AU2001236177A1 - T cell receptor libraries - Google Patents

T cell receptor libraries

Info

Publication number
AU2001236177A1
AU2001236177A1 AU2001236177A AU3617701A AU2001236177A1 AU 2001236177 A1 AU2001236177 A1 AU 2001236177A1 AU 2001236177 A AU2001236177 A AU 2001236177A AU 3617701 A AU3617701 A AU 3617701A AU 2001236177 A1 AU2001236177 A1 AU 2001236177A1
Authority
AU
Australia
Prior art keywords
cell receptor
receptor libraries
libraries
cell
receptor
Prior art date
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Abandoned
Application number
AU2001236177A
Inventor
Helmut Wilhelmus Hubertus Gerardus Kessels
Antonius Nicolaas Maria Schumacher
Current Assignee (The listed assignees may be inaccurate. Google has not performed a legal analysis and makes no representation or warranty as to the accuracy of the list.)
Het Nederlands Kanker Instituut
Original Assignee
HET NL KANKER I
Het Nederlands Kanker Instituut
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by HET NL KANKER I, Het Nederlands Kanker Instituut filed Critical HET NL KANKER I
Publication of AU2001236177A1 publication Critical patent/AU2001236177A1/en
Abandoned legal-status Critical Current

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C40—COMBINATORIAL TECHNOLOGY
    • C40B—COMBINATORIAL CHEMISTRY; LIBRARIES, e.g. CHEMICAL LIBRARIES
    • C40B40/00—Libraries per se, e.g. arrays, mixtures
    • C40B40/02—Libraries contained in or displayed by microorganisms, e.g. bacteria or animal cells; Libraries contained in or displayed by vectors, e.g. plasmids; Libraries containing only microorganisms or vectors
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K14/00—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof
    • C07K14/435—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from animals; from humans
    • C07K14/705—Receptors; Cell surface antigens; Cell surface determinants
    • C07K14/70503—Immunoglobulin superfamily
    • C07K14/7051—T-cell receptor (TcR)-CD3 complex
    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
    • C12N15/00—Mutation or genetic engineering; DNA or RNA concerning genetic engineering, vectors, e.g. plasmids, or their isolation, preparation or purification; Use of hosts therefor
    • C12N15/09—Recombinant DNA-technology
    • C12N15/10—Processes for the isolation, preparation or purification of DNA or RNA
    • C12N15/1034—Isolating an individual clone by screening libraries
    • C12N15/1037—Screening libraries presented on the surface of microorganisms, e.g. phage display, E. coli display
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K2319/00—Fusion polypeptide
    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
    • C12N2799/00—Uses of viruses
    • C12N2799/02—Uses of viruses as vector
    • C12N2799/021—Uses of viruses as vector for the expression of a heterologous nucleic acid
    • C12N2799/027—Uses of viruses as vector for the expression of a heterologous nucleic acid where the vector is derived from a retrovirus

Landscapes

  • Health & Medical Sciences (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Genetics & Genomics (AREA)
  • Immunology (AREA)
  • Engineering & Computer Science (AREA)
  • Zoology (AREA)
  • Biochemistry (AREA)
  • Molecular Biology (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • General Health & Medical Sciences (AREA)
  • Medicinal Chemistry (AREA)
  • Biophysics (AREA)
  • General Engineering & Computer Science (AREA)
  • Wood Science & Technology (AREA)
  • Microbiology (AREA)
  • Biotechnology (AREA)
  • Biomedical Technology (AREA)
  • Proteomics, Peptides & Aminoacids (AREA)
  • Crystallography & Structural Chemistry (AREA)
  • Physics & Mathematics (AREA)
  • Virology (AREA)
  • General Chemical & Material Sciences (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Gastroenterology & Hepatology (AREA)
  • Plant Pathology (AREA)
  • Toxicology (AREA)
  • Cell Biology (AREA)
  • Peptides Or Proteins (AREA)
  • Micro-Organisms Or Cultivation Processes Thereof (AREA)
AU2001236177A 2000-01-13 2001-01-15 T cell receptor libraries Abandoned AU2001236177A1 (en)

Applications Claiming Priority (3)

Application Number Priority Date Filing Date Title
EP00200110 2000-01-13
EP00200110A EP1118661A1 (en) 2000-01-13 2000-01-13 T cell receptor libraries
PCT/NL2001/000021 WO2001055366A1 (en) 2000-01-13 2001-01-15 T cell receptor libraries

Publications (1)

Publication Number Publication Date
AU2001236177A1 true AU2001236177A1 (en) 2001-08-07

Family

ID=8170906

Family Applications (1)

Application Number Title Priority Date Filing Date
AU2001236177A Abandoned AU2001236177A1 (en) 2000-01-13 2001-01-15 T cell receptor libraries

Country Status (5)

Country Link
US (1) US20030082719A1 (en)
EP (2) EP1118661A1 (en)
AU (1) AU2001236177A1 (en)
CA (1) CA2399109A1 (en)
WO (1) WO2001055366A1 (en)

Families Citing this family (50)

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WO2001062908A2 (en) * 2000-02-22 2001-08-30 Ahuva Nissim Chimeric and tcr phage display libraries, chimeric and tcr reagents and methods of use thereof
ATE432290T1 (en) 2002-11-09 2009-06-15 Immunocore Ltd T CELL RECEPTOR ßDISPLAYß
KR101131297B1 (en) 2003-11-10 2012-03-30 알토 바이오사이언스 코포레이션 Soluble tcr molecules and methods of use
GB0328363D0 (en) 2003-12-06 2004-01-14 Imp College Innovations Ltd Therapeutically useful molecules
GB0411125D0 (en) * 2004-05-19 2004-06-23 Avidex Ltd Method of improving T-cell receptors
NZ550815A (en) 2004-05-19 2009-04-30 Immunocore Ltd Method of improving T cell receptors
JP5563194B2 (en) * 2004-06-29 2014-07-30 イムノコア リミテッド Cells expressing modified T cell receptors
US7994298B2 (en) 2004-09-24 2011-08-09 Trustees Of Dartmouth College Chimeric NK receptor and methods for treating cancer
CN101098891B (en) 2005-01-05 2014-05-21 F-星生物技术研究与开发有限公司 Synthetic immunoglobulin domains with binding properties engineered in regions of the molecule different from the complementarity determining regions
EP2007911A4 (en) * 2006-04-05 2009-08-05 Gen Hospital Corp Soluble virus-specific t-cell receptor compositions
AT503861B1 (en) 2006-07-05 2008-06-15 F Star Biotech Forsch & Entw METHOD FOR MANIPULATING T-CELL RECEPTORS
AT503889B1 (en) 2006-07-05 2011-12-15 Star Biotechnologische Forschungs Und Entwicklungsges M B H F MULTIVALENT IMMUNE LOBULINE
US8921279B2 (en) 2007-06-26 2014-12-30 F-Star Biotechnologische Forschungs—und Entwicklungsges. m.b.H Display of binding agents
US9273283B2 (en) 2009-10-29 2016-03-01 The Trustees Of Dartmouth College Method of producing T cell receptor-deficient T cells expressing a chimeric receptor
WO2011059836A2 (en) 2009-10-29 2011-05-19 Trustees Of Dartmouth College T cell receptor-deficient t cell compositions
EP2596023A4 (en) * 2010-07-20 2014-03-05 Beth Israel Hospital Compositions and methods featuring il-6 and il-21 antagonists
US9833476B2 (en) 2011-08-31 2017-12-05 The Trustees Of Dartmouth College NKP30 receptor targeted therapeutics
NZ702108A (en) 2012-05-03 2016-09-30 Hutchinson Fred Cancer Res Enhanced affinity t cell receptors and methods for making the same
JP6389166B2 (en) 2012-05-07 2018-09-12 トラスティーズ・オブ・ダートマス・カレッジ Anti-B7-H6 antibodies, fusion proteins, and methods of using them
US20150191524A1 (en) * 2012-07-27 2015-07-09 The Board Of Trustees Of The University Of Illinoi Engineering t cell receptors
US9499855B2 (en) 2013-03-14 2016-11-22 Elwha Llc Compositions, methods, and computer systems related to making and administering modified T cells
EP2971288A4 (en) * 2013-03-14 2016-12-07 Elwha Llc Compositions, methods, and computer systems related to making and administering modified t cells
US9587237B2 (en) 2013-03-14 2017-03-07 Elwha Llc Compositions, methods, and computer systems related to making and administering modified T cells
TWI721929B (en) 2013-08-05 2021-03-11 美商扭轉生物科技有限公司 De novo synthesized gene libraries
CA2975852A1 (en) 2015-02-04 2016-08-11 Twist Bioscience Corporation Methods and devices for de novo oligonucleic acid assembly
WO2016172377A1 (en) 2015-04-21 2016-10-27 Twist Bioscience Corporation Devices and methods for oligonucleic acid library synthesis
AU2016273213B2 (en) 2015-06-01 2019-03-14 Medigene Immunotherapies Gmbh T cell receptor library
CA2987871A1 (en) 2015-06-01 2016-12-08 Medigene Immunotherapies Gmbh Method for generating antibodies against t cell receptor
IL258164B (en) 2015-09-18 2022-09-01 Twist Bioscience Corp Methods for modulating protein and cellular activity and method for nucleic acid synthesis
WO2017053450A1 (en) 2015-09-22 2017-03-30 Twist Bioscience Corporation Flexible substrates for nucleic acid synthesis
CN108603307A (en) 2015-12-01 2018-09-28 特韦斯特生物科学公司 functionalized surface and its preparation
KR20180089446A (en) 2015-12-23 2018-08-08 메디진 이뮤노테라피스 게엠바하 Dendritic cell composition
CA3019509A1 (en) 2016-04-05 2017-10-12 Glaxosmithkline Intellectual Property Development Limited Inhibition of tgfbeta in immunotherapy
WO2018038772A1 (en) 2016-08-22 2018-03-01 Twist Bioscience Corporation De novo synthesized nucleic acid libraries
JP6871364B2 (en) 2016-09-21 2021-05-12 ツイスト バイオサイエンス コーポレーション Nucleic acid-based data storage
EA201991262A1 (en) * 2016-12-16 2020-04-07 Твист Байосайенс Корпорейшн LIBRARIES OF OPTIONS OF IMMUNOLOGICAL SYNAPSIS AND THEIR SYNTHESIS
SG11201907713WA (en) 2017-02-22 2019-09-27 Twist Bioscience Corp Nucleic acid based data storage
EP3595674A4 (en) 2017-03-15 2020-12-16 Twist Bioscience Corporation Variant libraries of the immunological synapse and synthesis thereof
WO2018231864A1 (en) 2017-06-12 2018-12-20 Twist Bioscience Corporation Methods for seamless nucleic acid assembly
CN111566209A (en) 2017-06-12 2020-08-21 特韦斯特生物科学公司 Seamless nucleic acid assembly method
US11407837B2 (en) 2017-09-11 2022-08-09 Twist Bioscience Corporation GPCR binding proteins and synthesis thereof
KR20240024357A (en) 2017-10-20 2024-02-23 트위스트 바이오사이언스 코포레이션 Heated nanowells for polynucleotide synthesis
US10936953B2 (en) 2018-01-04 2021-03-02 Twist Bioscience Corporation DNA-based digital information storage with sidewall electrodes
KR20210013128A (en) 2018-05-18 2021-02-03 트위스트 바이오사이언스 코포레이션 Polynucleotides, reagents and methods for nucleic acid hybridization
US20220275043A1 (en) 2018-07-17 2022-09-01 Massachusetts Institute Of Technology Soluble multimeric immunoglobulin-scaffold based fusion proteins and uses thereof
EP3847266A1 (en) 2018-09-05 2021-07-14 GlaxoSmithKline Intellectual Property Development Ltd T cell modification
AU2020229349A1 (en) 2019-02-26 2021-10-14 Twist Bioscience Corporation Variant nucleic acid libraries for GLP1 receptor
SG11202109283UA (en) 2019-02-26 2021-09-29 Twist Bioscience Corp Variant nucleic acid libraries for antibody optimization
EP3987019A4 (en) 2019-06-21 2023-04-19 Twist Bioscience Corporation Barcode-based nucleic acid sequence assembly
TW202204379A (en) * 2020-06-08 2022-02-01 中央研究院 Method for selecting antibody fragments, recombinant antibodies produced therefrom, and uses thereof

Family Cites Families (8)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US5698426A (en) * 1990-09-28 1997-12-16 Ixsys, Incorporated Surface expression libraries of heteromeric receptors
US5635363A (en) * 1995-02-28 1997-06-03 The Board Of Trustees Of The Leland Stanford Junior University Compositions and methods for the detection, quantitation and purification of antigen-specific T cells
DE69723230T2 (en) * 1996-01-17 2004-05-27 Imperial College Innovations Ltd. IMMUNOTHERAPY USING CYTOTOXIC T LYMPHOCYTES (CTL)
DE19625191A1 (en) * 1996-06-24 1998-01-02 Boehringer Mannheim Gmbh Renal carcinoma-specific T cells
EP0977886A4 (en) * 1997-03-07 2002-10-23 Sunol Molecular Corp Fusion proteins comprising bacteriophage coat protein and a single-chain t cell receptor
US6759243B2 (en) * 1998-01-20 2004-07-06 Board Of Trustees Of The University Of Illinois High affinity TCR proteins and methods
FR2778669B1 (en) * 1998-05-14 2002-06-14 Centre Nat Rech Scient PROCESS FOR EXPRESSING A COMPLEX FORMED OF AT LEAST ONE PRODUCT OF THE MAJOR HISTOCOMPATIBILITY COMPLEX AND A PEPTIDE IN A PHAGE, PHAGES AND COMPLEXES OBTAINED THEREFROM AND THEIR APPLICATIONS
DK1066380T3 (en) * 1998-05-19 2002-01-28 Avidex Ltd Soluble T cell receptor

Also Published As

Publication number Publication date
WO2001055366A1 (en) 2001-08-02
WO2001055366A9 (en) 2002-07-18
EP1246910A1 (en) 2002-10-09
EP1118661A1 (en) 2001-07-25
CA2399109A1 (en) 2001-08-02
US20030082719A1 (en) 2003-05-01

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