AU2001285425A1 - Active nems arrays for biochemical analyses - Google Patents

Active nems arrays for biochemical analyses

Info

Publication number
AU2001285425A1
AU2001285425A1 AU2001285425A AU8542501A AU2001285425A1 AU 2001285425 A1 AU2001285425 A1 AU 2001285425A1 AU 2001285425 A AU2001285425 A AU 2001285425A AU 8542501 A AU8542501 A AU 8542501A AU 2001285425 A1 AU2001285425 A1 AU 2001285425A1
Authority
AU
Australia
Prior art keywords
active
biochemical analyses
resonator
mechanical
biofunctionalized nanoelectromechanical
Prior art date
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Abandoned
Application number
AU2001285425A
Inventor
Scott E Fraser
Michael L. Roukes
Current Assignee (The listed assignees may be inaccurate. Google has not performed a legal analysis and makes no representation or warranty as to the accuracy of the list.)
California Institute of Technology CalTech
Original Assignee
California Institute of Technology CalTech
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by California Institute of Technology CalTech filed Critical California Institute of Technology CalTech
Publication of AU2001285425A1 publication Critical patent/AU2001285425A1/en
Abandoned legal-status Critical Current

Links

Classifications

    • G—PHYSICS
    • G01—MEASURING; TESTING
    • G01N—INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
    • G01N29/00—Investigating or analysing materials by the use of ultrasonic, sonic or infrasonic waves; Visualisation of the interior of objects by transmitting ultrasonic or sonic waves through the object
    • G01N29/02—Analysing fluids
    • G01N29/036—Analysing fluids by measuring frequency or resonance of acoustic waves
    • G—PHYSICS
    • G01—MEASURING; TESTING
    • G01N—INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
    • G01N33/00—Investigating or analysing materials by specific methods not covered by groups G01N1/00 - G01N31/00
    • G01N33/48—Biological material, e.g. blood, urine; Haemocytometers
    • G01N33/50—Chemical analysis of biological material, e.g. blood, urine; Testing involving biospecific ligand binding methods; Immunological testing
    • G01N33/53—Immunoassay; Biospecific binding assay; Materials therefor
    • G01N33/543—Immunoassay; Biospecific binding assay; Materials therefor with an insoluble carrier for immobilising immunochemicals
    • G01N33/54366—Apparatus specially adapted for solid-phase testing
    • G01N33/54373—Apparatus specially adapted for solid-phase testing involving physiochemical end-point determination, e.g. wave-guides, FETS, gratings
    • B—PERFORMING OPERATIONS; TRANSPORTING
    • B82—NANOTECHNOLOGY
    • B82Y—SPECIFIC USES OR APPLICATIONS OF NANOSTRUCTURES; MEASUREMENT OR ANALYSIS OF NANOSTRUCTURES; MANUFACTURE OR TREATMENT OF NANOSTRUCTURES
    • B82Y35/00—Methods or apparatus for measurement or analysis of nanostructures
    • B—PERFORMING OPERATIONS; TRANSPORTING
    • B82—NANOTECHNOLOGY
    • B82Y—SPECIFIC USES OR APPLICATIONS OF NANOSTRUCTURES; MEASUREMENT OR ANALYSIS OF NANOSTRUCTURES; MANUFACTURE OR TREATMENT OF NANOSTRUCTURES
    • B82Y5/00—Nanobiotechnology or nanomedicine, e.g. protein engineering or drug delivery
    • G—PHYSICS
    • G01—MEASURING; TESTING
    • G01N—INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
    • G01N2291/00—Indexing codes associated with group G01N29/00
    • G01N2291/02—Indexing codes associated with the analysed material
    • G01N2291/025—Change of phase or condition
    • G01N2291/0256—Adsorption, desorption, surface mass change, e.g. on biosensors
    • G01N2291/0257—Adsorption, desorption, surface mass change, e.g. on biosensors with a layer containing at least one organic compound

Landscapes

  • Health & Medical Sciences (AREA)
  • Immunology (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Engineering & Computer Science (AREA)
  • Chemical & Material Sciences (AREA)
  • Physics & Mathematics (AREA)
  • Biomedical Technology (AREA)
  • Pathology (AREA)
  • Analytical Chemistry (AREA)
  • Hematology (AREA)
  • General Physics & Mathematics (AREA)
  • Molecular Biology (AREA)
  • Urology & Nephrology (AREA)
  • General Health & Medical Sciences (AREA)
  • Biochemistry (AREA)
  • Cell Biology (AREA)
  • Medicinal Chemistry (AREA)
  • Food Science & Technology (AREA)
  • Microbiology (AREA)
  • Biotechnology (AREA)
  • Acoustics & Sound (AREA)
  • Apparatus Associated With Microorganisms And Enzymes (AREA)
  • Measurement Of The Respiration, Hearing Ability, Form, And Blood Characteristics Of Living Organisms (AREA)
  • Investigating Or Analysing Biological Materials (AREA)
  • Measuring Or Testing Involving Enzymes Or Micro-Organisms (AREA)
  • Investigating Or Analyzing Materials By The Use Of Electric Means (AREA)

Abstract

A biofunctionalized nanoelectromechanical device (BioNEMS) for sensing single-molecules in solution by measuring the variation in the mechanical displacement of the BioNEMS device during a binding event is provided. The biofunctionalized nanoelectromechanical device according to the invention generally comprises a nanomechanical mechanical resonator, a detector integral with the mechanical resonator for measuring the mechanical displacement of the resonator, and electronics connected to the detector for communicating the results to a user. A system of biofunctionalized nanoelectromechanical devices and a method for utilizing the biofunctionalized nanoelectromechanical device of the present invention are also provided.
AU2001285425A 2000-08-09 2001-08-09 Active nems arrays for biochemical analyses Abandoned AU2001285425A1 (en)

Applications Claiming Priority (3)

Application Number Priority Date Filing Date Title
US22410900P 2000-08-09 2000-08-09
US60/224,109 2000-08-09
PCT/US2001/041645 WO2002012443A2 (en) 2000-08-09 2001-08-09 Active nems arrays for biochemical analyses

Publications (1)

Publication Number Publication Date
AU2001285425A1 true AU2001285425A1 (en) 2002-02-18

Family

ID=22839309

Family Applications (1)

Application Number Title Priority Date Filing Date
AU2001285425A Abandoned AU2001285425A1 (en) 2000-08-09 2001-08-09 Active nems arrays for biochemical analyses

Country Status (8)

Country Link
US (3) US7407814B2 (en)
EP (1) EP1325302B1 (en)
JP (1) JP2005504260A (en)
AT (1) ATE342225T1 (en)
AU (1) AU2001285425A1 (en)
CA (1) CA2417939A1 (en)
DE (1) DE60123818T2 (en)
WO (1) WO2002012443A2 (en)

Families Citing this family (59)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US7148017B1 (en) 2000-07-12 2006-12-12 Cornell Research Foundation, Inc. High sensitivity mechanical resonant sensor
DE60123818T2 (en) * 2000-08-09 2007-08-23 California Institute Of Technology, Pasadena NANOELECTROMECHANICAL DEVICE FOR IMPLEMENTING BIOCHEMICAL ANALYZES
US7375321B2 (en) * 2000-08-09 2008-05-20 California Institute Of Technology Dynamics bionems sensors and arrays of bionems sensor immersed in fluids
AU2003206679A1 (en) * 2002-02-08 2003-09-02 Cantion A/S Scion.Dtu A sensor comprising mechanical amplification of surface stress sensitive cantilever
JP2006506236A (en) * 2002-05-07 2006-02-23 カリフォルニア　インスティチュート　オブ　テクノロジー Apparatus and method for use in vacuum-based sensors of micromechanical energy, force and mass
US20040141541A1 (en) * 2002-12-02 2004-07-22 John Williams MEMS-based thermogravimetric analyzer
US7191639B2 (en) * 2003-04-08 2007-03-20 California Institute Of Technology On-chip magnetic force actuation of microcantilevers by coplanar coils
US7552645B2 (en) * 2003-05-07 2009-06-30 California Institute Of Technology Detection of resonator motion using piezoresistive signal downmixing
US7302856B2 (en) * 2003-05-07 2007-12-04 California Institute Of Technology Strain sensors based on nanowire piezoresistor wires and arrays
US7434476B2 (en) * 2003-05-07 2008-10-14 Califronia Institute Of Technology Metallic thin film piezoresistive transduction in micromechanical and nanomechanical devices and its application in self-sensing SPM probes
US6763705B1 (en) * 2003-06-16 2004-07-20 Ut-Battelle, Llc High throughput microcantilever detector
JP4222513B2 (en) * 2003-08-19 2009-02-12 日本碍子株式会社 Mass measuring apparatus and method
GB0328054D0 (en) 2003-12-04 2004-01-07 Council Cent Lab Res Councils Fluid probe
US7762719B2 (en) * 2004-04-20 2010-07-27 California Institute Of Technology Microscale calorimeter
JP4528926B2 (en) * 2004-05-20 2010-08-25 高知県 Field emission type device driving apparatus and driving method thereof
US8750957B2 (en) * 2004-06-01 2014-06-10 California Institute Of Technology Microfabricated neural probes and methods of making same
US7765854B2 (en) * 2004-11-16 2010-08-03 Exxonmobil Research And Engineering Company Microcantilever stress sensor for fluid analysis
JP2006214744A (en) * 2005-02-01 2006-08-17 Gunma Univ Biosensor and biosensor chip
US7409851B2 (en) * 2005-03-29 2008-08-12 Cornell Research Foundation, Inc. Detection of small bound mass
US20070140905A1 (en) * 2005-03-29 2007-06-21 Japan Science And Technology Agency Nanogap series substance capturing, detecting and identifying method and device
EP1913800A4 (en) * 2005-07-27 2016-09-21 Wisconsin Alumni Res Found Nanoelectromechanical and microelectromechanical sensors and analyzers
CN100425524C (en) * 2006-01-13 2008-10-15 中国科学院上海微系统与信息技术研究所 Electromagnet excitated high order mode silicon micromechanical cantilever driving structure, its production method and uses
GB0605273D0 (en) 2006-03-16 2006-04-26 Council Cent Lab Res Councils Fluid robe
WO2008091294A2 (en) 2006-07-28 2008-07-31 California Institute Of Technology Polymer nems for cell physiology and microfabricated cell positioning system for micro-biocalorimeter
JP4845649B2 (en) * 2006-09-07 2011-12-28 キヤノン株式会社 Minute object surface evaluation apparatus and minute object surface evaluation method
US20080245135A1 (en) * 2006-11-15 2008-10-09 Cornell Research Foundation, Inc. Microfluidic encapsulated nems resonators
JP4953140B2 (en) * 2006-12-05 2012-06-13 国立大学法人群馬大学 Mass measuring device and cantilever
US7884324B2 (en) 2007-06-03 2011-02-08 Wisconsin Alumni Research Foundation Nanopillar arrays for electron emission
GB0716202D0 (en) 2007-08-11 2007-09-26 Microvisk Ltd Improved fluid probe
KR100943707B1 (en) * 2007-10-05 2010-02-23 한국전자통신연구원 Three dimensional nano devices including nano structure
US8227747B2 (en) * 2008-01-25 2012-07-24 California Institute Of Technology Single molecule mass spectroscopy enabled by nanoelectromechanical systems (NEMS-MS)
US8476005B2 (en) * 2008-02-05 2013-07-02 California Institute Of Technology Microfluidic embedded polymer NEMS force sensors
US8459123B2 (en) * 2008-06-19 2013-06-11 The United States Of America, As Represented By The Secretary Of The Navy Micromechanical chemical sensors with multiple chemoselective resonant elements and frequency division multiplexed readout
US10566169B1 (en) 2008-06-30 2020-02-18 Nexgen Semi Holding, Inc. Method and device for spatial charged particle bunching
US9442021B2 (en) * 2008-08-05 2016-09-13 California Institute Of Technology Uncooled IR detector arrays based on nanoelectromechanical systems
US8487385B2 (en) * 2008-08-05 2013-07-16 California Institute Of Technology Uncooled IR detector arrays based on nanoelectromechanical systems
IT1392736B1 (en) 2008-12-09 2012-03-16 St Microelectronics Rousset INTEGRATED TORSIONAL MICRO-BALANCE DEVICE IN MEMS TECHNOLOGY AND ITS MANUFACTURING PROCESS
WO2010106331A2 (en) * 2009-03-20 2010-09-23 Attana Ab Analytical method and sensor
US8887381B2 (en) 2009-04-21 2014-11-18 Nicholas Antoniou Method of making a 3-D structure
ATE551608T1 (en) * 2009-08-05 2012-04-15 Nanoworld Ag MICROPROBE WITH SPRING BEAM ARRAY
WO2011047336A1 (en) * 2009-10-15 2011-04-21 Nexgen Semt Holding, Inc. Imaging devices for measuring the structure of a surface
US8347729B2 (en) * 2009-11-12 2013-01-08 International Business Machines Corporation Piezoresistive strain sensor based nanowire mechanical oscillator
GB2484454B (en) * 2010-09-03 2014-01-08 Cambridge Entpr Ltd Sensor and method for sensing a property of a fluid
DE102011053684B4 (en) 2010-09-17 2019-03-28 Wisconsin Alumni Research Foundation Method for carrying out jet impact activated dissociation in the already existing ion injection path of a mass spectrometer
US8495760B2 (en) * 2010-11-30 2013-07-23 The Board Of Trustees Of The Leland Stanford Junior University Atomic force microscope manipulation of living cells
US8857275B2 (en) 2011-05-02 2014-10-14 California Institute Of Technology NEMS sensors for cell force application and measurement
EP2715777A4 (en) 2011-06-02 2015-03-04 Wisconsin Alumni Res Found Membrane detector for time-of-flight mass spectrometry
WO2013146732A1 (en) * 2012-03-27 2013-10-03 住友精密工業株式会社 Physical quantity sensor
WO2013169940A2 (en) 2012-05-09 2013-11-14 California Institute Of Technology Single-protein nanomechanical mass spectrometry in real time
US9291600B2 (en) * 2013-01-02 2016-03-22 California Institute Of Technology Piezoresistive NEMS array network
EP2959274A2 (en) 2013-02-22 2015-12-30 California Institute of Technology Shape analysis and mass spectrometry of individual molecules by nanomechanical systems
US9407636B2 (en) 2014-05-19 2016-08-02 Intel Corporation Method and apparatus for securely saving and restoring the state of a computing platform
WO2016118821A1 (en) 2015-01-23 2016-07-28 California Institute Of Technology Integrated hybrid nems mass spectrometry
US11415551B2 (en) 2016-04-26 2022-08-16 Qorvo Biotechnologies, Llc Resonator for detecting single molecule binding
CN107697883A (en) * 2017-09-29 2018-02-16 江西师范大学 Coupled nanosecond mechanical vibrator and forming method thereof
CN107462609A (en) * 2017-09-29 2017-12-12 江西师范大学 Gas nanosensor and forming method thereof
CN107651650A (en) * 2017-09-29 2018-02-02 江西师范大学 Coupled nanosecond mechanical vibrator and forming method thereof
US11289319B2 (en) 2019-08-06 2022-03-29 Thermo Fisher Scientific (Bremen) Gmbh System to analyze particles, and particularly the mass of particles
LU102351B1 (en) * 2020-12-15 2022-06-15 Nanosurf Ag Device and method for determining mechanical properties of a system, use of two adjacent cantilevers and use of a system

Family Cites Families (23)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
EP0215669A3 (en) * 1985-09-17 1989-08-30 Seiko Instruments Inc. Analytical device and method for analysis of biochemicals, microbes and cells
US5003815A (en) * 1989-10-20 1991-04-02 International Business Machines Corporation Atomic photo-absorption force microscope
DE69012555T2 (en) * 1990-07-25 1995-04-06 International Business Machines Corp., Armonk, N.Y. Method of manufacturing micromechanical sensors for AFM / STM / MFM profilometry and micromechanical AFM / STM / MFM sensor head.
JPH05282717A (en) * 1992-03-31 1993-10-29 Canon Inc Manufacture of recording medium, and recording medium and information processor
US5736410A (en) 1992-09-14 1998-04-07 Sri International Up-converting reporters for biological and other assays using laser excitation techniques
US5559330A (en) * 1993-12-20 1996-09-24 Nippon Telegraph And Telephone Corporation Scanning tunneling microscope
JPH07225233A (en) 1994-02-15 1995-08-22 Kyowa Medex Co Ltd Immunoassay using crystal vibrator
JP3338551B2 (en) 1994-03-17 2002-10-28 塩野義製薬株式会社 Method for measuring human serum albumin
US6006594A (en) * 1994-05-11 1999-12-28 Dr. Khaled Und Dr. Miles Haines Gesellschaft Burgerlichen Rechts Scanning probe microscope head with signal processing circuit
US5807758A (en) * 1995-07-21 1998-09-15 Lee; Gil U. Chemical and biological sensor using an ultra-sensitive force transducer
DE19548376A1 (en) 1995-12-27 1997-07-03 Behringwerke Ag Mass sensitive biosensors
US6033852A (en) * 1996-09-27 2000-03-07 University Of Maine Monolithic piezoelectric sensor (MPS) for sensing chemical, biochemical and physical measurands
WO1998050773A2 (en) * 1997-05-08 1998-11-12 University Of Minnesota Microcantilever biosensor
US6203983B1 (en) * 1997-06-16 2001-03-20 Affymetrix, Inc. Method for detecting chemical interactions between naturally occurring bio-polymers which are non-identical binding partners
US5932953A (en) * 1997-06-30 1999-08-03 Iowa State University Research Foundation, Inc. Method and system for detecting material using piezoelectric resonators
US5992226A (en) * 1998-05-08 1999-11-30 The United States Of America As Represented By The Secretary Of The Navy Apparatus and method for measuring intermolecular interactions by atomic force microscopy
US6167748B1 (en) * 1998-08-31 2001-01-02 Lockheed Martin Energy Research Corporation Capacitively readout multi-element sensor array with common-mode cancellation
US6289717B1 (en) * 1999-03-30 2001-09-18 U. T. Battelle, Llc Micromechanical antibody sensor
US6911646B1 (en) * 1999-05-21 2005-06-28 California Institute Of Technology Measurements of electromagnetic properties and interactions based on radiation-excited polarizations
US6545492B1 (en) * 1999-09-20 2003-04-08 Europaisches Laboratorium Fur Molekularbiologie (Embl) Multiple local probe measuring device and method
EP1226437B1 (en) * 1999-11-03 2004-08-11 International Business Machines Corporation Cantilever sensors and transducers
US7148017B1 (en) * 2000-07-12 2006-12-12 Cornell Research Foundation, Inc. High sensitivity mechanical resonant sensor
DE60123818T2 (en) * 2000-08-09 2007-08-23 California Institute Of Technology, Pasadena NANOELECTROMECHANICAL DEVICE FOR IMPLEMENTING BIOCHEMICAL ANALYZES

Also Published As

Publication number Publication date
US20020166962A1 (en) 2002-11-14
WO2002012443A3 (en) 2002-05-10
US20090054267A1 (en) 2009-02-26
DE60123818T2 (en) 2007-08-23
CA2417939A1 (en) 2002-02-14
EP1325302A4 (en) 2004-08-18
WO2002012443A8 (en) 2004-02-12
EP1325302A2 (en) 2003-07-09
US8329452B2 (en) 2012-12-11
US7407814B2 (en) 2008-08-05
JP2005504260A (en) 2005-02-10
US20110269649A1 (en) 2011-11-03
US7989198B2 (en) 2011-08-02
ATE342225T1 (en) 2006-11-15
DE60123818D1 (en) 2006-11-23
EP1325302B1 (en) 2006-10-11
WO2002012443A2 (en) 2002-02-14

Similar Documents

Publication Publication Date Title
AU2001285425A1 (en) Active nems arrays for biochemical analyses
WO2002026103A3 (en) An immobilizable in vivo sensing device
AU2002225669A1 (en) Wrist-mounted blood pressure measurement device
WO2003050290A3 (en) Phosphoromonothioate and phosphorodithioate oligonucleotide aptamer chip for functional proteomics
WO2002006820A3 (en) Method for carrying out a saliva analysis
WO2001096595A3 (en) Method for the detection of influenza a/b viruses in saliva
WO2005040715A3 (en) Z-axis angular rate micro electro-mechanical systems (mems) sensor
AU4084199A (en) Piezoelectric quartz crystal hydrogen sensor, and hydrogen sensing method utilizing same
AU5513098A (en) Piezoelectric sensor for blood pressure measurement
AU7590300A (en) Small volume biosensor for continuous analyte monitoring
EP2365324A3 (en) Bridged element for detection of a target substance
AU2002365185A8 (en) A novel reagentless sensing system for measuring carbohydrates based on the galactose/glucose binding protein
SE9900853D0 (en) Method and vice for separating a mixture of source signals
SE9704354L (en) Sensor for detection of biological target complexes
WO2002079755A3 (en) Detection and amplification of ligands
WO1999013926A3 (en) Extracorporeal blood processing system
HK1040951A1 (en) Piezoelectric sensor for measuring bonding parameters.
WO2002065087A3 (en) Biological fluid analysis device
SE0101885D0 (en) A device in a vehicle brake arrangement
MXPA04005958A (en) A method for determining the biological activity of defibrotide.
WO2002093122A3 (en) Sensor arrangement, in particular micro-mechanical sensor arrangement
AU6718000A (en) Sensor accommodated in a housing
WO2001053818A3 (en) Measuring method and sensor device for carrying out chemical and pharmaceutical analysis and synthesis
BR9909909A (en) Process for the preparation of pentopyranylsilucleosides
WO2001069778A3 (en) Method for determining the parameters of an n-gate