WO2005014804A3 - Ubiquitin-specific protease - Google Patents

Ubiquitin-specific protease Download PDF

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Publication number
WO2005014804A3
WO2005014804A3 PCT/EP2004/008798 EP2004008798W WO2005014804A3 WO 2005014804 A3 WO2005014804 A3 WO 2005014804A3 EP 2004008798 W EP2004008798 W EP 2004008798W WO 2005014804 A3 WO2005014804 A3 WO 2005014804A3
Authority
WO
WIPO (PCT)
Prior art keywords
useful
ubiquitin
well
specific protease
present
Prior art date
Application number
PCT/EP2004/008798
Other languages
French (fr)
Other versions
WO2005014804A2 (en
Inventor
Adrian Bruengger
Richard Lie Cai
Sophia Kossida
Benoit Pierrat
Nanguneri R Nirmala
Original Assignee
Novartis Ag
Novartis Pharma Gmbh
Adrian Bruengger
Richard Lie Cai
Sophia Kossida
Benoit Pierrat
Nanguneri R Nirmala
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Novartis Ag, Novartis Pharma Gmbh, Adrian Bruengger, Richard Lie Cai, Sophia Kossida, Benoit Pierrat, Nanguneri R Nirmala filed Critical Novartis Ag
Priority to MXPA06001393A priority Critical patent/MXPA06001393A/en
Priority to AU2004262684A priority patent/AU2004262684A1/en
Priority to JP2006522322A priority patent/JP2007501008A/en
Priority to CA002534481A priority patent/CA2534481A1/en
Priority to EP04741374A priority patent/EP1651764A2/en
Priority to BRPI0413364-1A priority patent/BRPI0413364A/en
Publication of WO2005014804A2 publication Critical patent/WO2005014804A2/en
Publication of WO2005014804A3 publication Critical patent/WO2005014804A3/en

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
    • C12N9/00—Enzymes; Proenzymes; Compositions thereof; Processes for preparing, activating, inhibiting, separating or purifying enzymes
    • C12N9/14—Hydrolases (3)
    • C12N9/48—Hydrolases (3) acting on peptide bonds (3.4)
    • C12N9/50—Proteinases, e.g. Endopeptidases (3.4.21-3.4.25)
    • C12N9/64—Proteinases, e.g. Endopeptidases (3.4.21-3.4.25) derived from animal tissue
    • C12N9/6421—Proteinases, e.g. Endopeptidases (3.4.21-3.4.25) derived from animal tissue from mammals
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P35/00—Antineoplastic agents
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P35/00—Antineoplastic agents
    • A61P35/02—Antineoplastic agents specific for leukemia

Landscapes

  • Health & Medical Sciences (AREA)
  • Chemical & Material Sciences (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Organic Chemistry (AREA)
  • Engineering & Computer Science (AREA)
  • General Health & Medical Sciences (AREA)
  • Medicinal Chemistry (AREA)
  • Biomedical Technology (AREA)
  • Genetics & Genomics (AREA)
  • Pharmacology & Pharmacy (AREA)
  • General Chemical & Material Sciences (AREA)
  • Animal Behavior & Ethology (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Public Health (AREA)
  • Veterinary Medicine (AREA)
  • Zoology (AREA)
  • Wood Science & Technology (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • General Engineering & Computer Science (AREA)
  • Biotechnology (AREA)
  • Microbiology (AREA)
  • Hematology (AREA)
  • Oncology (AREA)
  • Biochemistry (AREA)
  • Molecular Biology (AREA)
  • Peptides Or Proteins (AREA)
  • Enzymes And Modification Thereof (AREA)
  • Medicines Containing Antibodies Or Antigens For Use As Internal Diagnostic Agents (AREA)
  • Measuring Or Testing Involving Enzymes Or Micro-Organisms (AREA)
  • Micro-Organisms Or Cultivation Processes Thereof (AREA)
  • Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
  • Preparation Of Compounds By Using Micro-Organisms (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)

Abstract

The present invention provides novel members of the family of deubiquitinating enzymes (DUBs) as well as biologically, diagnostically or therapeutically useful fragments, derivatives, and homologues thereof, which are useful in research, biological, clinical, therapeutic as well as prognostic and diagnostic purposes. Furthermore, the polynucleotides and polypeptides provided by the present invention are useful for the treatment and diagnosis of breast cancer, leukemia or brain disorders.
PCT/EP2004/008798 2003-08-06 2004-08-05 Ubiquitin-specific protease WO2005014804A2 (en)

Priority Applications (6)

Application Number Priority Date Filing Date Title
MXPA06001393A MXPA06001393A (en) 2003-08-06 2004-08-05 Ubiquitin-specific protease.
AU2004262684A AU2004262684A1 (en) 2003-08-06 2004-08-05 Ubiquitin-specific protease
JP2006522322A JP2007501008A (en) 2003-08-06 2004-08-05 Ubiquitin-specific protease
CA002534481A CA2534481A1 (en) 2003-08-06 2004-08-05 Ubiquitin-specific protease
EP04741374A EP1651764A2 (en) 2003-08-06 2004-08-05 Ubiquitin-specific protease
BRPI0413364-1A BRPI0413364A (en) 2003-08-06 2004-08-05 ubiquitin-specific proteases

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
US49308003P 2003-08-06 2003-08-06
US60/493,080 2003-08-06

Publications (2)

Publication Number Publication Date
WO2005014804A2 WO2005014804A2 (en) 2005-02-17
WO2005014804A3 true WO2005014804A3 (en) 2005-06-30

Family

ID=34135200

Family Applications (1)

Application Number Title Priority Date Filing Date
PCT/EP2004/008798 WO2005014804A2 (en) 2003-08-06 2004-08-05 Ubiquitin-specific protease

Country Status (8)

Country Link
EP (1) EP1651764A2 (en)
JP (1) JP2007501008A (en)
CN (1) CN1845994A (en)
AU (1) AU2004262684A1 (en)
BR (1) BRPI0413364A (en)
CA (1) CA2534481A1 (en)
MX (1) MXPA06001393A (en)
WO (1) WO2005014804A2 (en)

Families Citing this family (5)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
EP2182073B1 (en) * 2008-10-30 2014-04-16 Les Laboratoires Servier Ubiquitin specific proteases responsible for MCL-1 stability and uses thereof
EP2558496B1 (en) 2010-04-15 2018-07-25 Genentech, Inc. Anti-polyubiquitin antibodies and methods of use
CN103205400B (en) * 2013-04-19 2014-09-17 青岛大学医学院附属医院 Recombinant lentiviral vector containing ubiquitin-specific protease gene USP39-shRNA (short hairpin ribonucleic acid) and application thereof
CN113454217A (en) * 2018-12-07 2021-09-28 奥科坦特公司 System for screening protein-protein interaction
CN117106911A (en) * 2023-08-14 2023-11-24 首都医科大学附属北京天坛医院 Gene set for detecting schwannoma and multiplex PCR-high flux sequencing detection kit thereof

Citations (2)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
WO2002000860A2 (en) * 2000-06-26 2002-01-03 Sugen, Inc. Novel proteases
JP2002300880A (en) * 2001-04-04 2002-10-15 Dai Ichi Seiyaku Co Ltd New ubiquitin-specific protease

Patent Citations (2)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
WO2002000860A2 (en) * 2000-06-26 2002-01-03 Sugen, Inc. Novel proteases
JP2002300880A (en) * 2001-04-04 2002-10-15 Dai Ichi Seiyaku Co Ltd New ubiquitin-specific protease

Non-Patent Citations (4)

* Cited by examiner, † Cited by third party
Title
DATABASE EMBL 10 April 2003 (2003-04-10), OHARA,O.: "JP2002300880-A.", XP002314211, retrieved from EBI Database accession no. BD177518 *
DATABASE EMBL 16 April 2003 (2003-04-16), OHARA,O. ET AL.: "JP2002300880-A/5 15-OCT-2002", XP002314212, retrieved from EBI Database accession no. BD581538 *
DATABASE GENESEQ 4 December 2003 (2003-12-04), "JP2002300880-A.", XP002314213, retrieved from EBI Database accession no. ADB68579 *
DATABASE WPI Section Ch Week 200344, Derwent World Patents Index; Class B04, AN 2003-460661, XP002314214 *

Also Published As

Publication number Publication date
JP2007501008A (en) 2007-01-25
MXPA06001393A (en) 2006-08-25
EP1651764A2 (en) 2006-05-03
CN1845994A (en) 2006-10-11
BRPI0413364A (en) 2006-10-17
WO2005014804A2 (en) 2005-02-17
CA2534481A1 (en) 2005-02-17
AU2004262684A1 (en) 2005-02-17

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