AU2001287892A1 - Use of glp -2 in combination with another therapeutic agent in bone-related and nutrition-related disorders - Google Patents

Use of glp -2 in combination with another therapeutic agent in bone-related and nutrition-related disorders

Info

Publication number
AU2001287892A1
AU2001287892A1 AU2001287892A AU8789201A AU2001287892A1 AU 2001287892 A1 AU2001287892 A1 AU 2001287892A1 AU 2001287892 A AU2001287892 A AU 2001287892A AU 8789201 A AU8789201 A AU 8789201A AU 2001287892 A1 AU2001287892 A1 AU 2001287892A1
Authority
AU
Australia
Prior art keywords
glp
nutrition
bone
combination
therapeutic agent
Prior art date
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Abandoned
Application number
AU2001287892A
Inventor
Dennis Bang Henriksen
Current Assignee (The listed assignees may be inaccurate. Google has not performed a legal analysis and makes no representation or warranty as to the accuracy of the list.)
Immunodiagnostic Systems Nordic AS
Original Assignee
DONALD CARMICHAEL MACDOUGALL
Osteometer Biotech AS
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Priority claimed from GB0022844A external-priority patent/GB0022844D0/en
Priority claimed from GB0029920A external-priority patent/GB0029920D0/en
Application filed by DONALD CARMICHAEL MACDOUGALL, Osteometer Biotech AS filed Critical DONALD CARMICHAEL MACDOUGALL
Publication of AU2001287892A1 publication Critical patent/AU2001287892A1/en
Abandoned legal-status Critical Current

Links

Classifications

    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61KPREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K38/00Medicinal preparations containing peptides
    • A61K38/16Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof
    • A61K38/17Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from animals; from humans
    • A61K38/22Hormones
    • A61K38/27Growth hormone [GH] (Somatotropin)
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61KPREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K38/00Medicinal preparations containing peptides
    • A61K38/16Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof
    • A61K38/17Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from animals; from humans
    • A61K38/22Hormones
    • A61K38/26Glucagons
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61KPREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K38/00Medicinal preparations containing peptides
    • A61K38/16Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof
    • A61K38/17Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from animals; from humans
    • A61K38/22Hormones
    • A61K38/30Insulin-like growth factors (Somatomedins), e.g. IGF-1, IGF-2
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61PSPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P1/00Drugs for disorders of the alimentary tract or the digestive system
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61PSPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P1/00Drugs for disorders of the alimentary tract or the digestive system
    • A61P1/02Stomatological preparations, e.g. drugs for caries, aphtae, periodontitis
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61PSPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P11/00Drugs for disorders of the respiratory system
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61PSPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P19/00Drugs for skeletal disorders
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61PSPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P19/00Drugs for skeletal disorders
    • A61P19/02Drugs for skeletal disorders for joint disorders, e.g. arthritis, arthrosis
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61PSPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P19/00Drugs for skeletal disorders
    • A61P19/08Drugs for skeletal disorders for bone diseases, e.g. rachitism, Paget's disease
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61PSPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P19/00Drugs for skeletal disorders
    • A61P19/08Drugs for skeletal disorders for bone diseases, e.g. rachitism, Paget's disease
    • A61P19/10Drugs for skeletal disorders for bone diseases, e.g. rachitism, Paget's disease for osteoporosis
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61PSPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P29/00Non-central analgesic, antipyretic or antiinflammatory agents, e.g. antirheumatic agents; Non-steroidal antiinflammatory drugs [NSAID]
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61PSPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P3/00Drugs for disorders of the metabolism
    • A61P3/02Nutrients, e.g. vitamins, minerals
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61PSPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P3/00Drugs for disorders of the metabolism
    • A61P3/04Anorexiants; Antiobesity agents
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61PSPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P3/00Drugs for disorders of the metabolism
    • A61P3/06Antihyperlipidemics
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61PSPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P3/00Drugs for disorders of the metabolism
    • A61P3/08Drugs for disorders of the metabolism for glucose homeostasis
    • A61P3/10Drugs for disorders of the metabolism for glucose homeostasis for hyperglycaemia, e.g. antidiabetics
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61PSPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P35/00Antineoplastic agents
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61PSPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P37/00Drugs for immunological or allergic disorders
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61PSPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P5/00Drugs for disorders of the endocrine system
    • A61P5/14Drugs for disorders of the endocrine system of the thyroid hormones, e.g. T3, T4
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61PSPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P5/00Drugs for disorders of the endocrine system
    • A61P5/18Drugs for disorders of the endocrine system of the parathyroid hormones
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61PSPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P7/00Drugs for disorders of the blood or the extracellular fluid
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61PSPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P9/00Drugs for disorders of the cardiovascular system
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61PSPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P9/00Drugs for disorders of the cardiovascular system
    • A61P9/12Antihypertensives
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61KPREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K39/00Medicinal preparations containing antigens or antibodies
    • A61K2039/505Medicinal preparations containing antigens or antibodies comprising antibodies

Abstract

Glucagon-like peptide-2, its analogues and derivatives, for use in the treatment of hyperparathyroidism.
AU2001287892A 2000-09-18 2001-09-18 Use of glp -2 in combination with another therapeutic agent in bone-related and nutrition-related disorders Abandoned AU2001287892A1 (en)

Applications Claiming Priority (5)

Application Number Priority Date Filing Date Title
GB0022844.5 2000-09-18
GB0022844A GB0022844D0 (en) 2000-09-18 2000-09-18 Use of GLP-1 and GLP-2 peptides
GB0029920.6 2000-12-07
GB0029920A GB0029920D0 (en) 2000-12-07 2000-12-07 Use of glp-1 and glp-2 peptides
PCT/GB2001/004178 WO2002024214A2 (en) 2000-09-18 2001-09-18 Use of glp -2 in combination with another therapeutic agent in bone-related and nutrition-related disorders

Publications (1)

Publication Number Publication Date
AU2001287892A1 true AU2001287892A1 (en) 2002-04-02

Family

ID=26245018

Family Applications (2)

Application Number Title Priority Date Filing Date
AU2002213925A Abandoned AU2002213925A1 (en) 2000-09-18 2001-09-17 Use of glp-1 and flp-2 peptides for treatment of bone disorders
AU2001287892A Abandoned AU2001287892A1 (en) 2000-09-18 2001-09-18 Use of glp -2 in combination with another therapeutic agent in bone-related and nutrition-related disorders

Family Applications Before (1)

Application Number Title Priority Date Filing Date
AU2002213925A Abandoned AU2002213925A1 (en) 2000-09-18 2001-09-17 Use of glp-1 and flp-2 peptides for treatment of bone disorders

Country Status (11)

Country Link
US (2) US6770620B2 (en)
EP (3) EP1970072A1 (en)
JP (2) JP5161412B2 (en)
AT (2) ATE396738T1 (en)
AU (2) AU2002213925A1 (en)
CY (2) CY1108263T1 (en)
DE (2) DE60134251D1 (en)
DK (2) DK1326630T3 (en)
ES (2) ES2310192T3 (en)
PT (2) PT1326630E (en)
WO (2) WO2002022151A2 (en)

Families Citing this family (63)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US7371721B2 (en) * 2000-09-18 2008-05-13 Sanos Bioscience A/S Use of GLP-2 and related compounds for the treatment, prevention, diagnosis, and prognosis of bone-related disorders and calcium homeostasis related syndromes
US7186683B2 (en) * 2000-09-18 2007-03-06 Sanos Bioscience A/S Use of GLP for the treatment, prevention, diagnosis, and prognosis of bone-related and nutrition-related disorders
DE60134251D1 (en) * 2000-09-18 2008-07-10 Sanos Bioscience As USE OF GLP-2 PEPTIDES
US20070135345A1 (en) * 2000-09-18 2007-06-14 Henriksen Dennis B Use of GLP-2 for the treatment or prevention, of bone-related disorders
US20080249016A1 (en) * 2000-09-18 2008-10-09 Sanos Bioscience A/S Use of GLP-2 in a combination treatment for bone-related disorders
RO120121B1 (en) * 2000-12-18 2005-09-30 Elena Ionaşcu Injectable solution having antiinflammatory effect, process for preparing the same and method for treating autoimmune diseases
CA2347330C (en) * 2001-05-10 2002-03-12 Pharmaceutical Partners Of Canada Inc. Liquid injectable formulation of disodium pamidronate
DE10135315A1 (en) * 2001-07-19 2003-01-30 Bayer Ag stents
EP2261250B1 (en) 2001-12-21 2015-07-01 Human Genome Sciences, Inc. GCSF-Albumin fusion proteins
US20050215552A1 (en) * 2002-05-17 2005-09-29 Gadde Kishore M Method for treating obesity
EP1505967B1 (en) 2002-05-17 2016-07-13 Duke University Method for treating obesity
WO2004084859A2 (en) * 2003-03-21 2004-10-07 Nastech Pharmaceutical Company Inc. Nasal calcitonin formulations containing chlorobutanol
WO2004085471A2 (en) * 2003-03-24 2004-10-07 Novo Nordisk A/S Glp-2 derivatives
EP1870096A3 (en) * 2003-04-29 2011-04-20 Orexigen Therapeutics, Inc. Compositions for affecting weight loss
DK1617832T3 (en) * 2003-04-29 2008-07-07 Orexigen Therapeutics Inc Preparations for the effect of weight loss
US7259234B2 (en) 2003-05-15 2007-08-21 Trustees Of Tufts College Stable analogs of peptide and polypeptide therapeutics
US7713959B2 (en) * 2004-01-13 2010-05-11 Duke University Compositions of an anticonvulsant and mirtazapine to prevent weight gain
WO2005070461A2 (en) * 2004-01-13 2005-08-04 Duke University Compositions of an anticonvulsant and an antipsychotic drug for affecting weight loss
BRPI0510593A (en) * 2004-05-03 2007-11-20 Univ Duke compositions to affect weight loss
PT1877435E (en) * 2005-05-04 2011-05-24 Zealand Pharma As Glucagon-like-peptide-2 (glp-2) analogues
WO2006135660A2 (en) * 2005-06-10 2006-12-21 University Of Chicago Therapies involving lymphotoxin beta receptor
EP1951212A2 (en) 2005-11-22 2008-08-06 Orexigen Therapeutics, Inc. Compositions and methods for increasing insulin sensitivity
WO2007089318A2 (en) * 2005-11-23 2007-08-09 Orexigen Therapeutics, Inc. Compositions and methods for reducing food cravings
CA2651283A1 (en) * 2006-05-15 2007-11-22 Wisconsin Alumni Research Foundation Pulmonary delivery of 1.alpha.,25-dihydroxyvitamin d3 and co-administration of parathyroid hormone or calcitonin
US8916195B2 (en) 2006-06-05 2014-12-23 Orexigen Therapeutics, Inc. Sustained release formulation of naltrexone
NZ597554A (en) 2006-11-08 2014-04-30 Zealand Pharma As Selective glucagon-like-peptide-2 (glp-2) analogues
WO2008060964A2 (en) 2006-11-09 2008-05-22 Orexigen Therapeutics, Inc. Unit dosage package and methods for administering weight loss medications
KR20190042766A (en) 2006-11-09 2019-04-24 오렉시젠 세러퓨틱스 인크. Layered pharmaceutical formulations comprising an intermediate rapidly dissolving layer
EP2124907B1 (en) 2007-03-19 2018-05-30 Vita Sciences, Llc Transdermal patch and method for delivery of vitamin b12
WO2009039991A2 (en) * 2007-09-11 2009-04-02 Mondobiotech Laboratories Ag Use of aviptadil as a therapeutic agent
EP2303025A4 (en) * 2008-05-30 2012-07-04 Orexigen Therapeutics Inc Methods for treating visceral fat conditions
EP2337585A1 (en) * 2008-09-19 2011-06-29 Nektar Therapeutics Polymer conjugates of glp-2-like peptides
CA2737040C (en) 2008-09-19 2017-05-02 Nektar Therapeutics Polymer conjugates of therapeutic peptides
SI2349324T1 (en) 2008-10-17 2018-01-31 Sanofi-Aventis Deutschland Gmbh Combination of an insulin and a glp-1 agonist
EA201290158A1 (en) * 2009-09-23 2012-08-30 Биокиер, Инк. COMPOSITION AND METHOD OF TREATMENT OF DIABETES
EP2311486A1 (en) * 2009-10-07 2011-04-20 Nestec S.A. GLP-2 for use in intestine and muscle recovery
KR101836070B1 (en) 2009-11-13 2018-03-09 사노피-아벤티스 도이칠란트 게엠베하 Pharmaceutical composition comprising a glp-1 agonist, an insulin, and methionine
AR078973A1 (en) 2009-11-13 2011-12-14 Sanofi Aventis Deutschland PHARMACEUTICAL COMPOSITION THAT INCLUDES AN GLP-1 AND METIONINE AGONIST
BR112012016783A2 (en) 2010-01-11 2015-09-01 Orexigen Therapeutics Inc "Uses of the naltrexone compound or pharmaceutically acceptable salt thereof to bupropion or pharmaceutically acceptable salt thereof or composition thereof and methods for providing therapy"
AU2011202239C1 (en) 2010-05-19 2017-03-16 Sanofi Long-acting formulations of insulins
SI2611458T1 (en) 2010-08-30 2017-01-31 Sanofi-Aventis Deutschland Gmbh Use of ave0010 for the manufacture of a medicament for the treatment of diabetes mellitus type 2
US9821032B2 (en) 2011-05-13 2017-11-21 Sanofi-Aventis Deutschland Gmbh Pharmaceutical combination for improving glycemic control as add-on therapy to basal insulin
WO2012159215A1 (en) * 2011-05-24 2012-11-29 Polyvalor S.E.C. Compositions and methods for efficacious and safe delivery of sirna using specific chitosan-based nanocomplexes
MX370264B (en) 2011-08-29 2019-12-09 Sanofi Aventis Deutschland Pharmaceutical combination for use in glycemic control in diabetes type 2 patients.
TWI559929B (en) 2011-09-01 2016-12-01 Sanofi Aventis Deutschland Pharmaceutical composition for use in the treatment of a neurodegenerative disease
TR201802689T4 (en) 2012-05-03 2018-03-21 Zealand Pharma As Glucagon-like peptide-2 (glp-2) analogs.
KR20200035501A (en) 2012-06-06 2020-04-03 오렉시젠 세러퓨틱스 인크. Methods of treating overweight and obesity
CA2907848A1 (en) 2013-04-03 2014-10-09 Sanofi Treatment of diabetes mellitus by long-acting formulations of insulins
WO2015016682A1 (en) * 2013-08-01 2015-02-05 경희대학교 산학협력단 Pharmaceutical composition for preventing or treating diabetes mellitus, method for preventing or treating diabetes mellitus, and method for screening for diabetes mellitus therapeutic agent
KR101688639B1 (en) 2013-08-01 2016-12-21 경희대학교 산학협력단 Composition for preventing or treating diabetes mellitus, method for preventing or treating diabetes mellitus, and method for screening antidiabetics
US8969371B1 (en) 2013-12-06 2015-03-03 Orexigen Therapeutics, Inc. Compositions and methods for weight loss in at risk patient populations
HUE062573T2 (en) 2014-12-12 2023-11-28 Sanofi Aventis Deutschland Insulin glargine/lixisenatide fixed ratio formulation
TWI748945B (en) 2015-03-13 2021-12-11 德商賽諾菲阿凡提斯德意志有限公司 Treatment type 2 diabetes mellitus patients
TW201705975A (en) 2015-03-18 2017-02-16 賽諾菲阿凡提斯德意志有限公司 Treatment of type 2 diabetes mellitus patients
CA2990230A1 (en) 2015-06-19 2016-12-22 University Of Southern California Compositions and methods for modified nutrient delivery
US10744070B2 (en) 2015-06-19 2020-08-18 University Of Southern California Enteral fast access tract platform system
WO2018009778A1 (en) * 2016-07-07 2018-01-11 Baylor College Of Medicine Combination of glp-1 and glp-2 for treating or preventing metabolic diseases, disorders and syndromes
US10774127B2 (en) 2016-10-12 2020-09-15 University Of Copenhagen Peptide dual agonists of GIPR and GLP2R
BR112019010624A2 (en) 2016-12-09 2019-10-22 Zealand Pharma As double acylated glp-1 / glp-2 agonists and composition
US20200261543A1 (en) 2017-10-12 2020-08-20 University Of Copenhagen Combination therapy for treatment of bone disorders
US20210187077A1 (en) * 2019-12-23 2021-06-24 Idaho State University GLP-1 Agonist Conjugates for Sustained Glycemic Control
US20220362347A1 (en) * 2019-12-24 2022-11-17 Hanmi Pharm. Co., Ltd. Pharmaceutical composition for preventing or treating metabolic bone diseases, comprising glp-2 or conjugate thereof
US20230355720A1 (en) * 2020-09-25 2023-11-09 Hanmi Pharm. Co., Ltd. Pharmaceutical composition for preventing or treating bone diseases, comprising triple agonist or conjugate thereof having activity with respect to all of glucagon, glp-1 and glp receptors

Family Cites Families (48)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
WO1987006941A1 (en) 1986-05-05 1987-11-19 The General Hospital Corporation Insulinotropic hormone
ATE193541T1 (en) 1989-03-20 2000-06-15 Gen Hospital Corp INSULINOTROPIC HORMONE
EP0512042B1 (en) 1990-01-24 1998-04-08 BUCKLEY, Douglas I. Glp-1 analogs useful for diabetes treatment
NZ245015A (en) 1991-11-05 1995-12-21 Transkaryotic Therapies Inc Delivery of human growth hormone through the administration of transfected cell lines encoding human growth hormone, which are physically protected from host immune response; the transfected cells and their production
US5512459A (en) 1993-07-20 1996-04-30 Bionebraska, Inc. Enzymatic method for modification or recombinant polypeptides
US5990077A (en) 1995-04-14 1999-11-23 1149336 Ontario Inc. Glucagon-like peptide-2 and its therapeutic use
US6184201B1 (en) 1995-04-14 2001-02-06 Nps Allelix Corp. Intestinotrophic glucagon-like peptide-2 analogs
US5834428A (en) 1995-04-14 1998-11-10 1149336 Ontario Inc. Glucagon-like peptide-2 and its therapeutic use
US5789379A (en) 1995-04-14 1998-08-04 Allelix Biopharmaceutical Inc. Glucagon-like peptide-2 analogs
DE69740176D1 (en) * 1996-03-01 2011-05-26 Novo Nordisk As Appetite inhibiting peptide, composition and use
US5912229A (en) 1996-03-01 1999-06-15 Novo Nordisk Als Use of a pharmaceutical composition comprising an appetite-suppressing peptide
NZ332281A (en) 1996-04-12 2000-03-27 Allelix Biopharma Glucagon-like peptide-2 (GLP-2) analogs for the treatment of bowl disorders resistant to dipeptidyl peptidase IV (DPP-IV) digestion
EP0909312B1 (en) 1996-07-05 2002-12-04 Novo Nordisk A/S Method for the production of polypeptides
US5994500A (en) 1996-07-19 1999-11-30 1149336 Ontario Inc. Antagonists of intestinotrophic GLP-2 peptides
JP2000517308A (en) 1996-08-30 2000-12-26 ノボ ノルディスク アクティーゼルスカブ GLP-2 derivative
US6011155A (en) * 1996-11-07 2000-01-04 Novartis Ag N-(substituted glycyl)-2-cyanopyrrolidines, pharmaceutical compositions containing them and their use in inhibiting dipeptidyl peptidase-IV
WO1998024813A2 (en) 1996-12-06 1998-06-11 Amgen Inc. Keratinocyte growth factors and their use in combination with glucagon-like peptide derivatives
US5952301A (en) 1996-12-10 1999-09-14 1149336 Ontario Inc. Compositions and methods for enhancing intestinal function
CA2274989C (en) 1996-12-13 2012-01-31 Allelix Biopharmaceuticals Inc. Cloned glucagon-like peptide-2 receptors
US6077949A (en) 1996-12-13 2000-06-20 Allelix Biopharmaceuticals, Inc. Cloned glucagon-like peptide 2 receptors
WO1998052600A1 (en) * 1997-05-16 1998-11-26 1149336 Ontario Inc. Methods of enhancing functioning of the upper gastrointestinal tract
US6051557A (en) 1997-05-16 2000-04-18 1149336 Ontario Inc. Methods of enhancing functioning of the upper gastrointestinal tract
WO1999006059A2 (en) 1997-07-30 1999-02-11 Board Of Regents, The University Of Texas System Methods and compositions relating to no-mediated cytotoxicity
JP2001516765A (en) 1997-09-12 2001-10-02 ヴォルフ ゲオルグ フォースマン Compositions for the treatment of diabetes mellitus and obesity
WO1999037793A1 (en) 1998-01-23 1999-07-29 Novo Nordisk A/S Process for making desired polypeptides in yeast
EP2433623A1 (en) 1998-02-02 2012-03-28 Trustees Of Tufts College Use of dipeptidylpeptidase inhibitors to regulate glucose metabolism
JP2002504527A (en) 1998-02-27 2002-02-12 ノボ ノルディスク アクティーゼルスカブ GLP-2 derivatives with more than 25% helical component forming partially organized micellar-like aggregates
CA2321026A1 (en) 1998-03-09 1999-09-16 Zealand Pharmaceuticals A/S Pharmacologically active peptide conjugates having a reduced tendency towards enzymatic hydrolysis
FR2777283B1 (en) * 1998-04-10 2000-11-24 Adir NOVEL GLUCAGON-PEPTIDE- 1 (7-37) ANALOGUE PEPTIDE COMPOUNDS, PROCESS FOR THEIR PREPARATION AND THE PHARMACEUTICAL COMPOSITIONS CONTAINING THE SAME
AU7421598A (en) 1998-05-11 1999-11-29 1149336 Ontario Inc. Methods of enhancing functioning of the large intestine
KR20010079669A (en) 1998-08-21 2001-08-22 바바라 피. 월너 Regulation of Substrate Activity
US6193997B1 (en) 1998-09-27 2001-02-27 Generex Pharmaceuticals Inc. Proteinic drug delivery system using membrane mimetics
WO2000020592A1 (en) 1998-10-07 2000-04-13 Medical College Of Georgia Research Institute, Inc. Glucose-dependent insulinotropic peptide for use as an osteotropic hormone
US6416737B1 (en) * 1998-11-19 2002-07-09 Board Of Trustees Of The University Of Arkansas Increasing bone strength with selected bisphosphonates
JP3702181B2 (en) * 1998-12-07 2005-10-05 ソシエテ・ドゥ・コンセイユ・ドゥ・ルシェルシュ・エ・ダプリカーション・シャンティフィック・エス・ア・エス Analogs of GLP-1
EP1992641A3 (en) * 1998-12-07 2009-07-29 Ipsen Pharma GLP-1 analogues
CO5150173A1 (en) 1998-12-10 2002-04-29 Novartis Ag COMPOUNDS N- (REPLACED GLYCLE) -2-DIPEPTIDYL-IV PEPTIDASE INHIBITING CYANOPIRROLIDINS (DPP-IV) WHICH ARE EFFECTIVE IN THE TREATMENT OF CONDITIONS MEDIATED BY DPP-IV INHIBITION
US6271200B1 (en) 1998-12-21 2001-08-07 Generex Pharmaceuticals Inc. Proteinic drug delivery system using aerosolized membrane-mimetic amphiphiles
WO2000042026A1 (en) 1999-01-15 2000-07-20 Novo Nordisk A/S Non-peptide glp-1 agonists
GB9905416D0 (en) 1999-03-09 1999-05-05 Allelix Biopharma Small molecules having GLP-2 like activity
US6110949A (en) * 1999-06-24 2000-08-29 Novartis Ag N-(substituted glycyl)-4-cyanothiazolidines, pharmaceutical compositions containing them and their use in inhibiting dipeptidyl peptidase-IV
EP1076066A1 (en) 1999-07-12 2001-02-14 Zealand Pharmaceuticals A/S Peptides for lowering blood glucose levels
US20030040478A1 (en) 1999-12-08 2003-02-27 Drucker Daniel J Chemotherapy treatment
US20020061838A1 (en) * 2000-05-17 2002-05-23 Barton Holmquist Peptide pharmaceutical formulations
KR100847615B1 (en) * 2000-06-16 2008-07-21 일라이 릴리 앤드 캄파니 Glucagon-like Peptide-1 Analogs
EP1305338A2 (en) * 2000-08-02 2003-05-02 Theratechnologies Inc. Modified peptides with increased potency
DE60134251D1 (en) * 2000-09-18 2008-07-10 Sanos Bioscience As USE OF GLP-2 PEPTIDES
WO2002066062A2 (en) 2001-02-01 2002-08-29 Drucker Daniel J Enhancement of glp-2 activity

Also Published As

Publication number Publication date
JP5161412B2 (en) 2013-03-13
CY1108263T1 (en) 2014-02-12
PT1414486E (en) 2010-07-21
WO2002022151A2 (en) 2002-03-21
DK1326630T3 (en) 2008-09-15
EP1414486A2 (en) 2004-05-06
EP1326630B1 (en) 2008-05-28
US6943151B2 (en) 2005-09-13
ES2345874T3 (en) 2010-10-05
WO2002024214A3 (en) 2004-02-19
CY1110721T1 (en) 2015-06-10
EP1970072A1 (en) 2008-09-17
JP2004508410A (en) 2004-03-18
US20020037836A1 (en) 2002-03-28
WO2002024214A2 (en) 2002-03-28
EP1326630A2 (en) 2003-07-16
ATE466592T1 (en) 2010-05-15
US6770620B2 (en) 2004-08-03
JP2004524268A (en) 2004-08-12
DK1414486T3 (en) 2010-08-30
DE60142084D1 (en) 2010-06-17
DE60134251D1 (en) 2008-07-10
US20040082507A1 (en) 2004-04-29
AU2002213925A1 (en) 2002-03-26
ES2310192T3 (en) 2009-01-01
PT1326630E (en) 2008-09-02
JP5189723B2 (en) 2013-04-24
WO2002022151A3 (en) 2003-03-13
EP1414486B1 (en) 2010-05-05
ATE396738T1 (en) 2008-06-15

Similar Documents

Publication Publication Date Title
AU2001287892A1 (en) Use of glp -2 in combination with another therapeutic agent in bone-related and nutrition-related disorders
MXPA03003870A (en) Combination therapy comprising anti-diabetic and anticonvulsant agents.
HK1046105A1 (en) Methods for glucagon suppression
WO2002038052A3 (en) Steerable loop structure
MXPA05008406A (en) Phenylacetamides and their use as glucokinase modulators.
EP2261200A3 (en) Modified forms of pharmacacologically active agents and uses therefor
WO2003018516A3 (en) Glucagon-like peptide-1 analogs
HK1061516A1 (en) Combinations comprising an antidiarrheal agent and an epothilone or an epothilone derivative
AU2001264042A1 (en) 1,4-diazabicyclo(3.2.2)nonane-phenylisoxazole derivatives, preparation and therapeutic use thereof
AU2158601A (en) Antiviral agent for use in treatment of cancer
AU2001264044A1 (en) 1,4-diazabicyclo(3.2.2)nonabenzoxazole, -benzothiazole and benzimidazole derivatives, preparation and therapeutic use thereof
AU2001235595A1 (en) 4-heteroaryl-1,4-diazabicyclo(3.2.2)nonane, preparation and therapeutic use thereof
AUPQ879500A0 (en) Hyaluronan as cytotoxic agent, drug presensitizer and chemo-sensitizer in the treatment of disease
AU3301700A (en) (n)-sulfonyl-dipeptide derivatives, production and use thereof in therapy
AU4789099A (en) Therapeutic composition based on flavonoids for use in the treatment of tumours with cytotoxic agents
MXPA03003032A (en) Combination therapy for the treatment of estrogen-sensitive disease.
AU2002234165A1 (en) Combination therapy using pentafluorobenzenesulfonamides and antineoplastic agents
ZA200405173B (en) 2'-halo-3',5'-dialkoxyphen-1'yl-imino-2-imidazoline derivatives and the use thereof for the treatment of urinary incontinence.
AU2002210763A1 (en) Use of 1-ebio in the treatment of bipolar disorders
AU6091299A (en) Treatment device, treatment bed to be used therein and the use thereof
WO2002004073A3 (en) Therapeutic radiation arrangement
AU2002368208A8 (en) Use of 2,3 alkylcarbonyloxybenzoic acids in the treatment of anthrax
AU5969500A (en) 10-formyltetrahydrofolate dehydrogenase as therapeutical agent
AU2002223961A1 (en) Use of chelators in the treatment of macular degenerative disease
AU2002313087A1 (en) Product comprising mikanolide, dihydromikanolide or an analogue thereof combined with another anti-cancer agent for therapeutic use in cancer treatment