AU2002223860A1 - Nucleic acid vaccine comprising a fusion protein including an adjuvant sequence from a plant viral coat protein - Google Patents
Nucleic acid vaccine comprising a fusion protein including an adjuvant sequence from a plant viral coat proteinInfo
- Publication number
- AU2002223860A1 AU2002223860A1 AU2002223860A AU2386002A AU2002223860A1 AU 2002223860 A1 AU2002223860 A1 AU 2002223860A1 AU 2002223860 A AU2002223860 A AU 2002223860A AU 2386002 A AU2386002 A AU 2386002A AU 2002223860 A1 AU2002223860 A1 AU 2002223860A1
- Authority
- AU
- Australia
- Prior art keywords
- fusion protein
- nucleic acid
- viral coat
- plant viral
- acid vaccine
- Prior art date
- Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
- Abandoned
Links
- 108020001507 fusion proteins Proteins 0.000 title abstract 3
- 102000037865 fusion proteins Human genes 0.000 title abstract 3
- 108090000565 Capsid Proteins Proteins 0.000 title abstract 2
- 239000002671 adjuvant Substances 0.000 title abstract 2
- 108700001237 Nucleic Acid-Based Vaccines Proteins 0.000 title 1
- 229940023146 nucleic acid vaccine Drugs 0.000 title 1
- 206010028980 Neoplasm Diseases 0.000 abstract 2
- 239000000427 antigen Substances 0.000 abstract 2
- 102000036639 antigens Human genes 0.000 abstract 2
- 108091007433 antigens Proteins 0.000 abstract 2
- 201000011510 cancer Diseases 0.000 abstract 2
- 238000000034 method Methods 0.000 abstract 2
- 208000035473 Communicable disease Diseases 0.000 abstract 1
- 210000003719 b-lymphocyte Anatomy 0.000 abstract 1
- 210000004027 cell Anatomy 0.000 abstract 1
- 230000028993 immune response Effects 0.000 abstract 1
- 238000001727 in vivo Methods 0.000 abstract 1
- 230000001939 inductive effect Effects 0.000 abstract 1
- 208000015181 infectious disease Diseases 0.000 abstract 1
- 230000036210 malignancy Effects 0.000 abstract 1
- 102000039446 nucleic acids Human genes 0.000 abstract 1
- 108020004707 nucleic acids Proteins 0.000 abstract 1
- 150000007523 nucleic acids Chemical class 0.000 abstract 1
Classifications
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K14/00—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof
- C07K14/005—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from viruses
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K39/00—Medicinal preparations containing antigens or antibodies
- A61K39/0005—Vertebrate antigens
- A61K39/0011—Cancer antigens
- A61K39/001102—Receptors, cell surface antigens or cell surface determinants
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K39/00—Medicinal preparations containing antigens or antibodies
- A61K39/385—Haptens or antigens, bound to carriers
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K39/00—Medicinal preparations containing antigens or antibodies
- A61K2039/51—Medicinal preparations containing antigens or antibodies comprising whole cells, viruses or DNA/RNA
- A61K2039/53—DNA (RNA) vaccination
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K39/00—Medicinal preparations containing antigens or antibodies
- A61K2039/60—Medicinal preparations containing antigens or antibodies characteristics by the carrier linked to the antigen
- A61K2039/6031—Proteins
- A61K2039/6075—Viral proteins
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K2319/00—Fusion polypeptide
-
- C—CHEMISTRY; METALLURGY
- C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
- C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
- C12N2740/00—Reverse transcribing RNA viruses
- C12N2740/00011—Details
- C12N2740/10011—Retroviridae
- C12N2740/13011—Gammaretrovirus, e.g. murine leukeamia virus
- C12N2740/13022—New viral proteins or individual genes, new structural or functional aspects of known viral proteins or genes
Landscapes
- Health & Medical Sciences (AREA)
- Life Sciences & Earth Sciences (AREA)
- Chemical & Material Sciences (AREA)
- General Health & Medical Sciences (AREA)
- Medicinal Chemistry (AREA)
- Veterinary Medicine (AREA)
- Mycology (AREA)
- Pharmacology & Pharmacy (AREA)
- Epidemiology (AREA)
- Animal Behavior & Ethology (AREA)
- Microbiology (AREA)
- Public Health (AREA)
- Immunology (AREA)
- Organic Chemistry (AREA)
- Gastroenterology & Hepatology (AREA)
- Virology (AREA)
- Oncology (AREA)
- Biochemistry (AREA)
- Biophysics (AREA)
- Genetics & Genomics (AREA)
- Molecular Biology (AREA)
- Proteomics, Peptides & Aminoacids (AREA)
- Cell Biology (AREA)
- Medicines Containing Antibodies Or Antigens For Use As Internal Diagnostic Agents (AREA)
- Peptides Or Proteins (AREA)
- Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
Abstract
A nucleic acid construct is provided for delivery into living cells in vivo for inducing an immune response in a patient to an antigen; the construct directing the expression of a fusion protein, said fusion protein comprising said antigen and an adjuvant sequence derived from a plant viral coat protein. Methods for making constructs and methods of using such constructs for the treatment of infectious disease, cancer and B cell malignancy, are provided.
Applications Claiming Priority (3)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| GB0028319.2 | 2000-11-20 | ||
| GBGB0028319.2A GB0028319D0 (en) | 2000-11-20 | 2000-11-20 | Materials and methods relating to fusion proteins for inducing an immune response |
| PCT/GB2001/005142 WO2002040513A2 (en) | 2000-11-20 | 2001-11-20 | Nucleic acid vaccine comprising a fusion protein including an adjuvant sequence from a plant viral coat protein |
Publications (1)
| Publication Number | Publication Date |
|---|---|
| AU2002223860A1 true AU2002223860A1 (en) | 2002-05-27 |
Family
ID=9903545
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| AU2002223860A Abandoned AU2002223860A1 (en) | 2000-11-20 | 2001-11-20 | Nucleic acid vaccine comprising a fusion protein including an adjuvant sequence from a plant viral coat protein |
Country Status (10)
| Country | Link |
|---|---|
| US (2) | US7179471B2 (en) |
| EP (1) | EP1337553B1 (en) |
| AT (1) | ATE332920T1 (en) |
| AU (1) | AU2002223860A1 (en) |
| DE (1) | DE60121462T2 (en) |
| DK (1) | DK1337553T3 (en) |
| ES (1) | ES2267863T3 (en) |
| GB (1) | GB0028319D0 (en) |
| PT (1) | PT1337553E (en) |
| WO (1) | WO2002040513A2 (en) |
Families Citing this family (4)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| GB0028319D0 (en) * | 2000-11-20 | 2001-01-03 | Univ Southampton | Materials and methods relating to fusion proteins for inducing an immune response |
| PT1523329E (en) * | 2002-07-05 | 2013-10-08 | Folia Biotech Inc | Adjuvant viral particle |
| WO2013044061A1 (en) * | 2011-09-21 | 2013-03-28 | The Texas A&M University System | Plant viral vaccines and therapeutics |
| CN111544585A (en) * | 2019-02-11 | 2020-08-18 | 北京卡替医疗技术有限公司 | Adjuvant capable of boosting immune cells to expand in vivo |
Family Cites Families (3)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| JPH05506145A (en) * | 1990-04-06 | 1993-09-16 | コモンウエルス・サイエンティフィック・アンド・インダストリアル・リサーチ・オーガニゼイション | Self-polymerization expression system based on modified potyvirus coat protein |
| IT1317046B1 (en) | 2000-06-16 | 2003-05-26 | Ist Superiore Sanita | MELTING PROTEIN, VIRAL PARTICLES THAT EXPOSE IT ON SUCH CAPS, PLANTS INFECTED WITH SUCH PARTICLES, THEIR USES AND COMPOSITIONS |
| GB0028319D0 (en) * | 2000-11-20 | 2001-01-03 | Univ Southampton | Materials and methods relating to fusion proteins for inducing an immune response |
-
2000
- 2000-11-20 GB GBGB0028319.2A patent/GB0028319D0/en not_active Ceased
-
2001
- 2001-11-20 DE DE60121462T patent/DE60121462T2/en not_active Expired - Fee Related
- 2001-11-20 WO PCT/GB2001/005142 patent/WO2002040513A2/en active IP Right Grant
- 2001-11-20 US US10/416,290 patent/US7179471B2/en not_active Expired - Fee Related
- 2001-11-20 AT AT01996550T patent/ATE332920T1/en not_active IP Right Cessation
- 2001-11-20 AU AU2002223860A patent/AU2002223860A1/en not_active Abandoned
- 2001-11-20 ES ES01996550T patent/ES2267863T3/en not_active Expired - Lifetime
- 2001-11-20 EP EP01996550A patent/EP1337553B1/en not_active Expired - Lifetime
- 2001-11-20 DK DK01996550T patent/DK1337553T3/en active
- 2001-11-20 PT PT01996550T patent/PT1337553E/en unknown
-
2007
- 2007-01-10 US US11/651,497 patent/US7410643B2/en not_active Expired - Fee Related
Also Published As
| Publication number | Publication date |
|---|---|
| US20070128220A1 (en) | 2007-06-07 |
| ATE332920T1 (en) | 2006-08-15 |
| WO2002040513A3 (en) | 2002-11-07 |
| PT1337553E (en) | 2006-12-29 |
| WO2002040513A9 (en) | 2003-05-01 |
| US7179471B2 (en) | 2007-02-20 |
| DK1337553T3 (en) | 2006-11-13 |
| EP1337553A2 (en) | 2003-08-27 |
| DE60121462T2 (en) | 2007-02-08 |
| US20040072781A1 (en) | 2004-04-15 |
| GB0028319D0 (en) | 2001-01-03 |
| US7410643B2 (en) | 2008-08-12 |
| DE60121462D1 (en) | 2006-08-24 |
| EP1337553B1 (en) | 2006-07-12 |
| ES2267863T3 (en) | 2007-03-16 |
| WO2002040513A2 (en) | 2002-05-23 |
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