WO2005014804A3 - Ubiquitin-specific protease - Google Patents

Ubiquitin-specific protease Download PDF

Info

Publication number
WO2005014804A3
WO2005014804A3 PCT/EP2004/008798 EP2004008798W WO2005014804A3 WO 2005014804 A3 WO2005014804 A3 WO 2005014804A3 EP 2004008798 W EP2004008798 W EP 2004008798W WO 2005014804 A3 WO2005014804 A3 WO 2005014804A3
Authority
WO
WIPO (PCT)
Prior art keywords
useful
ubiquitin
well
specific protease
present
Prior art date
Application number
PCT/EP2004/008798
Other languages
French (fr)
Other versions
WO2005014804A2 (en
Inventor
Adrian Bruengger
Richard Lie Cai
Sophia Kossida
Benoit Pierrat
Nanguneri R Nirmala
Original Assignee
Novartis Ag
Novartis Pharma Gmbh
Adrian Bruengger
Richard Lie Cai
Sophia Kossida
Benoit Pierrat
Nanguneri R Nirmala
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Novartis Ag, Novartis Pharma Gmbh, Adrian Bruengger, Richard Lie Cai, Sophia Kossida, Benoit Pierrat, Nanguneri R Nirmala filed Critical Novartis Ag
Priority to JP2006522322A priority Critical patent/JP2007501008A/en
Priority to CA002534481A priority patent/CA2534481A1/en
Priority to EP04741374A priority patent/EP1651764A2/en
Priority to BRPI0413364-1A priority patent/BRPI0413364A/en
Priority to AU2004262684A priority patent/AU2004262684A1/en
Priority to MXPA06001393A priority patent/MXPA06001393A/en
Publication of WO2005014804A2 publication Critical patent/WO2005014804A2/en
Publication of WO2005014804A3 publication Critical patent/WO2005014804A3/en

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
    • C12N9/00—Enzymes; Proenzymes; Compositions thereof; Processes for preparing, activating, inhibiting, separating or purifying enzymes
    • C12N9/14—Hydrolases (3)
    • C12N9/48—Hydrolases (3) acting on peptide bonds (3.4)
    • C12N9/50—Proteinases, e.g. Endopeptidases (3.4.21-3.4.25)
    • C12N9/64—Proteinases, e.g. Endopeptidases (3.4.21-3.4.25) derived from animal tissue
    • C12N9/6421—Proteinases, e.g. Endopeptidases (3.4.21-3.4.25) derived from animal tissue from mammals
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P35/00—Antineoplastic agents
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P35/00—Antineoplastic agents
    • A61P35/02—Antineoplastic agents specific for leukemia

Landscapes

  • Health & Medical Sciences (AREA)
  • Chemical & Material Sciences (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Organic Chemistry (AREA)
  • Engineering & Computer Science (AREA)
  • General Health & Medical Sciences (AREA)
  • Medicinal Chemistry (AREA)
  • Biomedical Technology (AREA)
  • Genetics & Genomics (AREA)
  • Pharmacology & Pharmacy (AREA)
  • General Chemical & Material Sciences (AREA)
  • Animal Behavior & Ethology (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Public Health (AREA)
  • Veterinary Medicine (AREA)
  • Zoology (AREA)
  • Wood Science & Technology (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • General Engineering & Computer Science (AREA)
  • Biotechnology (AREA)
  • Microbiology (AREA)
  • Hematology (AREA)
  • Oncology (AREA)
  • Biochemistry (AREA)
  • Molecular Biology (AREA)
  • Peptides Or Proteins (AREA)
  • Enzymes And Modification Thereof (AREA)
  • Medicines Containing Antibodies Or Antigens For Use As Internal Diagnostic Agents (AREA)
  • Measuring Or Testing Involving Enzymes Or Micro-Organisms (AREA)
  • Micro-Organisms Or Cultivation Processes Thereof (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Preparation Of Compounds By Using Micro-Organisms (AREA)
  • Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)

Abstract

The present invention provides novel members of the family of deubiquitinating enzymes (DUBs) as well as biologically, diagnostically or therapeutically useful fragments, derivatives, and homologues thereof, which are useful in research, biological, clinical, therapeutic as well as prognostic and diagnostic purposes. Furthermore, the polynucleotides and polypeptides provided by the present invention are useful for the treatment and diagnosis of breast cancer, leukemia or brain disorders.
PCT/EP2004/008798 2003-08-06 2004-08-05 Ubiquitin-specific protease WO2005014804A2 (en)

Priority Applications (6)

Application Number Priority Date Filing Date Title
JP2006522322A JP2007501008A (en) 2003-08-06 2004-08-05 Ubiquitin-specific protease
CA002534481A CA2534481A1 (en) 2003-08-06 2004-08-05 Ubiquitin-specific protease
EP04741374A EP1651764A2 (en) 2003-08-06 2004-08-05 Ubiquitin-specific protease
BRPI0413364-1A BRPI0413364A (en) 2003-08-06 2004-08-05 ubiquitin-specific proteases
AU2004262684A AU2004262684A1 (en) 2003-08-06 2004-08-05 Ubiquitin-specific protease
MXPA06001393A MXPA06001393A (en) 2003-08-06 2004-08-05 Ubiquitin-specific protease.

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
US49308003P 2003-08-06 2003-08-06
US60/493,080 2003-08-06

Publications (2)

Publication Number Publication Date
WO2005014804A2 WO2005014804A2 (en) 2005-02-17
WO2005014804A3 true WO2005014804A3 (en) 2005-06-30

Family

ID=34135200

Family Applications (1)

Application Number Title Priority Date Filing Date
PCT/EP2004/008798 WO2005014804A2 (en) 2003-08-06 2004-08-05 Ubiquitin-specific protease

Country Status (8)

Country Link
EP (1) EP1651764A2 (en)
JP (1) JP2007501008A (en)
CN (1) CN1845994A (en)
AU (1) AU2004262684A1 (en)
BR (1) BRPI0413364A (en)
CA (1) CA2534481A1 (en)
MX (1) MXPA06001393A (en)
WO (1) WO2005014804A2 (en)

Families Citing this family (5)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
ES2481450T3 (en) * 2008-10-30 2014-07-30 Les Laboratoires Servier Ubiquitin specific proteases responsible for the stability of mcl 1 and its use
US8992919B2 (en) * 2010-04-15 2015-03-31 Genentech, Inc. Anti-polyubiquitin antibodies and methods of use
CN103205400B (en) * 2013-04-19 2014-09-17 青岛大学医学院附属医院 Recombinant lentiviral vector containing ubiquitin-specific protease gene USP39-shRNA (short hairpin ribonucleic acid) and application thereof
AU2019392906A1 (en) * 2018-12-07 2021-07-22 Octant, Inc. Systems for protein-protein interaction screening
CN117106911A (en) * 2023-08-14 2023-11-24 首都医科大学附属北京天坛医院 Gene set for detecting schwannoma and multiplex PCR-high flux sequencing detection kit thereof

Citations (2)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
WO2002000860A2 (en) * 2000-06-26 2002-01-03 Sugen, Inc. Novel proteases
JP2002300880A (en) * 2001-04-04 2002-10-15 Dai Ichi Seiyaku Co Ltd New ubiquitin-specific protease

Patent Citations (2)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
WO2002000860A2 (en) * 2000-06-26 2002-01-03 Sugen, Inc. Novel proteases
JP2002300880A (en) * 2001-04-04 2002-10-15 Dai Ichi Seiyaku Co Ltd New ubiquitin-specific protease

Non-Patent Citations (4)

* Cited by examiner, † Cited by third party
Title
DATABASE EMBL 10 April 2003 (2003-04-10), OHARA,O.: "JP2002300880-A.", XP002314211, retrieved from EBI Database accession no. BD177518 *
DATABASE EMBL 16 April 2003 (2003-04-16), OHARA,O. ET AL.: "JP2002300880-A/5 15-OCT-2002", XP002314212, retrieved from EBI Database accession no. BD581538 *
DATABASE GENESEQ 4 December 2003 (2003-12-04), "JP2002300880-A.", XP002314213, retrieved from EBI Database accession no. ADB68579 *
DATABASE WPI Section Ch Week 200344, Derwent World Patents Index; Class B04, AN 2003-460661, XP002314214 *

Also Published As

Publication number Publication date
CN1845994A (en) 2006-10-11
AU2004262684A1 (en) 2005-02-17
MXPA06001393A (en) 2006-08-25
JP2007501008A (en) 2007-01-25
BRPI0413364A (en) 2006-10-17
WO2005014804A2 (en) 2005-02-17
CA2534481A1 (en) 2005-02-17
EP1651764A2 (en) 2006-05-03

Similar Documents

Publication Publication Date Title
WO2004092405A3 (en) Juvenile hemochromatosis gene (hfe2a), expression products and uses thereof
WO2003029421A3 (en) Regulated breast cancer genes
WO2005014035A3 (en) Use of galactose oxidase for selective chemical conjugation of protractor molecules to proteins of therapeutic interest
WO2004046342A3 (en) Novel gene targets and ligands that bind thereto for treatment and diagnosis of carcinomas
MXPA02011656A (en) Nrg 2 nucleic acid molecules, polypeptides, and diagnostic and therapeutic methods.
WO1997025426A3 (en) Compositions and methods for the treatment and diagnosis of breast cancer
WO2003025121A3 (en) Igf-binding protein-derived peptide or small molecule
WO1998045328A3 (en) Compositions and methods for the treatment and diagnosis of breast cancer
WO2005040421A3 (en) Prognostic and diagnostic markers for cell proliferative disorders of the breast tissues
AU2002251366A1 (en) Proteins, genes and their use for diagnosis and treatment of breast cancer
WO2001071357A3 (en) Diagnosis and treatment of breast cancer
WO2002064839A3 (en) Methods for the diagnosis and treatment of tumors employing the hepsin gene
WO2004076614A3 (en) Human nucleic acid sequences obtained from prostatic carcinomas
WO2003063773A3 (en) Differentially-regulated prostate cancer genes
WO2005014804A3 (en) Ubiquitin-specific protease
WO2003031572A3 (en) Therapeutic polypeptides, nucleic acids encoding same, and methods of use
WO2002064741A3 (en) Compositions and methods relating to breast specific genes and proteins
WO2002081638A3 (en) Prostate cancer expression profiles
WO2004003166A3 (en) Antibodies and uses thereof
MXPA01010186A (en) Compositions and methods for the treatment and diagnosis of breast cancer.
WO2003076578A3 (en) Therapeutic polypeptides, nucleic acids encoding same, and methods of use
WO2004005540A3 (en) Uses of ngal-binding substances in the diagnosis and treatment of cancer diseases
WO2005023979A3 (en) Isolated s. mansoni nucleic acid molecules and uses thereof
WO2004074514A3 (en) Method of diagnosis of type 2 diabetes and early onset thereof
WO2002090991A3 (en) Proteins and genes for diagnosis and treatment of erbb2-related cancer

Legal Events

Date Code Title Description
WWE Wipo information: entry into national phase

Ref document number: 200480025654.4

Country of ref document: CN

AK Designated states

Kind code of ref document: A2

Designated state(s): AE AG AL AM AT AU AZ BA BB BG BR BW BY BZ CA CH CN CO CR CU CZ DE DK DM DZ EC EE EG ES FI GB GD GE GH GM HR HU ID IL IN IS JP KE KG KP KR KZ LC LK LR LS LT LU LV MA MD MG MK MN MW MX MZ NA NI NO NZ OM PG PH PL PT RO RU SC SD SE SG SK SL SY TJ TM TN TR TT TZ UA UG US UZ VC VN YU ZA ZM ZW

AL Designated countries for regional patents

Kind code of ref document: A2

Designated state(s): BW GH GM KE LS MW MZ NA SD SL SZ TZ UG ZM ZW AM AZ BY KG KZ MD RU TJ TM AT BE BG CH CY CZ DE DK EE ES FI FR GB GR HU IE IT LU MC NL PL PT RO SE SI SK TR BF BJ CF CG CI CM GA GN GQ GW ML MR NE SN TD TG

121 Ep: the epo has been informed by wipo that ep was designated in this application
WWE Wipo information: entry into national phase

Ref document number: 2004741374

Country of ref document: EP

WWE Wipo information: entry into national phase

Ref document number: 2004262684

Country of ref document: AU

ENP Entry into the national phase

Ref document number: 2534481

Country of ref document: CA

WWE Wipo information: entry into national phase

Ref document number: PA/a/2006/001393

Country of ref document: MX

Ref document number: 455/CHENP/2006

Country of ref document: IN

WWE Wipo information: entry into national phase

Ref document number: 2006522322

Country of ref document: JP

ENP Entry into the national phase

Ref document number: 2004262684

Country of ref document: AU

Date of ref document: 20040805

Kind code of ref document: A

WWP Wipo information: published in national office

Ref document number: 2004262684

Country of ref document: AU

WWP Wipo information: published in national office

Ref document number: 2004741374

Country of ref document: EP

ENP Entry into the national phase

Ref document number: PI0413364

Country of ref document: BR

WWW Wipo information: withdrawn in national office

Ref document number: 2004741374

Country of ref document: EP