AU2001291746A1 - Capsules encapsulating solid particles of signal-generating organic substances and their use in in vitro bioassays for detection of target molecules in a sample - Google Patents
Capsules encapsulating solid particles of signal-generating organic substances and their use in in vitro bioassays for detection of target molecules in a sampleInfo
- Publication number
- AU2001291746A1 AU2001291746A1 AU2001291746A AU9174601A AU2001291746A1 AU 2001291746 A1 AU2001291746 A1 AU 2001291746A1 AU 2001291746 A AU2001291746 A AU 2001291746A AU 9174601 A AU9174601 A AU 9174601A AU 2001291746 A1 AU2001291746 A1 AU 2001291746A1
- Authority
- AU
- Australia
- Prior art keywords
- signal
- organic substances
- target molecules
- sample
- detection
- Prior art date
- Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
- Abandoned
Links
- 239000000126 substance Substances 0.000 title abstract 4
- 239000002775 capsule Substances 0.000 title abstract 3
- 238000001514 detection method Methods 0.000 title abstract 3
- 239000002245 particle Substances 0.000 title abstract 2
- 239000007787 solid Substances 0.000 title abstract 2
- 238000004166 bioassay Methods 0.000 title 1
- 238000000338 in vitro Methods 0.000 title 1
- 238000004519 manufacturing process Methods 0.000 abstract 1
- 230000003287 optical effect Effects 0.000 abstract 1
Classifications
-
- G—PHYSICS
- G01—MEASURING; TESTING
- G01N—INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
- G01N33/00—Investigating or analysing materials by specific methods not covered by groups G01N1/00 - G01N31/00
- G01N33/48—Biological material, e.g. blood, urine; Haemocytometers
- G01N33/50—Chemical analysis of biological material, e.g. blood, urine; Testing involving biospecific ligand binding methods; Immunological testing
- G01N33/58—Chemical analysis of biological material, e.g. blood, urine; Testing involving biospecific ligand binding methods; Immunological testing involving labelled substances
- G01N33/585—Chemical analysis of biological material, e.g. blood, urine; Testing involving biospecific ligand binding methods; Immunological testing involving labelled substances with a particulate label, e.g. coloured latex
- G01N33/587—Nanoparticles
Abstract
The present invention refers to capsules encapsulating solid particles of signal-generating organic substances and carrying on the outer surface affinity molecules for specific recognition of and binding to target molecules in a sample. The invention is directed to the use of these capsules for signal production in the optical, electrochemical or chemical detection of target molecules. To obtain a signal the signal-generating organic substances are released and dissolved. A detection method and a kit are provided.
Applications Claiming Priority (3)
Application Number | Priority Date | Filing Date | Title |
---|---|---|---|
DE10042023A DE10042023C2 (en) | 2000-08-08 | 2000-08-08 | Capsules that encapsulate solid particles of signal-generating substances and their use in bioassays for the detection of target molecules in a sample |
DE10042023 | 2000-08-08 | ||
PCT/EP2001/009114 WO2002012888A2 (en) | 2000-08-08 | 2001-08-07 | Capsules encapsulating solid particles of signal-generating organic substances |
Publications (1)
Publication Number | Publication Date |
---|---|
AU2001291746A1 true AU2001291746A1 (en) | 2002-02-18 |
Family
ID=7653916
Family Applications (1)
Application Number | Title | Priority Date | Filing Date |
---|---|---|---|
AU2001291746A Abandoned AU2001291746A1 (en) | 2000-08-08 | 2001-08-07 | Capsules encapsulating solid particles of signal-generating organic substances and their use in in vitro bioassays for detection of target molecules in a sample |
Country Status (7)
Country | Link |
---|---|
US (1) | US20040014073A1 (en) |
EP (1) | EP1309867B1 (en) |
AT (1) | ATE342508T1 (en) |
AU (1) | AU2001291746A1 (en) |
CA (1) | CA2417714A1 (en) |
DE (2) | DE10042023C2 (en) |
WO (1) | WO2002012888A2 (en) |
Families Citing this family (54)
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US6251691B1 (en) | 1996-04-25 | 2001-06-26 | Bioarray Solutions, Llc | Light-controlled electrokinetic assembly of particles near surfaces |
US9709559B2 (en) | 2000-06-21 | 2017-07-18 | Bioarray Solutions, Ltd. | Multianalyte molecular analysis using application-specific random particle arrays |
DE60117556T2 (en) * | 2000-06-21 | 2006-11-02 | Bioarray Solutions Ltd. | MULTI-ANALYTIC MOLECULAR ANALYSIS THROUGH THE USE OF APPLICATION SPECIFIC RAPID PARTICLE ARRAYS |
US7262063B2 (en) | 2001-06-21 | 2007-08-28 | Bio Array Solutions, Ltd. | Directed assembly of functional heterostructures |
NZ532947A (en) | 2001-10-15 | 2006-01-27 | Bioarray Solutions Ltd | Multiplexed analysis of polymorphic loci by concurrent interrogation and enzyme-mediated detection |
US8367013B2 (en) | 2001-12-24 | 2013-02-05 | Kimberly-Clark Worldwide, Inc. | Reading device, method, and system for conducting lateral flow assays |
US20030119203A1 (en) | 2001-12-24 | 2003-06-26 | Kimberly-Clark Worldwide, Inc. | Lateral flow assay devices and methods for conducting assays |
US7285424B2 (en) | 2002-08-27 | 2007-10-23 | Kimberly-Clark Worldwide, Inc. | Membrane-based assay devices |
US7312040B2 (en) * | 2002-09-20 | 2007-12-25 | Agilent Technologies, Inc. | Microcapsule biosensors and methods of using the same |
AU2003298655A1 (en) | 2002-11-15 | 2004-06-15 | Bioarray Solutions, Ltd. | Analysis, secure access to, and transmission of array images |
US7781172B2 (en) | 2003-11-21 | 2010-08-24 | Kimberly-Clark Worldwide, Inc. | Method for extending the dynamic detection range of assay devices |
US7247500B2 (en) * | 2002-12-19 | 2007-07-24 | Kimberly-Clark Worldwide, Inc. | Reduction of the hook effect in membrane-based assay devices |
US7851209B2 (en) | 2003-04-03 | 2010-12-14 | Kimberly-Clark Worldwide, Inc. | Reduction of the hook effect in assay devices |
US20040197819A1 (en) * | 2003-04-03 | 2004-10-07 | Kimberly-Clark Worldwide, Inc. | Assay devices that utilize hollow particles |
WO2005029705A2 (en) * | 2003-09-18 | 2005-03-31 | Bioarray Solutions, Ltd. | Number coding for identification of subtypes of coded types of solid phase carriers |
ATE532066T1 (en) * | 2003-09-22 | 2011-11-15 | Bioarray Solutions Ltd | SURFACE-IMMOBILIZED POLYELECTROLYTE WITH MULTIPLE FUNCTIONAL GROUPS CAPABILITY OF COVALENT BINDING TO BIOMOLECULES |
NZ547494A (en) * | 2003-10-28 | 2008-05-30 | Bioarray Solutions Ltd | Gel-shell beads with absorbed or bound biomolecules |
WO2005045059A2 (en) * | 2003-10-28 | 2005-05-19 | Bioarray Solutions Ltd. | Allele assignment and probe selection in multiplexed assays of polymorphic targets |
WO2005042763A2 (en) * | 2003-10-28 | 2005-05-12 | Bioarray Solutions Ltd. | Optimization of gene expression analysis using immobilized capture probes |
EP1694859B1 (en) | 2003-10-29 | 2015-01-07 | Bioarray Solutions Ltd | Multiplexed nucleic acid analysis by fragmentation of double-stranded dna |
US7713748B2 (en) | 2003-11-21 | 2010-05-11 | Kimberly-Clark Worldwide, Inc. | Method of reducing the sensitivity of assay devices |
US20050112703A1 (en) | 2003-11-21 | 2005-05-26 | Kimberly-Clark Worldwide, Inc. | Membrane-based lateral flow assay devices that utilize phosphorescent detection |
US7943395B2 (en) * | 2003-11-21 | 2011-05-17 | Kimberly-Clark Worldwide, Inc. | Extension of the dynamic detection range of assay devices |
US7943089B2 (en) | 2003-12-19 | 2011-05-17 | Kimberly-Clark Worldwide, Inc. | Laminated assay devices |
US7906276B2 (en) | 2004-06-30 | 2011-03-15 | Kimberly-Clark Worldwide, Inc. | Enzymatic detection techniques |
US7094528B2 (en) * | 2004-06-30 | 2006-08-22 | Kimberly-Clark Worldwide, Inc. | Magnetic enzyme detection techniques |
US7363170B2 (en) * | 2004-07-09 | 2008-04-22 | Bio Array Solutions Ltd. | Transfusion registry network providing real-time interaction between users and providers of genetically characterized blood products |
US7848889B2 (en) | 2004-08-02 | 2010-12-07 | Bioarray Solutions, Ltd. | Automated analysis of multiplexed probe-target interaction patterns: pattern matching and allele identification |
US8486629B2 (en) | 2005-06-01 | 2013-07-16 | Bioarray Solutions, Ltd. | Creation of functionalized microparticle libraries by oligonucleotide ligation or elongation |
JP5189493B2 (en) * | 2005-11-14 | 2013-04-24 | ルイジアナ テク ユニバーシティ リサーチ ファウンデーション | Polypeptide membrane and method |
US8183184B2 (en) * | 2006-09-05 | 2012-05-22 | University Of Kansas | Polyelectrolyte complexes for oil and gas applications |
EP2162283B1 (en) | 2007-06-14 | 2015-08-12 | Massachusetts Institute of Technology | Self assembled films for protein and drug delivery applications |
US8530244B2 (en) * | 2007-10-02 | 2013-09-10 | Terapia Celular, L'N, Inc. | Methods and materials for amplification of a signal in an immunoassay |
CN101945990A (en) * | 2007-12-27 | 2011-01-12 | 尹菲戈诊断有限公司 | Small molecules and protein analysis devices based on molecular imprinted polymers |
DE102008019928A1 (en) * | 2008-04-21 | 2009-12-31 | Siemens Healthcare Diagnostics Gmbh | Procedures for applying spots with capture molecules on substrate surface for chip, particularly optical sensor, involve washing substrate surface of chip by dipping in aqueous solution of cationic polyelectrolyte |
US8383337B2 (en) * | 2008-07-18 | 2013-02-26 | General Electric Company | Methods using metal oxide particles for analyte detection |
GB2470939A (en) * | 2009-06-10 | 2010-12-15 | Dna Supernova Ltd | Signal amplification microspheres |
GB2470962A (en) * | 2009-06-12 | 2010-12-15 | Dna Supernova Ltd | Amplification medium for use with a solid-phase substrate |
FR2965273B1 (en) * | 2010-09-29 | 2015-07-17 | Centre Nat Rech Scient | PROCESS FOR PREPARING A CHEMICAL STRUCTURE HAVING A PHASE PARTITION, CAPABLE OF GENERATING A SPECIFIC FLUORESCENCE SPECTRUM AND ITS APPLICATIONS |
US8586387B2 (en) * | 2011-08-30 | 2013-11-19 | Supernova Diagnostics, Inc. | Methods of triggering activation of encapsulated signal-generating substances and apparatus utilising activated signal-generating substances |
US20130052748A1 (en) | 2011-08-30 | 2013-02-28 | Supernova Diagnostics, Inc. | Assay device and method of assaying |
EP2617759B1 (en) * | 2012-01-19 | 2014-12-03 | Acreo Swedish ICT AB | Method of modifying the properties of a surface |
JP5996234B2 (en) * | 2012-03-30 | 2016-09-21 | デンカ生研株式会社 | Immunoassay method and reagent |
WO2013163234A1 (en) | 2012-04-23 | 2013-10-31 | Massachusetts Institute Of Technology | Stable layer-by-layer coated particles |
CN102706929B (en) * | 2012-05-10 | 2017-09-01 | 江南大学 | A kind of preparation of Photocrosslinkable modified hyaluronic acid molecular engram sensor |
DE102013002575A1 (en) * | 2013-02-11 | 2014-08-14 | Max Renneberg | Method for the visualized exclusion of acute diseases by means of color-marked proteins |
CN104049079B (en) * | 2013-03-14 | 2016-05-18 | 苏州德沃生物技术有限公司 | A kind of orientation is from preparation method and the application thereof of labelled immune Nano microsphere |
WO2014150074A1 (en) | 2013-03-15 | 2014-09-25 | Massachusetts Institute Of Technology | Compositions and methods for nucleic acid delivery |
US20150125879A1 (en) * | 2013-09-25 | 2015-05-07 | Massachusetts Institute Of Technology | Biodegradable Layer-by-Layer (LbL) Films for Cell Capture and Release |
WO2016015027A1 (en) * | 2014-07-25 | 2016-01-28 | SeLux Diagnostics, Inc. | Assay methods involving dissociable nanoparticles |
DE102014113688A1 (en) * | 2014-09-22 | 2016-03-24 | Jacobs University Bremen Ggmbh | ANTIGEN-SPECIFIC IMMUNE COLORING OF T CELLS |
US20190091673A1 (en) * | 2015-07-17 | 2019-03-28 | SeLux Diagnostics, Inc. | Dissociable nanoparticles with inter alia transition-metal complex catalysts |
WO2019089567A1 (en) | 2017-10-30 | 2019-05-09 | Massachusetts Institute Of Technology | Layer-by-layer nanoparticles for cytokine therapy in cancer treatment |
CN113267529B (en) * | 2021-05-12 | 2022-10-25 | 江西师范大学 | Temperature type biosensor and method for detecting target aptamer by using temperature type biosensor |
Family Cites Families (19)
Publication number | Priority date | Publication date | Assignee | Title |
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US4389330A (en) * | 1980-10-06 | 1983-06-21 | Stolle Research And Development Corporation | Microencapsulation process |
US4528177A (en) * | 1982-10-18 | 1985-07-09 | Eli Lilly And Company | Imaging agents and method |
US4703017C1 (en) * | 1984-02-14 | 2001-12-04 | Becton Dickinson Co | Solid phase assay with visual readout |
JPS61277062A (en) * | 1985-05-31 | 1986-12-08 | Hitachi Ltd | Immunological assay and reagent used therein |
CA1291031C (en) * | 1985-12-23 | 1991-10-22 | Nikolaas C.J. De Jaeger | Method for the detection of specific binding agents and their correspondingbindable substances |
US4874710A (en) * | 1986-02-20 | 1989-10-17 | Becton Dickinson And Company | Assay and product in which binder and liposomes are supported on a solid support |
US6013531A (en) * | 1987-10-26 | 2000-01-11 | Dade International Inc. | Method to use fluorescent magnetic polymer particles as markers in an immunoassay |
ES2062551T3 (en) * | 1989-08-18 | 1994-12-16 | Monsanto Co | FERRITINE ANALOGS. |
JP2979414B2 (en) * | 1989-09-29 | 1999-11-15 | 富士レビオ株式会社 | Magnetic particles and immunoassay using the same |
US5460830A (en) * | 1990-06-22 | 1995-10-24 | The Regents Of The University Of California | Biochemically active agents for chemical catalysis and cell receptor activation |
DE4117782C2 (en) * | 1991-05-28 | 1997-07-17 | Diagnostikforschung Inst | Nanocrystalline magnetic iron oxide particles, processes for their production and diagnostic and / or therapeutic agents |
US5248590A (en) * | 1991-07-22 | 1993-09-28 | Becton, Dickinson And Company | Surface modified liposomes |
US5369036A (en) * | 1992-07-02 | 1994-11-29 | Becton, Dickinson And Company | Enhancement of signal in immunoassays using microparticles which contain different detectable substances |
US5393527A (en) * | 1993-01-04 | 1995-02-28 | Becton, Dickinson And Company | Stabilized microspheres and methods of preparation |
US5756362A (en) * | 1993-10-12 | 1998-05-26 | Cornell Research Foundation, Inc. | Liposome-enhanced immunoaggregation assay and test device |
US6129828A (en) * | 1996-09-06 | 2000-10-10 | Nanogen, Inc. | Apparatus and methods for active biological sample preparation |
US5786219A (en) * | 1996-10-28 | 1998-07-28 | Molecular Probes, Inc. | Microspheres with fluorescent spherical zones |
ATE316420T1 (en) * | 1998-03-19 | 2006-02-15 | Max Planck Gesellschaft | PRODUCTION OF NANO AND MICRO CAPSULES BY LAYER-WIDE POLYELECTROLYTE SELF-ASSEMBLY |
JP2003514650A (en) * | 1999-11-15 | 2003-04-22 | バイオキュア・インコーポレーテッド | Responsive polymeric hollow particles |
-
2000
- 2000-08-08 DE DE10042023A patent/DE10042023C2/en not_active Expired - Lifetime
-
2001
- 2001-08-07 DE DE60123806T patent/DE60123806D1/en not_active Expired - Lifetime
- 2001-08-07 WO PCT/EP2001/009114 patent/WO2002012888A2/en active IP Right Grant
- 2001-08-07 EP EP01971884A patent/EP1309867B1/en not_active Expired - Lifetime
- 2001-08-07 CA CA002417714A patent/CA2417714A1/en not_active Abandoned
- 2001-08-07 US US10/344,016 patent/US20040014073A1/en not_active Abandoned
- 2001-08-07 AU AU2001291746A patent/AU2001291746A1/en not_active Abandoned
- 2001-08-07 AT AT01971884T patent/ATE342508T1/en active
Also Published As
Publication number | Publication date |
---|---|
DE10042023A1 (en) | 2002-02-28 |
EP1309867A2 (en) | 2003-05-14 |
DE60123806D1 (en) | 2006-11-23 |
WO2002012888A3 (en) | 2002-05-16 |
EP1309867B1 (en) | 2006-10-11 |
US20040014073A1 (en) | 2004-01-22 |
CA2417714A1 (en) | 2002-02-14 |
ATE342508T1 (en) | 2006-11-15 |
WO2002012888A2 (en) | 2002-02-14 |
DE10042023C2 (en) | 2003-04-10 |
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