AU2001289710A1 - Inhalers - Google Patents

Inhalers

Info

Publication number
AU2001289710A1
AU2001289710A1 AU2001289710A AU8971001A AU2001289710A1 AU 2001289710 A1 AU2001289710 A1 AU 2001289710A1 AU 2001289710 A AU2001289710 A AU 2001289710A AU 8971001 A AU8971001 A AU 8971001A AU 2001289710 A1 AU2001289710 A1 AU 2001289710A1
Authority
AU
Australia
Prior art keywords
aerosol
cyclone
airflow
inlet
inhaler
Prior art date
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Abandoned
Application number
AU2001289710A
Inventor
Stephen William Eason
Quentin John Harmer
Matthew Neil Sarkar
Current Assignee (The listed assignees may be inaccurate. Google has not performed a legal analysis and makes no representation or warranty as to the accuracy of the list.)
Vectura Delivery Devices Ltd
Original Assignee
Cambridge Consultants Ltd
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Cambridge Consultants Ltd filed Critical Cambridge Consultants Ltd
Publication of AU2001289710A1 publication Critical patent/AU2001289710A1/en
Abandoned legal-status Critical Current

Links

Classifications

    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61MDEVICES FOR INTRODUCING MEDIA INTO, OR ONTO, THE BODY; DEVICES FOR TRANSDUCING BODY MEDIA OR FOR TAKING MEDIA FROM THE BODY; DEVICES FOR PRODUCING OR ENDING SLEEP OR STUPOR
    • A61M15/00Inhalators
    • A61M15/02Inhalators with activated or ionised fluids, e.g. electrohydrodynamic [EHD] or electrostatic devices; Ozone-inhalators with radioactive tagged particles
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61MDEVICES FOR INTRODUCING MEDIA INTO, OR ONTO, THE BODY; DEVICES FOR TRANSDUCING BODY MEDIA OR FOR TAKING MEDIA FROM THE BODY; DEVICES FOR PRODUCING OR ENDING SLEEP OR STUPOR
    • A61M11/00Sprayers or atomisers specially adapted for therapeutic purposes
    • A61M11/001Particle size control
    • A61M11/002Particle size control by flow deviation causing inertial separation of transported particles
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61MDEVICES FOR INTRODUCING MEDIA INTO, OR ONTO, THE BODY; DEVICES FOR TRANSDUCING BODY MEDIA OR FOR TAKING MEDIA FROM THE BODY; DEVICES FOR PRODUCING OR ENDING SLEEP OR STUPOR
    • A61M15/00Inhalators
    • A61M15/0001Details of inhalators; Constructional features thereof
    • A61M15/002Details of inhalators; Constructional features thereof with air flow regulating means
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61MDEVICES FOR INTRODUCING MEDIA INTO, OR ONTO, THE BODY; DEVICES FOR TRANSDUCING BODY MEDIA OR FOR TAKING MEDIA FROM THE BODY; DEVICES FOR PRODUCING OR ENDING SLEEP OR STUPOR
    • A61M15/00Inhalators
    • A61M15/0028Inhalators using prepacked dosages, one for each application, e.g. capsules to be perforated or broken-up
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61MDEVICES FOR INTRODUCING MEDIA INTO, OR ONTO, THE BODY; DEVICES FOR TRANSDUCING BODY MEDIA OR FOR TAKING MEDIA FROM THE BODY; DEVICES FOR PRODUCING OR ENDING SLEEP OR STUPOR
    • A61M15/00Inhalators
    • A61M15/0028Inhalators using prepacked dosages, one for each application, e.g. capsules to be perforated or broken-up
    • A61M15/003Inhalators using prepacked dosages, one for each application, e.g. capsules to be perforated or broken-up using capsules, e.g. to be perforated or broken-up
    • A61M15/0033Details of the piercing or cutting means
    • A61M15/0035Piercing means
    • A61M15/0036Piercing means hollow piercing means
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61MDEVICES FOR INTRODUCING MEDIA INTO, OR ONTO, THE BODY; DEVICES FOR TRANSDUCING BODY MEDIA OR FOR TAKING MEDIA FROM THE BODY; DEVICES FOR PRODUCING OR ENDING SLEEP OR STUPOR
    • A61M15/00Inhalators
    • A61M15/0028Inhalators using prepacked dosages, one for each application, e.g. capsules to be perforated or broken-up
    • A61M15/003Inhalators using prepacked dosages, one for each application, e.g. capsules to be perforated or broken-up using capsules, e.g. to be perforated or broken-up
    • A61M15/0033Details of the piercing or cutting means
    • A61M15/0041Details of the piercing or cutting means with movable piercing or cutting means
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61MDEVICES FOR INTRODUCING MEDIA INTO, OR ONTO, THE BODY; DEVICES FOR TRANSDUCING BODY MEDIA OR FOR TAKING MEDIA FROM THE BODY; DEVICES FOR PRODUCING OR ENDING SLEEP OR STUPOR
    • A61M15/00Inhalators
    • A61M15/0086Inhalation chambers
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61MDEVICES FOR INTRODUCING MEDIA INTO, OR ONTO, THE BODY; DEVICES FOR TRANSDUCING BODY MEDIA OR FOR TAKING MEDIA FROM THE BODY; DEVICES FOR PRODUCING OR ENDING SLEEP OR STUPOR
    • A61M16/00Devices for influencing the respiratory system of patients by gas treatment, e.g. mouth-to-mouth respiration; Tracheal tubes
    • A61M16/0057Pumps therefor
    • A61M16/0066Blowers or centrifugal pumps
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61MDEVICES FOR INTRODUCING MEDIA INTO, OR ONTO, THE BODY; DEVICES FOR TRANSDUCING BODY MEDIA OR FOR TAKING MEDIA FROM THE BODY; DEVICES FOR PRODUCING OR ENDING SLEEP OR STUPOR
    • A61M2202/00Special media to be introduced, removed or treated
    • A61M2202/06Solids
    • A61M2202/064Powder
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61MDEVICES FOR INTRODUCING MEDIA INTO, OR ONTO, THE BODY; DEVICES FOR TRANSDUCING BODY MEDIA OR FOR TAKING MEDIA FROM THE BODY; DEVICES FOR PRODUCING OR ENDING SLEEP OR STUPOR
    • A61M2206/00Characteristics of a physical parameter; associated device therefor
    • A61M2206/10Flow characteristics
    • A61M2206/16Rotating swirling helical flow, e.g. by tangential inflows

Abstract

An inhaler for producing an inhalable aerosol of a powdered medicament comprises a cyclone ( 1 ) with a tangential air inlet ( 3 ) and an axial air outlet ( 4 ). The cyclone ( 1 ) aerosolises and retains an aerosol of powdered medicament in an airflow circulating between the inlet ( 3 ) and the outlet ( 4 ). The cyclone ( 1 ) has an exit port ( 2 ) which is open to atmosphere. When the aerosol is to be inhaled, the pressure in the cyclone ( 1 ) is increased by increasing the airflow to the inlet ( 3 ) which causes the aerosol to discharge through the exit port ( 2 ). The inhaler has the advantage that the rate of discharge of the aerosol can be controlled independently of the rate of airflow required to aerosolise the medicament.
AU2001289710A 2000-07-21 2001-07-20 Inhalers Abandoned AU2001289710A1 (en)

Applications Claiming Priority (3)

Application Number Priority Date Filing Date Title
GB0018030A GB2364919A (en) 2000-07-21 2000-07-21 Inhalers
GB0018030 2000-07-21
PCT/EP2001/008416 WO2002007805A2 (en) 2000-07-21 2001-07-20 Inhalers

Publications (1)

Publication Number Publication Date
AU2001289710A1 true AU2001289710A1 (en) 2002-02-05

Family

ID=9896158

Family Applications (1)

Application Number Title Priority Date Filing Date
AU2001289710A Abandoned AU2001289710A1 (en) 2000-07-21 2001-07-20 Inhalers

Country Status (8)

Country Link
US (1) US6948496B2 (en)
EP (1) EP1301231B1 (en)
AT (1) ATE314110T1 (en)
AU (1) AU2001289710A1 (en)
DE (1) DE60116319T2 (en)
ES (1) ES2256293T3 (en)
GB (1) GB2364919A (en)
WO (1) WO2002007805A2 (en)

Families Citing this family (58)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US9006175B2 (en) 1999-06-29 2015-04-14 Mannkind Corporation Potentiation of glucose elimination
CA2444729A1 (en) * 2001-05-10 2002-11-14 Vectura Delivery Devices Limited Inhalers
WO2003080149A2 (en) 2002-03-20 2003-10-02 Mannkind Corporation Inhalation apparatus
ATE551087T1 (en) 2002-04-19 2012-04-15 3M Innovative Properties Co SPACER OR ACTUATOR FOR EARLY REMOVAL OF THE NON-INBREATHABLE PORTION OF A MEDICAL AEROSOL
DE60239639D1 (en) * 2002-07-31 2011-05-12 Chiesi Farma Spa powder inhaler
AU2006225222B2 (en) * 2002-07-31 2009-01-08 Chiesi Farmaceutici S.P.A. Powder inhaler
US20040206350A1 (en) * 2002-12-19 2004-10-21 Nektar Therapeutics Aerosolization apparatus with non-circular aerosolization chamber
US8869794B1 (en) * 2003-04-09 2014-10-28 Novartis Pharma Ag Aerosolization apparatus with capsule puncturing member
PT1610850E (en) * 2003-04-09 2012-06-15 Novartis Ag Aerosolization apparatus with air inlet shield
GB2405799A (en) * 2003-09-15 2005-03-16 Vectura Ltd Dry powder inhaler incorporating a valve which is opened and closed by pressurized gas
GB2407042B (en) 2003-10-17 2007-10-24 Vectura Ltd Inhaler
JP5078014B2 (en) 2004-08-20 2012-11-21 マンカインド コーポレイション Catalytic reaction of diketopiperazine synthesis.
HUE026797T2 (en) 2004-08-23 2016-07-28 Mannkind Corp Diketopiperazine salts for drug delivery
GB0425758D0 (en) 2004-11-23 2004-12-22 Vectura Ltd Preparation of pharmaceutical compositions
KR20120060245A (en) 2005-09-14 2012-06-11 맨카인드 코포레이션 Method of drug formulation based on increasing the affinity of crystalline microparticle surfaces for active agents
WO2007089477A2 (en) 2006-01-31 2007-08-09 Oriel Therapeutics, Inc. Dry powder inhalers having spiral travel paths, unit dose microcartridges with dry powder, related devices and methods
EP2497484A3 (en) 2006-02-22 2012-11-07 MannKind Corporation A method for improving the pharmaceutic properties of microparticles comprising diketopiperazine and an active agent
US20090151722A1 (en) * 2007-07-06 2009-06-18 Vectura Delivery Devices Limited Inhaler
EP2011537A1 (en) * 2007-07-06 2009-01-07 Vectura Delivery Devices Limited Inhaler
US20090048155A1 (en) 2007-08-15 2009-02-19 Endacea, Inc. Methods for preventing and treating tissue injury and sepsis associated with Yersinia pestis infection
US9522916B2 (en) 2007-12-21 2016-12-20 Constance Neely Wilson A1 adenosine receptor antagonists
US8485180B2 (en) 2008-06-13 2013-07-16 Mannkind Corporation Dry powder drug delivery system
EP3281663B8 (en) 2008-06-13 2022-09-21 MannKind Corporation Breath powered dry powder inhaler for drug delivery
US9364619B2 (en) 2008-06-20 2016-06-14 Mannkind Corporation Interactive apparatus and method for real-time profiling of inhalation efforts
TWI494123B (en) 2008-08-11 2015-08-01 Mannkind Corp Use of ultrarapid acting insulin
US8314106B2 (en) 2008-12-29 2012-11-20 Mannkind Corporation Substituted diketopiperazine analogs for use as drug delivery agents
CA2754595C (en) 2009-03-11 2017-06-27 Mannkind Corporation Apparatus, system and method for measuring resistance of an inhaler
WO2010144789A2 (en) 2009-06-12 2010-12-16 Mannkind Corporation Diketopiperazine microparticles with defined specific surface areas
US9180263B2 (en) * 2009-07-01 2015-11-10 Microdose Therapeutx, Inc. Laboratory animal pulmonary dosing device
CA2778698A1 (en) 2009-11-03 2011-05-12 Mannkind Corporation An apparatus and method for simulating inhalation efforts
US9227030B2 (en) * 2009-12-23 2016-01-05 Map Pharmaceuticals, Inc. Enhanced eductor design
US9877967B2 (en) 2010-01-26 2018-01-30 Endacea, Inc. Methods and pharmaceutical compositions for preventing and treating renal impairment
AU2011271097B2 (en) 2010-06-21 2014-11-27 Mannkind Corporation Dry powder drug delivery system and methods
TW201304822A (en) 2010-11-15 2013-02-01 Vectura Ltd Compositions and uses
TW201306847A (en) 2010-11-30 2013-02-16 Vectura Ltd Compositions and uses
CN105667994B (en) 2011-04-01 2018-04-06 曼金德公司 Blister package for pharmaceutical kit
WO2012174472A1 (en) 2011-06-17 2012-12-20 Mannkind Corporation High capacity diketopiperazine microparticles
KR20140095483A (en) 2011-10-24 2014-08-01 맨카인드 코포레이션 Methods and compositions for treating pain
DK2872205T3 (en) 2012-07-12 2017-02-27 Mannkind Corp DRY POWDER FORMAL ADMINISTRATION SYSTEM
WO2014066856A1 (en) 2012-10-26 2014-05-01 Mannkind Corporation Inhalable influenza vaccine compositions and methods
WO2014106727A1 (en) 2013-01-03 2014-07-10 Vectura Limited Inhaler and formulation
KR102499439B1 (en) 2013-03-15 2023-02-13 맨카인드 코포레이션 Microcrystalline diketopiperazine compositions and methods
GB201305813D0 (en) 2013-03-28 2013-05-15 Vectura Ltd Compositions and methods
GB201305825D0 (en) 2013-03-28 2013-05-15 Vectura Ltd New use
WO2015010092A1 (en) 2013-07-18 2015-01-22 Mannkind Corporation Heat-stable dry powder pharmaceutical compositions and methods
JP2016530930A (en) 2013-08-05 2016-10-06 マンカインド コーポレイション Ventilation device and method
NO2709641T3 (en) * 2014-03-10 2018-05-12
WO2015148905A1 (en) 2014-03-28 2015-10-01 Mannkind Corporation Use of ultrarapid acting insulin
US10300228B2 (en) 2014-08-26 2019-05-28 Innovosciences, Llc Thermal modulation of an inhalable medicament
US10737042B2 (en) 2014-08-26 2020-08-11 Michael Edward Breede Thermal modulation of an inhalable medicament
US10561806B2 (en) 2014-10-02 2020-02-18 Mannkind Corporation Mouthpiece cover for an inhaler
ES2908479T3 (en) 2015-08-26 2022-04-29 Achillion Pharmaceuticals Inc Compounds for the treatment of immune and inflammatory disorders
AR106018A1 (en) 2015-08-26 2017-12-06 Achillion Pharmaceuticals Inc ARYL, HETEROARYL AND HETEROCYCLIC COMPOUNDS FOR THE TREATMENT OF MEDICAL DISORDERS
RU2018145364A (en) 2016-06-27 2020-07-28 Ачиллион Фармасьютикалс, Инк. QUINAZOLINE AND INDOLE COMPOUNDS FOR THE TREATMENT OF MEDICAL DISORDERS
CN108190160B (en) * 2018-01-09 2023-11-28 成都瑞拓科技有限责任公司 Automatic removing device and method for soft capsule inner liquid
EP3773576A4 (en) 2018-03-26 2021-12-29 C4 Therapeutics, Inc. Cereblon binders for the degradation of ikaros
EP3841086A4 (en) 2018-08-20 2022-07-27 Achillion Pharmaceuticals, Inc. Pharmaceutical compounds for the treatment of complement factor d medical disorders
CN113365617A (en) 2018-10-16 2021-09-07 乔治亚州立大学研究基金会股份有限公司 Carbon monoxide prodrugs for the treatment of medical conditions

Family Cites Families (31)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US16066A (en) * 1856-11-11 Medical kespibatok
US3362405A (en) * 1964-04-06 1968-01-09 Hamilton O. Hazel Method and apparatus for admixing gas with solid particles
US3949751A (en) * 1970-03-03 1976-04-13 Fisons Limited Method and device for dispensing medicament to the body
US4069819A (en) * 1973-04-13 1978-01-24 Societa Farmaceutici S.P.A. Inhalation device
GB1521000A (en) 1975-06-13 1978-08-09 Syntex Puerto Rico Inc Inhalation device
US4143658A (en) * 1975-07-21 1979-03-13 Minnesota Mining And Manufacturing Company Intratracheal injection system for animals
FR2352556A1 (en) * 1976-05-26 1977-12-23 Pasteur Institut Nasal and oral powder inhaler for medicines etc. - uses cyclone chamber to entrain powder into air stream
IT1116047B (en) * 1979-04-27 1986-02-10 Sigma Tau Ind Farmaceuti DEVICE FOR THE QUICK INHALATION OF POWDER DRUGS BY PERSONS SUFFERING FROM ASTHMA
US4570630A (en) * 1983-08-03 1986-02-18 Miles Laboratories, Inc. Medicament inhalation device
US4534343A (en) * 1984-01-27 1985-08-13 Trutek Research, Inc. Metered dose inhaler
DE4004904A1 (en) * 1990-02-16 1990-09-13 Gerhard Brendel DRUM APPLICATOR
AU657492B2 (en) * 1990-09-12 1995-03-16 Hans Bisgaard An inhaling device
US5186164A (en) * 1991-03-15 1993-02-16 Puthalath Raghuprasad Mist inhaler
AU650953B2 (en) * 1991-03-21 1994-07-07 Novartis Ag Inhaler
ATE359842T1 (en) * 1991-07-02 2007-05-15 Nektar Therapeutics DISPENSING DEVICE FOR MIST-FORMED MEDICATIONS
US5337740A (en) * 1991-08-01 1994-08-16 New England Pharmaceuticals, Inc. Inhalation devices
US5161524A (en) * 1991-08-02 1992-11-10 Glaxo Inc. Dosage inhalator with air flow velocity regulating means
US5476093A (en) * 1992-02-14 1995-12-19 Huhtamaki Oy Device for more effective pulverization of a powdered inhalation medicament
US5785049A (en) * 1994-09-21 1998-07-28 Inhale Therapeutic Systems Method and apparatus for dispersion of dry powder medicaments
US5896855A (en) * 1992-12-24 1999-04-27 Rhone-Poulenc Rorer Limited Multi dose inhaler apparatus
US5349947A (en) * 1993-07-15 1994-09-27 Newhouse Michael T Dry powder inhaler and process that explosively discharges a dose of powder and gas from a soft plastic pillow
SE9302550D0 (en) * 1993-07-30 1993-07-30 Ernst Hoerlin POWDER INHALES
CA2169760C (en) * 1993-08-18 2006-06-06 Alastair Robert Clarke Inhalator with breath flow regulation
ATE205098T1 (en) * 1994-05-19 2001-09-15 Pari Gmbh DEVICE FOR DRYING AND BUFFERING AEROSOLS
US5988163A (en) * 1995-08-02 1999-11-23 Innovative Devices Dry powder medicament inhalator having an inhalation-activated flow diverting means for triggering delivery of delivery of medicament
US5823183A (en) * 1995-08-02 1998-10-20 Innovative Devices Dry powder medicament inhalator having an inhalation-activated flow diverting means for triggering delivery of medicament
US5692496A (en) * 1995-08-02 1997-12-02 Innovative Devices, Llc Dry powder medicament inhalator having an inhalation-activated flow diverting means for triggering delivery of medicament
US5875776A (en) * 1996-04-09 1999-03-02 Vivorx Pharmaceuticals, Inc. Dry powder inhaler
GB9626263D0 (en) * 1996-12-18 1997-02-05 Innovata Biomed Ltd Powder inhaler
GB9719093D0 (en) * 1997-09-10 1997-11-12 Ml Lab Plc Improvements to dry powder inhalers
US6595210B2 (en) * 2000-11-27 2003-07-22 Unisia Jecs Corporation Inhalator for administering powder composition

Also Published As

Publication number Publication date
EP1301231B1 (en) 2005-12-28
GB0018030D0 (en) 2000-09-13
ATE314110T1 (en) 2006-01-15
GB2364919A (en) 2002-02-13
DE60116319T2 (en) 2006-08-31
EP1301231A2 (en) 2003-04-16
DE60116319D1 (en) 2006-02-02
ES2256293T3 (en) 2006-07-16
WO2002007805A2 (en) 2002-01-31
WO2002007805A3 (en) 2002-06-13
US6948496B2 (en) 2005-09-27
US20030172926A1 (en) 2003-09-18

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