AU2001291746A1 - Capsules encapsulating solid particles of signal-generating organic substances and their use in in vitro bioassays for detection of target molecules in a sample - Google Patents

Capsules encapsulating solid particles of signal-generating organic substances and their use in in vitro bioassays for detection of target molecules in a sample

Info

Publication number
AU2001291746A1
AU2001291746A1 AU2001291746A AU9174601A AU2001291746A1 AU 2001291746 A1 AU2001291746 A1 AU 2001291746A1 AU 2001291746 A AU2001291746 A AU 2001291746A AU 9174601 A AU9174601 A AU 9174601A AU 2001291746 A1 AU2001291746 A1 AU 2001291746A1
Authority
AU
Australia
Prior art keywords
signal
organic substances
target molecules
sample
detection
Prior art date
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Abandoned
Application number
AU2001291746A
Inventor
Frank Caruso
Matthias Lehmann
Reinhard Renneberg
Dieter Trau
Current Assignee (The listed assignees may be inaccurate. Google has not performed a legal analysis and makes no representation or warranty as to the accuracy of the list.)
8sensbiognostic AG
Original Assignee
8SENS BIOGNOSTIC AG
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by 8SENS BIOGNOSTIC AG filed Critical 8SENS BIOGNOSTIC AG
Publication of AU2001291746A1 publication Critical patent/AU2001291746A1/en
Abandoned legal-status Critical Current

Links

Classifications

    • GPHYSICS
    • G01MEASURING; TESTING
    • G01NINVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
    • G01N33/00Investigating or analysing materials by specific methods not covered by groups G01N1/00 - G01N31/00
    • G01N33/48Biological material, e.g. blood, urine; Haemocytometers
    • G01N33/50Chemical analysis of biological material, e.g. blood, urine; Testing involving biospecific ligand binding methods; Immunological testing
    • G01N33/58Chemical analysis of biological material, e.g. blood, urine; Testing involving biospecific ligand binding methods; Immunological testing involving labelled substances
    • G01N33/585Chemical analysis of biological material, e.g. blood, urine; Testing involving biospecific ligand binding methods; Immunological testing involving labelled substances with a particulate label, e.g. coloured latex
    • G01N33/587Nanoparticles

Abstract

The present invention refers to capsules encapsulating solid particles of signal-generating organic substances and carrying on the outer surface affinity molecules for specific recognition of and binding to target molecules in a sample. The invention is directed to the use of these capsules for signal production in the optical, electrochemical or chemical detection of target molecules. To obtain a signal the signal-generating organic substances are released and dissolved. A detection method and a kit are provided.
AU2001291746A 2000-08-08 2001-08-07 Capsules encapsulating solid particles of signal-generating organic substances and their use in in vitro bioassays for detection of target molecules in a sample Abandoned AU2001291746A1 (en)

Applications Claiming Priority (3)

Application Number Priority Date Filing Date Title
DE10042023A DE10042023C2 (en) 2000-08-08 2000-08-08 Capsules that encapsulate solid particles of signal-generating substances and their use in bioassays for the detection of target molecules in a sample
DE10042023 2000-08-08
PCT/EP2001/009114 WO2002012888A2 (en) 2000-08-08 2001-08-07 Capsules encapsulating solid particles of signal-generating organic substances

Publications (1)

Publication Number Publication Date
AU2001291746A1 true AU2001291746A1 (en) 2002-02-18

Family

ID=7653916

Family Applications (1)

Application Number Title Priority Date Filing Date
AU2001291746A Abandoned AU2001291746A1 (en) 2000-08-08 2001-08-07 Capsules encapsulating solid particles of signal-generating organic substances and their use in in vitro bioassays for detection of target molecules in a sample

Country Status (7)

Country Link
US (1) US20040014073A1 (en)
EP (1) EP1309867B1 (en)
AT (1) ATE342508T1 (en)
AU (1) AU2001291746A1 (en)
CA (1) CA2417714A1 (en)
DE (2) DE10042023C2 (en)
WO (1) WO2002012888A2 (en)

Families Citing this family (54)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US6251691B1 (en) 1996-04-25 2001-06-26 Bioarray Solutions, Llc Light-controlled electrokinetic assembly of particles near surfaces
US9709559B2 (en) 2000-06-21 2017-07-18 Bioarray Solutions, Ltd. Multianalyte molecular analysis using application-specific random particle arrays
DE60117556T2 (en) * 2000-06-21 2006-11-02 Bioarray Solutions Ltd. MULTI-ANALYTIC MOLECULAR ANALYSIS THROUGH THE USE OF APPLICATION SPECIFIC RAPID PARTICLE ARRAYS
US7262063B2 (en) 2001-06-21 2007-08-28 Bio Array Solutions, Ltd. Directed assembly of functional heterostructures
NZ532947A (en) 2001-10-15 2006-01-27 Bioarray Solutions Ltd Multiplexed analysis of polymorphic loci by concurrent interrogation and enzyme-mediated detection
US8367013B2 (en) 2001-12-24 2013-02-05 Kimberly-Clark Worldwide, Inc. Reading device, method, and system for conducting lateral flow assays
US20030119203A1 (en) 2001-12-24 2003-06-26 Kimberly-Clark Worldwide, Inc. Lateral flow assay devices and methods for conducting assays
US7285424B2 (en) 2002-08-27 2007-10-23 Kimberly-Clark Worldwide, Inc. Membrane-based assay devices
US7312040B2 (en) * 2002-09-20 2007-12-25 Agilent Technologies, Inc. Microcapsule biosensors and methods of using the same
AU2003298655A1 (en) 2002-11-15 2004-06-15 Bioarray Solutions, Ltd. Analysis, secure access to, and transmission of array images
US7781172B2 (en) 2003-11-21 2010-08-24 Kimberly-Clark Worldwide, Inc. Method for extending the dynamic detection range of assay devices
US7247500B2 (en) * 2002-12-19 2007-07-24 Kimberly-Clark Worldwide, Inc. Reduction of the hook effect in membrane-based assay devices
US7851209B2 (en) 2003-04-03 2010-12-14 Kimberly-Clark Worldwide, Inc. Reduction of the hook effect in assay devices
US20040197819A1 (en) * 2003-04-03 2004-10-07 Kimberly-Clark Worldwide, Inc. Assay devices that utilize hollow particles
WO2005029705A2 (en) * 2003-09-18 2005-03-31 Bioarray Solutions, Ltd. Number coding for identification of subtypes of coded types of solid phase carriers
ATE532066T1 (en) * 2003-09-22 2011-11-15 Bioarray Solutions Ltd SURFACE-IMMOBILIZED POLYELECTROLYTE WITH MULTIPLE FUNCTIONAL GROUPS CAPABILITY OF COVALENT BINDING TO BIOMOLECULES
NZ547494A (en) * 2003-10-28 2008-05-30 Bioarray Solutions Ltd Gel-shell beads with absorbed or bound biomolecules
WO2005045059A2 (en) * 2003-10-28 2005-05-19 Bioarray Solutions Ltd. Allele assignment and probe selection in multiplexed assays of polymorphic targets
WO2005042763A2 (en) * 2003-10-28 2005-05-12 Bioarray Solutions Ltd. Optimization of gene expression analysis using immobilized capture probes
EP1694859B1 (en) 2003-10-29 2015-01-07 Bioarray Solutions Ltd Multiplexed nucleic acid analysis by fragmentation of double-stranded dna
US7713748B2 (en) 2003-11-21 2010-05-11 Kimberly-Clark Worldwide, Inc. Method of reducing the sensitivity of assay devices
US20050112703A1 (en) 2003-11-21 2005-05-26 Kimberly-Clark Worldwide, Inc. Membrane-based lateral flow assay devices that utilize phosphorescent detection
US7943395B2 (en) * 2003-11-21 2011-05-17 Kimberly-Clark Worldwide, Inc. Extension of the dynamic detection range of assay devices
US7943089B2 (en) 2003-12-19 2011-05-17 Kimberly-Clark Worldwide, Inc. Laminated assay devices
US7906276B2 (en) 2004-06-30 2011-03-15 Kimberly-Clark Worldwide, Inc. Enzymatic detection techniques
US7094528B2 (en) * 2004-06-30 2006-08-22 Kimberly-Clark Worldwide, Inc. Magnetic enzyme detection techniques
US7363170B2 (en) * 2004-07-09 2008-04-22 Bio Array Solutions Ltd. Transfusion registry network providing real-time interaction between users and providers of genetically characterized blood products
US7848889B2 (en) 2004-08-02 2010-12-07 Bioarray Solutions, Ltd. Automated analysis of multiplexed probe-target interaction patterns: pattern matching and allele identification
US8486629B2 (en) 2005-06-01 2013-07-16 Bioarray Solutions, Ltd. Creation of functionalized microparticle libraries by oligonucleotide ligation or elongation
JP5189493B2 (en) * 2005-11-14 2013-04-24 ルイジアナ テク ユニバーシティ リサーチ ファウンデーション Polypeptide membrane and method
US8183184B2 (en) * 2006-09-05 2012-05-22 University Of Kansas Polyelectrolyte complexes for oil and gas applications
EP2162283B1 (en) 2007-06-14 2015-08-12 Massachusetts Institute of Technology Self assembled films for protein and drug delivery applications
US8530244B2 (en) * 2007-10-02 2013-09-10 Terapia Celular, L'N, Inc. Methods and materials for amplification of a signal in an immunoassay
CN101945990A (en) * 2007-12-27 2011-01-12 尹菲戈诊断有限公司 Small molecules and protein analysis devices based on molecular imprinted polymers
DE102008019928A1 (en) * 2008-04-21 2009-12-31 Siemens Healthcare Diagnostics Gmbh Procedures for applying spots with capture molecules on substrate surface for chip, particularly optical sensor, involve washing substrate surface of chip by dipping in aqueous solution of cationic polyelectrolyte
US8383337B2 (en) * 2008-07-18 2013-02-26 General Electric Company Methods using metal oxide particles for analyte detection
GB2470939A (en) * 2009-06-10 2010-12-15 Dna Supernova Ltd Signal amplification microspheres
GB2470962A (en) * 2009-06-12 2010-12-15 Dna Supernova Ltd Amplification medium for use with a solid-phase substrate
FR2965273B1 (en) * 2010-09-29 2015-07-17 Centre Nat Rech Scient PROCESS FOR PREPARING A CHEMICAL STRUCTURE HAVING A PHASE PARTITION, CAPABLE OF GENERATING A SPECIFIC FLUORESCENCE SPECTRUM AND ITS APPLICATIONS
US8586387B2 (en) * 2011-08-30 2013-11-19 Supernova Diagnostics, Inc. Methods of triggering activation of encapsulated signal-generating substances and apparatus utilising activated signal-generating substances
US20130052748A1 (en) 2011-08-30 2013-02-28 Supernova Diagnostics, Inc. Assay device and method of assaying
EP2617759B1 (en) * 2012-01-19 2014-12-03 Acreo Swedish ICT AB Method of modifying the properties of a surface
JP5996234B2 (en) * 2012-03-30 2016-09-21 デンカ生研株式会社 Immunoassay method and reagent
WO2013163234A1 (en) 2012-04-23 2013-10-31 Massachusetts Institute Of Technology Stable layer-by-layer coated particles
CN102706929B (en) * 2012-05-10 2017-09-01 江南大学 A kind of preparation of Photocrosslinkable modified hyaluronic acid molecular engram sensor
DE102013002575A1 (en) * 2013-02-11 2014-08-14 Max Renneberg Method for the visualized exclusion of acute diseases by means of color-marked proteins
CN104049079B (en) * 2013-03-14 2016-05-18 苏州德沃生物技术有限公司 A kind of orientation is from preparation method and the application thereof of labelled immune Nano microsphere
WO2014150074A1 (en) 2013-03-15 2014-09-25 Massachusetts Institute Of Technology Compositions and methods for nucleic acid delivery
US20150125879A1 (en) * 2013-09-25 2015-05-07 Massachusetts Institute Of Technology Biodegradable Layer-by-Layer (LbL) Films for Cell Capture and Release
WO2016015027A1 (en) * 2014-07-25 2016-01-28 SeLux Diagnostics, Inc. Assay methods involving dissociable nanoparticles
DE102014113688A1 (en) * 2014-09-22 2016-03-24 Jacobs University Bremen Ggmbh ANTIGEN-SPECIFIC IMMUNE COLORING OF T CELLS
US20190091673A1 (en) * 2015-07-17 2019-03-28 SeLux Diagnostics, Inc. Dissociable nanoparticles with inter alia transition-metal complex catalysts
WO2019089567A1 (en) 2017-10-30 2019-05-09 Massachusetts Institute Of Technology Layer-by-layer nanoparticles for cytokine therapy in cancer treatment
CN113267529B (en) * 2021-05-12 2022-10-25 江西师范大学 Temperature type biosensor and method for detecting target aptamer by using temperature type biosensor

Family Cites Families (19)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US4389330A (en) * 1980-10-06 1983-06-21 Stolle Research And Development Corporation Microencapsulation process
US4528177A (en) * 1982-10-18 1985-07-09 Eli Lilly And Company Imaging agents and method
US4703017C1 (en) * 1984-02-14 2001-12-04 Becton Dickinson Co Solid phase assay with visual readout
JPS61277062A (en) * 1985-05-31 1986-12-08 Hitachi Ltd Immunological assay and reagent used therein
CA1291031C (en) * 1985-12-23 1991-10-22 Nikolaas C.J. De Jaeger Method for the detection of specific binding agents and their correspondingbindable substances
US4874710A (en) * 1986-02-20 1989-10-17 Becton Dickinson And Company Assay and product in which binder and liposomes are supported on a solid support
US6013531A (en) * 1987-10-26 2000-01-11 Dade International Inc. Method to use fluorescent magnetic polymer particles as markers in an immunoassay
ES2062551T3 (en) * 1989-08-18 1994-12-16 Monsanto Co FERRITINE ANALOGS.
JP2979414B2 (en) * 1989-09-29 1999-11-15 富士レビオ株式会社 Magnetic particles and immunoassay using the same
US5460830A (en) * 1990-06-22 1995-10-24 The Regents Of The University Of California Biochemically active agents for chemical catalysis and cell receptor activation
DE4117782C2 (en) * 1991-05-28 1997-07-17 Diagnostikforschung Inst Nanocrystalline magnetic iron oxide particles, processes for their production and diagnostic and / or therapeutic agents
US5248590A (en) * 1991-07-22 1993-09-28 Becton, Dickinson And Company Surface modified liposomes
US5369036A (en) * 1992-07-02 1994-11-29 Becton, Dickinson And Company Enhancement of signal in immunoassays using microparticles which contain different detectable substances
US5393527A (en) * 1993-01-04 1995-02-28 Becton, Dickinson And Company Stabilized microspheres and methods of preparation
US5756362A (en) * 1993-10-12 1998-05-26 Cornell Research Foundation, Inc. Liposome-enhanced immunoaggregation assay and test device
US6129828A (en) * 1996-09-06 2000-10-10 Nanogen, Inc. Apparatus and methods for active biological sample preparation
US5786219A (en) * 1996-10-28 1998-07-28 Molecular Probes, Inc. Microspheres with fluorescent spherical zones
ATE316420T1 (en) * 1998-03-19 2006-02-15 Max Planck Gesellschaft PRODUCTION OF NANO AND MICRO CAPSULES BY LAYER-WIDE POLYELECTROLYTE SELF-ASSEMBLY
JP2003514650A (en) * 1999-11-15 2003-04-22 バイオキュア・インコーポレーテッド Responsive polymeric hollow particles

Also Published As

Publication number Publication date
DE10042023A1 (en) 2002-02-28
EP1309867A2 (en) 2003-05-14
DE60123806D1 (en) 2006-11-23
WO2002012888A3 (en) 2002-05-16
EP1309867B1 (en) 2006-10-11
US20040014073A1 (en) 2004-01-22
CA2417714A1 (en) 2002-02-14
ATE342508T1 (en) 2006-11-15
WO2002012888A2 (en) 2002-02-14
DE10042023C2 (en) 2003-04-10

Similar Documents

Publication Publication Date Title
AU2001291746A1 (en) Capsules encapsulating solid particles of signal-generating organic substances and their use in in vitro bioassays for detection of target molecules in a sample
IL141774A0 (en) Monitoring methods using particle delivery methods
AU2002326633A1 (en) Separation column having a photopolymerized sol-gel component and associated methods
CA2285918A1 (en) Methods for concentrating ligands using magnetic particles
DE60331899D1 (en) Sensitives immunochromatografisches assay
WO2000073794A3 (en) Method for separating cells using immunorosettes
AU2001237057A1 (en) Functionalized encapsulated fluorescent nanocrystals
AU2204600A (en) Automated on-line evaporating light scattering detection to quantify isolated fluid sample compounds in microtiter plate format
AU2002210940A1 (en) Biosensor
WO2004063704A3 (en) Vitamin d assay
WO2004059280A3 (en) Methods, compositions and kits for biomarker extraction
WO2004069211A3 (en) Affinity proteins for controlled application of cosmetic substances
WO2004111612A3 (en) Porous nanostructures and methods involving the same
EP1335003A3 (en) Magnetic carrier capable of binding with protein and purification method of protein utilizing the magnetic carrier
CA2377815A1 (en) Fluorescent intensity method for assaying binding between proteins or peptides
WO2002059599A3 (en) System and method for in vitro analysis of therapeutic agents
WO2003008635A8 (en) η-SECRETASE IN VITRO SCREENING ASSAY
EP1652918A3 (en) Methods for detecting protein interactions using conformationally constrained peptides
CA2358065A1 (en) Fluorescent intensity assay for protein or peptide binding to nucleic acids
GB2427840A (en) Method and apparatus for the application of power material to substrates
WO2004013607A3 (en) Methods, devices and kits for multiplex blotting of biological samples from multi-well plates
WO2002073214A3 (en) Novel reagents for detecting cannabinoids
ATE418073T1 (en) ELEMENTARY ANALYSIS OF LABELED BIOLOGICALLY ACTIVE SUBSTANCES
WO2004085618A3 (en) Method of screening for target ligands
EP2407787A3 (en) Method for detection of L523S expression in biological samples