AU2001273347A1 - Process for preparing benzoxazin-4-one polymer conjugates - Google Patents

Process for preparing benzoxazin-4-one polymer conjugates

Info

Publication number
AU2001273347A1
AU2001273347A1 AU2001273347A AU7334701A AU2001273347A1 AU 2001273347 A1 AU2001273347 A1 AU 2001273347A1 AU 2001273347 A AU2001273347 A AU 2001273347A AU 7334701 A AU7334701 A AU 7334701A AU 2001273347 A1 AU2001273347 A1 AU 2001273347A1
Authority
AU
Australia
Prior art keywords
benzoxazin
base catalyst
polymer conjugates
preparing
chloroformate
Prior art date
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Abandoned
Application number
AU2001273347A
Inventor
Renae Dianna Fossum
Todd Laurence Underiner
Current Assignee (The listed assignees may be inaccurate. Google has not performed a legal analysis and makes no representation or warranty as to the accuracy of the list.)
Procter and Gamble Co
Original Assignee
Procter and Gamble Co
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Procter and Gamble Co filed Critical Procter and Gamble Co
Publication of AU2001273347A1 publication Critical patent/AU2001273347A1/en
Abandoned legal-status Critical Current

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C08—ORGANIC MACROMOLECULAR COMPOUNDS; THEIR PREPARATION OR CHEMICAL WORKING-UP; COMPOSITIONS BASED THEREON
    • C08F—MACROMOLECULAR COMPOUNDS OBTAINED BY REACTIONS ONLY INVOLVING CARBON-TO-CARBON UNSATURATED BONDS
    • C08F8/00—Chemical modification by after-treatment
    • C08F8/30—Introducing nitrogen atoms or nitrogen-containing groups
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P17/00—Drugs for dermatological disorders
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P29/00—Non-central analgesic, antipyretic or antiinflammatory agents, e.g. antirheumatic agents; Non-steroidal antiinflammatory drugs [NSAID]
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P43/00—Drugs for specific purposes, not provided for in groups A61P1/00-A61P41/00

Abstract

The present invention relates to a process for forming polymer conjugates which are useful as enzyme inhibitors. The process of the present invention comprises the steps of:a) reacting a polymer or copolymer alcohol to form a chloroformate;b) combining a substituted or unsubstituted anthranilic acid comprising an enzyme interaction attenuating unit; and a base catalyst wherein the base catalyst is a supported base catalyst, to form a substrate reactive admixture; andc) adding to said chloroformate formed in step (a) said substrate reactive admixture formed in step (b) to form a benzoxazin-4-one conjugate.
AU2001273347A 2000-07-11 2001-07-11 Process for preparing benzoxazin-4-one polymer conjugates Abandoned AU2001273347A1 (en)

Applications Claiming Priority (3)

Application Number Priority Date Filing Date Title
US21752100P 2000-07-11 2000-07-11
US60217521 2000-07-11
PCT/US2001/021816 WO2002004531A2 (en) 2000-07-11 2001-07-11 Process for preparing benzoxazin-4-one polymer conjugates

Publications (1)

Publication Number Publication Date
AU2001273347A1 true AU2001273347A1 (en) 2002-01-21

Family

ID=22811417

Family Applications (1)

Application Number Title Priority Date Filing Date
AU2001273347A Abandoned AU2001273347A1 (en) 2000-07-11 2001-07-11 Process for preparing benzoxazin-4-one polymer conjugates

Country Status (9)

Country Link
US (1) US6504028B2 (en)
EP (1) EP1299430B1 (en)
JP (1) JP5000064B2 (en)
AT (1) ATE304023T1 (en)
AU (1) AU2001273347A1 (en)
CA (1) CA2415547A1 (en)
DE (1) DE60113266T2 (en)
MX (1) MXPA02012882A (en)
WO (1) WO2002004531A2 (en)

Families Citing this family (2)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US6803496B2 (en) * 1997-09-10 2004-10-12 The Procter & Gamble Company Method for maintaining or improving skin health
US20030143186A1 (en) * 2001-11-13 2003-07-31 The Procter & Gamble Company Protease enzyme inhibitors

Family Cites Families (12)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
DE1933212A1 (en) * 1969-07-01 1971-01-07 Bayer Ag Process for the production of high molecular weight polybenzoxazinones
DE3000284A1 (en) * 1980-01-05 1981-07-09 Philips Patentverwaltung Gmbh, 2000 Hamburg Alkylation of anthranilic acid cpds. - using solid inorganic base and quat. ammonium salt as catalyst or organic base to give regio-specificity
US4745116A (en) * 1985-06-25 1988-05-17 Syntex (U.S.A.) Inc. 2-oxy-4H-3,1-benzoxazin-4-ones and related compounds and pharmaceutical use
US4874822A (en) * 1988-04-07 1989-10-17 Minnesota Mining And Manufacturing Company Process for the acrylamidoacylation of alcohols
GB8820129D0 (en) * 1988-08-24 1988-09-28 Schering Agrochemicals Ltd Fungicides
US5122614A (en) * 1989-04-19 1992-06-16 Enzon, Inc. Active carbonates of polyalkylene oxides for modification of polypeptides
DE4022752A1 (en) * 1990-07-18 1992-01-23 Bayer Ag NEW CARBONATES, THEIR PRODUCTION AND USE AS FLOW AGENTS
CA2065191A1 (en) * 1991-04-30 1992-10-31 William E. Slack Process for the preparation of aromatic amines and the use of the amines so produced
US5428021A (en) * 1994-01-27 1995-06-27 Sri International Human leukocyte elastase (HLE) inhibitors, and related pharmaceutical compositions and methods of use
JPH07309851A (en) * 1994-05-16 1995-11-28 Fuji Chem Ind Co Ltd Production of benzooxazinon derivative
AR022204A1 (en) * 1999-01-08 2002-09-04 Norgine Bv COMPOUND, PROCESS FOR PREPARATION, PHARMACEUTICAL COMPOSITION AND EDIBLE PRODUCT THAT UNDERSTANDS IT.
DE19946048A1 (en) * 1999-09-25 2004-03-18 Basf Coatings Ag Resins containing carbamate groups, process for their preparation and their use

Also Published As

Publication number Publication date
US6504028B2 (en) 2003-01-07
EP1299430B1 (en) 2005-09-07
MXPA02012882A (en) 2003-05-14
DE60113266D1 (en) 2005-10-13
DE60113266T2 (en) 2006-06-08
WO2002004531A2 (en) 2002-01-17
US20020028934A1 (en) 2002-03-07
EP1299430A2 (en) 2003-04-09
CA2415547A1 (en) 2002-01-17
ATE304023T1 (en) 2005-09-15
JP5000064B2 (en) 2012-08-15
JP2004502840A (en) 2004-01-29
WO2002004531A3 (en) 2002-04-11

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