AU2001248301A1 - Lipid-based drug delivery systems containing phospholipase a2 degradable lipid derivatives for topical application to the skin - Google Patents

Lipid-based drug delivery systems containing phospholipase a2 degradable lipid derivatives for topical application to the skin

Info

Publication number
AU2001248301A1
AU2001248301A1 AU2001248301A AU4830101A AU2001248301A1 AU 2001248301 A1 AU2001248301 A1 AU 2001248301A1 AU 2001248301 A AU2001248301 A AU 2001248301A AU 4830101 A AU4830101 A AU 4830101A AU 2001248301 A1 AU2001248301 A1 AU 2001248301A1
Authority
AU
Australia
Prior art keywords
lipid
skin
drug delivery
delivery systems
topical application
Prior art date
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Abandoned
Application number
AU2001248301A
Inventor
Jesper Davidsen
Sven Frokjaer
Kent Jorgensen
Ole G. Mouritsen
Charlotte Vermehren
Current Assignee (The listed assignees may be inaccurate. Google has not performed a legal analysis and makes no representation or warranty as to the accuracy of the list.)
Liplasome Pharma ApS
Original Assignee
Liplasome Pharma ApS
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Liplasome Pharma ApS filed Critical Liplasome Pharma ApS
Publication of AU2001248301A1 publication Critical patent/AU2001248301A1/en
Abandoned legal-status Critical Current

Links

Classifications

    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K9/00—Medicinal preparations characterised by special physical form
    • A61K9/10—Dispersions; Emulsions
    • A61K9/107—Emulsions ; Emulsion preconcentrates; Micelles
    • A61K9/1075—Microemulsions or submicron emulsions; Preconcentrates or solids thereof; Micelles, e.g. made of phospholipids or block copolymers
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K9/00—Medicinal preparations characterised by special physical form
    • A61K9/10—Dispersions; Emulsions
    • A61K9/127—Liposomes
    • A61K9/1271—Non-conventional liposomes, e.g. PEGylated liposomes, liposomes coated with polymers
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K9/00—Medicinal preparations characterised by special physical form
    • A61K9/10—Dispersions; Emulsions
    • A61K9/127—Liposomes
    • A61K9/1271—Non-conventional liposomes, e.g. PEGylated liposomes, liposomes coated with polymers
    • A61K9/1272—Non-conventional liposomes, e.g. PEGylated liposomes, liposomes coated with polymers with substantial amounts of non-phosphatidyl, i.e. non-acylglycerophosphate, surfactants as bilayer-forming substances, e.g. cationic lipids
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P17/00—Drugs for dermatological disorders
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P17/00—Drugs for dermatological disorders
    • A61P17/04—Antipruritics
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P17/00—Drugs for dermatological disorders
    • A61P17/06—Antipsoriatics
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P17/00—Drugs for dermatological disorders
    • A61P17/14—Drugs for dermatological disorders for baldness or alopecia
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P29/00—Non-central analgesic, antipyretic or antiinflammatory agents, e.g. antirheumatic agents; Non-steroidal antiinflammatory drugs [NSAID]
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P33/00—Antiparasitic agents
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P33/00—Antiparasitic agents
    • A61P33/02—Antiprotozoals, e.g. for leishmaniasis, trichomoniasis, toxoplasmosis
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P33/00—Antiparasitic agents
    • A61P33/02—Antiprotozoals, e.g. for leishmaniasis, trichomoniasis, toxoplasmosis
    • A61P33/04—Amoebicides
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P33/00—Antiparasitic agents
    • A61P33/02—Antiprotozoals, e.g. for leishmaniasis, trichomoniasis, toxoplasmosis
    • A61P33/06—Antimalarials
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P35/00—Antineoplastic agents
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P37/00—Drugs for immunological or allergic disorders
    • A61P37/08—Antiallergic agents
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P43/00—Drugs for specific purposes, not provided for in groups A61P1/00-A61P41/00
    • Y—GENERAL TAGGING OF NEW TECHNOLOGICAL DEVELOPMENTS; GENERAL TAGGING OF CROSS-SECTIONAL TECHNOLOGIES SPANNING OVER SEVERAL SECTIONS OF THE IPC; TECHNICAL SUBJECTS COVERED BY FORMER USPC CROSS-REFERENCE ART COLLECTIONS [XRACs] AND DIGESTS
    • Y02—TECHNOLOGIES OR APPLICATIONS FOR MITIGATION OR ADAPTATION AGAINST CLIMATE CHANGE
    • Y02A—TECHNOLOGIES FOR ADAPTATION TO CLIMATE CHANGE
    • Y02A50/00—TECHNOLOGIES FOR ADAPTATION TO CLIMATE CHANGE in human health protection, e.g. against extreme weather
    • Y02A50/30—Against vector-borne diseases, e.g. mosquito-borne, fly-borne, tick-borne or waterborne diseases whose impact is exacerbated by climate change

Landscapes

  • Health & Medical Sciences (AREA)
  • Chemical & Material Sciences (AREA)
  • Veterinary Medicine (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Public Health (AREA)
  • General Health & Medical Sciences (AREA)
  • Medicinal Chemistry (AREA)
  • Animal Behavior & Ethology (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Organic Chemistry (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • General Chemical & Material Sciences (AREA)
  • Dispersion Chemistry (AREA)
  • Engineering & Computer Science (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Epidemiology (AREA)
  • Tropical Medicine & Parasitology (AREA)
  • Dermatology (AREA)
  • Biophysics (AREA)
  • Molecular Biology (AREA)
  • Rheumatology (AREA)
  • Pain & Pain Management (AREA)
  • Immunology (AREA)
  • Pulmonology (AREA)
  • Medicinal Preparation (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Medicines Containing Antibodies Or Antigens For Use As Internal Diagnostic Agents (AREA)
  • Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
  • Acyclic And Carbocyclic Compounds In Medicinal Compositions (AREA)
  • Cosmetics (AREA)
  • Ultra Sonic Daignosis Equipment (AREA)
  • Magnetic Resonance Imaging Apparatus (AREA)
  • Infusion, Injection, And Reservoir Apparatuses (AREA)

Abstract

The invention relates to targeting of diagnostic agents by use of lipid-based compositions. The invention is useful in the diagnosis of various disorders which are associated with or resulting from increased levels of extracellular PLA<SUB>2 </SUB>activity in the diseased tissue, e.g. cancer, infectious, and inflammatory conditions.
AU2001248301A 2000-04-12 2001-04-11 Lipid-based drug delivery systems containing phospholipase a2 degradable lipid derivatives for topical application to the skin Abandoned AU2001248301A1 (en)

Applications Claiming Priority (3)

Application Number Priority Date Filing Date Title
DKPA200000616 2000-04-12
DKPA200000616 2000-04-12
PCT/DK2001/000267 WO2001076555A2 (en) 2000-04-12 2001-04-11 Lipid-based drug delivery systems for topical application

Publications (1)

Publication Number Publication Date
AU2001248301A1 true AU2001248301A1 (en) 2001-10-23

Family

ID=8159422

Family Applications (3)

Application Number Title Priority Date Filing Date
AU2001248301A Abandoned AU2001248301A1 (en) 2000-04-12 2001-04-11 Lipid-based drug delivery systems containing phospholipase a2 degradable lipid derivatives for topical application to the skin
AU2001248303A Abandoned AU2001248303A1 (en) 2000-04-12 2001-04-11 Lipid-based systems for targeting diagnostic agents
AU2001248302A Abandoned AU2001248302A1 (en) 2000-04-12 2001-04-11 Lipid-based drug delivery systems against parasitic infections

Family Applications After (2)

Application Number Title Priority Date Filing Date
AU2001248303A Abandoned AU2001248303A1 (en) 2000-04-12 2001-04-11 Lipid-based systems for targeting diagnostic agents
AU2001248302A Abandoned AU2001248302A1 (en) 2000-04-12 2001-04-11 Lipid-based drug delivery systems against parasitic infections

Country Status (11)

Country Link
US (4) US7166297B2 (en)
EP (3) EP1272160B1 (en)
JP (3) JP2003530338A (en)
AT (2) ATE382333T1 (en)
AU (3) AU2001248301A1 (en)
CY (2) CY1105792T1 (en)
DE (3) DE60126072T2 (en)
DK (3) DK1272160T3 (en)
ES (3) ES2270991T3 (en)
PT (3) PT1272160E (en)
WO (3) WO2001076556A2 (en)

Families Citing this family (26)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US20020001614A1 (en) * 2000-02-10 2002-01-03 Kent Jorgensen Lipid-based drug delivery systems containing phospholipase A2 degradable lipid derivatives and the therapeutic uses thereof
EP1391207A1 (en) * 2001-04-24 2004-02-25 Luis Alberto Costa Use of a phospholipase a2 for the preparation of pharmaceutical and/or cosmetic compositions for the local and/or systematic treatment and/or prevention of diseases and/or processes caused by intra- and extracellular pathogens expressing membrane phospholipids
US20050123925A1 (en) * 2002-11-15 2005-06-09 Genentech, Inc. Compositions and methods for the diagnosis and treatment of tumor
CA2530224A1 (en) * 2003-07-09 2005-02-24 California Pacific Medical Center Remote detection of substance delivery to cells
US20050266066A1 (en) * 2003-10-20 2005-12-01 Nof Corporation Phospholipid membrane preparation
WO2005077963A1 (en) * 2004-01-16 2005-08-25 Institut Superieur Agricole De Beauvais Saccharide and itol derivatives having an o-alkyl group or an o-alkyl group and an o-n butanyl group, uses as medicines in tumoral or benign proliferative pathologies
EP1710574A4 (en) * 2004-01-28 2008-09-17 Ltt Bio Pharma Co Ltd Method of screening compound safe to gastric mucosa
DE102004010387A1 (en) * 2004-03-03 2005-09-22 Siemens Ag Contrast agent for X-ray computed tomography
WO2006086992A2 (en) * 2005-02-18 2006-08-24 Liplasome Pharma A/S Drug delivery systems containing phqspholipase a2 degradable lipid prodrug derivatives and the therapeutic uses thereof as. e.g. wound healing agents and peroxisome proliferator activated receptor ligands
JP2006248978A (en) * 2005-03-10 2006-09-21 Mebiopharm Co Ltd New liposome preparation
US20090110633A1 (en) * 2005-03-14 2009-04-30 Shiladitya Sengupta Nanocells for Diagnosis and Treatment of Diseases and Disorders
PT1933809E (en) * 2005-10-11 2012-04-26 Yissum Res Dev Co Compositions for nasal delivery
AU2006328957C1 (en) * 2005-12-23 2013-01-10 Jado Technologies Gmbh Means and methods for the treatment and prevention of allergic diseases
JP2011026294A (en) * 2009-06-26 2011-02-10 Canon Inc Compound
US8993715B2 (en) * 2009-07-06 2015-03-31 Canon Kabushiki Kaisha Labeled protein and method for obtaining the same
JP2013502436A (en) 2009-08-21 2013-01-24 ターゲッティド デリバリー テクノロジーズ リミテッド Vesicular preparation
DK177532B1 (en) 2009-09-17 2013-09-08 Bio Bedst Aps Medical use of sPLA2 hydrolysable liposomes
DK177529B1 (en) * 2009-10-23 2013-09-08 Bio Bedst Aps Liposomes with improved storage stability
WO2011102906A1 (en) * 2010-02-19 2011-08-25 Robert Shorr Imageable lipid-oil-water nanoemulsion delivery system
WO2011102905A1 (en) * 2010-02-19 2011-08-25 Robert Shorr Imageable lipid-oil-water nanoemulsion diagnostic delivery system
WO2011102904A1 (en) * 2010-02-19 2011-08-25 Robert Shorr Imageable lipid-oil-water nanoemulsion therapeutic delivery system
WO2013131164A1 (en) * 2012-03-09 2013-09-12 Universidade Federal De Minas Gerais - Ufmg Pharmaceutical composition containing conventional liposomes and prolonged-circulation liposomes for the treatment of visceral leishmaniasis
GB201205642D0 (en) 2012-03-29 2012-05-16 Sequessome Technology Holdings Ltd Vesicular formulations
WO2014047116A1 (en) * 2012-09-18 2014-03-27 Comfort Care For Animals Llc Encapsulating liposomes
WO2017001617A1 (en) 2015-06-30 2017-01-05 Sequessome Technology Holdings Limited Blended formulations
JP2020500020A (en) 2016-11-14 2020-01-09 ノバルティス アーゲー Compositions, methods, and therapeutic uses related to the fusogenic protein MINION

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Also Published As

Publication number Publication date
US20070134153A1 (en) 2007-06-14
DE60126072D1 (en) 2007-03-08
DK1272161T3 (en) 2008-05-19
AU2001248302A1 (en) 2001-10-23
JP2003530339A (en) 2003-10-14
JP2003530338A (en) 2003-10-14
EP1272225B1 (en) 2006-08-16
ES2280355T3 (en) 2007-09-16
DE60122304T2 (en) 2007-08-09
ATE382333T1 (en) 2008-01-15
ES2295149T3 (en) 2008-04-16
US7368254B2 (en) 2008-05-06
CY1106462T1 (en) 2012-01-25
ES2270991T3 (en) 2007-04-16
US7166297B2 (en) 2007-01-23
WO2001076555A2 (en) 2001-10-18
WO2001076556A2 (en) 2001-10-18
EP1272161A2 (en) 2003-01-08
WO2001076556A3 (en) 2002-07-11
ATE336267T1 (en) 2006-09-15
DE60126072T2 (en) 2007-11-08
DK1272225T3 (en) 2006-12-27
PT1272225E (en) 2007-01-31
AU2001248303A1 (en) 2001-10-23
DE60122304D1 (en) 2006-09-28
JP2003530362A (en) 2003-10-14
DK1272160T3 (en) 2007-05-21
EP1272160A2 (en) 2003-01-08
US20030170297A1 (en) 2003-09-11
DE60132184D1 (en) 2008-02-14
PT1272161E (en) 2008-02-08
WO2001076644A2 (en) 2001-10-18
EP1272160B1 (en) 2007-01-17
US20030175205A1 (en) 2003-09-18
EP1272161B1 (en) 2008-01-02
EP1272225A2 (en) 2003-01-08
CY1105792T1 (en) 2011-02-02
DE60132184T2 (en) 2009-01-15
PT1272160E (en) 2007-04-30
WO2001076644A3 (en) 2002-03-14
WO2001076555A3 (en) 2002-03-14
US20030162748A1 (en) 2003-08-28

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