AU2001259829A1 - Chemoenzymatic synthesis of neotame - Google Patents

Chemoenzymatic synthesis of neotame

Info

Publication number
AU2001259829A1
AU2001259829A1 AU2001259829A AU5982901A AU2001259829A1 AU 2001259829 A1 AU2001259829 A1 AU 2001259829A1 AU 2001259829 A AU2001259829 A AU 2001259829A AU 5982901 A AU5982901 A AU 5982901A AU 2001259829 A1 AU2001259829 A1 AU 2001259829A1
Authority
AU
Australia
Prior art keywords
neotame
chemoenzymatic synthesis
chemoenzymatic
synthesis
Prior art date
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Abandoned
Application number
AU2001259829A
Inventor
Indra Prakash
Robert Y. Zhao
Current Assignee (The listed assignees may be inaccurate. Google has not performed a legal analysis and makes no representation or warranty as to the accuracy of the list.)
Nutrasweet Co
Original Assignee
Nutrasweet Co
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Nutrasweet Co filed Critical Nutrasweet Co
Publication of AU2001259829A1 publication Critical patent/AU2001259829A1/en
Abandoned legal-status Critical Current

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K5/00—Peptides containing up to four amino acids in a fully defined sequence; Derivatives thereof
    • C07K5/04—Peptides containing up to four amino acids in a fully defined sequence; Derivatives thereof containing only normal peptide links
    • C07K5/06—Dipeptides
    • C07K5/06104—Dipeptides with the first amino acid being acidic
    • C07K5/06113—Asp- or Asn-amino acid
    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12P—FERMENTATION OR ENZYME-USING PROCESSES TO SYNTHESISE A DESIRED CHEMICAL COMPOUND OR COMPOSITION OR TO SEPARATE OPTICAL ISOMERS FROM A RACEMIC MIXTURE
    • C12P21/00—Preparation of peptides or proteins
    • C12P21/02—Preparation of peptides or proteins having a known sequence of two or more amino acids, e.g. glutathione

Landscapes

  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Health & Medical Sciences (AREA)
  • Engineering & Computer Science (AREA)
  • Genetics & Genomics (AREA)
  • Molecular Biology (AREA)
  • General Health & Medical Sciences (AREA)
  • Biochemistry (AREA)
  • Zoology (AREA)
  • Proteomics, Peptides & Aminoacids (AREA)
  • Wood Science & Technology (AREA)
  • Microbiology (AREA)
  • General Chemical & Material Sciences (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • General Engineering & Computer Science (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Biotechnology (AREA)
  • Biophysics (AREA)
  • Medicinal Chemistry (AREA)
  • Preparation Of Compounds By Using Micro-Organisms (AREA)
AU2001259829A 2000-05-12 2001-05-07 Chemoenzymatic synthesis of neotame Abandoned AU2001259829A1 (en)

Applications Claiming Priority (3)

Application Number Priority Date Filing Date Title
US09/570,408 2000-05-12
US09/570,408 US6627431B1 (en) 2000-05-12 2000-05-12 Chemoenzymatic synthesis of neotame
PCT/US2001/040676 WO2001085977A2 (en) 2000-05-12 2001-05-07 Chemoenzymatic synthesis of neotame

Publications (1)

Publication Number Publication Date
AU2001259829A1 true AU2001259829A1 (en) 2001-11-20

Family

ID=24279530

Family Applications (1)

Application Number Title Priority Date Filing Date
AU2001259829A Abandoned AU2001259829A1 (en) 2000-05-12 2001-05-07 Chemoenzymatic synthesis of neotame

Country Status (3)

Country Link
US (1) US6627431B1 (en)
AU (1) AU2001259829A1 (en)
WO (1) WO2001085977A2 (en)

Families Citing this family (2)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
CN110563797A (en) * 2019-10-12 2019-12-13 山东奔月生物科技股份有限公司 Method for removing viscous components in neotame
CN110818774A (en) * 2019-11-21 2020-02-21 暨南大学 Synthetic method of 40000 times dipeptide high-power sweetener

Family Cites Families (9)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US3933781A (en) 1973-11-05 1976-01-20 Monsanto Company Process for the preparation of α-L-aspartyl-L-phenylalanine alkyl esters
US4293648A (en) 1979-12-12 1981-10-06 G. D. Searle & Co. Process for esterification of α-L-aspartyl-L-phenylalanine
JPS6274297A (en) 1985-09-30 1987-04-06 Asahi Chem Ind Co Ltd Production of alpha-l-aspartyl-l-phenylalanine methyl ester
FR2697844B1 (en) 1992-11-12 1995-01-27 Claude Nofre New compounds derived from dipeptides or dipeptide analogues useful as sweetening agents, process for their preparation.
FR2719590B1 (en) 1994-05-09 1996-07-26 Claude Nofre Improved process for the preparation of a compound derived from aspartame useful as a sweetening agent.
US5773261A (en) * 1996-08-26 1998-06-30 The Nutrasweet Company Regioselective α-hydrolysis of amino acid diesters using pig liver esterase
US5728862A (en) 1997-01-29 1998-03-17 The Nutrasweet Company Method for preparing and purifying an N-alkylated aspartame derivative
AU1832500A (en) 1998-11-25 2000-06-19 Nutrasweet Company, The Purification of N-(N-(3,3-dimethylbutyl)-l-alpha-aspartyl)-l-phenylalanine 1-methyl ester via crystallization
US6077962A (en) 1998-12-24 2000-06-20 The Nutrasweet Company N-3, 3-dimethylbutyl-L-aspartic acid and esters thereof, the process of preparing the same, and the process for preparing N-(N-(3,3-dimethylbutyl) -α L-aspartyl)-L- phenylalanine 1-methyl ester therefrom

Also Published As

Publication number Publication date
WO2001085977A3 (en) 2002-08-15
US6627431B1 (en) 2003-09-30
WO2001085977A2 (en) 2001-11-15

Similar Documents

Publication Publication Date Title
AU3771100A (en) Synthesis of epothilones
AU2001280201A1 (en) Methods of synthesizing cell-free protein
AU2001284697A1 (en) Method of synthesizing diketopiperazines
AU2002213248A1 (en) Synthesis of epothilones and relates analogs
AU2001291859A1 (en) Use of copolycarbonates
AU2001272904A1 (en) Synthesis of 17f labeled fluoroalkanes
AU2001227768A1 (en) Improved synthesis of sulfurized oligonucleotides
AU2002346548A1 (en) Regioisomerically pure oxochlorins and methods of synthesis
AU1488501A (en) Methods of inhibiting metastasis
AU2001267428A1 (en) Direct detection of individual molecules
AU2001238692A1 (en) Biocatalytic synthesis of galloid organics
AU2001269685A1 (en) Crystallization of 4-diphosphocytidyl-2-c-methylerythritol synthesis
AU2001229530A1 (en) Detection of fermentation-related microorganisms
AU2002316593A1 (en) Solid phase synthesis of arylretinamides
AU2001265935A1 (en) Production of biohydrolysates
AU2252101A (en) New synthesis of SPLA2 inhibitors
AUPR197000A0 (en) Synthesis of small particles
AU2001264095A1 (en) Synthesis of chlorinated pyrimidines
AU2001259829A1 (en) Chemoenzymatic synthesis of neotame
AU4450100A (en) 225Ac-heha and related compounds, methods of synthesis and methods of use
AU2001240150A1 (en) Quinazoline synthesis
AU2002247242A1 (en) Solid phase synthesis supports and methods
AU7711800A (en) Novel uses of 2-bromopalmitate
AU2001287422A1 (en) Synthesis of complex carbohydrates
AU3739300A (en) Synthesis of vapol ligands