AU2001274837A1 - Insulin purification using simulated moving bed technology - Google Patents

Insulin purification using simulated moving bed technology

Info

Publication number
AU2001274837A1
AU2001274837A1 AU2001274837A AU7483701A AU2001274837A1 AU 2001274837 A1 AU2001274837 A1 AU 2001274837A1 AU 2001274837 A AU2001274837 A AU 2001274837A AU 7483701 A AU7483701 A AU 7483701A AU 2001274837 A1 AU2001274837 A1 AU 2001274837A1
Authority
AU
Australia
Prior art keywords
simulated moving
insulin
moving bed
bed technology
purification
Prior art date
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Abandoned
Application number
AU2001274837A
Inventor
Benjamin J. Hritzko
Jin-Hyun Kim
Sungyong Mun
Nien-Hwa Linda Wang
Yi Xie
Current Assignee (The listed assignees may be inaccurate. Google has not performed a legal analysis and makes no representation or warranty as to the accuracy of the list.)
Purdue Research Foundation
Original Assignee
Purdue Research Foundation
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Purdue Research Foundation filed Critical Purdue Research Foundation
Publication of AU2001274837A1 publication Critical patent/AU2001274837A1/en
Abandoned legal-status Critical Current

Links

Classifications

    • B—PERFORMING OPERATIONS; TRANSPORTING
    • B01—PHYSICAL OR CHEMICAL PROCESSES OR APPARATUS IN GENERAL
    • B01D—SEPARATION
    • B01D15/00—Separating processes involving the treatment of liquids with solid sorbents; Apparatus therefor
    • B01D15/08—Selective adsorption, e.g. chromatography
    • B01D15/10—Selective adsorption, e.g. chromatography characterised by constructional or operational features
    • B01D15/18—Selective adsorption, e.g. chromatography characterised by constructional or operational features relating to flow patterns
    • B01D15/1814—Selective adsorption, e.g. chromatography characterised by constructional or operational features relating to flow patterns recycling of the fraction to be distributed
    • B01D15/1821—Simulated moving beds
    • B01D15/185—Simulated moving beds characterized by the components to be separated
    • B—PERFORMING OPERATIONS; TRANSPORTING
    • B01—PHYSICAL OR CHEMICAL PROCESSES OR APPARATUS IN GENERAL
    • B01D—SEPARATION
    • B01D15/00—Separating processes involving the treatment of liquids with solid sorbents; Apparatus therefor
    • B01D15/08—Selective adsorption, e.g. chromatography
    • B01D15/26—Selective adsorption, e.g. chromatography characterised by the separation mechanism
    • B01D15/265—Adsorption chromatography
    • B—PERFORMING OPERATIONS; TRANSPORTING
    • B01—PHYSICAL OR CHEMICAL PROCESSES OR APPARATUS IN GENERAL
    • B01D—SEPARATION
    • B01D15/00—Separating processes involving the treatment of liquids with solid sorbents; Apparatus therefor
    • B01D15/08—Selective adsorption, e.g. chromatography
    • B01D15/26—Selective adsorption, e.g. chromatography characterised by the separation mechanism
    • B01D15/30—Partition chromatography
    • B—PERFORMING OPERATIONS; TRANSPORTING
    • B01—PHYSICAL OR CHEMICAL PROCESSES OR APPARATUS IN GENERAL
    • B01D—SEPARATION
    • B01D15/00—Separating processes involving the treatment of liquids with solid sorbents; Apparatus therefor
    • B01D15/08—Selective adsorption, e.g. chromatography
    • B01D15/26—Selective adsorption, e.g. chromatography characterised by the separation mechanism
    • B01D15/34—Size selective separation, e.g. size exclusion chromatography, gel filtration, permeation
    • B—PERFORMING OPERATIONS; TRANSPORTING
    • B01—PHYSICAL OR CHEMICAL PROCESSES OR APPARATUS IN GENERAL
    • B01D—SEPARATION
    • B01D15/00—Separating processes involving the treatment of liquids with solid sorbents; Apparatus therefor
    • B01D15/08—Selective adsorption, e.g. chromatography
    • B01D15/26—Selective adsorption, e.g. chromatography characterised by the separation mechanism
    • B01D15/36—Selective adsorption, e.g. chromatography characterised by the separation mechanism involving ionic interaction
    • B01D15/361—Ion-exchange
    • B—PERFORMING OPERATIONS; TRANSPORTING
    • B01—PHYSICAL OR CHEMICAL PROCESSES OR APPARATUS IN GENERAL
    • B01D—SEPARATION
    • B01D15/00—Separating processes involving the treatment of liquids with solid sorbents; Apparatus therefor
    • B01D15/08—Selective adsorption, e.g. chromatography
    • B01D15/26—Selective adsorption, e.g. chromatography characterised by the separation mechanism
    • B01D15/38—Selective adsorption, e.g. chromatography characterised by the separation mechanism involving specific interaction not covered by one or more of groups B01D15/265 - B01D15/36
    • B01D15/3804—Affinity chromatography
    • B—PERFORMING OPERATIONS; TRANSPORTING
    • B01—PHYSICAL OR CHEMICAL PROCESSES OR APPARATUS IN GENERAL
    • B01D—SEPARATION
    • B01D2215/00—Separating processes involving the treatment of liquids with adsorbents
    • B01D2215/02—Separating processes involving the treatment of liquids with adsorbents with moving adsorbents
    • B01D2215/023—Simulated moving beds

Abstract

Simulated moving beds for the chromatographic purification of insulin are provided. The insulin can be resolved from one or more components, using one or more simulated moving bed rings. Methods for designing simulated moving beds for the purification of insulin, and optimizing the operating parameters of the simulated moving beds, are also provided based upon the standing wave design.
AU2001274837A 2000-05-16 2001-05-16 Insulin purification using simulated moving bed technology Abandoned AU2001274837A1 (en)

Applications Claiming Priority (3)

Application Number Priority Date Filing Date Title
US20470100P 2000-05-16 2000-05-16
US60/204,701 2000-05-16
PCT/US2001/015846 WO2001087924A2 (en) 2000-05-16 2001-05-16 Insulin purification using simulated moving bed technology

Publications (1)

Publication Number Publication Date
AU2001274837A1 true AU2001274837A1 (en) 2001-11-26

Family

ID=22759061

Family Applications (1)

Application Number Title Priority Date Filing Date
AU2001274837A Abandoned AU2001274837A1 (en) 2000-05-16 2001-05-16 Insulin purification using simulated moving bed technology

Country Status (6)

Country Link
EP (1) EP1349866B1 (en)
AT (1) ATE358679T1 (en)
AU (1) AU2001274837A1 (en)
DE (1) DE60127713T2 (en)
ES (1) ES2284653T3 (en)
WO (1) WO2001087924A2 (en)

Families Citing this family (13)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
DE102005026486A1 (en) 2005-06-09 2006-12-14 Bayer Technology Services Gmbh A chromatographic quasi-continuous process and apparatus for separating binary and multi-species mixtures
CN102271775A (en) * 2008-12-08 2011-12-07 诺沃-诺迪斯克有限公司 Counter current purification of polypeptides
EP3865469A3 (en) 2009-12-30 2021-11-17 BASF Pharma (Callanish) Limited Polyunsaturated fatty acid compositions obtainable by a simulated moving bed chromatographic separation process
GB201111589D0 (en) 2011-07-06 2011-08-24 Equateq Ltd New modified process
GB201111594D0 (en) 2011-07-06 2011-08-24 Equateq Ltd New improved process
GB201111595D0 (en) 2011-07-06 2011-08-24 Equateq Ltd Improved process
GB201111601D0 (en) 2011-07-06 2011-08-24 Equateq Ltd New process
GB201111591D0 (en) 2011-07-06 2011-08-24 Equateq Ltd Further new process
GB201300354D0 (en) 2013-01-09 2013-02-20 Basf Pharma Callanish Ltd Multi-step separation process
US9428711B2 (en) 2013-05-07 2016-08-30 Groupe Novasep Chromatographic process for the production of highly purified polyunsaturated fatty acids
US8802880B1 (en) 2013-05-07 2014-08-12 Group Novasep Chromatographic process for the production of highly purified polyunsaturated fatty acids
EP3118186B1 (en) 2013-12-11 2022-02-09 Novasep Process Chromatographic facility for producing polyunsaturated fatty acids
WO2015104464A1 (en) 2014-01-07 2015-07-16 Novasep Process Process for purifying aromatic amino acids

Also Published As

Publication number Publication date
WO2001087924A3 (en) 2003-08-07
DE60127713D1 (en) 2007-05-16
DE60127713T2 (en) 2007-12-27
EP1349866B1 (en) 2007-04-04
ATE358679T1 (en) 2007-04-15
EP1349866A2 (en) 2003-10-08
ES2284653T3 (en) 2007-11-16
WO2001087924A2 (en) 2001-11-22

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