AU2001251138A1 - Compositions and methods for tissue specific gene regulation therapy - Google Patents

Compositions and methods for tissue specific gene regulation therapy

Info

Publication number
AU2001251138A1
AU2001251138A1 AU2001251138A AU5113801A AU2001251138A1 AU 2001251138 A1 AU2001251138 A1 AU 2001251138A1 AU 2001251138 A AU2001251138 A AU 2001251138A AU 5113801 A AU5113801 A AU 5113801A AU 2001251138 A1 AU2001251138 A1 AU 2001251138A1
Authority
AU
Australia
Prior art keywords
compositions
methods
specific gene
tissue specific
gene regulation
Prior art date
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Abandoned
Application number
AU2001251138A
Inventor
Andrew Bateman
Kevin Harrington
Stephen Murphy
Richard G. Vile
Current Assignee (The listed assignees may be inaccurate. Google has not performed a legal analysis and makes no representation or warranty as to the accuracy of the list.)
Mayo Foundation for Medical Education and Research
Original Assignee
Mayo Foundation for Medical Education and Research
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Mayo Foundation for Medical Education and Research filed Critical Mayo Foundation for Medical Education and Research
Publication of AU2001251138A1 publication Critical patent/AU2001251138A1/en
Abandoned legal-status Critical Current

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
    • C12N15/00—Mutation or genetic engineering; DNA or RNA concerning genetic engineering, vectors, e.g. plasmids, or their isolation, preparation or purification; Use of hosts therefor
    • C12N15/09—Recombinant DNA-technology
    • C12N15/63—Introduction of foreign genetic material using vectors; Vectors; Use of hosts therefor; Regulation of expression
    • C12N15/79—Vectors or expression systems specially adapted for eukaryotic hosts
    • C12N15/85—Vectors or expression systems specially adapted for eukaryotic hosts for animal cells
    • C12N15/86—Viral vectors
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K48/00—Medicinal preparations containing genetic material which is inserted into cells of the living body to treat genetic diseases; Gene therapy
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K48/00—Medicinal preparations containing genetic material which is inserted into cells of the living body to treat genetic diseases; Gene therapy
    • A61K48/005—Medicinal preparations containing genetic material which is inserted into cells of the living body to treat genetic diseases; Gene therapy characterised by an aspect of the 'active' part of the composition delivered, i.e. the nucleic acid delivered
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P35/00—Antineoplastic agents
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K39/00—Medicinal preparations containing antigens or antibodies
    • A61K2039/51—Medicinal preparations containing antigens or antibodies comprising whole cells, viruses or DNA/RNA
    • A61K2039/515—Animal cells
    • A61K2039/5152—Tumor cells
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K39/00—Medicinal preparations containing antigens or antibodies
    • A61K2039/51—Medicinal preparations containing antigens or antibodies comprising whole cells, viruses or DNA/RNA
    • A61K2039/515—Animal cells
    • A61K2039/5154—Antigen presenting cells [APCs], e.g. dendritic cells or macrophages
    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
    • C12N2740/00—Reverse transcribing RNA viruses
    • C12N2740/00011—Details
    • C12N2740/10011—Retroviridae
    • C12N2740/16011—Human Immunodeficiency Virus, HIV
    • C12N2740/16041—Use of virus, viral particle or viral elements as a vector
    • C12N2740/16043—Use of virus, viral particle or viral elements as a vector viral genome or elements thereof as genetic vector
    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
    • C12N2800/00—Nucleic acids vectors
    • C12N2800/30—Vector systems comprising sequences for excision in presence of a recombinase, e.g. loxP or FRT
    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
    • C12N2830/00—Vector systems having a special element relevant for transcription
    • C12N2830/008—Vector systems having a special element relevant for transcription cell type or tissue specific enhancer/promoter combination
    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
    • C12N2830/00—Vector systems having a special element relevant for transcription
    • C12N2830/80—Vector systems having a special element relevant for transcription from vertebrates
    • C12N2830/85—Vector systems having a special element relevant for transcription from vertebrates mammalian
    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
    • C12N2840/00—Vectors comprising a special translation-regulating system
    • C12N2840/20—Vectors comprising a special translation-regulating system translation of more than one cistron
    • C12N2840/203—Vectors comprising a special translation-regulating system translation of more than one cistron having an IRES
AU2001251138A 2000-03-31 2001-03-30 Compositions and methods for tissue specific gene regulation therapy Abandoned AU2001251138A1 (en)

Applications Claiming Priority (3)

Application Number Priority Date Filing Date Title
US19397700P 2000-03-31 2000-03-31
US60/193,977 2000-03-31
PCT/US2001/010250 WO2001074861A2 (en) 2000-03-31 2001-03-30 Compositions and methods for tissue specific gene regulation therapy

Publications (1)

Publication Number Publication Date
AU2001251138A1 true AU2001251138A1 (en) 2001-10-15

Family

ID=22715820

Family Applications (1)

Application Number Title Priority Date Filing Date
AU2001251138A Abandoned AU2001251138A1 (en) 2000-03-31 2001-03-30 Compositions and methods for tissue specific gene regulation therapy

Country Status (3)

Country Link
US (1) US20020150556A1 (en)
AU (1) AU2001251138A1 (en)
WO (1) WO2001074861A2 (en)

Families Citing this family (10)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US20020187543A1 (en) * 2001-04-05 2002-12-12 Curiel David T. Enhanced dispersion of adenoviral vectors by fusogenic membrane glycoproteins
US20040009604A1 (en) * 2002-03-27 2004-01-15 Xiaoliu Zhang Potent oncolytic herpes simplex virus for cancer therapy
GB0415963D0 (en) * 2004-07-16 2004-08-18 Cxr Biosciences Ltd Detection of cellular stress
WO2016154299A1 (en) * 2015-03-24 2016-09-29 The Trustees Of Columbia University In The City Of New York Genetic modification of pigs for xenotransplantation
US11185555B2 (en) 2016-04-11 2021-11-30 Noah James Harrison Method to kill pathogenic microbes in a patient
EP3235908A1 (en) 2016-04-21 2017-10-25 Ecole Normale Superieure De Lyon Methods for selectively modulating the activity of distinct subtypes of cells
BR112019023323A2 (en) 2017-05-08 2020-07-21 Flagship Pioneering Innovations V, Inc. compositions to facilitate membrane fusion and uses thereof
CN109381701A (en) * 2017-08-11 2019-02-26 复旦大学 Promotion sensitivity gene JCAD and its as target spot preparation treatment liver cancer drug in purposes
BR112021000145A2 (en) * 2018-07-09 2021-04-06 Flagship Pioneering Innovations V, Inc FUSOSOME COMPOSITIONS AND USES OF THE SAME
AU2022253020A1 (en) 2021-04-08 2023-10-26 Shirisha AMATYA Cd8-specific antibody constructs and compositions thereof

Family Cites Families (3)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
JP4422804B2 (en) * 1997-03-11 2010-02-24 メイヨー・ファウンデーション・フォー・メディカル・エデュケーション・アンド・リサーチ Compositions and methods for eliminating unwanted cells
DE19834430C2 (en) * 1998-07-30 2000-05-31 Harald Von Melchner Self-deleting vectors for cancer therapy
GB9825429D0 (en) * 1998-11-20 1999-01-13 Medical Res Council Fusion hybrids expressing fusogenic membrane glycoproteins

Also Published As

Publication number Publication date
US20020150556A1 (en) 2002-10-17
WO2001074861A9 (en) 2002-12-27
WO2001074861A3 (en) 2002-03-14
WO2001074861A2 (en) 2001-10-11

Similar Documents

Publication Publication Date Title
AU2002332020A1 (en) Compositions for oral gene therapy and methods of using same
AU4193700A (en) Antisense oligonucleotide compositions and methods for the modulation of jnk proteins
AU2003200740A1 (en) Compositions and methods for the treatment of tumor
AU2003200731A1 (en) Compositions and methods for the treatment of tumor
AU2003200722A1 (en) Compositions and methods for the treatment of tumor
AU2495200A (en) Compositions and methods for the treatment of tumor
AU2001260847A1 (en) Compositions isolated from skin cells and methods for their use
AU2001245987A1 (en) Compositions and methods for gene therapy
AU2002223593A1 (en) Regulation of human sphingosine kinase-like protein
AU2001251138A1 (en) Compositions and methods for tissue specific gene regulation therapy
AU1723001A (en) Methods and means for regulation of gene expression
AU6094200A (en) Nor gene compositions and methods for use thereof
AU2001269077A1 (en) Methods and means for regulation of gene expression
AU2001255730A1 (en) Methods and compositions for the treatment of cardiac indications
AU2000231423A1 (en) Specific therapeutic composition for treating aids
AU2001253528A1 (en) Methods and compositions for culturing spirochetes and treating spirochetal diseases
AU2001281950A1 (en) Regulation of human thimet oligopeptidase-like enzyme
AU2001253469A1 (en) Compositions and methods for stabilizing modified tissue
AU2001274080A1 (en) Regulation of human transketolase-like enzyme
AU2002231620A1 (en) Regulation of human patched-like protein
AU2002215956A1 (en) Regulation of human pgc-1-like protein
AU2002210525A1 (en) Regulation of human phospholipase-like enzyme
AU2001285782A1 (en) Regulation of human phosphodiesterase-like enzyme
AU2002215942A1 (en) Regulation of human carboxylesterase-like enzyme
AU2001281969A1 (en) Regulation of human carboxylesterase-like enzyme