AU2002222274A1 - Crystal structure of glycogen synthase kinase 3 beta - Google Patents

Crystal structure of glycogen synthase kinase 3 beta

Info

Publication number
AU2002222274A1
AU2002222274A1 AU2002222274A AU2227402A AU2002222274A1 AU 2002222274 A1 AU2002222274 A1 AU 2002222274A1 AU 2002222274 A AU2002222274 A AU 2002222274A AU 2227402 A AU2227402 A AU 2227402A AU 2002222274 A1 AU2002222274 A1 AU 2002222274A1
Authority
AU
Australia
Prior art keywords
beta
crystal structure
glycogen synthase
synthase kinase
kinase
Prior art date
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Abandoned
Application number
AU2002222274A
Inventor
Benjamin Bax
Murray Brown
Alastair Reith
Current Assignee (The listed assignees may be inaccurate. Google has not performed a legal analysis and makes no representation or warranty as to the accuracy of the list.)
SmithKline Beecham Ltd
Original Assignee
SmithKline Beecham Ltd
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Priority claimed from GB0030846A external-priority patent/GB0030846D0/en
Priority claimed from GB0119796A external-priority patent/GB0119796D0/en
Application filed by SmithKline Beecham Ltd filed Critical SmithKline Beecham Ltd
Publication of AU2002222274A1 publication Critical patent/AU2002222274A1/en
Abandoned legal-status Critical Current

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
    • C12N9/00—Enzymes; Proenzymes; Compositions thereof; Processes for preparing, activating, inhibiting, separating or purifying enzymes
    • C12N9/10—Transferases (2.)
    • C12N9/12—Transferases (2.) transferring phosphorus containing groups, e.g. kinases (2.7)
    • C12N9/1205—Phosphotransferases with an alcohol group as acceptor (2.7.1), e.g. protein kinases
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K38/00—Medicinal preparations containing peptides
    • A61K38/16—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof
    • A61K38/43—Enzymes; Proenzymes; Derivatives thereof
    • A61K38/45—Transferases (2)
    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12Q—MEASURING OR TESTING PROCESSES INVOLVING ENZYMES, NUCLEIC ACIDS OR MICROORGANISMS; COMPOSITIONS OR TEST PAPERS THEREFOR; PROCESSES OF PREPARING SUCH COMPOSITIONS; CONDITION-RESPONSIVE CONTROL IN MICROBIOLOGICAL OR ENZYMOLOGICAL PROCESSES
    • C12Q1/00—Measuring or testing processes involving enzymes, nucleic acids or microorganisms; Compositions therefor; Processes of preparing such compositions
    • C12Q1/48—Measuring or testing processes involving enzymes, nucleic acids or microorganisms; Compositions therefor; Processes of preparing such compositions involving transferase
    • C12Q1/485—Measuring or testing processes involving enzymes, nucleic acids or microorganisms; Compositions therefor; Processes of preparing such compositions involving transferase involving kinase
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K2299/00—Coordinates from 3D structures of peptides, e.g. proteins or enzymes
    • G—PHYSICS
    • G01—MEASURING; TESTING
    • G01N—INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
    • G01N2500/00—Screening for compounds of potential therapeutic value
    • G01N2500/04—Screening involving studying the effect of compounds C directly on molecule A (e.g. C are potential ligands for a receptor A, or potential substrates for an enzyme A)

Landscapes

  • Health & Medical Sciences (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Chemical & Material Sciences (AREA)
  • Engineering & Computer Science (AREA)
  • Organic Chemistry (AREA)
  • Zoology (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Wood Science & Technology (AREA)
  • Molecular Biology (AREA)
  • Proteomics, Peptides & Aminoacids (AREA)
  • Genetics & Genomics (AREA)
  • General Health & Medical Sciences (AREA)
  • Immunology (AREA)
  • Medicinal Chemistry (AREA)
  • General Engineering & Computer Science (AREA)
  • Microbiology (AREA)
  • Biotechnology (AREA)
  • Biochemistry (AREA)
  • Physics & Mathematics (AREA)
  • Biophysics (AREA)
  • Biomedical Technology (AREA)
  • Analytical Chemistry (AREA)
  • Gastroenterology & Hepatology (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Epidemiology (AREA)
  • Animal Behavior & Ethology (AREA)
  • Public Health (AREA)
  • Veterinary Medicine (AREA)
  • Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Enzymes And Modification Thereof (AREA)
AU2002222274A 2000-12-18 2001-12-18 Crystal structure of glycogen synthase kinase 3 beta Abandoned AU2002222274A1 (en)

Applications Claiming Priority (5)

Application Number Priority Date Filing Date Title
GB0030846.0 2000-12-18
GB0030846A GB0030846D0 (en) 2000-12-18 2000-12-18 Novel method and compounds
GB0119796A GB0119796D0 (en) 2001-08-14 2001-08-14 Novel method and compounds
GB0119796.1 2001-08-14
PCT/GB2001/005632 WO2002050254A2 (en) 2000-12-18 2001-12-18 Crystal structure of glycogen synthase kinase 3 beta

Publications (1)

Publication Number Publication Date
AU2002222274A1 true AU2002222274A1 (en) 2002-07-01

Family

ID=26245439

Family Applications (1)

Application Number Title Priority Date Filing Date
AU2002222274A Abandoned AU2002222274A1 (en) 2000-12-18 2001-12-18 Crystal structure of glycogen synthase kinase 3 beta

Country Status (2)

Country Link
AU (1) AU2002222274A1 (en)
WO (1) WO2002050254A2 (en)

Families Citing this family (3)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
KR100793263B1 (en) * 2000-09-19 2008-01-10 노바티스 백신즈 앤드 다이아그노스틱스 인코포레이티드 Characterization of the gsk-3? protein and methods of use thereof
JP2005504731A (en) * 2001-04-30 2005-02-17 バーテックス　ファーマシューティカルズ　インコーポレイテッド Inhibitors of GSK-3 and crystal structures of GSK-3β proteins and protein complexes
AU2003225569A1 (en) * 2002-02-11 2003-09-04 Chiron Corporation Method for crystallizing human gsk3 and novel crystal structure thereof

Family Cites Families (2)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
WO1998016528A1 (en) * 1996-10-11 1998-04-23 Chiron Corporation Purine inhibitors of glycogen synthase kinase 3 (gsk3)
KR100793263B1 (en) * 2000-09-19 2008-01-10 노바티스 백신즈 앤드 다이아그노스틱스 인코포레이티드 Characterization of the gsk-3? protein and methods of use thereof

Also Published As

Publication number Publication date
WO2002050254A2 (en) 2002-06-27
WO2002050254A3 (en) 2003-01-23

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