AU2002224363A1 - Hydrophilic light absorbing compositions for determination of physiological function in critically ill patients - Google Patents

Hydrophilic light absorbing compositions for determination of physiological function in critically ill patients

Info

Publication number
AU2002224363A1
AU2002224363A1 AU2002224363A AU2436302A AU2002224363A1 AU 2002224363 A1 AU2002224363 A1 AU 2002224363A1 AU 2002224363 A AU2002224363 A AU 2002224363A AU 2436302 A AU2436302 A AU 2436302A AU 2002224363 A1 AU2002224363 A1 AU 2002224363A1
Authority
AU
Australia
Prior art keywords
determination
light absorbing
physiological function
critically ill
ill patients
Prior art date
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Abandoned
Application number
AU2002224363A
Inventor
Samuel Achilefu
Joseph E. Bugaj
Richard B. Dorshow
Raghavan Rajagopalan
Current Assignee (The listed assignees may be inaccurate. Google has not performed a legal analysis and makes no representation or warranty as to the accuracy of the list.)
Mallinckrodt Inc
Original Assignee
Mallinckrodt Inc
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Mallinckrodt Inc filed Critical Mallinckrodt Inc
Publication of AU2002224363A1 publication Critical patent/AU2002224363A1/en
Abandoned legal-status Critical Current

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D209/00—Heterocyclic compounds containing five-membered rings, condensed with other rings, with one nitrogen atom as the only ring hetero atom
    • C07D209/56—Ring systems containing three or more rings
    • C07D209/58—[b]- or [c]-condensed
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/33—Heterocyclic compounds
    • A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
    • A61K31/40—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having five-membered rings with one nitrogen as the only ring hetero atom, e.g. sulpiride, succinimide, tolmetin, buflomedil
    • A61K31/403—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having five-membered rings with one nitrogen as the only ring hetero atom, e.g. sulpiride, succinimide, tolmetin, buflomedil condensed with carbocyclic rings, e.g. carbazole
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K49/00—Preparations for testing in vivo
    • A61K49/001—Preparation for luminescence or biological staining
    • A61K49/0013—Luminescence
    • A61K49/0017—Fluorescence in vivo
    • A61K49/0019—Fluorescence in vivo characterised by the fluorescent group, e.g. oligomeric, polymeric or dendritic molecules
    • A61K49/0021—Fluorescence in vivo characterised by the fluorescent group, e.g. oligomeric, polymeric or dendritic molecules the fluorescent group being a small organic molecule
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K49/00—Preparations for testing in vivo
    • A61K49/001—Preparation for luminescence or biological staining
    • A61K49/0013—Luminescence
    • A61K49/0017—Fluorescence in vivo
    • A61K49/0019—Fluorescence in vivo characterised by the fluorescent group, e.g. oligomeric, polymeric or dendritic molecules
    • A61K49/0021—Fluorescence in vivo characterised by the fluorescent group, e.g. oligomeric, polymeric or dendritic molecules the fluorescent group being a small organic molecule
    • A61K49/0032—Methine dyes, e.g. cyanine dyes
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P13/00—Drugs for disorders of the urinary system
    • A61P13/12—Drugs for disorders of the urinary system of the kidneys
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P43/00—Drugs for specific purposes, not provided for in groups A61P1/00-A61P41/00
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D209/00—Heterocyclic compounds containing five-membered rings, condensed with other rings, with one nitrogen atom as the only ring hetero atom
    • C07D209/02—Heterocyclic compounds containing five-membered rings, condensed with other rings, with one nitrogen atom as the only ring hetero atom condensed with one carbocyclic ring
    • C07D209/04—Indoles; Hydrogenated indoles
    • C07D209/08—Indoles; Hydrogenated indoles with only hydrogen atoms or radicals containing only hydrogen and carbon atoms, directly attached to carbon atoms of the hetero ring
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D209/00—Heterocyclic compounds containing five-membered rings, condensed with other rings, with one nitrogen atom as the only ring hetero atom
    • C07D209/02—Heterocyclic compounds containing five-membered rings, condensed with other rings, with one nitrogen atom as the only ring hetero atom condensed with one carbocyclic ring
    • C07D209/04—Indoles; Hydrogenated indoles
    • C07D209/10—Indoles; Hydrogenated indoles with substituted hydrocarbon radicals attached to carbon atoms of the hetero ring
    • C07D209/12—Radicals substituted by oxygen atoms
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D209/00—Heterocyclic compounds containing five-membered rings, condensed with other rings, with one nitrogen atom as the only ring hetero atom
    • C07D209/56—Ring systems containing three or more rings
    • C07D209/58—[b]- or [c]-condensed
    • C07D209/60—Naphtho [b] pyrroles; Hydrogenated naphtho [b] pyrroles
AU2002224363A 2000-10-16 2001-10-05 Hydrophilic light absorbing compositions for determination of physiological function in critically ill patients Abandoned AU2002224363A1 (en)

Applications Claiming Priority (3)

Application Number Priority Date Filing Date Title
US09/688,943 US6669926B1 (en) 2000-10-16 2000-10-16 Hydrophilic light absorbing indole compounds for determination of physiological function in critically ill patients
US09/688,943 2000-10-16
PCT/US2001/031717 WO2002032285A2 (en) 2000-10-16 2001-10-05 Hydrophilic light absorbing compositions for determination of physiological function in critically ill patients

Publications (1)

Publication Number Publication Date
AU2002224363A1 true AU2002224363A1 (en) 2002-04-29

Family

ID=24766429

Family Applications (1)

Application Number Title Priority Date Filing Date
AU2002224363A Abandoned AU2002224363A1 (en) 2000-10-16 2001-10-05 Hydrophilic light absorbing compositions for determination of physiological function in critically ill patients

Country Status (6)

Country Link
US (4) US6669926B1 (en)
EP (1) EP1326650A4 (en)
JP (2) JP4179873B2 (en)
AU (1) AU2002224363A1 (en)
CA (1) CA2425698A1 (en)
WO (1) WO2002032285A2 (en)

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US20030105300A1 (en) * 2001-10-17 2003-06-05 Mallinckrodt Inc. Tumor targeted photodiagnostic-phototherapeutic agents
US20030105299A1 (en) * 2001-10-17 2003-06-05 Mallinckrodt Inc. Carbocyanine dyes for tandem, photodiagnostic and therapeutic applications
US6761878B2 (en) 2001-10-17 2004-07-13 Mallinckrodt, Inc. Pathological tissue detection and treatment employing targeted benzoindole optical agents
US20070122344A1 (en) 2005-09-02 2007-05-31 University Of Rochester Medical Center Office Of Technology Transfer Intraoperative determination of nerve location
EP1815870A1 (en) * 2006-02-01 2007-08-08 DKFZ Deutsches Krebsforschungszentrum Cyanine dye compounds linked to metal chelator for bi-modal diagnostic imaging
ES2390314T3 (en) * 2006-02-24 2012-11-08 Medibeacon Development, Llc Optical agents for use in surgery
US20080161744A1 (en) 2006-09-07 2008-07-03 University Of Rochester Medical Center Pre-And Intra-Operative Localization of Penile Sentinel Nodes
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US8406860B2 (en) 2008-01-25 2013-03-26 Novadaq Technologies Inc. Method for evaluating blush in myocardial tissue
US10219742B2 (en) 2008-04-14 2019-03-05 Novadaq Technologies ULC Locating and analyzing perforator flaps for plastic and reconstructive surgery
EP2285421B1 (en) 2008-05-02 2018-04-11 Novadaq Technologies ULC Methods for production and use of substance-loaded erythrocytes for observation and treatment of microvascular hemodynamics
US8901455B2 (en) 2008-06-18 2014-12-02 Lincoln Global, Inc. Welding wire for submerged arc welding
WO2010129258A2 (en) 2009-04-27 2010-11-11 Mallinckrodt Inc. Tissue sealant compositions, vascular closure devices, and uses thereof
US10492671B2 (en) 2009-05-08 2019-12-03 Novadaq Technologies ULC Near infra red fluorescence imaging for visualization of blood vessels during endoscopic harvest
EP2764406B1 (en) * 2011-10-07 2018-03-14 Cedars-Sinai Medical Center Compositions and methods for tumor imaging and targeting by a class of organic heptamethine cyanine dyes that possess dual nuclear and near-infrared properties
US10278585B2 (en) 2012-06-21 2019-05-07 Novadaq Technologies ULC Quantification and analysis of angiography and perfusion
CZ304948B6 (en) * 2013-01-02 2015-02-04 Vysoká škola chemicko-technologická v Praze Use of polymethine salts as sensors for tumor markers
EP2944326B1 (en) * 2014-05-16 2018-11-21 Cyanagen Srl Tricarbocyanine-cyclodextrin-conjugates and their use for the diagnosis of kidney diseases
CZ2014451A3 (en) 2014-06-30 2016-01-13 Contipro Pharma A.S. Antitumor composition based on hyaluronic acid and inorganic nanoparticles, process of its preparation and use
CN107209118B (en) 2014-09-29 2021-05-28 史赛克欧洲运营有限公司 Imaging of target fluorophores in biological materials in the presence of autofluorescence
KR102012880B1 (en) 2014-10-09 2019-08-22 노바다크 테크놀러지즈 유엘씨 Quantification of absolute blood flow in tissue using fluorescence-mediated photoplethysmography
CZ309295B6 (en) 2015-03-09 2022-08-10 Contipro A.S. Self-supporting, biodegradable film based on hydrophobized hyaluronic acid, method of its preparation and use
JP6552236B2 (en) * 2015-03-23 2019-07-31 キヤノン株式会社 Near-infrared dye-bound transferrin, contrast agent for photoacoustic imaging comprising the near-infrared dye-bound transferrin
CZ2015398A3 (en) 2015-06-15 2017-02-08 Contipro A.S. A method of crosslinking polysaccharides by using photolabile protecting groups
CZ306662B6 (en) 2015-06-26 2017-04-26 Contipro A.S. Sulphated polysaccharides derivatives, the method of their preparation, the method of their modification and the use
CZ307511B6 (en) 2015-12-23 2018-10-31 Contipro A.S. A fluorescent conjugate of hyaluronic acid or a salt thereof, a hydrophobized conjugate, a method of their preparation and use
US9862682B2 (en) 2016-01-08 2018-01-09 BroadPharm Functionalized pegylated cyanine compounds, pharmaceutical compositions, and methods of use thereof
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Also Published As

Publication number Publication date
US7608244B2 (en) 2009-10-27
JP2004511500A (en) 2004-04-15
US20070269368A1 (en) 2007-11-22
WO2002032285A2 (en) 2002-04-25
JP2008231113A (en) 2008-10-02
US20070269373A1 (en) 2007-11-22
EP1326650A2 (en) 2003-07-16
US20040223913A1 (en) 2004-11-11
US7297325B2 (en) 2007-11-20
CA2425698A1 (en) 2002-04-25
JP4179873B2 (en) 2008-11-12
US6669926B1 (en) 2003-12-30
EP1326650A4 (en) 2006-08-16
US7468177B2 (en) 2008-12-23
WO2002032285A3 (en) 2002-08-01

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