12-27 | Cardiac Dimensions Pty. Ltd. | Mitral valve annuloplasty device with twisted anchor |
US7837728B2 (en) * | 2003-12-19 | 2010-11-23 | Cardiac Dimensions, Inc. | Reduced length tissue shaping device |
US7794496B2 (en) | 2003-12-19 | 2010-09-14 | Cardiac Dimensions, Inc. | Tissue shaping device with integral connector and crimp |
US7431726B2 (en) * | 2003-12-23 | 2008-10-07 | Mitralign, Inc. | Tissue fastening systems and methods utilizing magnetic guidance |
US8864822B2 (en) | 2003-12-23 | 2014-10-21 | Mitralign, Inc. | Devices and methods for introducing elements into tissue |
US7942927B2 (en) | 2004-03-15 | 2011-05-17 | Baker Medical Research Institute | Treating valve failure |
US7993397B2 (en) * | 2004-04-05 | 2011-08-09 | Edwards Lifesciences Ag | Remotely adjustable coronary sinus implant |
WO2005112792A2 (en) | 2004-05-14 | 2005-12-01 | Evalve, Inc. | Locking mechanisms for fixation devices and methods of engaging tissue |
WO2006002492A1 (en) * | 2004-07-06 | 2006-01-12 | Baker Medical Research Institute | Treating valvular insufficiency |
US8052592B2 (en) | 2005-09-27 | 2011-11-08 | Evalve, Inc. | Methods and devices for tissue grasping and assessment |
WO2006037073A2 (en) | 2004-09-27 | 2006-04-06 | Evalve, Inc. | Methods and devices for tissue grasping and assessment |
US7211110B2 (en) * | 2004-12-09 | 2007-05-01 | Edwards Lifesciences Corporation | Diagnostic kit to assist with heart valve annulus adjustment |
WO2006079000A1 (en) * | 2005-01-20 | 2006-07-27 | Cardiac Dimensions, Inc. | Tissue shaping device |
WO2006097931A2 (en) | 2005-03-17 | 2006-09-21 | Valtech Cardio, Ltd. | Mitral valve treatment techniques |
US7357815B2 (en) * | 2005-04-21 | 2008-04-15 | Micardia Corporation | Dynamically adjustable implants and methods for reshaping tissue |
US7500989B2 (en) * | 2005-06-03 | 2009-03-10 | Edwards Lifesciences Corp. | Devices and methods for percutaneous repair of the mitral valve via the coronary sinus |
US8951285B2 (en) | 2005-07-05 | 2015-02-10 | Mitralign, Inc. | Tissue anchor, anchoring system and methods of using the same |
WO2007021893A1 (en) * | 2005-08-12 | 2007-02-22 | Edwards Lifesciences Corporation | Medical implant with reinforcement mechanism |
US20080221673A1 (en) * | 2005-08-12 | 2008-09-11 | Donald Bobo | Medical implant with reinforcement mechanism |
US9492277B2 (en) | 2005-08-30 | 2016-11-15 | Mayo Foundation For Medical Education And Research | Soft body tissue remodeling methods and apparatus |
US20070073391A1 (en) * | 2005-09-28 | 2007-03-29 | Henry Bourang | System and method for delivering a mitral valve repair device |
US20070173926A1 (en) * | 2005-12-09 | 2007-07-26 | Bobo Donald E Jr | Anchoring system for medical implant |
US7637946B2 (en) | 2006-02-09 | 2009-12-29 | Edwards Lifesciences Corporation | Coiled implant for mitral valve repair |
US7749249B2 (en) | 2006-02-21 | 2010-07-06 | Kardium Inc. | Method and device for closing holes in tissue |
US7503932B2 (en) * | 2006-04-11 | 2009-03-17 | Cardiac Dimensions, Inc. | Mitral valve annuloplasty device with vena cava anchor |
WO2007136532A2 (en) | 2006-05-03 | 2007-11-29 | St. Jude Medical, Inc. | Soft body tissue remodeling methods and apparatus |
US20070270688A1 (en) | 2006-05-19 | 2007-11-22 | Daniel Gelbart | Automatic atherectomy system |
US10028783B2 (en) | 2006-06-28 | 2018-07-24 | Kardium Inc. | Apparatus and method for intra-cardiac mapping and ablation |
US9119633B2 (en) | 2006-06-28 | 2015-09-01 | Kardium Inc. | Apparatus and method for intra-cardiac mapping and ablation |
US11389232B2 (en) | 2006-06-28 | 2022-07-19 | Kardium Inc. | Apparatus and method for intra-cardiac mapping and ablation |
US8920411B2 (en) | 2006-06-28 | 2014-12-30 | Kardium Inc. | Apparatus and method for intra-cardiac mapping and ablation |
US8449605B2 (en) | 2006-06-28 | 2013-05-28 | Kardium Inc. | Method for anchoring a mitral valve |
US11285005B2 (en) | 2006-07-17 | 2022-03-29 | Cardiac Dimensions Pty. Ltd. | Mitral valve annuloplasty device with twisted anchor |
US7837610B2 (en) | 2006-08-02 | 2010-11-23 | Kardium Inc. | System for improving diastolic dysfunction |
US20080065205A1 (en) * | 2006-09-11 | 2008-03-13 | Duy Nguyen | Retrievable implant and method for treatment of mitral regurgitation |
US7854849B2 (en) * | 2006-10-10 | 2010-12-21 | Multiphase Systems Integration | Compact multiphase inline bulk water separation method and system for hydrocarbon production |
US9883943B2 (en) | 2006-12-05 | 2018-02-06 | Valtech Cardio, Ltd. | Implantation of repair devices in the heart |
US11259924B2 (en) | 2006-12-05 | 2022-03-01 | Valtech Cardio Ltd. | Implantation of repair devices in the heart |
EP2088965B1 (en) | 2006-12-05 | 2012-11-28 | Valtech Cardio, Ltd. | Segmented ring placement |
US8911461B2 (en) | 2007-03-13 | 2014-12-16 | Mitralign, Inc. | Suture cutter and method of cutting suture |
US11660190B2 (en) | 2007-03-13 | 2023-05-30 | Edwards Lifesciences Corporation | Tissue anchors, systems and methods, and devices |
US20080228266A1 (en) * | 2007-03-13 | 2008-09-18 | Mitralign, Inc. | Plication assistance devices and methods |
US20080255447A1 (en) * | 2007-04-16 | 2008-10-16 | Henry Bourang | Diagnostic catheter |
US8100820B2 (en) | 2007-08-22 | 2012-01-24 | Edwards Lifesciences Corporation | Implantable device for treatment of ventricular dilation |
US8906011B2 (en) | 2007-11-16 | 2014-12-09 | Kardium Inc. | Medical device for use in bodily lumens, for example an atrium |
US8489172B2 (en) | 2008-01-25 | 2013-07-16 | Kardium Inc. | Liposuction system |
US8382829B1 (en) | 2008-03-10 | 2013-02-26 | Mitralign, Inc. | Method to reduce mitral regurgitation by cinching the commissure of the mitral valve |
US20090287304A1 (en) | 2008-05-13 | 2009-11-19 | Kardium Inc. | Medical Device for Constricting Tissue or a Bodily Orifice, for example a mitral valve |
CA2728078A1 (en) | 2008-06-16 | 2010-01-14 | Valtech Cardio, Ltd. | Annuloplasty devices and methods of delivery therefor |
US8647254B2 (en) | 2008-07-01 | 2014-02-11 | Maquet Cardiovascular Llc | Epicardial clip |
US8006594B2 (en) | 2008-08-11 | 2011-08-30 | Cardiac Dimensions, Inc. | Catheter cutting tool |
EP2379008B1 (en) | 2008-12-22 | 2021-02-17 | Valtech Cardio, Ltd. | Adjustable annuloplasty devices |
US8911494B2 (en) | 2009-05-04 | 2014-12-16 | Valtech Cardio, Ltd. | Deployment techniques for annuloplasty ring |
US9011530B2 (en) | 2008-12-22 | 2015-04-21 | Valtech Cardio, Ltd. | Partially-adjustable annuloplasty structure |
US10517719B2 (en) | 2008-12-22 | 2019-12-31 | Valtech Cardio, Ltd. | Implantation of repair devices in the heart |
US8241351B2 (en) | 2008-12-22 | 2012-08-14 | Valtech Cardio, Ltd. | Adjustable partial annuloplasty ring and mechanism therefor |
US8715342B2 (en) | 2009-05-07 | 2014-05-06 | Valtech Cardio, Ltd. | Annuloplasty ring with intra-ring anchoring |
US8353956B2 (en) | 2009-02-17 | 2013-01-15 | Valtech Cardio, Ltd. | Actively-engageable movement-restriction mechanism for use with an annuloplasty structure |
US9968452B2 (en) | 2009-05-04 | 2018-05-15 | Valtech Cardio, Ltd. | Annuloplasty ring delivery cathethers |
US20110082538A1 (en) | 2009-10-01 | 2011-04-07 | Jonathan Dahlgren | Medical device, kit and method for constricting tissue or a bodily orifice, for example, a mitral valve |
US9011520B2 (en) | 2009-10-29 | 2015-04-21 | Valtech Cardio, Ltd. | Tissue anchor for annuloplasty device |
US10098737B2 (en) | 2009-10-29 | 2018-10-16 | Valtech Cardio, Ltd. | Tissue anchor for annuloplasty device |
US9180007B2 (en) | 2009-10-29 | 2015-11-10 | Valtech Cardio, Ltd. | Apparatus and method for guide-wire based advancement of an adjustable implant |
US8734467B2 (en) | 2009-12-02 | 2014-05-27 | Valtech Cardio, Ltd. | Delivery tool for implantation of spool assembly coupled to a helical anchor |
US8870950B2 (en) | 2009-12-08 | 2014-10-28 | Mitral Tech Ltd. | Rotation-based anchoring of an implant |
US9107749B2 (en) | 2010-02-03 | 2015-08-18 | Edwards Lifesciences Corporation | Methods for treating a heart |
US8579964B2 (en) | 2010-05-05 | 2013-11-12 | Neovasc Inc. | Transcatheter mitral valve prosthesis |
US9050066B2 (en) | 2010-06-07 | 2015-06-09 | Kardium Inc. | Closing openings in anatomical tissue |
US11653910B2 (en) | 2010-07-21 | 2023-05-23 | Cardiovalve Ltd. | Helical anchor implantation |
US8940002B2 (en) | 2010-09-30 | 2015-01-27 | Kardium Inc. | Tissue anchor system |
US9452016B2 (en) | 2011-01-21 | 2016-09-27 | Kardium Inc. | Catheter system |
CA2764494A1 (en) | 2011-01-21 | 2012-07-21 | Kardium Inc. | Enhanced medical device for use in bodily cavities, for example an atrium |
US11259867B2 (en) | 2011-01-21 | 2022-03-01 | Kardium Inc. | High-density electrode-based medical device system |
US9480525B2 (en) | 2011-01-21 | 2016-11-01 | Kardium, Inc. | High-density electrode-based medical device system |
US9072511B2 (en) | 2011-03-25 | 2015-07-07 | Kardium Inc. | Medical kit for constricting tissue or a bodily orifice, for example, a mitral valve |
US9308087B2 (en) | 2011-04-28 | 2016-04-12 | Neovasc Tiara Inc. | Sequentially deployed transcatheter mitral valve prosthesis |
US9554897B2 (en) | 2011-04-28 | 2017-01-31 | Neovasc Tiara Inc. | Methods and apparatus for engaging a valve prosthesis with tissue |
US10792152B2 (en) | 2011-06-23 | 2020-10-06 | Valtech Cardio, Ltd. | Closed band for percutaneous annuloplasty |
US8945177B2 (en) | 2011-09-13 | 2015-02-03 | Abbott Cardiovascular Systems Inc. | Gripper pusher mechanism for tissue apposition systems |
US8858623B2 (en) | 2011-11-04 | 2014-10-14 | Valtech Cardio, Ltd. | Implant having multiple rotational assemblies |
EP2775896B1 (en) | 2011-11-08 | 2020-01-01 | Valtech Cardio, Ltd. | Controlled steering functionality for implant-delivery tool |
WO2013088327A1 (en) | 2011-12-12 | 2013-06-20 | David Alon | Heart valve repair device |
USD777926S1 (en) | 2012-01-20 | 2017-01-31 | Kardium Inc. | Intra-cardiac procedure device |
USD777925S1 (en) | 2012-01-20 | 2017-01-31 | Kardium Inc. | Intra-cardiac procedure device |
WO2013123059A1 (en) | 2012-02-13 | 2013-08-22 | Mitraspan, Inc | Method and apparatus for repairing a mitral valve |
US10076414B2 (en) | 2012-02-13 | 2018-09-18 | Mitraspan, Inc. | Method and apparatus for repairing a mitral valve |
US9198592B2 (en) | 2012-05-21 | 2015-12-01 | Kardium Inc. | Systems and methods for activating transducers |
US9693832B2 (en) | 2012-05-21 | 2017-07-04 | Kardium Inc. | Systems and methods for selecting, activating, or selecting and activating transducers |
US10827977B2 (en) | 2012-05-21 | 2020-11-10 | Kardium Inc. | Systems and methods for activating transducers |
US9345573B2 (en) | 2012-05-30 | 2016-05-24 | Neovasc Tiara Inc. | Methods and apparatus for loading a prosthesis onto a delivery system |
EP2900150B1 (en) | 2012-09-29 | 2018-04-18 | Mitralign, Inc. | Plication lock delivery system |
US9949828B2 (en) | 2012-10-23 | 2018-04-24 | Valtech Cardio, Ltd. | Controlled steering functionality for implant-delivery tool |
EP3730066A1 (en) | 2012-10-23 | 2020-10-28 | Valtech Cardio, Ltd. | Percutaneous tissue anchor techniques |
WO2014087402A1 (en) | 2012-12-06 | 2014-06-12 | Valtech Cardio, Ltd. | Techniques for guide-wire based advancement of a tool |
US9681952B2 (en) | 2013-01-24 | 2017-06-20 | Mitraltech Ltd. | Anchoring of prosthetic valve supports |
EP2961351B1 (en) | 2013-02-26 | 2018-11-28 | Mitralign, Inc. | Devices for percutaneous tricuspid valve repair |
US10449333B2 (en) | 2013-03-14 | 2019-10-22 | Valtech Cardio, Ltd. | Guidewire feeder |
WO2014152503A1 (en) | 2013-03-15 | 2014-09-25 | Mitralign, Inc. | Translation catheters, systems, and methods of use thereof |
US9572665B2 (en) | 2013-04-04 | 2017-02-21 | Neovasc Tiara Inc. | Methods and apparatus for delivering a prosthetic valve to a beating heart |
US10070857B2 (en) | 2013-08-31 | 2018-09-11 | Mitralign, Inc. | Devices and methods for locating and implanting tissue anchors at mitral valve commissure |
WO2015059699A2 (en) | 2013-10-23 | 2015-04-30 | Valtech Cardio, Ltd. | Anchor magazine |
US9610162B2 (en) | 2013-12-26 | 2017-04-04 | Valtech Cardio, Ltd. | Implantation of flexible implant |
US10390943B2 (en) | 2014-03-17 | 2019-08-27 | Evalve, Inc. | Double orifice device for transcatheter mitral valve replacement |
KR101581021B1 (en) * | 2014-05-28 | 2015-12-29 | (주) 타우피엔유메디칼 | Tissue protective device for the cerclage annuloplasty procedure in use of the coil spring, and tissue protective device making method |
EP3206629B1 (en) | 2014-10-14 | 2021-07-14 | Valtech Cardio, Ltd. | Apparatus for heart valve leaflet restraining |
US10722184B2 (en) | 2014-11-17 | 2020-07-28 | Kardium Inc. | Systems and methods for selecting, activating, or selecting and activating transducers |
US10368936B2 (en) | 2014-11-17 | 2019-08-06 | Kardium Inc. | Systems and methods for selecting, activating, or selecting and activating transducers |
US10188392B2 (en) | 2014-12-19 | 2019-01-29 | Abbott Cardiovascular Systems, Inc. | Grasping for tissue repair |
CA3162308A1 (en) | 2015-02-05 | 2016-08-11 | Cardiovalve Ltd. | Prosthetic valve with axially-sliding frames |
US20160256269A1 (en) | 2015-03-05 | 2016-09-08 | Mitralign, Inc. | Devices for treating paravalvular leakage and methods use thereof |
US10524912B2 (en) | 2015-04-02 | 2020-01-07 | Abbott Cardiovascular Systems, Inc. | Tissue fixation devices and methods |
SG10202010021SA (en) | 2015-04-30 | 2020-11-27 | Valtech Cardio Ltd | Annuloplasty technologies |
US10376673B2 (en) | 2015-06-19 | 2019-08-13 | Evalve, Inc. | Catheter guiding system and methods |
US10238494B2 (en) | 2015-06-29 | 2019-03-26 | Evalve, Inc. | Self-aligning radiopaque ring |
US10667815B2 (en) | 2015-07-21 | 2020-06-02 | Evalve, Inc. | Tissue grasping devices and related methods |
US10413408B2 (en) | 2015-08-06 | 2019-09-17 | Evalve, Inc. | Delivery catheter systems, methods, and devices |
US10238495B2 (en) | 2015-10-09 | 2019-03-26 | Evalve, Inc. | Delivery catheter handle and methods of use |
US10751182B2 (en) | 2015-12-30 | 2020-08-25 | Edwards Lifesciences Corporation | System and method for reshaping right heart |
US10828160B2 (en) | 2015-12-30 | 2020-11-10 | Edwards Lifesciences Corporation | System and method for reducing tricuspid regurgitation |
US10433952B2 (en) | 2016-01-29 | 2019-10-08 | Neovasc Tiara Inc. | Prosthetic valve for avoiding obstruction of outflow |
US10531866B2 (en) | 2016-02-16 | 2020-01-14 | Cardiovalve Ltd. | Techniques for providing a replacement valve and transseptal communication |
US10702274B2 (en) | 2016-05-26 | 2020-07-07 | Edwards Lifesciences Corporation | Method and system for closing left atrial appendage |
US10736632B2 (en) | 2016-07-06 | 2020-08-11 | Evalve, Inc. | Methods and devices for valve clip excision |
GB201611910D0 (en) | 2016-07-08 | 2016-08-24 | Valtech Cardio Ltd | Adjustable annuloplasty device with alternating peaks and troughs |
CA3031187A1 (en) | 2016-08-10 | 2018-02-15 | Cardiovalve Ltd. | Prosthetic valve with concentric frames |
US11071564B2 (en) | 2016-10-05 | 2021-07-27 | Evalve, Inc. | Cardiac valve cutting device |
US10363138B2 (en) | 2016-11-09 | 2019-07-30 | Evalve, Inc. | Devices for adjusting the curvature of cardiac valve structures |
US10398553B2 (en) | 2016-11-11 | 2019-09-03 | Evalve, Inc. | Opposing disk device for grasping cardiac valve tissue |
US10426616B2 (en) | 2016-11-17 | 2019-10-01 | Evalve, Inc. | Cardiac implant delivery system |
CN109996581B (en) | 2016-11-21 | 2021-10-15 | 内奥瓦斯克迪亚拉公司 | Methods and systems for rapid retrieval of transcatheter heart valve delivery systems |
US10779837B2 (en) | 2016-12-08 | 2020-09-22 | Evalve, Inc. | Adjustable arm device for grasping tissues |
US10314586B2 (en) | 2016-12-13 | 2019-06-11 | Evalve, Inc. | Rotatable device and method for fixing tricuspid valve tissue |
US10390953B2 (en) | 2017-03-08 | 2019-08-27 | Cardiac Dimensions Pty. Ltd. | Methods and devices for reducing paravalvular leakage |
US11045627B2 (en) | 2017-04-18 | 2021-06-29 | Edwards Lifesciences Corporation | Catheter system with linear actuation control mechanism |
EP3621529A1 (en) | 2017-05-12 | 2020-03-18 | Evalve, Inc. | Long arm valve repair clip |
WO2019028264A1 (en) | 2017-08-03 | 2019-02-07 | The Regents Of The University Of California | Atrial cage for placement, securing and anchoring of atrioventricular valves |
WO2019036810A1 (en) | 2017-08-25 | 2019-02-28 | Neovasc Tiara Inc. | Sequentially deployed transcatheter mitral valve prosthesis |
US10835221B2 (en) | 2017-11-02 | 2020-11-17 | Valtech Cardio, Ltd. | Implant-cinching devices and systems |
US11135062B2 (en) | 2017-11-20 | 2021-10-05 | Valtech Cardio Ltd. | Cinching of dilated heart muscle |
CN111655200B (en) | 2018-01-24 | 2023-07-14 | 爱德华兹生命科学创新(以色列)有限公司 | Contraction of annuloplasty structures |
WO2019145941A1 (en) | 2018-01-26 | 2019-08-01 | Valtech Cardio, Ltd. | Techniques for facilitating heart valve tethering and chord replacement |
US11957586B2 (en) | 2018-01-27 | 2024-04-16 | Mitre Medical Corp. | Epicardial valve repair system |
US11285003B2 (en) | 2018-03-20 | 2022-03-29 | Medtronic Vascular, Inc. | Prolapse prevention device and methods of use thereof |
US11026791B2 (en) | 2018-03-20 | 2021-06-08 | Medtronic Vascular, Inc. | Flexible canopy valve repair systems and methods of use |
SG11202013066PA (en) | 2018-07-12 | 2021-01-28 | Valtech Cardio Ltd | Annuloplasty systems and locking tools therefor |
CN113271890A (en) | 2018-11-08 | 2021-08-17 | 内奥瓦斯克迪亚拉公司 | Ventricular deployment of transcatheter mitral valve prosthesis |
US11452601B2 (en) | 2018-12-13 | 2022-09-27 | Medtronic Vascular, Inc. | Wire annuloplasty ring |
US11517434B2 (en) | 2018-12-13 | 2022-12-06 | Medtronic Vascular, Inc. | Annuloplasty device including tube-like structure |
CA3132873A1 (en) | 2019-03-08 | 2020-09-17 | Neovasc Tiara Inc. | Retrievable prosthesis delivery system |
JP7438236B2 (en) | 2019-04-01 | 2024-02-26 | ニオバスク ティアラ インコーポレイテッド | Controllably deployable prosthetic valve |
CN113924065A (en) | 2019-04-10 | 2022-01-11 | 内奥瓦斯克迪亚拉公司 | Prosthetic valve with natural blood flow |
EP3972673A4 (en) | 2019-05-20 | 2023-06-07 | Neovasc Tiara Inc. | Introducer with hemostasis mechanism |
CA3143344A1 (en) | 2019-06-20 | 2020-12-24 | Neovasc Tiara Inc. | Low profile prosthetic mitral valve |
EP4051182A1 (en) | 2019-10-29 | 2022-09-07 | Edwards Lifesciences Innovation (Israel) Ltd. | Annuloplasty and tissue anchor technologies |
JP2023554000A (en) | 2020-12-14 | 2023-12-26 | カーディアック・ディメンションズ・プロプライエタリー・リミテッド | Modular preloaded medical implants and delivery systems |
Family Cites Families (43)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
GB741604A (en) | 1952-10-16 | 1955-12-07 | S & R J Everett & Co Ltd | Improvements relating to hypodermic syringes |
US3995623A (en) | 1974-12-23 | 1976-12-07 | American Hospital Supply Corporation | Multipurpose flow-directed catheter |
FR2306671A1 (en) | 1975-04-11 | 1976-11-05 | Rhone Poulenc Ind | VALVULAR IMPLANT |
US4164046A (en) * | 1977-05-16 | 1979-08-14 | Cooley Denton | Valve prosthesis |
US4588395A (en) | 1978-03-10 | 1986-05-13 | Lemelson Jerome H | Catheter and method |
CA1303298C (en) * | 1986-08-06 | 1992-06-16 | Alain Carpentier | Flexible cardiac valvular support prosthesis |
US5350420A (en) | 1989-07-31 | 1994-09-27 | Baxter International Inc. | Flexible annuloplasty ring and holder |
FR2710254B1 (en) | 1993-09-21 | 1995-10-27 | Mai Christian | Multi-branch osteosynthesis clip with self-retaining dynamic compression. |
US5899882A (en) | 1994-10-27 | 1999-05-04 | Novoste Corporation | Catheter apparatus for radiation treatment of a desired area in the vascular system of a patient |
US5676671A (en) | 1995-04-12 | 1997-10-14 | Inoue; Kanji | Device for introducing an appliance to be implanted into a catheter |
IL119911A (en) | 1996-12-25 | 2001-03-19 | Niti Alloys Tech Ltd | Surgical clip |
WO1998056435A1 (en) | 1997-06-13 | 1998-12-17 | Micro Therapeutics, Inc. | Contoured syringe and novel luer hub and methods for embolizing blood vessels |
FR2766374B1 (en) | 1997-07-24 | 2000-01-28 | Medex Sa | DEVICE FOR INJECTING A LIQUID FOR MEDICAL SYRINGE ASSOCIATED WITH THE DEVICE AND METHOD FOR PLACING THE SYRINGE |
US6096064A (en) | 1997-09-19 | 2000-08-01 | Intermedics Inc. | Four chamber pacer for dilated cardiomyopthy |
US5928258A (en) | 1997-09-26 | 1999-07-27 | Corvita Corporation | Method and apparatus for loading a stent or stent-graft into a delivery sheath |
US6475177B1 (en) | 1998-11-20 | 2002-11-05 | New X-National Technology K.K. | Hemostatic agent inserting device |
US6629534B1 (en) | 1999-04-09 | 2003-10-07 | Evalve, Inc. | Methods and apparatus for cardiac valve repair |
US6602289B1 (en) | 1999-06-08 | 2003-08-05 | S&A Rings, Llc | Annuloplasty rings of particular use in surgery for the mitral valve |
US6626899B2 (en) * | 1999-06-25 | 2003-09-30 | Nidus Medical, Llc | Apparatus and methods for treating tissue |
SE514718C2 (en) | 1999-06-29 | 2001-04-09 | Jan Otto Solem | Apparatus for treating defective closure of the mitral valve apparatus |
US7192442B2 (en) | 1999-06-30 | 2007-03-20 | Edwards Lifesciences Ag | Method and device for treatment of mitral insufficiency |
US6391038B2 (en) | 1999-07-28 | 2002-05-21 | Cardica, Inc. | Anastomosis system and method for controlling a tissue site |
ATE380529T1 (en) | 1999-10-22 | 2007-12-15 | Archus Orthopedics Inc | FACET ARTHROPLASTY DEVICES |
US6613075B1 (en) | 1999-10-27 | 2003-09-02 | Cordis Corporation | Rapid exchange self-expanding stent delivery catheter system |
US6692513B2 (en) | 2000-06-30 | 2004-02-17 | Viacor, Inc. | Intravascular filter with debris entrapment mechanism |
US6402781B1 (en) | 2000-01-31 | 2002-06-11 | Mitralife | Percutaneous mitral annuloplasty and cardiac reinforcement |
US6358195B1 (en) | 2000-03-09 | 2002-03-19 | Neoseed Technology Llc | Method and apparatus for loading radioactive seeds into brachytherapy needles |
US6569198B1 (en) * | 2000-03-31 | 2003-05-27 | Richard A. Wilson | Mitral or tricuspid valve annuloplasty prosthetic device |
US6419696B1 (en) * | 2000-07-06 | 2002-07-16 | Paul A. Spence | Annuloplasty devices and related heart valve repair methods |
US6602288B1 (en) * | 2000-10-05 | 2003-08-05 | Edwards Lifesciences Corporation | Minimally-invasive annuloplasty repair segment delivery template, system and method of use |
US6723038B1 (en) | 2000-10-06 | 2004-04-20 | Myocor, Inc. | Methods and devices for improving mitral valve function |
US7070618B2 (en) | 2000-10-25 | 2006-07-04 | Viacor, Inc. | Mitral shield |
WO2002034118A2 (en) | 2000-10-27 | 2002-05-02 | Viacor, Inc. | Intracardiovascular access (icvatm) system |
US7591826B2 (en) | 2000-12-28 | 2009-09-22 | Cardiac Dimensions, Inc. | Device implantable in the coronary sinus to provide mitral valve therapy |
US6810882B2 (en) | 2001-01-30 | 2004-11-02 | Ev3 Santa Rosa, Inc. | Transluminal mitral annuloplasty |
JP4195612B2 (en) | 2001-01-30 | 2008-12-10 | エドワーズ ライフサイエンシーズ アーゲー | Medical system and method for improving extracorporeal tissue structure |
US6800090B2 (en) * | 2001-05-14 | 2004-10-05 | Cardiac Dimensions, Inc. | Mitral valve therapy device, system and method |
US6676702B2 (en) * | 2001-05-14 | 2004-01-13 | Cardiac Dimensions, Inc. | Mitral valve therapy assembly and method |
US7144363B2 (en) | 2001-10-16 | 2006-12-05 | Extensia Medical, Inc. | Systems for heart treatment |
US6908478B2 (en) * | 2001-12-05 | 2005-06-21 | Cardiac Dimensions, Inc. | Anchor and pull mitral valve device and method |
US6976995B2 (en) * | 2002-01-30 | 2005-12-20 | Cardiac Dimensions, Inc. | Fixed length anchor and pull mitral valve device and method |
SE524709C2 (en) * | 2002-01-11 | 2004-09-21 | Edwards Lifesciences Ag | Device for delayed reshaping of a heart vessel and a heart valve |
US6797001B2 (en) * | 2002-03-11 | 2004-09-28 | Cardiac Dimensions, Inc. | Device, assembly and method for mitral valve repair |
-
2000
- 2000-12-28 US US09/751,271 patent/US7591826B2/en not_active Expired - Fee Related
-
2001
- 2001-12-27 AT AT01991615T patent/ATE422863T1/en not_active IP Right Cessation
- 2001-12-27 WO PCT/US2001/050860 patent/WO2002053206A2/en active IP Right Grant
- 2001-12-27 DE DE60137724T patent/DE60137724D1/en not_active Expired - Lifetime
- 2001-12-27 AU AU2002231342A patent/AU2002231342B2/en not_active Expired
- 2001-12-27 ES ES01991615T patent/ES2322552T3/en not_active Expired - Lifetime
- 2001-12-27 EP EP01991615A patent/EP1395182B1/en not_active Expired - Lifetime
- 2001-12-27 JP JP2002554155A patent/JP4113431B2/en not_active Expired - Lifetime
- 2001-12-27 CA CA002433672A patent/CA2433672C/en not_active Expired - Lifetime
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