AU2001265717A1 - A recombinant cell line expressing gpcrx11 as a functional receptor validated byangiopeptin and useful for screening of agonists and antagonists - Google Patents

A recombinant cell line expressing gpcrx11 as a functional receptor validated byangiopeptin and useful for screening of agonists and antagonists

Info

Publication number
AU2001265717A1
AU2001265717A1 AU2001265717A AU6571701A AU2001265717A1 AU 2001265717 A1 AU2001265717 A1 AU 2001265717A1 AU 2001265717 A AU2001265717 A AU 2001265717A AU 6571701 A AU6571701 A AU 6571701A AU 2001265717 A1 AU2001265717 A1 AU 2001265717A1
Authority
AU
Australia
Prior art keywords
gpcrx11
byangiopeptin
validated
agonists
antagonists
Prior art date
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Abandoned
Application number
AU2001265717A
Other languages
English (en)
Inventor
Stephane Brezillon
Michel Detheux
Cedric Govarts
Vincent Lannoy
Marc Parmentier
Current Assignee (The listed assignees may be inaccurate. Google has not performed a legal analysis and makes no representation or warranty as to the accuracy of the list.)
Ogeda SA
Original Assignee
Euroscreen SA
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Euroscreen SA filed Critical Euroscreen SA
Publication of AU2001265717A1 publication Critical patent/AU2001265717A1/en
Abandoned legal-status Critical Current

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    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K14/00—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof
    • C07K14/435—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from animals; from humans
    • C07K14/705—Receptors; Cell surface antigens; Cell surface determinants
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P1/00—Drugs for disorders of the alimentary tract or the digestive system
    • A61P1/04—Drugs for disorders of the alimentary tract or the digestive system for ulcers, gastritis or reflux esophagitis, e.g. antacids, inhibitors of acid secretion, mucosal protectants
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P1/00—Drugs for disorders of the alimentary tract or the digestive system
    • A61P1/08—Drugs for disorders of the alimentary tract or the digestive system for nausea, cinetosis or vertigo; Antiemetics
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P1/00—Drugs for disorders of the alimentary tract or the digestive system
    • A61P1/14—Prodigestives, e.g. acids, enzymes, appetite stimulants, antidyspeptics, tonics, antiflatulents
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P13/00—Drugs for disorders of the urinary system
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    • A61P37/02—Immunomodulators
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
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    • A—HUMAN NECESSITIES
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    • A61P9/00—Drugs for disorders of the cardiovascular system
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P9/00—Drugs for disorders of the cardiovascular system
    • A61P9/02—Non-specific cardiovascular stimulants, e.g. drugs for syncope, antihypotensives
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P9/00—Drugs for disorders of the cardiovascular system
    • A61P9/04—Inotropic agents, i.e. stimulants of cardiac contraction; Drugs for heart failure
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    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
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    • A61P9/00—Drugs for disorders of the cardiovascular system
    • A61P9/10—Drugs for disorders of the cardiovascular system for treating ischaemic or atherosclerotic diseases, e.g. antianginal drugs, coronary vasodilators, drugs for myocardial infarction, retinopathy, cerebrovascula insufficiency, renal arteriosclerosis
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
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    • A61P9/12—Antihypertensives
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
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    • A61P9/00—Drugs for disorders of the cardiovascular system
    • A61P9/14—Vasoprotectives; Antihaemorrhoidals; Drugs for varicose therapy; Capillary stabilisers
    • A—HUMAN NECESSITIES
    • A01—AGRICULTURE; FORESTRY; ANIMAL HUSBANDRY; HUNTING; TRAPPING; FISHING
    • A01K—ANIMAL HUSBANDRY; AVICULTURE; APICULTURE; PISCICULTURE; FISHING; REARING OR BREEDING ANIMALS, NOT OTHERWISE PROVIDED FOR; NEW BREEDS OF ANIMALS
    • A01K2217/00—Genetically modified animals
    • A01K2217/05—Animals comprising random inserted nucleic acids (transgenic)
    • A—HUMAN NECESSITIES
    • A01—AGRICULTURE; FORESTRY; ANIMAL HUSBANDRY; HUNTING; TRAPPING; FISHING
    • A01K—ANIMAL HUSBANDRY; AVICULTURE; APICULTURE; PISCICULTURE; FISHING; REARING OR BREEDING ANIMALS, NOT OTHERWISE PROVIDED FOR; NEW BREEDS OF ANIMALS
    • A01K2217/00—Genetically modified animals
    • A01K2217/07—Animals genetically altered by homologous recombination
    • A01K2217/075—Animals genetically altered by homologous recombination inducing loss of function, i.e. knock out

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  • Health & Medical Sciences (AREA)
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  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • General Health & Medical Sciences (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Engineering & Computer Science (AREA)
  • Medicinal Chemistry (AREA)
  • Public Health (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Pharmacology & Pharmacy (AREA)
  • General Chemical & Material Sciences (AREA)
  • Animal Behavior & Ethology (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Veterinary Medicine (AREA)
  • Neurosurgery (AREA)
  • Neurology (AREA)
  • Biomedical Technology (AREA)
  • Cardiology (AREA)
  • Heart & Thoracic Surgery (AREA)
  • Physical Education & Sports Medicine (AREA)
  • Diabetes (AREA)
  • Rheumatology (AREA)
  • Oncology (AREA)
  • Pain & Pain Management (AREA)
  • Immunology (AREA)
  • Hematology (AREA)
  • Orthopedic Medicine & Surgery (AREA)
  • Communicable Diseases (AREA)
  • Hospice & Palliative Care (AREA)
  • Psychiatry (AREA)
  • Obesity (AREA)
  • Psychology (AREA)
  • Urology & Nephrology (AREA)
  • Vascular Medicine (AREA)
  • Otolaryngology (AREA)
  • Virology (AREA)
  • Biophysics (AREA)
  • Gastroenterology & Hepatology (AREA)
  • Zoology (AREA)
AU2001265717A 2000-06-20 2001-06-20 A recombinant cell line expressing gpcrx11 as a functional receptor validated byangiopeptin and useful for screening of agonists and antagonists Abandoned AU2001265717A1 (en)

Applications Claiming Priority (9)

Application Number Priority Date Filing Date Title
US21291300P 2000-06-20 2000-06-20
US60212913 2000-06-20
US21749400P 2000-07-11 2000-07-11
US60217494 2000-07-11
EP01870015 2001-01-26
EP01870015 2001-01-26
EP01870024 2001-02-12
EP01870024 2001-02-12
PCT/BE2001/000104 WO2001098330A2 (en) 2000-06-20 2001-06-20 A RECOMBINANT CELL LINE EXPRESSING GPCRx11 AS A FUNCTIONAL RECEPTOR VALIDATED BY ANGIOPEPTIN AND USEFUL FOR SCREENING OF AGONISTS AND ANTAGONISTS

Publications (1)

Publication Number Publication Date
AU2001265717A1 true AU2001265717A1 (en) 2002-01-02

Family

ID=56290152

Family Applications (1)

Application Number Title Priority Date Filing Date
AU2001265717A Abandoned AU2001265717A1 (en) 2000-06-20 2001-06-20 A recombinant cell line expressing gpcrx11 as a functional receptor validated byangiopeptin and useful for screening of agonists and antagonists

Country Status (5)

Country Link
EP (1) EP1297003A2 (de)
JP (1) JP2004500125A (de)
AU (1) AU2001265717A1 (de)
CA (1) CA2413435A1 (de)
WO (1) WO2001098330A2 (de)

Families Citing this family (14)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US20020119493A1 (en) * 2000-07-21 2002-08-29 Glucksmann Maria Alexandra 65494, a novel human G-protein-coupled receptor family member and uses thereof
GB2367297A (en) * 2000-07-07 2002-04-03 Smithkline Beecham Corp AXOR95 polypeptides and polynucleotides
MXPA03007270A (es) * 2001-02-14 2003-12-04 Amgen Inc Moleculas de receptores acoplados a proteina g y usos de las mismas.
WO2002088355A1 (fr) * 2001-04-25 2002-11-07 Fujisawa Pharmaceutical Co., Ltd. Recepteur couple a la proteine fixant la guanosine triphosphate, place 6002312, gene correspondant, production et utilisation
JPWO2003027142A1 (ja) * 2001-09-21 2005-01-06 山之内製薬株式会社 新規ｇ蛋白質共役型受容体
US20030157525A1 (en) * 2001-11-26 2003-08-21 Mintier Gabriel A. Novel human G-protein coupled receptor, HGPRBMY31, and variants and methods of use thereof
EP1340979A3 (de) * 2002-02-27 2004-02-04 Pfizer Limited Neuropeptid Rezeptor und dessen Anwendungen
DE10225443A1 (de) 2002-06-08 2003-12-18 Aventis Pharma Gmbh Verfahren zur Identifizierung von Agonisten oder Antagonisten für den G-Protein gekoppelten Rezeptor mas like 1
AU2003276136A1 (en) * 2002-11-04 2004-06-07 Bayer Healthcare Ag Diagnostics and therapeutics for diseases associated with human mas-related gene x1 (mrgx1)
US7056685B1 (en) 2002-11-05 2006-06-06 Amgen Inc. Receptor ligands and methods of modulating receptors
EP1565748A2 (de) * 2002-11-22 2005-08-24 Bayer HealthCare AG Diagnostika und therapeutika für krankheiten, die mit dem g-protein gekoppelte rezeptor bg37 assoziiert sind
US7189524B1 (en) 2002-11-25 2007-03-13 Amgen, Inc. Receptor ligands and methods of modulating receptors
DK1644513T3 (da) * 2003-06-20 2011-10-17 Discoverx Corp Assay til detektion af proteinbinding
WO2008063321A2 (en) 2006-10-13 2008-05-29 Janssen Pharmaceutica N.V. Gpr81-ligand complexes and their preparation and use

Family Cites Families (7)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
SE9704836D0 (sv) * 1997-12-22 1997-12-22 Astra Pharma Inc Novel receptor
WO2001016159A1 (en) * 1999-08-27 2001-03-08 Smithkline Beecham Corporation Gpcr, theant
CA2383177A1 (en) * 1999-09-16 2001-03-22 Solvay Pharmaceuticals B.V. Human g-protein coupled receptor
CA2388865A1 (en) * 1999-11-16 2001-05-25 Pharmacia & Upjohn Company Novel g protein-coupled receptors
CA2390547A1 (en) * 1999-11-17 2001-05-25 Arena Pharmaceuticals, Inc. Endogenous and non-endogenous versions of human g protein-coupled receptors
AU2230401A (en) * 1999-12-28 2001-07-09 Helix Research Institute Novel guanosine triphosphate-binding protein-coupled receptors, genes thereof and production and use of the same
EP1242454A2 (de) * 1999-12-28 2002-09-25 PHARMACIA & UPJOHN COMPANY G-proteingekoppelte rezeptoren

Also Published As

Publication number Publication date
WO2001098330A2 (en) 2001-12-27
JP2004500125A (ja) 2004-01-08
CA2413435A1 (en) 2001-12-27
WO2001098330A3 (en) 2002-05-02
EP1297003A2 (de) 2003-04-02

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