AU2002211281A1 - Quaternary amidino based inhibitors of factor xa - Google Patents
Quaternary amidino based inhibitors of factor xaInfo
- Publication number
- AU2002211281A1 AU2002211281A1 AU2002211281A AU1128102A AU2002211281A1 AU 2002211281 A1 AU2002211281 A1 AU 2002211281A1 AU 2002211281 A AU2002211281 A AU 2002211281A AU 1128102 A AU1128102 A AU 1128102A AU 2002211281 A1 AU2002211281 A1 AU 2002211281A1
- Authority
- AU
- Australia
- Prior art keywords
- amidino
- quaternary
- factor
- based inhibitors
- inhibitors
- Prior art date
- Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
- Abandoned
Links
- 108010074860 Factor Xa Proteins 0.000 title 1
- 125000003739 carbamimidoyl group Chemical group C(N)(=N)* 0.000 title 1
- 239000003112 inhibitor Substances 0.000 title 1
Classifications
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D213/00—Heterocyclic compounds containing six-membered rings, not condensed with other rings, with one nitrogen atom as the only ring hetero atom and three or more double bonds between ring members or between ring members and non-ring members
- C07D213/02—Heterocyclic compounds containing six-membered rings, not condensed with other rings, with one nitrogen atom as the only ring hetero atom and three or more double bonds between ring members or between ring members and non-ring members having three double bonds between ring members or between ring members and non-ring members
- C07D213/04—Heterocyclic compounds containing six-membered rings, not condensed with other rings, with one nitrogen atom as the only ring hetero atom and three or more double bonds between ring members or between ring members and non-ring members having three double bonds between ring members or between ring members and non-ring members having no bond between the ring nitrogen atom and a non-ring member or having only hydrogen or carbon atoms directly attached to the ring nitrogen atom
- C07D213/60—Heterocyclic compounds containing six-membered rings, not condensed with other rings, with one nitrogen atom as the only ring hetero atom and three or more double bonds between ring members or between ring members and non-ring members having three double bonds between ring members or between ring members and non-ring members having no bond between the ring nitrogen atom and a non-ring member or having only hydrogen or carbon atoms directly attached to the ring nitrogen atom with hetero atoms or with carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals, directly attached to ring carbon atoms
- C07D213/72—Nitrogen atoms
- C07D213/75—Amino or imino radicals, acylated by carboxylic or carbonic acids, or by sulfur or nitrogen analogues thereof, e.g. carbamates
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P7/00—Drugs for disorders of the blood or the extracellular fluid
- A61P7/02—Antithrombotic agents; Anticoagulants; Platelet aggregation inhibitors
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D401/00—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom
- C07D401/02—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom containing two hetero rings
- C07D401/12—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom containing two hetero rings linked by a chain containing hetero atoms as chain links
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D401/00—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom
- C07D401/14—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom containing three or more hetero rings
Landscapes
- Chemical & Material Sciences (AREA)
- Organic Chemistry (AREA)
- Health & Medical Sciences (AREA)
- Medicinal Chemistry (AREA)
- Engineering & Computer Science (AREA)
- Diabetes (AREA)
- Chemical Kinetics & Catalysis (AREA)
- General Chemical & Material Sciences (AREA)
- Bioinformatics & Cheminformatics (AREA)
- Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
- Hematology (AREA)
- Pharmacology & Pharmacy (AREA)
- Life Sciences & Earth Sciences (AREA)
- Animal Behavior & Ethology (AREA)
- General Health & Medical Sciences (AREA)
- Public Health (AREA)
- Veterinary Medicine (AREA)
- Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
- Acyclic And Carbocyclic Compounds In Medicinal Compositions (AREA)
Applications Claiming Priority (3)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| US23638500P | 2000-09-29 | 2000-09-29 | |
| US60/236,385 | 2000-09-29 | ||
| PCT/US2001/030314 WO2002026731A2 (en) | 2000-09-29 | 2001-10-01 | Quaternary amidino based inhibitors of factor xa |
Publications (1)
| Publication Number | Publication Date |
|---|---|
| AU2002211281A1 true AU2002211281A1 (en) | 2002-04-08 |
Family
ID=22889271
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| AU2002211281A Abandoned AU2002211281A1 (en) | 2000-09-29 | 2001-10-01 | Quaternary amidino based inhibitors of factor xa |
Country Status (4)
| Country | Link |
|---|---|
| US (1) | US20040077690A1 (en) |
| EP (1) | EP1322637A2 (en) |
| AU (1) | AU2002211281A1 (en) |
| WO (1) | WO2002026731A2 (en) |
Families Citing this family (8)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| SE0102764D0 (en) | 2001-08-17 | 2001-08-17 | Astrazeneca Ab | Compounds |
| EP1678161B1 (en) * | 2003-10-09 | 2009-12-30 | Millennium Pharmaceuticals, Inc. | Thioether-substituted benzamides as inhibitors of factor xa |
| PT2101760E (en) | 2006-12-08 | 2013-05-07 | Millennium Pharm Inc | Unit dose formulations and methods of treating thrombosis with an oral factor xa inhibitor |
| US10059723B2 (en) | 2011-02-28 | 2018-08-28 | Biomarin Pharmaceutical Inc. | Histone deacetylase inhibitors |
| US8957066B2 (en) | 2011-02-28 | 2015-02-17 | Biomarin Pharmaceutical Inc. | Histone deacetylase inhibitors |
| TW201711566A (en) * | 2015-09-28 | 2017-04-01 | 拜耳作物科學公司 | Method for preparing N-(1,3,4-oxadiazol-2-yl)arylcarboxamides |
| CN108530349A (en) * | 2018-04-09 | 2018-09-14 | 重庆三圣实业股份有限公司 | The preparation method and products thereof of betrixaban intermediate and betrixaban |
| CN115057854A (en) * | 2022-04-19 | 2022-09-16 | 河北常山生化药业股份有限公司 | Preparation method of Alvatripopa maleate intermediate |
Family Cites Families (2)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| JP2002510313A (en) * | 1997-06-26 | 2002-04-02 | イーライ・リリー・アンド・カンパニー | Antithrombotic substance |
| RU2226529C2 (en) * | 1997-12-19 | 2004-04-10 | Шеринг Акциенгезельшафт | Derivatives of ortho-antranilamide as anti-coagulating agents, pharmaceutical composition and method for treatment |
-
2001
- 2001-10-01 AU AU2002211281A patent/AU2002211281A1/en not_active Abandoned
- 2001-10-01 WO PCT/US2001/030314 patent/WO2002026731A2/en not_active Application Discontinuation
- 2001-10-01 US US10/381,929 patent/US20040077690A1/en not_active Abandoned
- 2001-10-01 EP EP01979305A patent/EP1322637A2/en not_active Withdrawn
Also Published As
| Publication number | Publication date |
|---|---|
| US20040077690A1 (en) | 2004-04-22 |
| WO2002026731A2 (en) | 2002-04-04 |
| WO2002026731A3 (en) | 2002-10-03 |
| EP1322637A2 (en) | 2003-07-02 |
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