AU2001279042A1 - Blood-organ barrier opening - Google Patents

Blood-organ barrier opening

Info

Publication number
AU2001279042A1
AU2001279042A1 AU2001279042A AU7904201A AU2001279042A1 AU 2001279042 A1 AU2001279042 A1 AU 2001279042A1 AU 2001279042 A AU2001279042 A AU 2001279042A AU 7904201 A AU7904201 A AU 7904201A AU 2001279042 A1 AU2001279042 A1 AU 2001279042A1
Authority
AU
Australia
Prior art keywords
blood
barrier opening
organ barrier
organ
opening
Prior art date
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Abandoned
Application number
AU2001279042A
Inventor
Kullervo H. Hynynen
Nathan J. Mc Dannold
Current Assignee (The listed assignees may be inaccurate. Google has not performed a legal analysis and makes no representation or warranty as to the accuracy of the list.)
Brigham and Womens Hospital Inc
Original Assignee
Brigham and Womens Hospital Inc
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Brigham and Womens Hospital Inc filed Critical Brigham and Womens Hospital Inc
Publication of AU2001279042A1 publication Critical patent/AU2001279042A1/en
Abandoned legal-status Critical Current

Links

Classifications

    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61MDEVICES FOR INTRODUCING MEDIA INTO, OR ONTO, THE BODY; DEVICES FOR TRANSDUCING BODY MEDIA OR FOR TAKING MEDIA FROM THE BODY; DEVICES FOR PRODUCING OR ENDING SLEEP OR STUPOR
    • A61M37/00Other apparatus for introducing media into the body; Percutany, i.e. introducing medicines into the body by diffusion through the skin
    • A61M37/0092Other apparatus for introducing media into the body; Percutany, i.e. introducing medicines into the body by diffusion through the skin using ultrasonic, sonic or infrasonic vibrations, e.g. phonophoresis
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61BDIAGNOSIS; SURGERY; IDENTIFICATION
    • A61B8/00Diagnosis using ultrasonic, sonic or infrasonic waves
    • A61B8/08Detecting organic movements or changes, e.g. tumours, cysts, swellings
    • A61B8/0808Detecting organic movements or changes, e.g. tumours, cysts, swellings for diagnosis of the brain
    • A61B8/0816Detecting organic movements or changes, e.g. tumours, cysts, swellings for diagnosis of the brain using echo-encephalography
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61NELECTROTHERAPY; MAGNETOTHERAPY; RADIATION THERAPY; ULTRASOUND THERAPY
    • A61N7/00Ultrasound therapy
    • A61N2007/0056Beam shaping elements
    • A61N2007/006Lenses
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61NELECTROTHERAPY; MAGNETOTHERAPY; RADIATION THERAPY; ULTRASOUND THERAPY
    • A61N7/00Ultrasound therapy
    • A61N2007/0078Ultrasound therapy with multiple treatment transducers
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61NELECTROTHERAPY; MAGNETOTHERAPY; RADIATION THERAPY; ULTRASOUND THERAPY
    • A61N7/00Ultrasound therapy
    • A61N2007/0086Beam steering
    • A61N2007/0095Beam steering by modifying an excitation signal

Landscapes

  • Health & Medical Sciences (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Engineering & Computer Science (AREA)
  • General Health & Medical Sciences (AREA)
  • Veterinary Medicine (AREA)
  • Biomedical Technology (AREA)
  • Heart & Thoracic Surgery (AREA)
  • Public Health (AREA)
  • Medical Informatics (AREA)
  • Animal Behavior & Ethology (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Hematology (AREA)
  • Anesthesiology (AREA)
  • Neurology (AREA)
  • Physics & Mathematics (AREA)
  • Biophysics (AREA)
  • Dermatology (AREA)
  • Pathology (AREA)
  • Radiology & Medical Imaging (AREA)
  • Molecular Biology (AREA)
  • Surgery (AREA)
  • Surgical Instruments (AREA)
  • Magnetic Resonance Imaging Apparatus (AREA)
AU2001279042A 2000-07-27 2001-07-27 Blood-organ barrier opening Abandoned AU2001279042A1 (en)

Applications Claiming Priority (5)

Application Number Priority Date Filing Date Title
US22106400P 2000-07-27 2000-07-27
US60221064 2000-07-27
US09915599 2001-07-26
US09/915,599 US6514221B2 (en) 2000-07-27 2001-07-26 Blood-brain barrier opening
PCT/US2001/023643 WO2002009608A2 (en) 2000-07-27 2001-07-27 Blood-organ barrier opening

Publications (1)

Publication Number Publication Date
AU2001279042A1 true AU2001279042A1 (en) 2002-02-13

Family

ID=26915461

Family Applications (1)

Application Number Title Priority Date Filing Date
AU2001279042A Abandoned AU2001279042A1 (en) 2000-07-27 2001-07-27 Blood-organ barrier opening

Country Status (3)

Country Link
US (1) US6514221B2 (en)
AU (1) AU2001279042A1 (en)
WO (1) WO2002009608A2 (en)

Families Citing this family (175)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US20040049134A1 (en) * 2002-07-02 2004-03-11 Tosaya Carol A. System and methods for treatment of alzheimer's and other deposition-related disorders of the brain
US20050020945A1 (en) * 2002-07-02 2005-01-27 Tosaya Carol A. Acoustically-aided cerebrospinal-fluid manipulation for neurodegenerative disease therapy
US8353853B1 (en) * 2003-01-24 2013-01-15 Boston Scientific Scimed, Inc. Encephalic insonication
US7485706B2 (en) * 2003-07-30 2009-02-03 The Board Of Trustees Of The Leland Stanford Junior University Neurodegenerative protein aggregation inhibition methods and compounds
US20050074506A1 (en) * 2003-10-02 2005-04-07 Brainsgate Ltd. Targeted release of nitric oxide in the CNS circulation for modulating the BBB and treating disorders
US7896821B1 (en) * 2003-11-14 2011-03-01 Perfusion Technology, LLC Low intensity directed ultrasound (LODUS) mediated blood brain barrier disruption
US7641660B2 (en) * 2004-03-08 2010-01-05 Biomet Manufacturing Corporation Method, apparatus, and system for image guided bone cutting
WO2006044996A2 (en) * 2004-10-15 2006-04-27 The Trustees Of Columbia University In The City Of New York System and method for automated boundary detection of body structures
WO2006044997A2 (en) * 2004-10-15 2006-04-27 The Trustees Of Columbia University In The City Of New York System and method for localized measurement and imaging of viscosity of tissues
US7674229B2 (en) * 2005-03-07 2010-03-09 The Brigham And Women's Hospital, Inc. Adaptive ultrasound delivery system
WO2006124603A2 (en) * 2005-05-12 2006-11-23 The Trustees Of Columbia University In The City Of New York System and method for electromechanical wave imaging of body structures
US10687785B2 (en) 2005-05-12 2020-06-23 The Trustees Of Columbia Univeristy In The City Of New York System and method for electromechanical activation of arrhythmias
US20070016040A1 (en) * 2005-06-24 2007-01-18 Henry Nita Methods and apparatus for intracranial ultrasound delivery
EP1937151A4 (en) * 2005-09-19 2011-07-06 Univ Columbia Systems and methods for opening of the blood-brain barrier of a subject using ultrasound
EP1963805A4 (en) * 2005-12-09 2010-01-06 Univ Columbia Systems and methods for elastography imaging
WO2007120334A2 (en) 2005-12-15 2007-10-25 Genentech, Inc. Methods and compositions for targeting polyubiquitin
JP2009536526A (en) 2006-05-04 2009-10-15 ジェネンテック・インコーポレーテッド Methods and compositions related to ZPA polypeptides
EP2046833B9 (en) 2006-07-14 2014-02-19 AC Immune S.A. Humanized antibody against amyloid beta
RS53160B (en) 2006-07-14 2014-06-30 Ac Immune S.A. Humanized antibody against amyloid beta
WO2008027520A2 (en) * 2006-08-30 2008-03-06 The Trustees Of Columbia University In The City Of New York Systems and methods for composite elastography and wave imaging
US7960139B2 (en) 2007-03-23 2011-06-14 Academia Sinica Alkynyl sugar analogs for the labeling and visualization of glycoconjugates in cells
NZ601843A (en) 2007-06-12 2014-01-31 Ac Immune Sa Monoclonal anti beta amyloid antibody
SI2170389T1 (en) 2007-06-12 2015-03-31 Ac Immune S.A. Humanized antibodies to amyloid beta
ES2609918T3 (en) 2007-10-05 2017-04-25 Genentech, Inc. Use of anti-amyloid beta antibody in eye diseases
WO2009047362A2 (en) * 2007-10-12 2009-04-16 The Provost, Fellows And Scholars Of The College Of The Holy And Undivided Trinity Of Queen Elizabeth, Near Dublin Method for opening tight junctions
TWI580694B (en) 2007-11-30 2017-05-01 建南德克公司 Anti-vegf antibodies
WO2010009271A2 (en) 2008-07-15 2010-01-21 Academia Sinica Glycan arrays on ptfe-like aluminum coated glass slides and related methods
WO2010014977A1 (en) 2008-08-01 2010-02-04 The Trustees Of Columbia University In The City Of New York Systems and methods for matching and imaging tissue characteristics
WO2010030819A1 (en) * 2008-09-10 2010-03-18 The Trustees Of Columbia University In The City Of New York Systems and methods for opening a tissue
KR20190025057A (en) 2008-10-14 2019-03-08 제넨테크, 인크. Immunoglobulin variants and uses thereof
CN104689316A (en) 2008-10-22 2015-06-10 弗·哈夫曼-拉罗切有限公司 Modulation of Axon Degeneration
EP2382234A2 (en) 2008-12-23 2011-11-02 Genentech, Inc. Immunoglobulin variants with altered binding to protein a
CA2772715C (en) 2009-09-02 2019-03-26 Genentech, Inc. Mutant smoothened and methods of using the same
EP2480144B1 (en) * 2009-09-21 2024-03-06 The Trustees of Columbia University in the City of New York Systems for opening of a tissue barrier
US8517962B2 (en) 2009-10-12 2013-08-27 Kona Medical, Inc. Energetic modulation of nerves
US20110118600A1 (en) 2009-11-16 2011-05-19 Michael Gertner External Autonomic Modulation
US8986211B2 (en) 2009-10-12 2015-03-24 Kona Medical, Inc. Energetic modulation of nerves
US20110092880A1 (en) * 2009-10-12 2011-04-21 Michael Gertner Energetic modulation of nerves
US9174065B2 (en) * 2009-10-12 2015-11-03 Kona Medical, Inc. Energetic modulation of nerves
US8295912B2 (en) 2009-10-12 2012-10-23 Kona Medical, Inc. Method and system to inhibit a function of a nerve traveling with an artery
US11998266B2 (en) 2009-10-12 2024-06-04 Otsuka Medical Devices Co., Ltd Intravascular energy delivery
US9119951B2 (en) * 2009-10-12 2015-09-01 Kona Medical, Inc. Energetic modulation of nerves
US8986231B2 (en) 2009-10-12 2015-03-24 Kona Medical, Inc. Energetic modulation of nerves
US8469904B2 (en) 2009-10-12 2013-06-25 Kona Medical, Inc. Energetic modulation of nerves
US20160059044A1 (en) 2009-10-12 2016-03-03 Kona Medical, Inc. Energy delivery to intraparenchymal regions of the kidney to treat hypertension
CA2778483A1 (en) 2009-10-22 2011-04-28 Genentech, Inc. Modulation of axon degeneration
US11377485B2 (en) 2009-12-02 2022-07-05 Academia Sinica Methods for modifying human antibodies by glycan engineering
US10087236B2 (en) 2009-12-02 2018-10-02 Academia Sinica Methods for modifying human antibodies by glycan engineering
EP2509626B1 (en) 2009-12-11 2016-02-10 F.Hoffmann-La Roche Ag Anti-vegf-c antibodies and methods using same
RU2559542C2 (en) 2009-12-23 2015-08-10 Дженентек, Инк. Anti-bv8 antibodies and using them
WO2011130332A1 (en) 2010-04-12 2011-10-20 Academia Sinica Glycan arrays for high throughput screening of viruses
KR101745386B1 (en) 2010-05-10 2017-06-09 아카데미아 시니카 Zanamivir phosphonate congeners with anti-influenza activity and determining oseltamivir susceptibility of influenza viruses
MY164579A (en) 2010-07-30 2018-01-15 Ac Immune Sa Safe and functional humanized antibodies
WO2012020124A1 (en) 2010-08-12 2012-02-16 Ac Immune S.A. Vaccine engineering
DK2625197T3 (en) 2010-10-05 2016-10-03 Genentech Inc Smoothened MUTANT AND METHODS OF USING THE SAME
MX338421B (en) 2010-10-07 2016-04-15 Ac Immune Sa Phosphospecific antibodies recognising tau.
CN103189050B (en) 2010-10-26 2017-09-29 Ac免疫有限公司 The construct based on liposome comprising the peptide modified by hydrophobic part
CA2815840A1 (en) 2010-11-10 2012-05-18 Genentech, Inc. Methods and compositions for neural disease immunotherapy
US9320491B2 (en) 2011-04-18 2016-04-26 The Trustees Of Columbia University In The City Of New York Ultrasound devices methods and systems
WO2012162664A1 (en) 2011-05-26 2012-11-29 The Trustees Of Columbia University In The City Of New York Systems and methods for opening of a tissue barrier in primates
JP6358953B2 (en) 2011-10-07 2018-07-18 エーシー イミューン エス.エー. Phospho-specific antibody that recognizes tau
CN106977587A (en) 2011-10-14 2017-07-25 霍夫曼-拉罗奇有限公司 BACE1 inhibitor peptides
WO2013071119A2 (en) 2011-11-10 2013-05-16 Genentech, Inc Methods for treating, diagnosing and monitoring alzheimer's disease
KR102132041B1 (en) 2012-04-05 2020-07-09 에이씨 이뮨 에스.에이. Humanized Tau Antibody
US10130714B2 (en) 2012-04-14 2018-11-20 Academia Sinica Enhanced anti-influenza agents conjugated with anti-inflammatory activity
IN2014MN02574A (en) 2012-05-22 2015-07-24 Genentech Inc
RU2014148732A (en) 2012-05-22 2016-07-20 Ф. Хоффманн-Ля Рош Аг SUBSTITUTED DIPYRIDYLAMINES AND THEIR APPLICATION
BR112015000187A2 (en) 2012-07-06 2017-06-27 Genentech Inc benzamides substituted with n and methods of use thereof
EP2885311B1 (en) 2012-08-18 2020-01-01 Academia Sinica Cell-permeable probes for identification and imaging of sialidases
US9547009B2 (en) 2012-08-21 2017-01-17 Academia Sinica Benzocyclooctyne compounds and uses thereof
GB2505740A (en) * 2012-09-05 2014-03-12 Surf Technology As Instrument and method for ultrasound mediated drug delivery
TW201418201A (en) 2012-09-27 2014-05-16 Hoffmann La Roche Substituted sulfonamide compounds
WO2014059170A1 (en) 2012-10-10 2014-04-17 The Trustees Of Columbia University In The City Of New York Systems and methods for mechanical mapping of cardiac rhythm
AU2013204200B2 (en) 2012-10-11 2016-10-20 Brandeis University Treatment of amyotrophic lateral sclerosis
DE102012222778A1 (en) * 2012-12-11 2014-06-12 Siemens Aktiengesellschaft Intravascular ultrasound source for reversible overcoming of blood-brain barrier in e.g. human, has catheter to move source through blood vessel to place within skull of human or animal, so as to locally overcome blood-brain barrier
EP2945938B1 (en) 2013-01-18 2018-03-07 F. Hoffmann-La Roche AG 3-substituted pyrazoles and use as dlk inhibitors
JP6096370B2 (en) 2013-03-14 2017-03-15 ジェネンテック, インコーポレイテッド Substituted triazolopyridines and methods of use
CN105143258B (en) 2013-03-15 2020-06-23 Ac免疫有限公司 anti-Tau antibodies and methods of use
CA2911051C (en) 2013-05-01 2021-08-17 F. Hoffmann-La Roche Ag Biheteroaryl compounds and uses thereof
CA2907912A1 (en) 2013-05-01 2014-11-06 F. Hoffmann-La Roche Ag C-linked heterocycloalkyl substituted pyrimidines and their uses
US9247921B2 (en) 2013-06-07 2016-02-02 The Trustees Of Columbia University In The City Of New York Systems and methods of high frame rate streaming for treatment monitoring
US10086054B2 (en) 2013-06-26 2018-10-02 Academia Sinica RM2 antigens and use thereof
WO2014210564A1 (en) 2013-06-27 2014-12-31 Academia Sinica Glycan conjugates and use thereof
US10322178B2 (en) 2013-08-09 2019-06-18 The Trustees Of Columbia University In The City Of New York Systems and methods for targeted drug delivery
US10028723B2 (en) 2013-09-03 2018-07-24 The Trustees Of Columbia University In The City Of New York Systems and methods for real-time, transcranial monitoring of blood-brain barrier opening
JP6486368B2 (en) 2013-09-06 2019-03-20 アカデミア シニカAcademia Sinica Activation of human iNKT cells using glycolipids containing modified glycosyl groups
AU2014391422A1 (en) 2013-09-17 2015-12-17 Obi Pharma, Inc. Compositions of a carbohydrate vaccine for inducing immune responses and uses thereof in cancer treatment
MX363457B (en) 2013-10-11 2019-03-25 Hoffmann La Roche Substituted heterocyclic sulfonamide compounds useful as trpa1 modulators.
MX2016008110A (en) 2013-12-20 2016-08-19 Hoffmann La Roche Pyrazole derivatives and uses thereof as inhibitors of dlk.
WO2016114819A1 (en) 2015-01-16 2016-07-21 Academia Sinica Compositions and methods for treatment and detection of cancers
CA2937123A1 (en) 2014-01-16 2015-07-23 Academia Sinica Compositions and methods for treatment and detection of cancers
US10150818B2 (en) 2014-01-16 2018-12-11 Academia Sinica Compositions and methods for treatment and detection of cancers
JP6736467B2 (en) 2014-02-04 2020-08-05 ジェネンテック, インコーポレイテッド Smoothing mutant and method of using the same
JP6562942B2 (en) 2014-03-27 2019-08-28 アカデミア シニカAcademia Sinica Reactive labeled compounds and uses thereof
WO2015179258A2 (en) * 2014-05-17 2015-11-26 The Johns Hopkins University Mri-guided intraarterial catheter-based method for predicting territory of local blood brain barrier opening
KR20240096599A (en) 2014-05-27 2024-06-26 아카데미아 시니카 Anti-cd20 glycoantibodies and uses thereof
CA2950440A1 (en) 2014-05-27 2015-12-03 Academia Sinica Anti-her2 glycoantibodies and uses thereof
KR20230033737A (en) 2014-05-27 2023-03-08 아카데미아 시니카 Compositions and methods relating to universal glycoforms for enhanced antibody efficacy
US10118969B2 (en) 2014-05-27 2018-11-06 Academia Sinica Compositions and methods relating to universal glycoforms for enhanced antibody efficacy
JP7063538B2 (en) 2014-05-28 2022-05-09 アカデミア シニカ Anti-TNFα sugar-manipulated antibody group and its use
AU2015278254A1 (en) * 2014-06-20 2016-12-22 The University Of Queensland Neurodegenerative disease treatment
JP2017525677A (en) 2014-07-07 2017-09-07 ジェネンテック, インコーポレイテッド Therapeutic compounds and methods of use thereof
US9879042B2 (en) 2014-09-08 2018-01-30 Academia Sinica Human iNKT cell activation using glycolipids
US10925579B2 (en) 2014-11-05 2021-02-23 Otsuka Medical Devices Co., Ltd. Systems and methods for real-time tracking of a target tissue using imaging before and during therapy delivery
AU2015348012B2 (en) 2014-11-19 2020-07-02 Axon Neuroscience Se Humanized tau antibodies in Alzheimer's disease
JP6859259B2 (en) 2014-11-19 2021-04-14 ジェネンテック, インコーポレイテッド Antibodies to BACEl and its use for neurological disease immunotherapy
WO2016097867A2 (en) 2014-12-19 2016-06-23 Université Pierre Et Marie Curie (Paris 6) Implantable ultrasound generating treating device for brain treatment, apparatus comprising such device and method implementing such device
US9975965B2 (en) 2015-01-16 2018-05-22 Academia Sinica Compositions and methods for treatment and detection of cancers
US10495645B2 (en) 2015-01-16 2019-12-03 Academia Sinica Cancer markers and methods of use thereof
KR102691114B1 (en) 2015-01-24 2024-08-01 아카데미아 시니카 Novel glycan conjugates and methods of using them
AU2016209056B2 (en) 2015-01-24 2021-01-28 Academia Sinica Cancer markers and methods of use thereof
ES2901173T3 (en) 2015-01-30 2022-03-21 Academia Sinica Compositions and Methods Related to Universal Glycoforms for Enhanced Anti-SSEA4 Antibody Efficacy
CA2975875A1 (en) 2015-02-04 2016-08-11 Genentech, Inc. Mutant smoothened and methods of using the same
WO2016142310A1 (en) 2015-03-09 2016-09-15 F. Hoffmann-La Roche Ag Tricyclic dlk inhibitors and uses thereof
EP3297989A1 (en) 2015-05-22 2018-03-28 Genentech, Inc. Substituted benzamides and methods of use thereof
EP3341353A1 (en) 2015-08-27 2018-07-04 Genentech, Inc. Therapeutic compounds and methods of use thereof
EP3344806A4 (en) 2015-09-04 2019-03-20 OBI Pharma, Inc. Glycan arrays and method of use
JP2018535234A (en) 2015-11-25 2018-11-29 ジェネンテック, インコーポレイテッド Substituted benzamides useful as sodium channel blockers
EP3411396A1 (en) 2016-02-04 2018-12-12 Curis, Inc. Mutant smoothened and methods of using the same
KR20180114210A (en) 2016-03-08 2018-10-17 아카데미아 시니카 Method for synthesizing N-glycan and its array
JP6772288B2 (en) 2016-03-11 2020-10-21 ソルボンヌ・ユニヴェルシテSorbonne Universite An extracorporeal ultrasound generation therapy device for the treatment of the spinal cord and spinal nerves, a device equipped with the device, and a method using the device.
JP6783319B2 (en) 2016-03-11 2020-11-11 ソルボンヌ・ユニヴェルシテSorbonne Universite Implantable ultrasound generation therapy devices for the treatment of the spinal cord and / or spinal nerves, devices and methods comprising the devices.
US10980894B2 (en) 2016-03-29 2021-04-20 Obi Pharma, Inc. Antibodies, pharmaceutical compositions and methods
AU2017239637A1 (en) 2016-03-29 2018-11-15 Obi Pharma, Inc. Antibodies, pharmaceutical compositions and methods
JP2019513714A (en) 2016-03-30 2019-05-30 ジェネンテック, インコーポレイテッド Substituted benzamides and methods of use thereof
CN109379889A (en) 2016-04-22 2019-02-22 台湾浩鼎生技股份有限公司 Pass through the immune activation or immunoregulatory immunotherapy for cancer via GLOBO series antigen
JP7043483B2 (en) 2016-07-20 2022-03-29 エフ.ホフマン-ラ ロシュ アーゲー Bicyclic proline compound
JP6975515B2 (en) 2016-07-20 2021-12-01 エフ.ホフマン−ラ ロシュ アーゲーF. Hoffmann−La Roche Aktiengesellschaft Sulfonylcycloalkylcarboxamide compounds as TRPA1 modulators
BR112019001656A2 (en) 2016-07-27 2019-05-28 Obi Pharma Inc composition, pharmaceutical composition, vaccine, method for inducing antibodies in an individual, method for treating cancer in a patient in need thereof and method for inducing or ameliorating the immune reaction in an individual in need thereof
TWI786054B (en) 2016-07-29 2022-12-11 台灣浩鼎生技股份有限公司 Human antibodies, pharmaceutical compositions and methods
WO2018029288A1 (en) 2016-08-12 2018-02-15 F. Hoffmann-La Roche Ag Sulfonyl pyridyl trp inhibitors
US10538592B2 (en) 2016-08-22 2020-01-21 Cho Pharma, Inc. Antibodies, binding fragments, and methods of use
EP3526219B1 (en) 2016-10-17 2021-12-15 F. Hoffmann-La Roche AG Bicyclic pyridone lactams and methods of use thereof
WO2018094414A1 (en) 2016-11-21 2018-05-24 Obi Pharma, Inc. Conjugated biological molecules, pharmaceutical compositions and methods
TW201831477A (en) 2016-11-28 2018-09-01 瑞士商赫孚孟拉羅股份公司 Oxadiazolone transient receptor potential channel inhibitors
US11071721B2 (en) 2016-12-02 2021-07-27 Genentech, Inc. Bicyclic amide compounds and methods of use thereof
US11072607B2 (en) 2016-12-16 2021-07-27 Genentech, Inc. Inhibitors of RIP1 kinase and methods of use thereof
JP7178357B2 (en) 2017-03-07 2022-11-25 エフ.ホフマン-ラ ロシュ アーゲー Oxadiazole transient receptor potential channel inhibitor
WO2018175707A1 (en) 2017-03-24 2018-09-27 Genentech, Inc. 4-piperidin-n-(pyrimidin-4-yl)chroman-7-sulfonamide derivatives as sodium channel inhibitors
MA49560B1 (en) 2017-07-14 2024-05-31 Hoffmann La Roche BICYCLIC KETONE COMPOUNDS AND METHODS OF USE
EP3460057A1 (en) 2017-09-22 2019-03-27 Max-Planck-Gesellschaft zur Förderung der Wissenschaften e.V. Kdac variants and uses thereof
KR20200070297A (en) 2017-10-11 2020-06-17 에프. 호프만-라 로슈 아게 Bicyclic compounds for use as RIP1 kinase inhibitors
JP2021501183A (en) 2017-10-31 2021-01-14 エフ.ホフマン−ラ ロシュ アーゲーF. Hoffmann−La Roche Aktiengesellschaft Bicyclic sulfones and sulfoxides, and how to use them
TWI805653B (en) 2017-11-30 2023-06-21 韓商韓美藥品股份有限公司 Salts of 4-amino-n-(1-((3-chloro-2-fluorophenyl)amino)-6-methylisoquinolin-5-yl)thieno[3,2-d]pyrimidine-7-carboxamide, and crystalline forms thereof
TW202000201A (en) 2018-02-20 2020-01-01 瑞士商赫孚孟拉羅股份公司 Process for preparing 1-arylsulfonyl-pyrrolidine-2-carboxamide Transient Receptor Potential channel antagonist compounds and crystalline forms thereof
US11028075B2 (en) 2018-02-26 2021-06-08 Genentech, Inc. Therapeutic compounds and methods of use thereof
US10710994B2 (en) 2018-03-19 2020-07-14 Genentech, Inc. Oxadiazole transient receptor potential channel inhibitors
MX2020009991A (en) 2018-03-28 2020-10-14 Axon Neuroscience Se Antibody-based methods of detecting and treating alzheimer's disease.
WO2019191702A1 (en) 2018-03-30 2019-10-03 F. Hoffmann-La Roche Ag Substituted hydro-pyrido-azines as sodium channel inhibitors
EP3781571B1 (en) 2018-04-20 2024-01-17 F. Hoffmann-La Roche AG N-[4-oxo-2,3-dihydro-pyrido[3,2-b][1,4]oxazepin-3-yl]-5,6-dihydro-4h-pyrrolo[1,2-b]pyrazole-2-carboxamide derivatives and related compounds as rip1 kinase inhibitors for treating e.g. irritable bowel syndrome (ibs)
TW202003490A (en) 2018-05-22 2020-01-16 瑞士商赫孚孟拉羅股份公司 Therapeutic compounds and methods of use thereof
US11203645B2 (en) 2018-06-27 2021-12-21 Obi Pharma, Inc. Glycosynthase variants for glycoprotein engineering and methods of use
TW202024023A (en) 2018-09-03 2020-07-01 瑞士商赫孚孟拉羅股份公司 Therapeutic compounds and methods of use
CA3217998A1 (en) * 2018-10-04 2020-04-09 Synaptec Network, Inc. Systems and methods for delivering exosomes through the blood-brain barrier
US11554267B2 (en) 2018-10-05 2023-01-17 Synaptec Network, Inc. Systems and methods for delivering therapeutic agents to the brain using TMS
WO2020077380A1 (en) * 2018-10-17 2020-04-23 The University Of Queensland Methods and compositions for treating tauopathies
FR3089128B1 (en) 2018-11-30 2020-12-18 Carthera ACOUSTIC WINDOW FOR IMAGING AND / OR TREATMENT OF CEREBRAL TISSUE
EP3908586B1 (en) 2019-01-11 2022-12-21 F. Hoffmann-La Roche AG Bicyclic pyrrolotriazolr ketone compounds and methods of use thereof
EP3924046B1 (en) 2019-02-13 2023-11-22 Alpheus Medical, Inc. Non-invasive sonodynamic therapy
EP4058435A1 (en) 2019-11-13 2022-09-21 Genentech, Inc. Therapeutic compounds and methods of use
CN115151562A (en) 2019-12-04 2022-10-04 Ac免疫有限公司 Novel molecules for therapy and diagnosis
US11787775B2 (en) 2020-07-24 2023-10-17 Genentech, Inc. Therapeutic compounds and methods of use
EP4192404A4 (en) 2020-08-07 2024-04-03 Alpheus Medical, Inc. Ultrasound arrays for enhanced sonodynamic therapy for treating cancer
AR123254A1 (en) 2020-08-14 2022-11-16 Ac Immune Sa HUMANIZED ANTI-TDP-43 BINDING MOLECULES AND THEIR USES
MX2023003759A (en) 2020-10-02 2023-04-24 Genentech Inc Process for the preparation of biheteroaryl compounds and crystal forms thereof.
WO2022079297A1 (en) 2020-10-16 2022-04-21 Ac Immune Sa Antibodies binding to alpha-synuclein for therapy and diagnosis
US20240285763A1 (en) * 2021-06-17 2024-08-29 Aselsan Elektronik Sanayi Ve Ticaret Anonim Sirketi Arrangement for vaporizing nanoagents suitable for therapy inside the human body and device comprising the arrangement
WO2023028077A1 (en) 2021-08-24 2023-03-02 Genentech, Inc. Sodium channel inhibitors and methods of designing same
WO2023028056A1 (en) 2021-08-24 2023-03-02 Genentech, Inc. 3-amino piperidyl sodium channel inhibitors
TW202340212A (en) 2021-11-24 2023-10-16 美商建南德克公司 Therapeutic compounds and methods of use
EP4436957A1 (en) 2021-11-24 2024-10-02 Genentech, Inc. Therapeutic indazole compounds and methods of use in the treatment of cancer
MX2024009948A (en) 2022-02-16 2024-08-22 Ac Immune Sa Humanized anti-tdp-43 binding molecules and uses thereof.
WO2023194565A1 (en) 2022-04-08 2023-10-12 Ac Immune Sa Anti-tdp-43 binding molecules
WO2024079662A1 (en) 2022-10-11 2024-04-18 Meiragtx Uk Ii Limited Upf1 expression constructs
WO2024184494A1 (en) 2023-03-08 2024-09-12 Ac Immune Sa Anti-tdp-43 binding molecules and uses thereof

Family Cites Families (9)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US5149319A (en) * 1990-09-11 1992-09-22 Unger Evan C Methods for providing localized therapeutic heat to biological tissues and fluids
EP0732106A3 (en) * 1991-03-22 2003-04-09 Katsuro Tachibana Microbubbles containing booster for therapy of disease with ultrasound
US5540909A (en) * 1994-09-28 1996-07-30 Alliance Pharmaceutical Corp. Harmonic ultrasound imaging with microbubbles
US5752515A (en) * 1996-08-21 1998-05-19 Brigham & Women's Hospital Methods and apparatus for image-guided ultrasound delivery of compounds through the blood-brain barrier
CA2270120A1 (en) * 1996-10-28 1998-05-07 Pal Rongved Improvements in or relating to diagnostic/therapeutic agents
US6416740B1 (en) * 1997-05-13 2002-07-09 Bristol-Myers Squibb Medical Imaging, Inc. Acoustically active drug delivery systems
US6066123A (en) * 1998-04-09 2000-05-23 The Board Of Trustees Of The Leland Stanford Junior University Enhancement of bioavailability by use of focused energy delivery to a target tissue
US6135976A (en) * 1998-09-25 2000-10-24 Ekos Corporation Method, device and kit for performing gene therapy
US6346098B1 (en) * 2000-03-07 2002-02-12 The Board Of Trustees Of The Leland Stanford Junior University Methods and kits for locally administering an active agent to an interstitial space of a host

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