AU2001273840A1 - Detection of variations in the DNA methylation profile - Google Patents

Detection of variations in the DNA methylation profile

Info

Publication number
AU2001273840A1
AU2001273840A1 AU2001273840A AU7384001A AU2001273840A1 AU 2001273840 A1 AU2001273840 A1 AU 2001273840A1 AU 2001273840 A AU2001273840 A AU 2001273840A AU 7384001 A AU7384001 A AU 7384001A AU 2001273840 A1 AU2001273840 A1 AU 2001273840A1
Authority
AU
Australia
Prior art keywords
variations
detection
dna methylation
methylation profile
profile
Prior art date
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Abandoned
Application number
AU2001273840A
Inventor
Kurt Berlin
Alexander Olek
Christian Piepenbrock
Current Assignee (The listed assignees may be inaccurate. Google has not performed a legal analysis and makes no representation or warranty as to the accuracy of the list.)
Epigenomics AG
Original Assignee
Epigenomics AG
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Epigenomics AG filed Critical Epigenomics AG
Publication of AU2001273840A1 publication Critical patent/AU2001273840A1/en
Abandoned legal-status Critical Current

Links

Classifications

    • CCHEMISTRY; METALLURGY
    • C07ORGANIC CHEMISTRY
    • C07KPEPTIDES
    • C07K14/00Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof
    • C07K14/82Translation products from oncogenes
    • CCHEMISTRY; METALLURGY
    • C07ORGANIC CHEMISTRY
    • C07KPEPTIDES
    • C07K14/00Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof
    • C07K14/435Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from animals; from humans
    • C07K14/46Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from animals; from humans from vertebrates
    • C07K14/47Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from animals; from humans from vertebrates from mammals
    • C07K14/4701Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from animals; from humans from vertebrates from mammals not used
    • C07K14/4702Regulators; Modulating activity
    • C07K14/4703Inhibitors; Suppressors
    • CCHEMISTRY; METALLURGY
    • C12BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12QMEASURING OR TESTING PROCESSES INVOLVING ENZYMES, NUCLEIC ACIDS OR MICROORGANISMS; COMPOSITIONS OR TEST PAPERS THEREFOR; PROCESSES OF PREPARING SUCH COMPOSITIONS; CONDITION-RESPONSIVE CONTROL IN MICROBIOLOGICAL OR ENZYMOLOGICAL PROCESSES
    • C12Q1/00Measuring or testing processes involving enzymes, nucleic acids or microorganisms; Compositions therefor; Processes of preparing such compositions
    • C12Q1/68Measuring or testing processes involving enzymes, nucleic acids or microorganisms; Compositions therefor; Processes of preparing such compositions involving nucleic acids
    • C12Q1/6876Nucleic acid products used in the analysis of nucleic acids, e.g. primers or probes
    • C12Q1/6883Nucleic acid products used in the analysis of nucleic acids, e.g. primers or probes for diseases caused by alterations of genetic material
    • CCHEMISTRY; METALLURGY
    • C12BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12QMEASURING OR TESTING PROCESSES INVOLVING ENZYMES, NUCLEIC ACIDS OR MICROORGANISMS; COMPOSITIONS OR TEST PAPERS THEREFOR; PROCESSES OF PREPARING SUCH COMPOSITIONS; CONDITION-RESPONSIVE CONTROL IN MICROBIOLOGICAL OR ENZYMOLOGICAL PROCESSES
    • C12Q2600/00Oligonucleotides characterized by their use
    • C12Q2600/154Methylation markers
AU2001273840A 2000-04-06 2001-04-06 Detection of variations in the DNA methylation profile Abandoned AU2001273840A1 (en)

Applications Claiming Priority (3)

Application Number Priority Date Filing Date Title
DE10019058A DE10019058A1 (en) 2000-04-06 2000-04-06 Designing primers and probes for analyzing diseases associated with cytosine methylation state e.g. arthritis, cancer, aging, arteriosclerosis comprising fragments of chemically modified genes associated with cell cycle
DE10019058 2000-04-06
PCT/DE2001/001486 WO2001077373A2 (en) 2000-04-06 2001-04-06 Detection of variations in the dna methylation profile

Publications (1)

Publication Number Publication Date
AU2001273840A1 true AU2001273840A1 (en) 2001-10-23

Family

ID=7639087

Family Applications (1)

Application Number Title Priority Date Filing Date
AU2001273840A Abandoned AU2001273840A1 (en) 2000-04-06 2001-04-06 Detection of variations in the DNA methylation profile

Country Status (5)

Country Link
US (1) US20070026393A1 (en)
EP (1) EP1278892A1 (en)
AU (1) AU2001273840A1 (en)
DE (1) DE10019058A1 (en)
WO (1) WO2001077373A2 (en)

Cited By (1)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
CN109852687A (en) * 2019-03-26 2019-06-07 普文博泰生物科技(佛山)有限公司 A kind of composite amplification primer sets, kit and method for genetic screening

Families Citing this family (52)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
EP1340818A1 (en) * 2002-02-27 2003-09-03 Epigenomics AG Method and nucleic acids for the analysis of a colon cell proliferative disorder
WO2004020662A2 (en) * 2002-08-27 2004-03-11 Epigenomics Ag Method and nucleic acids for the analysis of breast cell proliferative disorders
JP4781267B2 (en) * 2003-08-14 2011-09-28 ケース ウエスタン リザーブ ユニバーシティ Method and composition for detecting colorectal cancer
US8415100B2 (en) 2003-08-14 2013-04-09 Case Western Reserve University Methods and compositions for detecting gastrointestinal and other cancers
CA3050151C (en) * 2003-11-26 2023-03-07 Celera Corporation Single nucleotide polymorphisms associated with cardiovascular disorders and statin response, methods of detection and uses thereof
US7608458B2 (en) * 2004-02-05 2009-10-27 Medtronic, Inc. Identifying patients at risk for life threatening arrhythmias
WO2005118872A2 (en) 2004-06-01 2005-12-15 The Regents Of The University Of Michigan Methods and kits for diagnosing or monitoring autoimmune and chronic inflammatory diseases
US8027791B2 (en) * 2004-06-23 2011-09-27 Medtronic, Inc. Self-improving classification system
US20050287574A1 (en) * 2004-06-23 2005-12-29 Medtronic, Inc. Genetic diagnostic method for SCD risk stratification
US8335652B2 (en) * 2004-06-23 2012-12-18 Yougene Corp. Self-improving identification method
WO2006088978A1 (en) 2005-02-16 2006-08-24 Epigenomics, Inc. Method for determining the methylation pattern of a polynucleic acid
US7932027B2 (en) 2005-02-16 2011-04-26 Epigenomics Ag Method for determining the methylation pattern of a polynucleic acid
WO2006110585A2 (en) * 2005-04-07 2006-10-19 Novartis Vaccines And Diagnostics Inc. Cancer-related genes (prlr)
US7449297B2 (en) 2005-04-14 2008-11-11 Euclid Diagnostics Llc Methods of copying the methylation pattern of DNA during isothermal amplification and microarrays
JP5133238B2 (en) 2005-04-15 2013-01-30 エピゲノミックス アクチェンゲゼルシャフト Method for providing a DNA fragment from a remote sample
US7439024B2 (en) 2005-06-01 2008-10-21 The United States Of America As Represented By The Department Of Veterans Affairs Methods and kits for diagnosing or monitoring autoimmune and chronic inflammatory diseases
WO2007003397A2 (en) * 2005-07-01 2007-01-11 Epigenomics Ag Method and nucleic acids for the improved treatment of cancers
AU2006339538A1 (en) * 2005-11-08 2007-09-13 Euclid Diagnostics Llc Materials and methods for assaying for methylation of CpG islands associated with genes in the evaluation of cancer
CA2648385C (en) 2006-04-04 2020-09-01 Singulex, Inc. Highly sensitive system and methods for analysis of troponin
US7838250B1 (en) 2006-04-04 2010-11-23 Singulex, Inc. Highly sensitive system and methods for analysis of troponin
EP2229588A4 (en) * 2007-11-14 2011-05-25 Medtronic Inc Diagnostic kits and methods for scd or sca therapy selection
US20110143956A1 (en) * 2007-11-14 2011-06-16 Medtronic, Inc. Diagnostic Kits and Methods for SCD or SCA Therapy Selection
EP2297346B1 (en) 2008-05-15 2015-04-15 Ribomed Biotechnologies, Inc. METHODS AND REAGENTS FOR DETECTING CpG METHYLATION WITH A METHYL CpG BINDING PROTEIN (MBP)
CA2728171A1 (en) * 2008-08-27 2010-03-04 H. Lundbeck A/S System and methods for measuring biomarker profiles
US9115386B2 (en) 2008-09-26 2015-08-25 Children's Medical Center Corporation Selective oxidation of 5-methylcytosine by TET-family proteins
KR20120007002A (en) 2009-03-15 2012-01-19 리보메드 바이오테크놀로지스, 인코퍼레이티드 Abscription based molecular detection
US8950910B2 (en) 2009-03-26 2015-02-10 Cree, Inc. Lighting device and method of cooling lighting device
EP2430184A2 (en) * 2009-05-12 2012-03-21 Medtronic, Inc. Sca risk stratification by predicting patient response to anti-arrhythmics
WO2010144358A1 (en) 2009-06-08 2010-12-16 Singulex, Inc. Highly sensitive biomarker panels
EP2308998A1 (en) * 2009-09-18 2011-04-13 Universitätsklinikum Jena Körperschaft des öffentlichen Rechts und Teilkörperschaft der Friedrich-Schiller-Universität Jena Method for early diagnosis of carcinomas of the anogenital tract
ES2715226T3 (en) * 2010-09-13 2019-06-03 Clinical Genomics Pty Ltd Epigenetic markers of colorectal cancers and diagnostic methods that use them
US9797016B2 (en) 2010-10-19 2017-10-24 Oslo Universitetssykehus Hf Methods and biomarkers for detection of bladder cancer
JP6003033B2 (en) * 2010-11-11 2016-10-05 ソニー株式会社 Nucleic acid detection method, sample optical observation method, and phosphor
US20140323321A1 (en) * 2010-12-13 2014-10-30 The Johns Hopkins University Detection of head and neck cancer using hypermethylated gene detection
RU2475740C1 (en) * 2011-09-26 2013-02-20 Федеральное государственное бюджетное учреждение "Ивановский научно-исследовательский институт материнства и детства имени В.Н. Городкова" Министерства здравоохранения и социального развития Российской Федерации Method of detecting hereditary predisposition to fast growth of uterine myoma
GB201207788D0 (en) * 2012-05-03 2012-06-13 Univ Newcastle Methods relating to identification of susceptibility to liver injury
ES2669214T3 (en) 2011-12-13 2018-05-24 Oslo Universitetssykehus Hf Procedures and kits for the detection of methylation status
EP3351644B1 (en) 2012-11-30 2020-01-29 Cambridge Epigenetix Limited Oxidising agent for modified nucleotides
WO2015017575A2 (en) * 2013-08-01 2015-02-05 Dignify Therapeutics, Inc. Compositions and methods for inducing urinary voiding and defecation
CN104195229A (en) * 2014-07-24 2014-12-10 益善生物技术股份有限公司 Epidermal growth factor receptor inhibitor drug curative effect related gene expression detection liquid chip kit
US11459573B2 (en) 2015-09-30 2022-10-04 Trustees Of Boston University Deadman and passcode microbial kill switches
EP3481953A4 (en) * 2016-07-06 2020-04-15 Youhealth Biotech, Limited Liver cancer methylation markers and uses thereof
RU2630669C1 (en) * 2016-07-21 2017-09-11 Федеральное бюджетное учреждение науки "Государственный научный центр вирусологии и биотехнологии "Вектор" (ФБУН ГНЦ ВБ "Вектор") Method for determination of methylation of colorectal cancer tumor marker genes regulatory regions pucgpy sites by glad-pcr analysis, and set of oligonucleotide primers and fluorescence-labelled probes for implementation of this method
US20220049305A1 (en) * 2018-09-14 2022-02-17 Gen Shinozaki Systems and methods for detection of delirium risk using epigenetic markers
KR102281657B1 (en) * 2019-12-23 2021-07-26 한림대학교 산학협력단 CDHR5 Gene hypermethylation marker for diagnosis of delayed cerebral ischemia
KR102281644B1 (en) * 2019-12-23 2021-07-23 한림대학교 산학협력단 INSR Gene hypermethylation marker for diagnosis of delayed cerebral ischemia
EP4083231A1 (en) 2020-07-30 2022-11-02 Cambridge Epigenetix Limited Compositions and methods for nucleic acid analysis
CN111972399B (en) * 2020-08-06 2021-11-30 温州医科大学 Preservation solution for maintaining activity of liver cells
EP4196611A1 (en) 2020-08-15 2023-06-21 Regeneron Pharmaceuticals, Inc. Treatment of obesity in subjects having variant nucleic acid molecules encoding calcitonin receptor (calcr)
CN115521956B (en) * 2022-10-21 2024-04-19 江苏诚信药业有限公司 Method for synthesizing L-carnosine by biological enzyme catalysis
CN115487301B (en) * 2022-11-08 2023-07-07 四川大学华西医院 Use of IL-13 inhibitors for the preparation of a medicament for the delay or treatment of retinitis pigmentosa
CN116790761B (en) * 2023-08-22 2023-11-17 湖南宏雅基因技术有限公司 Biomarker for benign and malignant lesions of endometrium and application of biomarker

Family Cites Families (13)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
FR2672618B1 (en) * 1991-02-13 1994-12-02 Centre Nat Rech Scient NUCLEIC ACID FRAGMENT OF THE X CHROMOSOME REGION INVOLVED IN FRAGILE X SYNDROME, NUCLEOTIDE PROBE AND METHOD FOR DIAGNOSING MENTAL DELAY WITH X FRAGILE.
GB9311113D0 (en) * 1993-05-28 1993-07-14 Medical Res Council Probes
US5912147A (en) * 1996-10-22 1999-06-15 Health Research, Inc. Rapid means of quantitating genomic instability
US6251594B1 (en) * 1997-06-09 2001-06-26 Usc/Norris Comprehensive Cancer Ctr. Cancer diagnostic method based upon DNA methylation differences
DE19754482A1 (en) * 1997-11-27 1999-07-01 Epigenomics Gmbh Process for making complex DNA methylation fingerprints
US6692909B1 (en) * 1998-04-01 2004-02-17 Whitehead Institute For Biomedical Research Coding sequence polymorphisms in vascular pathology genes
WO1999055915A2 (en) * 1998-04-29 1999-11-04 The Government Of The United States Of America As Represented By The Secretary, Department Of Health And Human Services IDENTIFICATION OF POLYMORPHISMS IN THE PCTG4 REGION OF Xq13
US6525185B1 (en) * 1998-05-07 2003-02-25 Affymetrix, Inc. Polymorphisms associated with hypertension
EP1112381A1 (en) * 1998-09-19 2001-07-04 AstraZeneca AB Polymorphisms in the human alpha4 integrin subunit gene, suitable for diagnosis and treatment of integrin ligand mediated diseases
US7700324B1 (en) * 1998-11-03 2010-04-20 The Johns Hopkins University School Of Medicine Methylated CpG island amplification (MCA)
WO2000029622A2 (en) * 1998-11-17 2000-05-25 Curagen Corporation Nucleic acids containing single nucleotide polymorphisms and methods of use thereof
US6670464B1 (en) * 1998-11-17 2003-12-30 Curagen Corporation Nucleic acids containing single nucleotide polymorphisms and methods of use thereof
DE19853398C1 (en) * 1998-11-19 2000-03-16 Epigenomics Gmbh Identification of 5-methylcytosine positions in genomic DNA by chemical modification, amplification and heteroduplex formation

Cited By (1)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
CN109852687A (en) * 2019-03-26 2019-06-07 普文博泰生物科技(佛山)有限公司 A kind of composite amplification primer sets, kit and method for genetic screening

Also Published As

Publication number Publication date
DE10019058A1 (en) 2001-12-20
EP1278892A1 (en) 2003-01-29
WO2001077373A2 (en) 2001-10-18
US20070026393A1 (en) 2007-02-01

Similar Documents

Publication Publication Date Title
AU2001273840A1 (en) Detection of variations in the DNA methylation profile
AU2002225807A1 (en) Object detection
AU2001288268A1 (en) Near object detection system
AU5083101A (en) Personal locatiom detection system
AU2001293998A1 (en) Detection system
AU1481102A (en) Detection of methylated dna molecules
HK1161308A1 (en) Assay for methylation in the gst-pi gene gst-pi
AU2001249343A1 (en) Location detection system
AU4351201A (en) Heparinase iii and uses thereof
AU2002220234A1 (en) Single user detection
AU2001296554A1 (en) Fluorescence detection
AU2001293336A1 (en) Nucleic acid detection medium
AU2002224328A1 (en) Methods and compositions for detecting cancers associated with methylation of hmlh1promoter dna
AU2001281633A1 (en) Detection method
AU2002225789A1 (en) Detection systems and methods
AU2001283890A1 (en) Window detection
AUPQ667800A0 (en) Detection method
AUPQ664300A0 (en) Macromolecule detection
AU2002213164A1 (en) Detection of dna damage
AU2001264852A1 (en) Lactobacillusbeta -glucuronidase and dna encoding the same
AU2001275032A1 (en) Methods for detecting dna damage and screening for cancer therapeutics
AU2001292922A1 (en) Nucleic acid detection
AU2001285155A1 (en) Polymorphic dna fragments and uses thereof
GB0018002D0 (en) Novel detection technique
AU2001280690A1 (en) Extended pathlength detection in separations

Legal Events

Date Code Title Description
MK6 Application lapsed section 142(2)(f)/reg. 8.3(3) - pct applic. not entering national phase
TH Corrigenda

Free format text: IN VOL 16, NO 10, PAGE(S) 2150-2167 UNDER THE HEADING APPLICATIONS LAPSED, REFUSED OR WITHDRAWN PLEASE DELETE ALL REFERENCE TO APPLICATION NO. 37189/01, 39165/01, 42263/01, 44489/01, 48491/01, 48494/01, 50604/01, 50624/01, 50628/01, 58215/01, 60018/01, 60051/01, 63811/01, 73840/01 AND 87748/01

MK4 Application lapsed section 142(2)(d) - no continuation fee paid for the application