AU2001257913A1 - Polymorphisms in the human cyp2d6 gene promoter region and their use in diagnostic and therapeutic applications - Google Patents
Polymorphisms in the human cyp2d6 gene promoter region and their use in diagnostic and therapeutic applicationsInfo
- Publication number
- AU2001257913A1 AU2001257913A1 AU2001257913A AU5791301A AU2001257913A1 AU 2001257913 A1 AU2001257913 A1 AU 2001257913A1 AU 2001257913 A AU2001257913 A AU 2001257913A AU 5791301 A AU5791301 A AU 5791301A AU 2001257913 A1 AU2001257913 A1 AU 2001257913A1
- Authority
- AU
- Australia
- Prior art keywords
- polymorphisms
- diagnostic
- cyp2d6 gene
- promoter region
- therapeutic applications
- Prior art date
- Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
- Abandoned
Links
Classifications
-
- C—CHEMISTRY; METALLURGY
- C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
- C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
- C12N9/00—Enzymes; Proenzymes; Compositions thereof; Processes for preparing, activating, inhibiting, separating or purifying enzymes
- C12N9/0004—Oxidoreductases (1.)
- C12N9/0071—Oxidoreductases (1.) acting on paired donors with incorporation of molecular oxygen (1.14)
- C12N9/0077—Oxidoreductases (1.) acting on paired donors with incorporation of molecular oxygen (1.14) with a reduced iron-sulfur protein as one donor (1.14.15)
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P25/00—Drugs for disorders of the nervous system
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P25/00—Drugs for disorders of the nervous system
- A61P25/04—Centrally acting analgesics, e.g. opioids
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P25/00—Drugs for disorders of the nervous system
- A61P25/24—Antidepressants
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P35/00—Antineoplastic agents
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P43/00—Drugs for specific purposes, not provided for in groups A61P1/00-A61P41/00
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P9/00—Drugs for disorders of the cardiovascular system
- A61P9/06—Antiarrhythmics
-
- C—CHEMISTRY; METALLURGY
- C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
- C12Q—MEASURING OR TESTING PROCESSES INVOLVING ENZYMES, NUCLEIC ACIDS OR MICROORGANISMS; COMPOSITIONS OR TEST PAPERS THEREFOR; PROCESSES OF PREPARING SUCH COMPOSITIONS; CONDITION-RESPONSIVE CONTROL IN MICROBIOLOGICAL OR ENZYMOLOGICAL PROCESSES
- C12Q1/00—Measuring or testing processes involving enzymes, nucleic acids or microorganisms; Compositions therefor; Processes of preparing such compositions
- C12Q1/68—Measuring or testing processes involving enzymes, nucleic acids or microorganisms; Compositions therefor; Processes of preparing such compositions involving nucleic acids
- C12Q1/6876—Nucleic acid products used in the analysis of nucleic acids, e.g. primers or probes
- C12Q1/6883—Nucleic acid products used in the analysis of nucleic acids, e.g. primers or probes for diseases caused by alterations of genetic material
-
- C—CHEMISTRY; METALLURGY
- C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
- C12Q—MEASURING OR TESTING PROCESSES INVOLVING ENZYMES, NUCLEIC ACIDS OR MICROORGANISMS; COMPOSITIONS OR TEST PAPERS THEREFOR; PROCESSES OF PREPARING SUCH COMPOSITIONS; CONDITION-RESPONSIVE CONTROL IN MICROBIOLOGICAL OR ENZYMOLOGICAL PROCESSES
- C12Q2600/00—Oligonucleotides characterized by their use
- C12Q2600/156—Polymorphic or mutational markers
Landscapes
- Health & Medical Sciences (AREA)
- Chemical & Material Sciences (AREA)
- Life Sciences & Earth Sciences (AREA)
- Organic Chemistry (AREA)
- Engineering & Computer Science (AREA)
- Bioinformatics & Cheminformatics (AREA)
- General Health & Medical Sciences (AREA)
- Genetics & Genomics (AREA)
- Wood Science & Technology (AREA)
- Medicinal Chemistry (AREA)
- Zoology (AREA)
- Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
- General Chemical & Material Sciences (AREA)
- Pharmacology & Pharmacy (AREA)
- Chemical Kinetics & Catalysis (AREA)
- Animal Behavior & Ethology (AREA)
- Proteomics, Peptides & Aminoacids (AREA)
- Public Health (AREA)
- Veterinary Medicine (AREA)
- Biomedical Technology (AREA)
- Biochemistry (AREA)
- Analytical Chemistry (AREA)
- Microbiology (AREA)
- Biotechnology (AREA)
- Molecular Biology (AREA)
- General Engineering & Computer Science (AREA)
- Neurology (AREA)
- Neurosurgery (AREA)
- Pathology (AREA)
- Physics & Mathematics (AREA)
- Biophysics (AREA)
- Immunology (AREA)
- Pain & Pain Management (AREA)
- Cardiology (AREA)
- Heart & Thoracic Surgery (AREA)
- Psychiatry (AREA)
- Measuring Or Testing Involving Enzymes Or Micro-Organisms (AREA)
- Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
- Medicines Containing Antibodies Or Antigens For Use As Internal Diagnostic Agents (AREA)
- Micro-Organisms Or Cultivation Processes Thereof (AREA)
Abstract
Provided are polynucleotides of molecular variant promoters of the CYP2D6 gene which, for example, are associated with abnormal drug response or individual predisposition to several common diseases and disorders caused by drug under- or over-metabolization, and vectors comprising such polynucleotides. Furthermore, methods of diagnosing the status of disorders related to intermediate metabolization of drugs are described. In addition, kits comprising oligonucleotides hybridizing to the CYP2D6 promoter and/or being capable of being extended into this region useful for diagnosing subjects that are ultrarapid or intermediate metabolizer of drugs are provided.
Applications Claiming Priority (3)
Application Number | Priority Date | Filing Date | Title |
---|---|---|---|
EP00101889.4 | 2000-01-31 | ||
EP00101889 | 2000-01-31 | ||
PCT/EP2001/000954 WO2001055432A2 (en) | 2000-01-31 | 2001-01-30 | Polymorphisms in the human cyp2d6 gene promoter region and their use in diagnostic and therapeutic applications |
Publications (1)
Publication Number | Publication Date |
---|---|
AU2001257913A1 true AU2001257913A1 (en) | 2001-08-07 |
Family
ID=8167736
Family Applications (1)
Application Number | Title | Priority Date | Filing Date |
---|---|---|---|
AU2001257913A Abandoned AU2001257913A1 (en) | 2000-01-31 | 2001-01-30 | Polymorphisms in the human cyp2d6 gene promoter region and their use in diagnostic and therapeutic applications |
Country Status (9)
Country | Link |
---|---|
US (2) | US8129112B2 (en) |
EP (1) | EP1276880B1 (en) |
JP (1) | JP2004506405A (en) |
AT (1) | ATE333504T1 (en) |
AU (1) | AU2001257913A1 (en) |
CA (1) | CA2398104C (en) |
DE (1) | DE60121567T2 (en) |
ES (1) | ES2267787T3 (en) |
WO (1) | WO2001055432A2 (en) |
Families Citing this family (4)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
GB0021286D0 (en) * | 2000-08-30 | 2000-10-18 | Gemini Genomics Ab | Identification of drug metabolic capacity |
ATE471991T1 (en) * | 2004-06-30 | 2010-07-15 | Luminex Molecular Diagnostics | METHOD FOR DETECTING MUTATIONS IN THE GENE CODING FOR CYTOCHROME P450-2D6 |
GB0614396D0 (en) * | 2006-07-20 | 2006-08-30 | Knox Geoffrey M | Test for the presence of active CYP450 2D6 |
CN114317533B (en) * | 2022-01-12 | 2023-08-29 | 武汉艾迪康医学检验所有限公司 | A set of probes and a kit for constructing a library for detecting polymorphism of CYP2D6 gene related to pharmacogenomics by utilizing hybrid capture method |
Family Cites Families (2)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
AU8126694A (en) * | 1993-10-26 | 1995-05-22 | Affymax Technologies N.V. | Arrays of nucleic acid probes on biological chips |
WO2001096604A2 (en) * | 2000-06-12 | 2001-12-20 | Genicon Sciences Corporation | Assay for genetic polymorphisms using scattered light detectable labels |
-
2001
- 2001-01-30 AU AU2001257913A patent/AU2001257913A1/en not_active Abandoned
- 2001-01-30 DE DE60121567T patent/DE60121567T2/en not_active Expired - Lifetime
- 2001-01-30 JP JP2001554461A patent/JP2004506405A/en active Pending
- 2001-01-30 AT AT01946895T patent/ATE333504T1/en active
- 2001-01-30 EP EP01946895A patent/EP1276880B1/en not_active Expired - Lifetime
- 2001-01-30 WO PCT/EP2001/000954 patent/WO2001055432A2/en active IP Right Grant
- 2001-01-30 ES ES01946895T patent/ES2267787T3/en not_active Expired - Lifetime
- 2001-01-30 US US10/182,977 patent/US8129112B2/en not_active Expired - Fee Related
- 2001-01-30 CA CA2398104A patent/CA2398104C/en not_active Expired - Fee Related
-
2012
- 2012-01-13 US US13/350,635 patent/US20120270948A1/en not_active Abandoned
Also Published As
Publication number | Publication date |
---|---|
DE60121567T2 (en) | 2007-07-05 |
CA2398104A1 (en) | 2001-08-02 |
WO2001055432A2 (en) | 2001-08-02 |
EP1276880B1 (en) | 2006-07-19 |
DE60121567D1 (en) | 2006-08-31 |
WO2001055432A3 (en) | 2002-10-31 |
US20120270948A1 (en) | 2012-10-25 |
ATE333504T1 (en) | 2006-08-15 |
CA2398104C (en) | 2015-03-10 |
ES2267787T3 (en) | 2007-03-16 |
JP2004506405A (en) | 2004-03-04 |
EP1276880A2 (en) | 2003-01-22 |
US20040224424A1 (en) | 2004-11-11 |
US8129112B2 (en) | 2012-03-06 |
Similar Documents
Publication | Publication Date | Title |
---|---|---|
WO2002002624A3 (en) | B7-like molecules and uses thereof | |
WO2002024891A3 (en) | B7-like molecules and uses thereof | |
WO2001070977A3 (en) | Fibroblast growth factor receptor-like molecules and uses thereof | |
WO2001061007A3 (en) | Fibroblast growth factor-23 molecules and uses thereof | |
WO2001068854A3 (en) | Fibroblast growth factor-like molecules and uses thereof | |
WO2004041212A3 (en) | Apkc isoforms in nervous system disorders and cancer | |
WO2003024991A3 (en) | Tall-1 receptor molecules and uses thereof | |
WO2006003520A3 (en) | Human autism predisposition gene encoding a transcription factor and uses thereof | |
WO2002081745A3 (en) | Genes involved in osteogenesis, and methods of use | |
AU2001257913A1 (en) | Polymorphisms in the human cyp2d6 gene promoter region and their use in diagnostic and therapeutic applications | |
BRPI0408889A (en) | Clusterin use for treatment and / or prevention of peripheral neurological diseases | |
WO2006003523A3 (en) | Human autism susceptibility gene encoding PRKCB1 and uses thereof | |
WO2005019474A3 (en) | Human autism susceptibility gene and uses thereof | |
WO2001020025A3 (en) | Polymorphisms in the human cyp3a4 and cyp3a7 genes and their use in diagnostic and therapeutic applications | |
MXPA03010728A (en) | B7 related protein-2 molecules and uses thereof. | |
WO2003038130A3 (en) | Therapeutics and diagnostics for disorders of erythropoiesis | |
WO2003055980A3 (en) | Il-17 like molecules and uses thereof | |
WO2006100608A3 (en) | Human autism susceptibility gene encoding a transmembrane protein and uses thereof | |
WO2006090288A3 (en) | Human autism susceptibility genes encoding a neurotransmitter transporter and uses thereof | |
JP2004506405A5 (en) | ||
WO2005014804A3 (en) | Ubiquitin-specific protease | |
WO2004058949A3 (en) | Wnt-1 inhibitory factor-1 (wif-1) molecules and uses thereof | |
EP0854186A3 (en) | Staphylococcus aureus cell division gene DivIB | |
WO2003008640A3 (en) | Asthma-associated gene | |
WO2001059152A3 (en) | Polymorphisms in the human cyp2b6 gene and their use in diagnostic and therapeutic applications |