AU2001290864A1 - Optimized cardiac contraction through differential phosphorylation of myosin - Google Patents
Optimized cardiac contraction through differential phosphorylation of myosinInfo
- Publication number
- AU2001290864A1 AU2001290864A1 AU2001290864A AU9086401A AU2001290864A1 AU 2001290864 A1 AU2001290864 A1 AU 2001290864A1 AU 2001290864 A AU2001290864 A AU 2001290864A AU 9086401 A AU9086401 A AU 9086401A AU 2001290864 A1 AU2001290864 A1 AU 2001290864A1
- Authority
- AU
- Australia
- Prior art keywords
- myosin
- cardiac contraction
- differential phosphorylation
- optimized cardiac
- optimized
- Prior art date
- Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
- Abandoned
Links
- 102000003505 Myosin Human genes 0.000 title 1
- 108060008487 Myosin Proteins 0.000 title 1
- 230000010247 heart contraction Effects 0.000 title 1
- 230000026731 phosphorylation Effects 0.000 title 1
- 238000006366 phosphorylation reaction Methods 0.000 title 1
Classifications
-
- C—CHEMISTRY; METALLURGY
- C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
- C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
- C12N9/00—Enzymes; Proenzymes; Compositions thereof; Processes for preparing, activating, inhibiting, separating or purifying enzymes
- C12N9/10—Transferases (2.)
- C12N9/12—Transferases (2.) transferring phosphorus containing groups, e.g. kinases (2.7)
- C12N9/1205—Phosphotransferases with an alcohol group as acceptor (2.7.1), e.g. protein kinases
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P9/00—Drugs for disorders of the cardiovascular system
- A61P9/04—Inotropic agents, i.e. stimulants of cardiac contraction; Drugs for heart failure
-
- A—HUMAN NECESSITIES
- A01—AGRICULTURE; FORESTRY; ANIMAL HUSBANDRY; HUNTING; TRAPPING; FISHING
- A01K—ANIMAL HUSBANDRY; AVICULTURE; APICULTURE; PISCICULTURE; FISHING; REARING OR BREEDING ANIMALS, NOT OTHERWISE PROVIDED FOR; NEW BREEDS OF ANIMALS
- A01K2217/00—Genetically modified animals
- A01K2217/07—Animals genetically altered by homologous recombination
- A01K2217/075—Animals genetically altered by homologous recombination inducing loss of function, i.e. knock out
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K38/00—Medicinal preparations containing peptides
-
- C—CHEMISTRY; METALLURGY
- C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
- C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
- C12N2799/00—Uses of viruses
- C12N2799/02—Uses of viruses as vector
- C12N2799/021—Uses of viruses as vector for the expression of a heterologous nucleic acid
- C12N2799/026—Uses of viruses as vector for the expression of a heterologous nucleic acid where the vector is derived from a baculovirus
Landscapes
- Health & Medical Sciences (AREA)
- Life Sciences & Earth Sciences (AREA)
- Chemical & Material Sciences (AREA)
- Engineering & Computer Science (AREA)
- Bioinformatics & Cheminformatics (AREA)
- Organic Chemistry (AREA)
- Molecular Biology (AREA)
- Genetics & Genomics (AREA)
- Zoology (AREA)
- Wood Science & Technology (AREA)
- General Health & Medical Sciences (AREA)
- Medicinal Chemistry (AREA)
- General Engineering & Computer Science (AREA)
- Microbiology (AREA)
- Biochemistry (AREA)
- Cardiology (AREA)
- Biotechnology (AREA)
- Biomedical Technology (AREA)
- Chemical Kinetics & Catalysis (AREA)
- Veterinary Medicine (AREA)
- Public Health (AREA)
- Animal Behavior & Ethology (AREA)
- Pharmacology & Pharmacy (AREA)
- Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
- General Chemical & Material Sciences (AREA)
- Heart & Thoracic Surgery (AREA)
- Hospice & Palliative Care (AREA)
- Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
- Enzymes And Modification Thereof (AREA)
- Micro-Organisms Or Cultivation Processes Thereof (AREA)
Applications Claiming Priority (5)
Application Number | Priority Date | Filing Date | Title |
---|---|---|---|
US23224600P | 2000-09-12 | 2000-09-12 | |
US60/232,246 | 2000-09-12 | ||
US23245600P | 2000-09-13 | 2000-09-13 | |
US60/232,456 | 2000-09-13 | ||
PCT/US2001/028639 WO2002024889A2 (fr) | 2000-09-12 | 2001-09-12 | Contraction cardiaque optimisee par la phosphorylation differentielle de la myosine |
Publications (1)
Publication Number | Publication Date |
---|---|
AU2001290864A1 true AU2001290864A1 (en) | 2002-04-02 |
Family
ID=26925797
Family Applications (1)
Application Number | Title | Priority Date | Filing Date |
---|---|---|---|
AU2001290864A Abandoned AU2001290864A1 (en) | 2000-09-12 | 2001-09-12 | Optimized cardiac contraction through differential phosphorylation of myosin |
Country Status (3)
Country | Link |
---|---|
US (2) | US7375185B2 (fr) |
AU (1) | AU2001290864A1 (fr) |
WO (1) | WO2002024889A2 (fr) |
Families Citing this family (9)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
EP1073756A4 (fr) * | 1998-03-26 | 2003-01-22 | Gene Logic Inc | IDENTIFICATION D'UN ADNc ASSOCIE A L'ISCHEMIE DANS UN TISSU CARDIAQUE HUMAIN |
WO2005003303A2 (fr) * | 2003-06-19 | 2005-01-13 | Exelixis, Inc. | Genes nadk utilises comme modificateurs de la morphogenese de ramification et procedes d'utilisation |
US9580515B2 (en) * | 2006-08-21 | 2017-02-28 | Zensun (Shanghai) Science & Technology, Co., Ltd. | Neukinase, a downstream protein of neuregulin |
US20100129815A1 (en) * | 2007-04-13 | 2010-05-27 | Univeristy Of Florida Research Foundation Inc. | Identification of cardiac specific myosin light chain kinase |
WO2013053076A1 (fr) | 2011-10-10 | 2013-04-18 | Zensun (Shanghai)Science & Technology Limited | Compositions et procédés pour le traitement de l'insuffisance cardiaque |
JP6568052B2 (ja) | 2013-05-22 | 2019-09-04 | ゼンサン (シャンハイ) サイエンス アンド テクノロジー,シーオー.,エルティーディー. | 心不全を治療するためのニューレグリンの徐放 |
CN110946993A (zh) | 2014-01-03 | 2020-04-03 | 上海泽生科技开发股份有限公司 | 纽兰格林制剂的配方 |
CN111407882A (zh) | 2014-10-17 | 2020-07-14 | 上海泽生科技开发股份有限公司 | 神经调节蛋白用于预防、治疗或延迟射血分数保留的心力衰竭的方法和组合物 |
CN111388682A (zh) * | 2015-05-08 | 2020-07-10 | 上海泽生科技开发股份有限公司 | cMLCK基因导入 |
Family Cites Families (5)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
EP0357856A1 (fr) * | 1988-09-08 | 1990-03-14 | Sansone, Antonio | ADN codant pour la chaîne 2 légère de la myosine ventriculaire humaine |
US6730491B2 (en) * | 2000-02-29 | 2004-05-04 | Millennium Pharmaceuticals, Inc. | 2504, 15977, and 14760, novel protein kinase family members and uses therefor |
EP1240194A2 (fr) | 1999-11-24 | 2002-09-18 | Sugen, Inc. | Nouvelles proteines kinases humaines et enzymes analogues |
US20030139358A1 (en) * | 2000-05-05 | 2003-07-24 | Spytek Kimberly A. | Novel human proteins, polynucleotides encoding them and methods of using the same |
CA2410610A1 (fr) * | 2000-06-15 | 2001-12-20 | Incyte Genomics, Inc. | Kinases humaines |
-
2001
- 2001-09-12 US US10/380,236 patent/US7375185B2/en not_active Expired - Fee Related
- 2001-09-12 AU AU2001290864A patent/AU2001290864A1/en not_active Abandoned
- 2001-09-12 WO PCT/US2001/028639 patent/WO2002024889A2/fr active Application Filing
-
2008
- 2008-04-11 US US12/101,812 patent/US7824682B2/en not_active Expired - Fee Related
Also Published As
Publication number | Publication date |
---|---|
US7375185B2 (en) | 2008-05-20 |
WO2002024889A2 (fr) | 2002-03-28 |
US7824682B2 (en) | 2010-11-02 |
US20080274994A1 (en) | 2008-11-06 |
US20040126860A1 (en) | 2004-07-01 |
WO2002024889A3 (fr) | 2003-09-04 |
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