AU2001293208A1 - Nitrogenous heterocyclic compounds - Google Patents
Nitrogenous heterocyclic compoundsInfo
- Publication number
- AU2001293208A1 AU2001293208A1 AU2001293208A AU9320801A AU2001293208A1 AU 2001293208 A1 AU2001293208 A1 AU 2001293208A1 AU 2001293208 A AU2001293208 A AU 2001293208A AU 9320801 A AU9320801 A AU 9320801A AU 2001293208 A1 AU2001293208 A1 AU 2001293208A1
- Authority
- AU
- Australia
- Prior art keywords
- kinases
- heterocyclic compounds
- phosphorylation
- pharmaceutically acceptable
- inhibiting
- Prior art date
- Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
- Abandoned
Links
- -1 Nitrogenous heterocyclic compounds Chemical class 0.000 title abstract 3
- 108091000080 Phosphotransferase Proteins 0.000 abstract 3
- 230000002401 inhibitory effect Effects 0.000 abstract 3
- 230000026731 phosphorylation Effects 0.000 abstract 3
- 238000006366 phosphorylation reaction Methods 0.000 abstract 3
- 102000020233 phosphotransferase Human genes 0.000 abstract 3
- 201000010099 disease Diseases 0.000 abstract 2
- 208000037265 diseases, disorders, signs and symptoms Diseases 0.000 abstract 2
- 238000000034 method Methods 0.000 abstract 2
- 150000003839 salts Chemical class 0.000 abstract 2
- 206010003210 Arteriosclerosis Diseases 0.000 abstract 1
- 241000124008 Mammalia Species 0.000 abstract 1
- 206010028980 Neoplasm Diseases 0.000 abstract 1
- 108091008606 PDGF receptors Proteins 0.000 abstract 1
- 102000011653 Platelet-Derived Growth Factor Receptors Human genes 0.000 abstract 1
- 102000001253 Protein Kinase Human genes 0.000 abstract 1
- 230000002159 abnormal effect Effects 0.000 abstract 1
- 208000011775 arteriosclerosis disease Diseases 0.000 abstract 1
- 201000011510 cancer Diseases 0.000 abstract 1
- 230000010261 cell growth Effects 0.000 abstract 1
- 230000000694 effects Effects 0.000 abstract 1
- 206010061989 glomerulosclerosis Diseases 0.000 abstract 1
- 108060006633 protein kinase Proteins 0.000 abstract 1
- 230000002792 vascular Effects 0.000 abstract 1
Classifications
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D401/00—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom
- C07D401/02—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom containing two hetero rings
- C07D401/12—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom containing two hetero rings linked by a chain containing hetero atoms as chain links
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P35/00—Antineoplastic agents
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D239/00—Heterocyclic compounds containing 1,3-diazine or hydrogenated 1,3-diazine rings
- C07D239/70—Heterocyclic compounds containing 1,3-diazine or hydrogenated 1,3-diazine rings condensed with carbocyclic rings or ring systems
- C07D239/72—Quinazolines; Hydrogenated quinazolines
- C07D239/86—Quinazolines; Hydrogenated quinazolines with hetero atoms directly attached in position 4
- C07D239/94—Nitrogen atoms
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D403/00—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, not provided for by group C07D401/00
- C07D403/02—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, not provided for by group C07D401/00 containing two hetero rings
- C07D403/12—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, not provided for by group C07D401/00 containing two hetero rings linked by a chain containing hetero atoms as chain links
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D405/00—Heterocyclic compounds containing both one or more hetero rings having oxygen atoms as the only ring hetero atoms, and one or more rings having nitrogen as the only ring hetero atom
- C07D405/02—Heterocyclic compounds containing both one or more hetero rings having oxygen atoms as the only ring hetero atoms, and one or more rings having nitrogen as the only ring hetero atom containing two hetero rings
- C07D405/12—Heterocyclic compounds containing both one or more hetero rings having oxygen atoms as the only ring hetero atoms, and one or more rings having nitrogen as the only ring hetero atom containing two hetero rings linked by a chain containing hetero atoms as chain links
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D409/00—Heterocyclic compounds containing two or more hetero rings, at least one ring having sulfur atoms as the only ring hetero atoms
- C07D409/02—Heterocyclic compounds containing two or more hetero rings, at least one ring having sulfur atoms as the only ring hetero atoms containing two hetero rings
- C07D409/12—Heterocyclic compounds containing two or more hetero rings, at least one ring having sulfur atoms as the only ring hetero atoms containing two hetero rings linked by a chain containing hetero atoms as chain links
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D417/00—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and sulfur atoms as the only ring hetero atoms, not provided for by group C07D415/00
- C07D417/02—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and sulfur atoms as the only ring hetero atoms, not provided for by group C07D415/00 containing two hetero rings
- C07D417/12—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and sulfur atoms as the only ring hetero atoms, not provided for by group C07D415/00 containing two hetero rings linked by a chain containing hetero atoms as chain links
Landscapes
- Chemical & Material Sciences (AREA)
- Organic Chemistry (AREA)
- Health & Medical Sciences (AREA)
- Chemical Kinetics & Catalysis (AREA)
- General Chemical & Material Sciences (AREA)
- Medicinal Chemistry (AREA)
- Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
- Pharmacology & Pharmacy (AREA)
- Life Sciences & Earth Sciences (AREA)
- Animal Behavior & Ethology (AREA)
- General Health & Medical Sciences (AREA)
- Public Health (AREA)
- Veterinary Medicine (AREA)
- Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
- Pyridine Compounds (AREA)
- Plural Heterocyclic Compounds (AREA)
Applications Claiming Priority (3)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| US22612100P | 2000-08-18 | 2000-08-18 | |
| US60226121 | 2000-08-18 | ||
| PCT/US2001/041750 WO2002016361A2 (en) | 2000-08-18 | 2001-08-17 | Nitrogenous heterocyclic compounds |
Publications (1)
| Publication Number | Publication Date |
|---|---|
| AU2001293208A1 true AU2001293208A1 (en) | 2002-03-04 |
Family
ID=22847635
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| AU2001293208A Abandoned AU2001293208A1 (en) | 2000-08-18 | 2001-08-17 | Nitrogenous heterocyclic compounds |
Country Status (7)
| Country | Link |
|---|---|
| US (2) | US7329655B2 (es) |
| EP (1) | EP1309568B1 (es) |
| AT (1) | ATE498614T1 (es) |
| AU (1) | AU2001293208A1 (es) |
| DE (1) | DE60144050D1 (es) |
| ES (1) | ES2361582T3 (es) |
| WO (1) | WO2002016361A2 (es) |
Families Citing this family (8)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| EP1309569B1 (en) | 2000-08-18 | 2010-10-06 | Millennium Pharmaceuticals, Inc. | N-aryl-{4-[7-(alkoxy)quinazolin-4-yl]piperazinyl}carboxamide derivatives as PDGFRs inhibitors |
| HU228668B1 (hu) | 2000-08-18 | 2013-05-28 | Millennium Pharmaceuticals | Kináz inhibitor kinazolin-származékok és az ezeket tartalmazó gyógyszerkészítmények |
| AU2002217999A1 (en) | 2000-11-01 | 2002-05-15 | Cor Therapeutics, Inc. | Process for the production of 4-quinazolinylpiperazin-1-carboxylic acid phenylamides |
| WO2002072578A2 (en) | 2001-03-08 | 2002-09-19 | Millennium Pharmaceuticals | (homo) piperazine substituted quinolines for inhibiting the phosphorylation of kinases |
| JP2006514101A (ja) * | 2002-11-08 | 2006-04-27 | ノボ・ノルデイスク・エー／エス | 肥満症の治療のための安全な化学的脱共役剤 |
| CA2612459A1 (en) * | 2005-07-20 | 2007-01-25 | Millennium Pharmaceuticals, Inc. | New crystal forms of 4-[6-methoxy-7-(3-piperidin-1-yl-propoxy)quinazolin-4-yl]piperazine-1-carboxylic acid(4-isopropoxyphenyl)-amide |
| EP1991531A1 (en) * | 2006-02-28 | 2008-11-19 | Amgen Inc. | Cinnoline and quinoxaline derivates as phosphodiesterase 10 inhibitors |
| WO2010059239A2 (en) * | 2008-11-21 | 2010-05-27 | Millennium Pharmaceuticals, Inc | Lactate salt of 4-(6-methoxy-7-(3-piperidin-1-yl-propoxy)quinazolin-4-yl]piperazine-1-carboxylic acid(4-isopropoxyphenyl)-amide and pharmaceutical compositions thereof for the treatment of cancer and other diseases or disorders |
Family Cites Families (6)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| WO1998014431A1 (fr) * | 1996-10-01 | 1998-04-09 | Kyowa Hakko Kogyo Co., Ltd. | Composes azotes heterocycliques |
| WO1999051582A1 (fr) | 1998-03-31 | 1999-10-14 | Kyowa Hakko Kogyo Co., Ltd. | Composes heterocycliques azotes |
| EP1309569B1 (en) | 2000-08-18 | 2010-10-06 | Millennium Pharmaceuticals, Inc. | N-aryl-{4-[7-(alkoxy)quinazolin-4-yl]piperazinyl}carboxamide derivatives as PDGFRs inhibitors |
| EP1309567A2 (en) | 2000-08-18 | 2003-05-14 | Millennium Pharmaceuticals, Inc. | Nitrogenous heterocyclic compounds |
| HU228668B1 (hu) | 2000-08-18 | 2013-05-28 | Millennium Pharmaceuticals | Kináz inhibitor kinazolin-származékok és az ezeket tartalmazó gyógyszerkészítmények |
| WO2002072578A2 (en) | 2001-03-08 | 2002-09-19 | Millennium Pharmaceuticals | (homo) piperazine substituted quinolines for inhibiting the phosphorylation of kinases |
-
2001
- 2001-08-17 US US10/344,625 patent/US7329655B2/en not_active Expired - Fee Related
- 2001-08-17 AT AT01973653T patent/ATE498614T1/de not_active IP Right Cessation
- 2001-08-17 EP EP01973653A patent/EP1309568B1/en not_active Expired - Lifetime
- 2001-08-17 DE DE60144050T patent/DE60144050D1/de not_active Expired - Lifetime
- 2001-08-17 WO PCT/US2001/041750 patent/WO2002016361A2/en active Application Filing
- 2001-08-17 AU AU2001293208A patent/AU2001293208A1/en not_active Abandoned
- 2001-08-17 ES ES01973653T patent/ES2361582T3/es not_active Expired - Lifetime
-
2007
- 2007-12-18 US US11/959,341 patent/US8022071B2/en not_active Expired - Fee Related
Also Published As
| Publication number | Publication date |
|---|---|
| US20040176594A1 (en) | 2004-09-09 |
| ES2361582T3 (es) | 2011-06-20 |
| ATE498614T1 (de) | 2011-03-15 |
| WO2002016361A3 (en) | 2002-06-13 |
| DE60144050D1 (de) | 2011-03-31 |
| US20090176780A1 (en) | 2009-07-09 |
| EP1309568A2 (en) | 2003-05-14 |
| US7329655B2 (en) | 2008-02-12 |
| WO2002016361A2 (en) | 2002-02-28 |
| EP1309568B1 (en) | 2011-02-16 |
| US8022071B2 (en) | 2011-09-20 |
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