AU2001282364A1 - Diagnosis and treatment of prostate cancer - Google Patents
Diagnosis and treatment of prostate cancerInfo
- Publication number
- AU2001282364A1 AU2001282364A1 AU2001282364A AU8236401A AU2001282364A1 AU 2001282364 A1 AU2001282364 A1 AU 2001282364A1 AU 2001282364 A AU2001282364 A AU 2001282364A AU 8236401 A AU8236401 A AU 8236401A AU 2001282364 A1 AU2001282364 A1 AU 2001282364A1
- Authority
- AU
- Australia
- Prior art keywords
- hne
- gated
- voltage
- nucleic acid
- cancer
- Prior art date
- Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
- Abandoned
Links
Classifications
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- C—CHEMISTRY; METALLURGY
- C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
- C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
- C12N15/00—Mutation or genetic engineering; DNA or RNA concerning genetic engineering, vectors, e.g. plasmids, or their isolation, preparation or purification; Use of hosts therefor
- C12N15/09—Recombinant DNA-technology
- C12N15/11—DNA or RNA fragments; Modified forms thereof; Non-coding nucleic acids having a biological activity
- C12N15/113—Non-coding nucleic acids modulating the expression of genes, e.g. antisense oligonucleotides; Antisense DNA or RNA; Triplex- forming oligonucleotides; Catalytic nucleic acids, e.g. ribozymes; Nucleic acids used in co-suppression or gene silencing
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P35/00—Antineoplastic agents
-
- C—CHEMISTRY; METALLURGY
- C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
- C12Q—MEASURING OR TESTING PROCESSES INVOLVING ENZYMES, NUCLEIC ACIDS OR MICROORGANISMS; COMPOSITIONS OR TEST PAPERS THEREFOR; PROCESSES OF PREPARING SUCH COMPOSITIONS; CONDITION-RESPONSIVE CONTROL IN MICROBIOLOGICAL OR ENZYMOLOGICAL PROCESSES
- C12Q1/00—Measuring or testing processes involving enzymes, nucleic acids or microorganisms; Compositions therefor; Processes of preparing such compositions
- C12Q1/68—Measuring or testing processes involving enzymes, nucleic acids or microorganisms; Compositions therefor; Processes of preparing such compositions involving nucleic acids
- C12Q1/6876—Nucleic acid products used in the analysis of nucleic acids, e.g. primers or probes
- C12Q1/6883—Nucleic acid products used in the analysis of nucleic acids, e.g. primers or probes for diseases caused by alterations of genetic material
- C12Q1/6886—Nucleic acid products used in the analysis of nucleic acids, e.g. primers or probes for diseases caused by alterations of genetic material for cancer
-
- G—PHYSICS
- G01—MEASURING; TESTING
- G01N—INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
- G01N33/00—Investigating or analysing materials by specific methods not covered by groups G01N1/00 - G01N31/00
- G01N33/48—Biological material, e.g. blood, urine; Haemocytometers
- G01N33/50—Chemical analysis of biological material, e.g. blood, urine; Testing involving biospecific ligand binding methods; Immunological testing
- G01N33/53—Immunoassay; Biospecific binding assay; Materials therefor
- G01N33/574—Immunoassay; Biospecific binding assay; Materials therefor for cancer
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K38/00—Medicinal preparations containing peptides
-
- C—CHEMISTRY; METALLURGY
- C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
- C12Q—MEASURING OR TESTING PROCESSES INVOLVING ENZYMES, NUCLEIC ACIDS OR MICROORGANISMS; COMPOSITIONS OR TEST PAPERS THEREFOR; PROCESSES OF PREPARING SUCH COMPOSITIONS; CONDITION-RESPONSIVE CONTROL IN MICROBIOLOGICAL OR ENZYMOLOGICAL PROCESSES
- C12Q2600/00—Oligonucleotides characterized by their use
- C12Q2600/136—Screening for pharmacological compounds
-
- C—CHEMISTRY; METALLURGY
- C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
- C12Q—MEASURING OR TESTING PROCESSES INVOLVING ENZYMES, NUCLEIC ACIDS OR MICROORGANISMS; COMPOSITIONS OR TEST PAPERS THEREFOR; PROCESSES OF PREPARING SUCH COMPOSITIONS; CONDITION-RESPONSIVE CONTROL IN MICROBIOLOGICAL OR ENZYMOLOGICAL PROCESSES
- C12Q2600/00—Oligonucleotides characterized by their use
- C12Q2600/158—Expression markers
Landscapes
- Health & Medical Sciences (AREA)
- Life Sciences & Earth Sciences (AREA)
- Chemical & Material Sciences (AREA)
- Engineering & Computer Science (AREA)
- Genetics & Genomics (AREA)
- Organic Chemistry (AREA)
- Molecular Biology (AREA)
- Biomedical Technology (AREA)
- Immunology (AREA)
- Biotechnology (AREA)
- Wood Science & Technology (AREA)
- Zoology (AREA)
- General Health & Medical Sciences (AREA)
- Proteomics, Peptides & Aminoacids (AREA)
- Microbiology (AREA)
- Bioinformatics & Cheminformatics (AREA)
- Analytical Chemistry (AREA)
- Physics & Mathematics (AREA)
- Biochemistry (AREA)
- Pathology (AREA)
- General Engineering & Computer Science (AREA)
- Urology & Nephrology (AREA)
- Hematology (AREA)
- Oncology (AREA)
- Biophysics (AREA)
- Hospice & Palliative Care (AREA)
- Medicinal Chemistry (AREA)
- Plant Pathology (AREA)
- General Physics & Mathematics (AREA)
- Food Science & Technology (AREA)
- Cell Biology (AREA)
- General Chemical & Material Sciences (AREA)
- Public Health (AREA)
- Animal Behavior & Ethology (AREA)
- Pharmacology & Pharmacy (AREA)
- Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
- Veterinary Medicine (AREA)
- Chemical Kinetics & Catalysis (AREA)
- Measuring Or Testing Involving Enzymes Or Micro-Organisms (AREA)
- Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
Abstract
A method of diagnosing cancer in a human patient comprising the steps of (i) obtaining a sample containing nucleic acid and/or protein from the patient; and (ii) determining whether the sample contains a level of hNe—Na voltage-gated Na+ channel nucleic acid or protein associated with cancer. A method of treating cancer comprising the step of administering to the patient an agent which selectively prevents the function of hNe—Na voltage-gated Na+ channel. A genetic construct comprising a nucleic acid encoding a molecule capable of preventing the function of hNe—Na voltage-gated Na+ channel expressed in a cell. The methods and compositions are particularly suited to prostate cancer.
Applications Claiming Priority (3)
Application Number | Priority Date | Filing Date | Title |
---|---|---|---|
GBGB0021617.6A GB0021617D0 (en) | 2000-09-02 | 2000-09-02 | Diagnosis and treatment of cancer |
GB0021617.6 | 2000-09-02 | ||
PCT/GB2001/003940 WO2002018637A2 (en) | 2000-09-02 | 2001-09-03 | Diagnosis and treatment of prostate cancer |
Publications (1)
Publication Number | Publication Date |
---|---|
AU2001282364A1 true AU2001282364A1 (en) | 2002-03-13 |
Family
ID=9898761
Family Applications (1)
Application Number | Title | Priority Date | Filing Date |
---|---|---|---|
AU2001282364A Abandoned AU2001282364A1 (en) | 2000-09-02 | 2001-09-03 | Diagnosis and treatment of prostate cancer |
Country Status (10)
Country | Link |
---|---|
US (2) | US20060166194A1 (en) |
EP (1) | EP1313882B1 (en) |
JP (1) | JP2004507254A (en) |
AT (1) | ATE361993T1 (en) |
AU (1) | AU2001282364A1 (en) |
CY (1) | CY1107715T1 (en) |
DE (1) | DE60128368T2 (en) |
ES (1) | ES2288979T3 (en) |
GB (1) | GB0021617D0 (en) |
WO (1) | WO2002018637A2 (en) |
Families Citing this family (17)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
WO2002084284A2 (en) * | 2001-04-12 | 2002-10-24 | Imperial College Innovations Limited | Diagnosis and treatment of cancer:ii |
US7393657B2 (en) | 2001-04-12 | 2008-07-01 | Imperial College Innovations Limited | Diagnosis and treatment of cancer: I |
US7670771B2 (en) * | 2004-01-21 | 2010-03-02 | University Of Utah Research Foundation | Mutant sodium channel Nav1.7 nucleic acid methods |
AU2005249492B2 (en) * | 2004-05-27 | 2011-09-22 | The Regents Of The University Of Colorado | Methods for prediction of clinical outcome to epidermal growth factor receptor inhibitors by cancer patients |
US8921102B2 (en) | 2005-07-29 | 2014-12-30 | Gpb Scientific, Llc | Devices and methods for enrichment and alteration of circulating tumor cells and other particles |
US20080070792A1 (en) | 2006-06-14 | 2008-03-20 | Roland Stoughton | Use of highly parallel snp genotyping for fetal diagnosis |
US8137912B2 (en) | 2006-06-14 | 2012-03-20 | The General Hospital Corporation | Methods for the diagnosis of fetal abnormalities |
US20080050739A1 (en) | 2006-06-14 | 2008-02-28 | Roland Stoughton | Diagnosis of fetal abnormalities using polymorphisms including short tandem repeats |
US8372584B2 (en) | 2006-06-14 | 2013-02-12 | The General Hospital Corporation | Rare cell analysis using sample splitting and DNA tags |
WO2009067429A1 (en) * | 2007-11-19 | 2009-05-28 | Genentech, Inc. | Compositions and methods for inhibiting tumor progression |
GB0811360D0 (en) * | 2008-06-20 | 2008-07-30 | Imp Innovations Ltd | Methods |
PT2334812T (en) | 2008-09-20 | 2017-03-29 | Univ Leland Stanford Junior | Noninvasive diagnosis of fetal aneuploidy by sequencing |
US20120283116A1 (en) | 2009-09-11 | 2012-11-08 | Leppert Mark F | Mutant Sodium Channel Nav1.7 and Methods Related Thereto |
US9340590B2 (en) | 2011-03-16 | 2016-05-17 | Amgen Inc. | Potent and selective inhibitors of NaV1.3 and NaV1.7 |
WO2014165277A2 (en) | 2013-03-12 | 2014-10-09 | Amgen Inc. | POTENT AND SELECTIVE INHIBITORS OF Nav1.7 |
US9636418B2 (en) | 2013-03-12 | 2017-05-02 | Amgen Inc. | Potent and selective inhibitors of NAV1.7 |
JP2021527437A (en) * | 2018-06-22 | 2021-10-14 | エフ.ホフマン−ラ ロシュ アーゲーF. Hoffmann−La Roche Aktiengesellschaft | Oligonucleotides for regulating SCN9A expression |
Family Cites Families (2)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
EP0789575B8 (en) * | 1994-11-02 | 2009-01-14 | Allelix Neuroscience, Inc. | Peripheral nervous system specific sodium channels, dna encoding therefor, drug screening, and methods of making and using thereof |
US7312043B2 (en) * | 2000-07-10 | 2007-12-25 | Vertex Pharmaceuticals (San Diego) Llc | Ion channel assay methods |
-
2000
- 2000-09-02 GB GBGB0021617.6A patent/GB0021617D0/en not_active Ceased
-
2001
- 2001-09-03 ES ES01960979T patent/ES2288979T3/en not_active Expired - Lifetime
- 2001-09-03 US US10/362,747 patent/US20060166194A1/en not_active Abandoned
- 2001-09-03 JP JP2002522542A patent/JP2004507254A/en active Pending
- 2001-09-03 AT AT01960979T patent/ATE361993T1/en not_active IP Right Cessation
- 2001-09-03 WO PCT/GB2001/003940 patent/WO2002018637A2/en active IP Right Grant
- 2001-09-03 EP EP01960979A patent/EP1313882B1/en not_active Expired - Lifetime
- 2001-09-03 DE DE60128368T patent/DE60128368T2/en not_active Expired - Lifetime
- 2001-09-03 AU AU2001282364A patent/AU2001282364A1/en not_active Abandoned
-
2007
- 2007-08-09 CY CY20071101073T patent/CY1107715T1/en unknown
- 2007-10-31 US US11/980,978 patent/US7759078B2/en not_active Expired - Fee Related
Also Published As
Publication number | Publication date |
---|---|
US20080145859A1 (en) | 2008-06-19 |
DE60128368T2 (en) | 2008-01-10 |
WO2002018637A2 (en) | 2002-03-07 |
ATE361993T1 (en) | 2007-06-15 |
ES2288979T3 (en) | 2008-02-01 |
WO2002018637A3 (en) | 2002-11-21 |
GB0021617D0 (en) | 2000-10-18 |
EP1313882B1 (en) | 2007-05-09 |
US7759078B2 (en) | 2010-07-20 |
JP2004507254A (en) | 2004-03-11 |
US20060166194A1 (en) | 2006-07-27 |
EP1313882A2 (en) | 2003-05-28 |
DE60128368D1 (en) | 2007-06-21 |
CY1107715T1 (en) | 2013-04-18 |
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