AU2002215911A1 - Oligonucleotides, agents containing these oligonucleotides, and the use thereof - Google Patents

Oligonucleotides, agents containing these oligonucleotides, and the use thereof

Info

Publication number
AU2002215911A1
AU2002215911A1 AU2002215911A AU1591102A AU2002215911A1 AU 2002215911 A1 AU2002215911 A1 AU 2002215911A1 AU 2002215911 A AU2002215911 A AU 2002215911A AU 1591102 A AU1591102 A AU 1591102A AU 2002215911 A1 AU2002215911 A1 AU 2002215911A1
Authority
AU
Australia
Prior art keywords
oligonucleotides
agents containing
agents
Prior art date
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Abandoned
Application number
AU2002215911A
Inventor
Ernst Bayer
Alexander Fiedler
Michael Gerster
Holger Kalthoff
Thomas Ketterer
Hendrik Ungefroren
Current Assignee (The listed assignees may be inaccurate. Google has not performed a legal analysis and makes no representation or warranty as to the accuracy of the list.)
Individual
Original Assignee
Individual
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Individual filed Critical Individual
Publication of AU2002215911A1 publication Critical patent/AU2002215911A1/en
Abandoned legal-status Critical Current

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
    • C12N15/00—Mutation or genetic engineering; DNA or RNA concerning genetic engineering, vectors, e.g. plasmids, or their isolation, preparation or purification; Use of hosts therefor
    • C12N15/09—Recombinant DNA-technology
    • C12N15/11—DNA or RNA fragments; Modified forms thereof; Non-coding nucleic acids having a biological activity
    • C12N15/117—Nucleic acids having immunomodulatory properties, e.g. containing CpG-motifs
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K39/00—Medicinal preparations containing antigens or antibodies
    • A61K2039/555—Medicinal preparations containing antigens or antibodies characterised by a specific combination antigen/adjuvant
    • A61K2039/55511—Organic adjuvants
    • A61K2039/55561—CpG containing adjuvants; Oligonucleotide containing adjuvants
    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
    • C12N2310/00—Structure or type of the nucleic acid
    • C12N2310/10—Type of nucleic acid
    • C12N2310/18—Type of nucleic acid acting by a non-sequence specific mechanism
    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
    • C12N2310/00—Structure or type of the nucleic acid
    • C12N2310/30—Chemical structure
    • C12N2310/31—Chemical structure of the backbone
    • C12N2310/315—Phosphorothioates
    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
    • C12N2310/00—Structure or type of the nucleic acid
    • C12N2310/30—Chemical structure
    • C12N2310/35—Nature of the modification
    • C12N2310/351—Conjugate
    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
    • C12N2310/00—Structure or type of the nucleic acid
    • C12N2310/30—Chemical structure
    • C12N2310/35—Nature of the modification
    • C12N2310/351—Conjugate
    • C12N2310/3515—Lipophilic moiety, e.g. cholesterol
AU2002215911A 2000-09-28 2001-09-28 Oligonucleotides, agents containing these oligonucleotides, and the use thereof Abandoned AU2002215911A1 (en)

Applications Claiming Priority (3)

Application Number Priority Date Filing Date Title
DE10048091.8 2000-09-28
DE10048091A DE10048091A1 (en) 2000-09-28 2000-09-28 Use of chemically modified oligodeoxyribonucleotides to suppress the proliferation of human pancreatic tumors
PCT/EP2001/011258 WO2002026754A2 (en) 2000-09-28 2001-09-28 Oligonucleotides, agents containing these oligonucleotides, and the use thereof

Publications (1)

Publication Number Publication Date
AU2002215911A1 true AU2002215911A1 (en) 2002-04-08

Family

ID=7657971

Family Applications (1)

Application Number Title Priority Date Filing Date
AU2002215911A Abandoned AU2002215911A1 (en) 2000-09-28 2001-09-28 Oligonucleotides, agents containing these oligonucleotides, and the use thereof

Country Status (5)

Country Link
US (1) US7608705B2 (en)
EP (1) EP1326878A2 (en)
AU (1) AU2002215911A1 (en)
DE (1) DE10048091A1 (en)
WO (1) WO2002026754A2 (en)

Families Citing this family (2)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
DE10048091A1 (en) 2000-09-28 2002-04-25 Ernst Bayer Use of chemically modified oligodeoxyribonucleotides to suppress the proliferation of human pancreatic tumors
DE10346721A1 (en) * 2003-10-08 2005-05-04 Holger Kalthoff New oligonucleotides, useful for treating cancer, especially of the pancreas, are not species specific but induce apoptosis or inhibit proliferation

Family Cites Families (18)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
JPS638396A (en) * 1986-06-30 1988-01-14 Wakunaga Pharmaceut Co Ltd Poly-labeled oligonucleotide derivative
US6395492B1 (en) * 1990-01-11 2002-05-28 Isis Pharmaceuticals, Inc. Derivatized oligonucleotides having improved uptake and other properties
US5245022A (en) * 1990-08-03 1993-09-14 Sterling Drug, Inc. Exonuclease resistant terminally substituted oligonucleotides
AU2916292A (en) * 1991-10-24 1993-05-21 Isis Pharmaceuticals, Inc. Derivatized oligonucleotides having improved uptake and other properties
US6033909A (en) * 1992-01-22 2000-03-07 Hoechst Aktiengesellschaft Oligonucleotide analogs, their preparation and use
US5552390A (en) * 1993-12-09 1996-09-03 The Board Of Regents Of The University Of Nebraska Phosphorothioate inhibitors of metastatic breast cancer
AU726406B2 (en) * 1996-04-12 2000-11-09 Regents Of The University Of Michigan, The Mutant plasminogen activator-inhibitor type 1 (PAI-1) and uses thereof
EP0856579A1 (en) * 1997-01-31 1998-08-05 BIOGNOSTIK GESELLSCHAFT FÜR BIOMOLEKULARE DIAGNOSTIK mbH An antisense oligonucleotide preparation method
US6100090A (en) * 1999-06-25 2000-08-08 Isis Pharmaceuticals Inc. Antisense inhibition of PI3K p85 expression
DE69932346T2 (en) * 1998-10-26 2007-07-05 Avi Biopharma, Inc., Portland Morpholine-based p53 antisense oligonucleotide and its uses
US6107091A (en) * 1998-12-03 2000-08-22 Isis Pharmaceuticals Inc. Antisense inhibition of G-alpha-16 expression
US6037142A (en) * 1999-02-23 2000-03-14 Isis Pharmaceuticals Inc. Antisense inhibition of SMAD2 expression
US6124272A (en) * 1999-04-09 2000-09-26 Isis Pharmaceutical Inc. Antisense modulation of PDK-1 expression
US6013788A (en) * 1999-04-09 2000-01-11 Isis Pharmaceuticals Inc. Antisense modulation of Smad3 expression
US6080546A (en) * 1999-07-23 2000-06-27 Isis Pharmaceuticals Inc. Antisense modulation of MEKK5 expression
AU1375801A (en) * 1999-11-18 2001-05-30 Genesense Technologies, Inc. Antisense oligonucleotide sequences derived from groEL and groES as inhibitors of microorganisms
WO2001077384A2 (en) * 2000-04-07 2001-10-18 Epigenomics Ag Detection of single nucleotide polymorphisms (snp's) and cytosine-methylations
DE10048091A1 (en) 2000-09-28 2002-04-25 Ernst Bayer Use of chemically modified oligodeoxyribonucleotides to suppress the proliferation of human pancreatic tumors

Also Published As

Publication number Publication date
WO2002026754A9 (en) 2003-05-15
WO2002026754A2 (en) 2002-04-04
DE10048091A1 (en) 2002-04-25
WO2002026754A3 (en) 2002-12-05
US7608705B2 (en) 2009-10-27
EP1326878A2 (en) 2003-07-16
US20050019761A1 (en) 2005-01-27

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