AU2001261280A1 - Coumermycin analogs as chemical dimerizers of chimeric proteins - Google Patents

Coumermycin analogs as chemical dimerizers of chimeric proteins

Info

Publication number
AU2001261280A1
AU2001261280A1 AU2001261280A AU6128001A AU2001261280A1 AU 2001261280 A1 AU2001261280 A1 AU 2001261280A1 AU 2001261280 A AU2001261280 A AU 2001261280A AU 6128001 A AU6128001 A AU 6128001A AU 2001261280 A1 AU2001261280 A1 AU 2001261280A1
Authority
AU
Australia
Prior art keywords
chimeric proteins
coumermycin
analogs
chemical dimerizers
dimerizers
Prior art date
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Abandoned
Application number
AU2001261280A
Inventor
Michael A Farrar
Steven H. Olson
Roger M. Perlmutter
Llnon H. Slossberg
Current Assignee (The listed assignees may be inaccurate. Google has not performed a legal analysis and makes no representation or warranty as to the accuracy of the list.)
Merck and Co Inc
Original Assignee
Merck and Co Inc
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Merck and Co Inc filed Critical Merck and Co Inc
Publication of AU2001261280A1 publication Critical patent/AU2001261280A1/en
Abandoned legal-status Critical Current

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07H—SUGARS; DERIVATIVES THEREOF; NUCLEOSIDES; NUCLEOTIDES; NUCLEIC ACIDS
    • C07H13/00—Compounds containing saccharide radicals esterified by carbonic acid or derivatives thereof, or by organic acids, e.g. phosphonic acids
    • C07H13/02—Compounds containing saccharide radicals esterified by carbonic acid or derivatives thereof, or by organic acids, e.g. phosphonic acids by carboxylic acids
    • C07H13/10—Compounds containing saccharide radicals esterified by carbonic acid or derivatives thereof, or by organic acids, e.g. phosphonic acids by carboxylic acids having the esterifying carboxyl radicals directly attached to heterocyclic rings
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07H—SUGARS; DERIVATIVES THEREOF; NUCLEOSIDES; NUCLEOTIDES; NUCLEIC ACIDS
    • C07H17/00—Compounds containing heterocyclic radicals directly attached to hetero atoms of saccharide radicals
    • C07H17/04—Heterocyclic radicals containing only oxygen as ring hetero atoms
    • C07H17/06—Benzopyran radicals
    • C07H17/065—Benzo[b]pyrans
    • C07H17/075—Benzo[b]pyran-2-ones

Landscapes

  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Health & Medical Sciences (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Engineering & Computer Science (AREA)
  • Biochemistry (AREA)
  • Biotechnology (AREA)
  • General Health & Medical Sciences (AREA)
  • Genetics & Genomics (AREA)
  • Molecular Biology (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
AU2001261280A 2000-05-12 2001-05-08 Coumermycin analogs as chemical dimerizers of chimeric proteins Abandoned AU2001261280A1 (en)

Applications Claiming Priority (3)

Application Number Priority Date Filing Date Title
US20365600P 2000-05-12 2000-05-12
US60203656 2000-05-12
PCT/US2001/014870 WO2001087309A1 (en) 2000-05-12 2001-05-08 Coumermycin analogs as chemical dimerizers of chimeric proteins

Publications (1)

Publication Number Publication Date
AU2001261280A1 true AU2001261280A1 (en) 2001-11-26

Family

ID=22754803

Family Applications (1)

Application Number Title Priority Date Filing Date
AU2001261280A Abandoned AU2001261280A1 (en) 2000-05-12 2001-05-08 Coumermycin analogs as chemical dimerizers of chimeric proteins

Country Status (3)

Country Link
US (1) US6916846B2 (en)
AU (1) AU2001261280A1 (en)
WO (1) WO2001087309A1 (en)

Families Citing this family (18)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
DOP2002000332A (en) * 2001-02-14 2002-08-30 Warner Lambert Co MATRIX METALOPROTEINAS PYRIDINE INHIBITORS
JP4719147B2 (en) 2003-06-10 2011-07-06 ナショナル リサーチ カウンシル オブ カナダ Coumermycin / Novobiocin-regulated gene expression system
WO2005005389A2 (en) * 2003-07-07 2005-01-20 Merck Patent Gmbh Malonamide derivatives
US8212012B2 (en) 2004-11-03 2012-07-03 University Of Kansas Novobiocin analogues having modified sugar moieties
MX2009010667A (en) * 2007-04-12 2010-02-24 Joyant Pharmaceuticals Inc Smac mimetic dimers and trimers useful as anti-cancer agents.
WO2009002607A1 (en) * 2007-05-01 2008-12-31 Dana-Farber Cancer Institute, Inc. Compositions and methods for identifying transforming and tumor suppressor genes
US8497361B2 (en) * 2010-08-23 2013-07-30 Sri International Topoisomerase binding probe and method of use
GB201017450D0 (en) * 2010-10-15 2010-12-01 School Of Pharmacy The University Of London Glycosylation of aminocoumarins
ES2758227T3 (en) 2013-02-15 2020-05-04 Univ California Chimeric antigen receptor and methods of using it
WO2016196655A1 (en) 2015-06-03 2016-12-08 The Regents Of The University Of California Cas9 variants and methods of use thereof
US10669320B2 (en) 2015-11-18 2020-06-02 The Regents Of The University Of Michigan Mps1 and KNL1 phosphorylation system
WO2020047527A2 (en) 2018-09-02 2020-03-05 F1 Bioventures, Llc Methods and compositions for genetically modifying lymphocytes in blood or in enriched pbmcs
SG11201907814SA (en) 2017-03-03 2019-09-27 F1 Oncology Inc Methods and compositions for transducing and expanding lymphocytes and regulating the activity thereof
US11713335B2 (en) * 2018-03-12 2023-08-01 President And Fellows Of Harvard College Aminocoumarin compounds and methods of their use
CN113164576A (en) 2018-10-05 2021-07-23 圣安娜儿童癌症研究中心 Chimeric Antigen Receptor (CAR) groups
EP3632461A1 (en) 2018-10-05 2020-04-08 St. Anna Kinderkrebsforschung A group of chimeric antigen receptors (cars)
WO2022187289A1 (en) 2021-03-01 2022-09-09 Exuma Biotech Corp. Methods and compositions for the delivery of retroviral particles
WO2023168305A1 (en) 2022-03-01 2023-09-07 Exuma Biotech Corp. Viral particles with membrane-bound hyaluronidase

Family Cites Families (4)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US3627886A (en) 1968-04-15 1971-12-14 Hoffmann La Roche Methods of solubilizing coumermycin employing urea, dimethylacetamide or mixtures thereof
US5830462A (en) 1993-02-12 1998-11-03 President & Fellows Of Harvard College Regulated transcription of targeted genes and other biological events
US5834266A (en) 1993-02-12 1998-11-10 President & Fellows Of Harvard College Regulated apoptosis
TW538046B (en) 1998-01-08 2003-06-21 Hoechst Marion Roussel Inc Aromatic amides having antiobiotic activities and the preparation processes, intermediates and pharmaceutical composition thereof

Also Published As

Publication number Publication date
US6916846B2 (en) 2005-07-12
US20020095026A1 (en) 2002-07-18
WO2001087309A1 (en) 2001-11-22

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