AU2001245849A1 - Structural modification of 19-norprogesterone i: 17-alpha-substituted-11-beta-substituted-4-aryl and 21-substituted 19-norpregnadienedione as new antiprogestational agents - Google Patents
Structural modification of 19-norprogesterone i: 17-alpha-substituted-11-beta-substituted-4-aryl and 21-substituted 19-norpregnadienedione as new antiprogestational agentsInfo
- Publication number
- AU2001245849A1 AU2001245849A1 AU2001245849A AU2001245849A AU2001245849A1 AU 2001245849 A1 AU2001245849 A1 AU 2001245849A1 AU 2001245849 A AU2001245849 A AU 2001245849A AU 2001245849 A AU2001245849 A AU 2001245849A AU 2001245849 A1 AU2001245849 A1 AU 2001245849A1
- Authority
- AU
- Australia
- Prior art keywords
- substituted
- norpregnadienedione
- norprogesterone
- beta
- aryl
- Prior art date
- Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
- Granted
Links
- NVUUMOOKVFONOM-GPBSYSOESA-N 19-Norprogesterone Chemical compound C1CC2=CC(=O)CC[C@@H]2[C@@H]2[C@@H]1[C@@H]1CC[C@H](C(=O)C)[C@@]1(C)CC2 NVUUMOOKVFONOM-GPBSYSOESA-N 0.000 title 1
- 230000001911 anti-progestational Effects 0.000 title 1
- 230000004048 modification Effects 0.000 title 1
- 238000006011 modification reaction Methods 0.000 title 1
Applications Claiming Priority (3)
Application Number | Priority Date | Filing Date | Title |
---|---|---|---|
US09/526,855 | 2000-03-17 | ||
US09/526,855 US6900193B1 (en) | 1996-05-01 | 2000-03-17 | Structural modification of 19-norprogesterone I: 17-α-substituted-11-β-substituted-4-aryl and 21-substituted 19-norpregnadienedione as new antiprogestational agents |
PCT/US2001/008681 WO2001074840A2 (en) | 2000-03-17 | 2001-03-16 | 17-alpha-substituted-11-beta-substituted-4-aryl and 21-substituted 19-norpregna 21-substituted 19-norpregnadienedione as antiprogestational agents |
Publications (2)
Publication Number | Publication Date |
---|---|
AU2001245849A1 true AU2001245849A1 (en) | 2002-01-03 |
AU2001245849B2 AU2001245849B2 (en) | 2007-01-04 |
Family
ID=24099075
Family Applications (2)
Application Number | Title | Priority Date | Filing Date |
---|---|---|---|
AU4584901A Pending AU4584901A (en) | 2000-03-17 | 2001-03-16 | Structural modification of 19-norprogesterone i: 17-alpha-substituted-11-beta-substituted-4-aryl and 21-substituted 19-norpregnadienedione as new antiprogestational agents |
AU2001245849A Expired AU2001245849B2 (en) | 2000-03-17 | 2001-03-16 | Structural modification of 19-norprogesterone i: 17-alpha-substituted-11-beta-substituted-4-aryl and 21-substituted 19-norpregnadienedione as new antiprogestational agents |
Family Applications Before (1)
Application Number | Title | Priority Date | Filing Date |
---|---|---|---|
AU4584901A Pending AU4584901A (en) | 2000-03-17 | 2001-03-16 | Structural modification of 19-norprogesterone i: 17-alpha-substituted-11-beta-substituted-4-aryl and 21-substituted 19-norpregnadienedione as new antiprogestational agents |
Country Status (11)
Country | Link |
---|---|
EP (4) | EP2348031B9 (en) |
JP (2) | JP5417562B2 (en) |
AT (1) | ATE396197T1 (en) |
AU (2) | AU4584901A (en) |
CA (1) | CA2403756C (en) |
CY (1) | CY1108281T1 (en) |
DE (1) | DE60134126D1 (en) |
DK (1) | DK1265911T3 (en) |
ES (3) | ES2546291T3 (en) |
PT (1) | PT1265911E (en) |
WO (1) | WO2001074840A2 (en) |
Families Citing this family (23)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
EP2348031B9 (en) * | 2000-03-17 | 2016-08-10 | The Government of the United States of America as represented by the Secretary of the Department of Health and Human Services | 17-Alpha-substituted-11-beta-substituted-4-aryl and 21-substituted 19-norpregnadienediones as antiprogestational agents |
ES2212912B1 (en) * | 2003-01-22 | 2005-10-01 | Crystal Pharma, S.A. | PROCEDURE FOR OBTAINING 17ALFA-ACETOXI-11BETA- (4-N, N-DIMETHYLAMINEPHENYL) -19-NORPREGNA-4,9-DIEN-3,20-DIONA. |
US8173626B2 (en) * | 2006-03-08 | 2012-05-08 | Danco Laboratories Llc | Methods, dosing regimens and medications using anti-progestational agents for the treatment of disorders |
CA2673128C (en) | 2006-10-24 | 2018-07-03 | Repros Therapeutics Inc. | Compositions and methods for suppressing endometrial proliferation |
HU228636B1 (en) * | 2007-06-27 | 2013-04-29 | Richter Gedeon Nyrt | Industrial method for the synthesis of 17-acetoxy-11betha-4[-(dimethylamino)-phenyl]-21-methoxy-19-norpregna-4,9-dien-3,20-dione and the key intermediates of the process |
TW201002736A (en) * | 2008-04-28 | 2010-01-16 | Repros Therapeutics Inc | Compositions and methods for treating progesterone-dependent conditions |
TWI539953B (en) * | 2008-04-28 | 2016-07-01 | 瑞波若斯治療學公司 | Compositions and methods for treating breast cancer |
TWI477276B (en) * | 2008-04-28 | 2015-03-21 | Repros Therapeutics Inc | Antiprogestin dosing regimens |
HUP0900171A2 (en) | 2009-03-20 | 2010-12-28 | Richter Gedeon Nyrt | Novel crystal form of 17-acetoxy-11-[4-(dimethyl-amino)-phenyl]-21-metoxy-19-norpregna-4,9-dien-3,20-dione and process for it's preparation |
JP5951480B2 (en) * | 2009-04-14 | 2016-07-13 | ラボラトワール・アシュエールア−ファルマLaboratoire Hra−Pharma | On-demand contraceptive methods |
HUP0900487A2 (en) | 2009-08-05 | 2011-03-28 | Richter Gedeon Nyrt | Novel crystal polymorphic form of 17-acetoxy-11 -[4-(dimethylamino)phenyl]-21-methoxy-4,9-diene-3,20-dione and process for it's preparation |
UA113283C2 (en) * | 2010-12-23 | 2017-01-10 | 19-NORSTEROIDS AND THEIR APPLICATIONS FOR THE TREATMENT OF PROGESTERON-STAINLESS STATES | |
CN102516345B (en) * | 2011-11-01 | 2014-11-26 | 上海优拓医药科技有限公司 | Preparation method of ulipristal acetate and key intermediate thereof |
US9109005B2 (en) * | 2012-02-23 | 2015-08-18 | Boehringer Ingelheim International Gmbh | Method for manufacturing of ciclesonide |
NZ702467A (en) * | 2012-05-31 | 2016-07-29 | Repros Therapeutics Inc | Formulations and methods for vaginal delivery of antiprogestins |
CN102702296B (en) * | 2012-06-19 | 2014-09-03 | 山东诚创医药技术开发有限公司 | Preparation method of cyclo-3,20-bi(1, 2-ethidene acetal)-17alpha-hydroxyl-17beta-acetyl-estra-5(10),9(11)-diene-3-ketone |
CN102942612A (en) * | 2012-10-30 | 2013-02-27 | 四川大学 | Novel method for synthesizing ulipristal acetate |
CA2888377C (en) | 2012-11-02 | 2021-02-02 | Repros Therapeutics Inc. | Methods and compositions for treating progesterone-dependent conditions |
CN103073612B (en) * | 2013-02-04 | 2015-11-04 | 山东大学 | The preparation method of CDB-2914 key intermediate |
HU230319B1 (en) * | 2013-10-01 | 2016-01-28 | Richter Gedeon Nyrt. | Industrial process for producing steroid derivatives |
CN104774231A (en) * | 2014-01-13 | 2015-07-15 | 上海医药工业研究院 | 17alpha-hydroxy-19-norpregn-4,9-diene-3,20-dione preparation process |
HU230381B1 (en) | 2014-02-17 | 2016-03-29 | Richter Gedeon Nyrt | Process for producing steroid intermediate |
CN107840865A (en) * | 2016-09-20 | 2018-03-27 | 天津金耀集团有限公司 | A kind of preparation method of methylprednisolone |
Family Cites Families (13)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
JPS582607B2 (en) | 1976-03-12 | 1983-01-18 | パイオニア株式会社 | temperature detection circuit |
FR2522328B1 (en) * | 1982-03-01 | 1986-02-14 | Roussel Uclaf | NEW PRODUCTS DERIVED FROM THE STRUCTURE 3-CETO 4,9 19-NOR STEROIDS, THEIR PREPARATION PROCESS AND THEIR APPLICATION AS MEDICAMENTS |
DE3321826A1 (en) * | 1983-06-15 | 1984-12-20 | Schering AG, 1000 Berlin und 4709 Bergkamen | 13 alpha -Alkylgonanes, the preparation thereof and pharmaceutical products containing these |
DE3504421A1 (en) * | 1985-02-07 | 1986-08-07 | Schering AG, 1000 Berlin und 4709 Bergkamen | 11 beta -Phenylgonanes, the preparation thereof and pharmaceutical products containing these |
CA1317283C (en) | 1986-11-05 | 1993-05-04 | Douglas Alan Livingston | Steroidal 17-silyl ethers and process to corticoids and progesterones |
US4954490A (en) * | 1988-06-23 | 1990-09-04 | Research Triangle Institute | 11 β-substituted progesterone analogs |
US5929262A (en) * | 1995-03-30 | 1999-07-27 | The United States Of America As Represented By The Department Of Health And Human Services | Method for preparing 17α-acetoxy-11β-(4-N, N-dimethylaminophyl)-19-Norpregna-4,9-diene-3, 20-dione, intermediates useful in the method, and methods for the preparation of such intermediates |
ES2152671T3 (en) * | 1996-05-01 | 2001-02-01 | Us Gov Health & Human Serv | PROGESTERONE DERIVATIVES REPLACED IN POSITION 21 AS NEW ANTIPROGESTATIONAL AGENTS. |
US6020328A (en) * | 1998-03-06 | 2000-02-01 | Research Triangle Institute | 20-keto-11β-arylsteroids and their derivatives having agonist or antagonist hormonal properties |
US6172052B1 (en) * | 1998-12-04 | 2001-01-09 | Research Triangle Institute | 17β-acyl-17α-propynyl-11β-arylsteroids and their derivatives having agonist or antagonist hormonal properties |
US6740645B1 (en) * | 1999-09-03 | 2004-05-25 | Research Triangle Institute | 17β-acyl-17α-propynyl-11β-(cyclic amino) aryl steroids and their derivatives having antagonist hormonal properties |
EP2348031B9 (en) * | 2000-03-17 | 2016-08-10 | The Government of the United States of America as represented by the Secretary of the Department of Health and Human Services | 17-Alpha-substituted-11-beta-substituted-4-aryl and 21-substituted 19-norpregnadienediones as antiprogestational agents |
RU38486U1 (en) | 2003-11-03 | 2004-06-20 | Закрытое акционерное общество "Пермский проектно-конструкторский и экспериментальный институт горного и нефтяного машиностроения" | HYDRAULIC DRINKING MACHINE |
-
2001
- 2001-03-16 EP EP10010646.7A patent/EP2348031B9/en not_active Expired - Lifetime
- 2001-03-16 EP EP01918812A patent/EP1265911B1/en not_active Expired - Lifetime
- 2001-03-16 WO PCT/US2001/008681 patent/WO2001074840A2/en active Application Filing
- 2001-03-16 ES ES10010646.7T patent/ES2546291T3/en not_active Expired - Lifetime
- 2001-03-16 ES ES01918812T patent/ES2307604T3/en not_active Expired - Lifetime
- 2001-03-16 DK DK01918812T patent/DK1265911T3/en active
- 2001-03-16 JP JP2001572529A patent/JP5417562B2/en not_active Expired - Fee Related
- 2001-03-16 AU AU4584901A patent/AU4584901A/en active Pending
- 2001-03-16 PT PT01918812T patent/PT1265911E/en unknown
- 2001-03-16 ES ES10010647.5T patent/ES2546336T3/en not_active Expired - Lifetime
- 2001-03-16 EP EP08009259A patent/EP2033965A3/en not_active Withdrawn
- 2001-03-16 EP EP20100010647 patent/EP2348030B1/en not_active Expired - Lifetime
- 2001-03-16 AT AT01918812T patent/ATE396197T1/en active
- 2001-03-16 DE DE60134126T patent/DE60134126D1/en not_active Expired - Lifetime
- 2001-03-16 CA CA2403756A patent/CA2403756C/en not_active Expired - Lifetime
- 2001-03-16 AU AU2001245849A patent/AU2001245849B2/en not_active Expired
-
2008
- 2008-08-21 CY CY20081100895T patent/CY1108281T1/en unknown
-
2011
- 2011-11-07 JP JP2011244014A patent/JP2012051935A/en active Pending
Similar Documents
Publication | Publication Date | Title |
---|---|---|
AU2001245849A1 (en) | Structural modification of 19-norprogesterone i: 17-alpha-substituted-11-beta-substituted-4-aryl and 21-substituted 19-norpregnadienedione as new antiprogestational agents | |
AU1803601A (en) | Methods and compositions for the introduction of molecules into cells | |
AU6333499A (en) | Use of nanoscale sterols and sterol esters | |
AU2001251136A1 (en) | Compositions and methods for promoting wound healing | |
AUPQ419099A0 (en) | Novel compositions and methods | |
AU2001245437A1 (en) | Lightweight methods and compositions for well treating | |
NZ514350A (en) | Compositions and methods for effecting the levels of cholesterol | |
AU4584901A (en) | Structural modification of 19-norprogesterone i: 17-alpha-substituted-11-beta-substituted-4-aryl and 21-substituted 19-norpregnadienedione as new antiprogestational agents | |
AU3671099A (en) | Methods and compositions pertaining to pd-loops | |
AU2001280604A1 (en) | Compositions comprising icariside i and anhydroicaritin and methods for making the same | |
AU2001260847A1 (en) | Compositions isolated from skin cells and methods for their use | |
AU2001234437A1 (en) | Deicing compositions and methods of use | |
AU1460801A (en) | Cholesterol reducing sterol compositions, preparation and method of use | |
AU2001271031A1 (en) | Cosmetic compositions for reducing and method of using the same | |
AU2001266638A1 (en) | Compositions containing alpha-sulfofatty acid esters and methods of making the same | |
AU2786100A (en) | Method of selecting transformed cells and tissues | |
AU3065999A (en) | Compositions and methods for treatment of asthma | |
AU1463601A (en) | Cholesterol reducing stanol compositions, preparation and method of use | |
AU2001268232A1 (en) | Compositions, methods, and kits relating to resistin-like molecules | |
AU2001269730A1 (en) | Low carbohydrate compositions, kits thereof, and methods of use | |
AU2002239739A1 (en) | Compositions, methods and kits relating to remodelin | |
AU2962400A (en) | Cleaner composition and method of use thereof | |
AU5179800A (en) | Mycolactone and related compounds, compositions and methods of use | |
AU2001225856A1 (en) | Optimized anaerobic adhesive compositions and methods of preparing same | |
AU4839100A (en) | Methods of using and compositions comprising n-desmethylzolpidem |