AU2001290864A1 - Optimized cardiac contraction through differential phosphorylation of myosin - Google Patents

Optimized cardiac contraction through differential phosphorylation of myosin

Info

Publication number
AU2001290864A1
AU2001290864A1 AU2001290864A AU9086401A AU2001290864A1 AU 2001290864 A1 AU2001290864 A1 AU 2001290864A1 AU 2001290864 A AU2001290864 A AU 2001290864A AU 9086401 A AU9086401 A AU 9086401A AU 2001290864 A1 AU2001290864 A1 AU 2001290864A1
Authority
AU
Australia
Prior art keywords
myosin
cardiac contraction
differential phosphorylation
optimized cardiac
optimized
Prior art date
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Abandoned
Application number
AU2001290864A
Other languages
English (en)
Inventor
Julien S. Davis
Neal D. Epstein
Shahin Hassanzadeh
Steven Winitsky
Current Assignee (The listed assignees may be inaccurate. Google has not performed a legal analysis and makes no representation or warranty as to the accuracy of the list.)
US Department of Health and Human Services
Original Assignee
US Department of Health and Human Services
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by US Department of Health and Human Services filed Critical US Department of Health and Human Services
Publication of AU2001290864A1 publication Critical patent/AU2001290864A1/en
Abandoned legal-status Critical Current

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
    • C12N9/00—Enzymes; Proenzymes; Compositions thereof; Processes for preparing, activating, inhibiting, separating or purifying enzymes
    • C12N9/10—Transferases (2.)
    • C12N9/12—Transferases (2.) transferring phosphorus containing groups, e.g. kinases (2.7)
    • C12N9/1205—Phosphotransferases with an alcohol group as acceptor (2.7.1), e.g. protein kinases
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P9/00—Drugs for disorders of the cardiovascular system
    • A61P9/04—Inotropic agents, i.e. stimulants of cardiac contraction; Drugs for heart failure
    • A—HUMAN NECESSITIES
    • A01—AGRICULTURE; FORESTRY; ANIMAL HUSBANDRY; HUNTING; TRAPPING; FISHING
    • A01K—ANIMAL HUSBANDRY; AVICULTURE; APICULTURE; PISCICULTURE; FISHING; REARING OR BREEDING ANIMALS, NOT OTHERWISE PROVIDED FOR; NEW BREEDS OF ANIMALS
    • A01K2217/00—Genetically modified animals
    • A01K2217/07—Animals genetically altered by homologous recombination
    • A01K2217/075—Animals genetically altered by homologous recombination inducing loss of function, i.e. knock out
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K38/00—Medicinal preparations containing peptides
    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
    • C12N2799/00—Uses of viruses
    • C12N2799/02—Uses of viruses as vector
    • C12N2799/021—Uses of viruses as vector for the expression of a heterologous nucleic acid
    • C12N2799/026—Uses of viruses as vector for the expression of a heterologous nucleic acid where the vector is derived from a baculovirus

Landscapes

  • Health & Medical Sciences (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Chemical & Material Sciences (AREA)
  • Engineering & Computer Science (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Organic Chemistry (AREA)
  • Molecular Biology (AREA)
  • Genetics & Genomics (AREA)
  • Zoology (AREA)
  • Wood Science & Technology (AREA)
  • General Health & Medical Sciences (AREA)
  • Medicinal Chemistry (AREA)
  • General Engineering & Computer Science (AREA)
  • Microbiology (AREA)
  • Biochemistry (AREA)
  • Cardiology (AREA)
  • Biotechnology (AREA)
  • Biomedical Technology (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Veterinary Medicine (AREA)
  • Public Health (AREA)
  • Animal Behavior & Ethology (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • General Chemical & Material Sciences (AREA)
  • Heart & Thoracic Surgery (AREA)
  • Hospice & Palliative Care (AREA)
  • Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
  • Enzymes And Modification Thereof (AREA)
  • Micro-Organisms Or Cultivation Processes Thereof (AREA)
AU2001290864A 2000-09-12 2001-09-12 Optimized cardiac contraction through differential phosphorylation of myosin Abandoned AU2001290864A1 (en)

Applications Claiming Priority (5)

Application Number Priority Date Filing Date Title
US23224600P 2000-09-12 2000-09-12
US60/232,246 2000-09-12
US23245600P 2000-09-13 2000-09-13
US60/232,456 2000-09-13
PCT/US2001/028639 WO2002024889A2 (fr) 2000-09-12 2001-09-12 Contraction cardiaque optimisee par la phosphorylation differentielle de la myosine

Publications (1)

Publication Number Publication Date
AU2001290864A1 true AU2001290864A1 (en) 2002-04-02

Family

ID=26925797

Family Applications (1)

Application Number Title Priority Date Filing Date
AU2001290864A Abandoned AU2001290864A1 (en) 2000-09-12 2001-09-12 Optimized cardiac contraction through differential phosphorylation of myosin

Country Status (3)

Country Link
US (2) US7375185B2 (fr)
AU (1) AU2001290864A1 (fr)
WO (1) WO2002024889A2 (fr)

Families Citing this family (9)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
EP1073756A4 (fr) * 1998-03-26 2003-01-22 Gene Logic Inc IDENTIFICATION D'UN ADNc ASSOCIE A L'ISCHEMIE DANS UN TISSU CARDIAQUE HUMAIN
WO2005003303A2 (fr) * 2003-06-19 2005-01-13 Exelixis, Inc. Genes nadk utilises comme modificateurs de la morphogenese de ramification et procedes d'utilisation
US9580515B2 (en) * 2006-08-21 2017-02-28 Zensun (Shanghai) Science & Technology, Co., Ltd. Neukinase, a downstream protein of neuregulin
US20100129815A1 (en) * 2007-04-13 2010-05-27 Univeristy Of Florida Research Foundation Inc. Identification of cardiac specific myosin light chain kinase
WO2013053076A1 (fr) 2011-10-10 2013-04-18 Zensun （Shanghai）Science & Technology Limited Compositions et procédés pour le traitement de l'insuffisance cardiaque
JP6568052B2 (ja) 2013-05-22 2019-09-04 ゼンサン （シャンハイ） サイエンス アンド テクノロジー，シーオー．，エルティーディー． 心不全を治療するためのニューレグリンの徐放
CN110946993A (zh) 2014-01-03 2020-04-03 上海泽生科技开发股份有限公司 纽兰格林制剂的配方
CN111407882A (zh) 2014-10-17 2020-07-14 上海泽生科技开发股份有限公司 神经调节蛋白用于预防、治疗或延迟射血分数保留的心力衰竭的方法和组合物
CN111388682A (zh) * 2015-05-08 2020-07-10 上海泽生科技开发股份有限公司 cMLCK基因导入

Family Cites Families (5)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
EP0357856A1 (fr) * 1988-09-08 1990-03-14 Sansone, Antonio ADN codant pour la chaîne 2 légère de la myosine ventriculaire humaine
US6730491B2 (en) * 2000-02-29 2004-05-04 Millennium Pharmaceuticals, Inc. 2504, 15977, and 14760, novel protein kinase family members and uses therefor
EP1240194A2 (fr) 1999-11-24 2002-09-18 Sugen, Inc. Nouvelles proteines kinases humaines et enzymes analogues
US20030139358A1 (en) * 2000-05-05 2003-07-24 Spytek Kimberly A. Novel human proteins, polynucleotides encoding them and methods of using the same
CA2410610A1 (fr) * 2000-06-15 2001-12-20 Incyte Genomics, Inc. Kinases humaines

Also Published As

Publication number Publication date
US7375185B2 (en) 2008-05-20
WO2002024889A2 (fr) 2002-03-28
US7824682B2 (en) 2010-11-02
US20080274994A1 (en) 2008-11-06
US20040126860A1 (en) 2004-07-01
WO2002024889A3 (fr) 2003-09-04

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