AU2001234760A1 - Rolling circle amplification assay for nucleic acid analysis - Google Patents

Rolling circle amplification assay for nucleic acid analysis

Info

Publication number
AU2001234760A1
AU2001234760A1 AU2001234760A AU3476001A AU2001234760A1 AU 2001234760 A1 AU2001234760 A1 AU 2001234760A1 AU 2001234760 A AU2001234760 A AU 2001234760A AU 3476001 A AU3476001 A AU 3476001A AU 2001234760 A1 AU2001234760 A1 AU 2001234760A1
Authority
AU
Australia
Prior art keywords
nucleic acid
acid analysis
rolling circle
circle amplification
amplification assay
Prior art date
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Abandoned
Application number
AU2001234760A
Inventor
Melanie M. Mahtani
Current Assignee (The listed assignees may be inaccurate. Google has not performed a legal analysis and makes no representation or warranty as to the accuracy of the list.)
Integenx Acquisition Corp
Original Assignee
Molecular Dynamics Inc
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Molecular Dynamics Inc filed Critical Molecular Dynamics Inc
Publication of AU2001234760A1 publication Critical patent/AU2001234760A1/en
Abandoned legal-status Critical Current

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12Q—MEASURING OR TESTING PROCESSES INVOLVING ENZYMES, NUCLEIC ACIDS OR MICROORGANISMS; COMPOSITIONS OR TEST PAPERS THEREFOR; PROCESSES OF PREPARING SUCH COMPOSITIONS; CONDITION-RESPONSIVE CONTROL IN MICROBIOLOGICAL OR ENZYMOLOGICAL PROCESSES
    • C12Q1/00—Measuring or testing processes involving enzymes, nucleic acids or microorganisms; Compositions therefor; Processes of preparing such compositions
    • C12Q1/68—Measuring or testing processes involving enzymes, nucleic acids or microorganisms; Compositions therefor; Processes of preparing such compositions involving nucleic acids
    • C12Q1/6813—Hybridisation assays
    • C12Q1/6827—Hybridisation assays for detection of mutation or polymorphism
    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12Q—MEASURING OR TESTING PROCESSES INVOLVING ENZYMES, NUCLEIC ACIDS OR MICROORGANISMS; COMPOSITIONS OR TEST PAPERS THEREFOR; PROCESSES OF PREPARING SUCH COMPOSITIONS; CONDITION-RESPONSIVE CONTROL IN MICROBIOLOGICAL OR ENZYMOLOGICAL PROCESSES
    • C12Q1/00—Measuring or testing processes involving enzymes, nucleic acids or microorganisms; Compositions therefor; Processes of preparing such compositions
    • C12Q1/68—Measuring or testing processes involving enzymes, nucleic acids or microorganisms; Compositions therefor; Processes of preparing such compositions involving nucleic acids
    • C12Q1/6813—Hybridisation assays
    • C12Q1/6816—Hybridisation assays characterised by the detection means
    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12Q—MEASURING OR TESTING PROCESSES INVOLVING ENZYMES, NUCLEIC ACIDS OR MICROORGANISMS; COMPOSITIONS OR TEST PAPERS THEREFOR; PROCESSES OF PREPARING SUCH COMPOSITIONS; CONDITION-RESPONSIVE CONTROL IN MICROBIOLOGICAL OR ENZYMOLOGICAL PROCESSES
    • C12Q1/00—Measuring or testing processes involving enzymes, nucleic acids or microorganisms; Compositions therefor; Processes of preparing such compositions
    • C12Q1/68—Measuring or testing processes involving enzymes, nucleic acids or microorganisms; Compositions therefor; Processes of preparing such compositions involving nucleic acids
    • C12Q1/6844—Nucleic acid amplification reactions
AU2001234760A 2000-02-04 2001-02-02 Rolling circle amplification assay for nucleic acid analysis Abandoned AU2001234760A1 (en)

Applications Claiming Priority (3)

Application Number Priority Date Filing Date Title
US09/498,585 US6221603B1 (en) 2000-02-04 2000-02-04 Rolling circle amplification assay for nucleic acid analysis
US09/498,585 2000-02-04
PCT/US2001/003439 WO2001057256A2 (en) 2000-02-04 2001-02-02 Rolling circle amplification assay for nucleic acid analysis

Publications (1)

Publication Number Publication Date
AU2001234760A1 true AU2001234760A1 (en) 2001-08-14

Family

ID=23981667

Family Applications (1)

Application Number Title Priority Date Filing Date
AU2001234760A Abandoned AU2001234760A1 (en) 2000-02-04 2001-02-02 Rolling circle amplification assay for nucleic acid analysis

Country Status (4)

Country Link
US (1) US6221603B1 (en)
EP (1) EP1252334A2 (en)
AU (1) AU2001234760A1 (en)
WO (1) WO2001057256A2 (en)

Families Citing this family (132)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
WO1994003624A1 (en) * 1992-08-04 1994-02-17 Auerbach Jeffrey I Methods for the isothermal amplification of nucleic acid molecules
US6261808B1 (en) * 1992-08-04 2001-07-17 Replicon, Inc. Amplification of nucleic acid molecules via circular replicons
US20120160687A1 (en) 1995-03-17 2012-06-28 President And Fellows Of Harvard College Characterization of individual polymer molecules based on monomer-interface interactions
US6362002B1 (en) * 1995-03-17 2002-03-26 President And Fellows Of Harvard College Characterization of individual polymer molecules based on monomer-interface interactions
US5854033A (en) * 1995-11-21 1998-12-29 Yale University Rolling circle replication reporter systems
WO1997019193A2 (en) * 1995-11-21 1997-05-29 Yale University Unimolecular segment amplification and detection
CA2352363A1 (en) * 1998-11-27 2000-06-08 Synaptics (Uk) Limited Position sensor
US20030215821A1 (en) * 1999-04-20 2003-11-20 Kevin Gunderson Detection of nucleic acid reactions on bead arrays
US20060275782A1 (en) 1999-04-20 2006-12-07 Illumina, Inc. Detection of nucleic acid reactions on bead arrays
EP1192453B1 (en) 1999-06-22 2012-02-15 President and Fellows of Harvard College Molecular and atomic scale evaluation of biopolymers
JP2003521252A (en) * 2000-02-07 2003-07-15 イルミナ インコーポレイテッド Nucleic acid detection method using universal priming
US7611869B2 (en) * 2000-02-07 2009-11-03 Illumina, Inc. Multiplexed methylation detection methods
US8076063B2 (en) * 2000-02-07 2011-12-13 Illumina, Inc. Multiplexed methylation detection methods
US7955794B2 (en) * 2000-09-21 2011-06-07 Illumina, Inc. Multiplex nucleic acid reactions
US7582420B2 (en) 2001-07-12 2009-09-01 Illumina, Inc. Multiplex nucleic acid reactions
US7205129B1 (en) 2000-02-28 2007-04-17 Qiagen Gmbh Method for reducing artifacts in nucleic acid amplification
US20060166227A1 (en) * 2000-06-20 2006-07-27 Stephen Kingsmore Protein expression profiling
US6531283B1 (en) 2000-06-20 2003-03-11 Molecular Staging, Inc. Protein expression profiling
US6323009B1 (en) * 2000-06-28 2001-11-27 Molecular Staging, Inc. Multiply-primed amplification of nucleic acid sequences
US6686157B2 (en) 2000-06-30 2004-02-03 Molecular Staging Inc. Signal amplification with lollipop probes
ATE380883T1 (en) * 2000-10-24 2007-12-15 Univ Leland Stanford Junior DIRECT MULTIPLEX CHARACTERIZATION OF GENOMIC DNA
WO2002061133A2 (en) 2000-11-09 2002-08-08 Yale University Nucleic acid detection using structured probes
US6573051B2 (en) * 2001-03-09 2003-06-03 Molecular Staging, Inc. Open circle probes with intramolecular stem structures
AU2003303395A1 (en) * 2001-05-22 2004-07-22 Dahl, Gary, A. Target-dependent transcription using deletion mutants of n4 rna polymerase
US20030104428A1 (en) * 2001-06-21 2003-06-05 President And Fellows Of Harvard College Method for characterization of nucleic acid molecules
DE60232523D1 (en) * 2001-07-26 2009-07-16 Stratagene California MULTI-JOBS Mutagenesis
US20040078837A1 (en) * 2001-08-02 2004-04-22 Shannon Mark E. Four human zinc-finger-containing proteins: MDZ3, MDZ4, MDZ7 and MDZ12
GB2378245A (en) 2001-08-03 2003-02-05 Mats Nilsson Nucleic acid amplification method
US6617137B2 (en) * 2001-10-15 2003-09-09 Molecular Staging Inc. Method of amplifying whole genomes without subjecting the genome to denaturing conditions
US6977148B2 (en) * 2001-10-15 2005-12-20 Qiagen Gmbh Multiple displacement amplification
US7297485B2 (en) * 2001-10-15 2007-11-20 Qiagen Gmbh Method for nucleic acid amplification that results in low amplification bias
GB2382137A (en) * 2001-11-20 2003-05-21 Mats Gullberg Nucleic acid enrichment
EP1319718A1 (en) * 2001-12-14 2003-06-18 Keygene N.V. High throughput analysis and detection of multiple target sequences
WO2003066817A2 (en) * 2002-02-06 2003-08-14 Amersham Biosciences Ab Compositions and methods for rolling circle amplification
US7553619B2 (en) * 2002-02-08 2009-06-30 Qiagen Gmbh Detection method using dissociated rolling circle amplification
US20040029142A1 (en) * 2002-02-11 2004-02-12 Schon Eric A. Concatenation-based nucleic acid detection compositions and methods
US6815167B2 (en) * 2002-04-25 2004-11-09 Geneohm Sciences Amplification of DNA to produce single-stranded product of defined sequence and length
US20040048287A1 (en) * 2002-05-20 2004-03-11 Smith Lloyd M. Label-free detection of single nucleotide polymorphisms using surface plasmon resonance imaging
US7295706B2 (en) * 2002-07-12 2007-11-13 Chroma Group, Inc. Pattern recognition applied to graphic imaging
US20040110205A1 (en) * 2002-09-23 2004-06-10 Hui Wang Methods and systems for nanopore data analysis
US20040259105A1 (en) * 2002-10-03 2004-12-23 Jian-Bing Fan Multiplex nucleic acid analysis using archived or fixed samples
GB0228614D0 (en) * 2002-12-07 2003-01-15 Fu Guoliang Oligonucleotide guided analysis of gene expression
US20040115643A1 (en) * 2002-12-12 2004-06-17 Lizardi Paul M. Thermodynamic equilibrium extension of primers
WO2004057017A2 (en) * 2002-12-18 2004-07-08 Third Wave Technologies, Inc. Detection of small nucleic acids
US7851150B2 (en) 2002-12-18 2010-12-14 Third Wave Technologies, Inc. Detection of small nucleic acids
AU2008201522B2 (en) * 2002-12-18 2011-11-24 Third Wave Technologies, Inc. Detection of small nucleic acids
US8206904B2 (en) 2002-12-18 2012-06-26 Third Wave Technologies, Inc. Detection of nucleic acids
AU2012200597B2 (en) * 2002-12-18 2013-09-26 Third Wave Technologies, Inc. Detection of small nucleic acids
US9487823B2 (en) 2002-12-20 2016-11-08 Qiagen Gmbh Nucleic acid amplification
US7955795B2 (en) * 2003-06-06 2011-06-07 Qiagen Gmbh Method of whole genome amplification with reduced artifact production
BRPI0408967B8 (en) 2003-03-31 2021-07-27 Hoffmann La Roche kit and methods for detecting a nucleic acid from various members of the Japanese encephalitis virus serogroup in a biological sample under stringent hybridization conditions
US8043834B2 (en) * 2003-03-31 2011-10-25 Qiagen Gmbh Universal reagents for rolling circle amplification and methods of use
US20040248103A1 (en) * 2003-06-04 2004-12-09 Feaver William John Proximity-mediated rolling circle amplification
US7846738B2 (en) 2003-08-15 2010-12-07 President And Fellows Of Harvard College Study of polymer molecules and conformations with a nanopore
EP1602733A1 (en) * 2004-06-02 2005-12-07 Keygene N.V. Detection of target nucleotide sequences using an asymmetric oligonucleotide ligation assay
JP5117722B2 (en) 2003-09-02 2013-01-16 キージーン ナムローゼ フェンノートシャップ OLA-based method for detection of target nucleic acid sequences
US7238485B2 (en) 2004-03-23 2007-07-03 President And Fellows Of Harvard College Methods and apparatus for characterizing polynucleotides
US7939251B2 (en) 2004-05-06 2011-05-10 Roche Molecular Systems, Inc. SENP1 as a marker for cancer
WO2005113804A1 (en) * 2004-05-20 2005-12-01 Trillion Genomics Limited Use of mass labelled probes to detect target nucleic acids using mass spectrometry
BRPI0515777A (en) * 2004-12-11 2008-08-05 Cytogenix Inc biosynthesis free from high quality nucleic acid cells and uses thereof
EP2319940A1 (en) * 2005-01-04 2011-05-11 Hitachi Chemical Company, Ltd. Primer generation rolling circle amplification
EP1856293A2 (en) * 2005-03-16 2007-11-21 Compass Genetics, Llc Methods and compositions for assay readouts on multiple analytical platforms
EP1863908B1 (en) 2005-04-01 2010-11-17 Qiagen GmbH Reverse transcription and amplification of rna with simultaneous degradation of dna
CN101238221B (en) * 2005-04-12 2011-11-16 Novia公司名下的现场Rcp公司 Ring probe and its uses in identifying biomolecule
ATE483032T1 (en) * 2005-04-12 2010-10-15 Olink Ab METHOD FOR PRODUCING OLIGONUCLEOTIDES
JP5331476B2 (en) * 2005-06-15 2013-10-30 カリダ・ジェノミックス・インコーポレイテッド Single molecule array for genetic and chemical analysis
US9424392B2 (en) 2005-11-26 2016-08-23 Natera, Inc. System and method for cleaning noisy genetic data from target individuals using genetic data from genetically related individuals
US11111544B2 (en) 2005-07-29 2021-09-07 Natera, Inc. System and method for cleaning noisy genetic data and determining chromosome copy number
US11111543B2 (en) 2005-07-29 2021-09-07 Natera, Inc. System and method for cleaning noisy genetic data and determining chromosome copy number
EP1762627A1 (en) 2005-09-09 2007-03-14 Qiagen GmbH Method for the activation of a nucleic acid for performing a polymerase reaction
US7960104B2 (en) 2005-10-07 2011-06-14 Callida Genomics, Inc. Self-assembled single molecule arrays and uses thereof
US20070141594A1 (en) * 2005-10-11 2007-06-21 Biao Luo Method of producing short hairpin library
US20070087355A1 (en) * 2005-10-14 2007-04-19 Barrett Michael T Comparative genomic hybridization assays and compositions for practicing the same
US20080057499A1 (en) * 2006-02-06 2008-03-06 Affymetrix, Inc. Methods for high specificity whole genome amplification and hybridization
SG10201405158QA (en) * 2006-02-24 2014-10-30 Callida Genomics Inc High throughput genome sequencing on dna arrays
EP1994180A4 (en) * 2006-02-24 2009-11-25 Callida Genomics Inc High throughput genome sequencing on dna arrays
US7897747B2 (en) * 2006-05-25 2011-03-01 The Board Of Trustees Of The Leland Stanford Junior University Method to produce single stranded DNA of defined length and sequence and DNA probes produced thereby
US20080096258A1 (en) * 2006-10-24 2008-04-24 Christian Korfhage Rolling circle amplification of circular genomes
US7910302B2 (en) * 2006-10-27 2011-03-22 Complete Genomics, Inc. Efficient arrays of amplified polynucleotides
US20090111705A1 (en) 2006-11-09 2009-04-30 Complete Genomics, Inc. Selection of dna adaptor orientation by hybrid capture
US20080221832A1 (en) * 2006-11-09 2008-09-11 Complete Genomics, Inc. Methods for computing positional base probabilities using experminentals base value distributions
US20080242560A1 (en) * 2006-11-21 2008-10-02 Gunderson Kevin L Methods for generating amplified nucleic acid arrays
WO2008141514A1 (en) * 2007-05-17 2008-11-27 Wondergen Bio-Medicine Technology Co., Ltd. System substitute pcr
US8298768B2 (en) * 2007-11-29 2012-10-30 Complete Genomics, Inc. Efficient shotgun sequencing methods
US20090263872A1 (en) * 2008-01-23 2009-10-22 Complete Genomics Inc. Methods and compositions for preventing bias in amplification and sequencing reactions
US8518640B2 (en) * 2007-10-29 2013-08-27 Complete Genomics, Inc. Nucleic acid sequencing and process
US8415099B2 (en) 2007-11-05 2013-04-09 Complete Genomics, Inc. Efficient base determination in sequencing reactions
US7897344B2 (en) * 2007-11-06 2011-03-01 Complete Genomics, Inc. Methods and oligonucleotide designs for insertion of multiple adaptors into library constructs
WO2009061840A1 (en) * 2007-11-05 2009-05-14 Complete Genomics, Inc. Methods and oligonucleotide designs for insertion of multiple adaptors employing selective methylation
US8592150B2 (en) 2007-12-05 2013-11-26 Complete Genomics, Inc. Methods and compositions for long fragment read sequencing
WO2009097368A2 (en) 2008-01-28 2009-08-06 Complete Genomics, Inc. Methods and compositions for efficient base calling in sequencing reactions
KR101419980B1 (en) 2008-03-15 2014-07-15 홀로직, 인크. Compositions and methods for analysis of nucleic acid molecules during amplification reactions
WO2009132028A1 (en) * 2008-04-21 2009-10-29 Complete Genomics, Inc. Array structures for nucleic acid detection
JP2009268665A (en) * 2008-05-07 2009-11-19 Canon Inc Inhalation device
US9524369B2 (en) 2009-06-15 2016-12-20 Complete Genomics, Inc. Processing and analysis of complex nucleic acid sequence data
US8871524B2 (en) * 2009-08-12 2014-10-28 Caliper Life Sciences, Inc. Methods of performing a sizing analysis using a corrected sizing ladder
US11408031B2 (en) 2010-05-18 2022-08-09 Natera, Inc. Methods for non-invasive prenatal paternity testing
WO2011146632A1 (en) 2010-05-18 2011-11-24 Gene Security Network Inc. Methods for non-invasive prenatal ploidy calling
US11939634B2 (en) 2010-05-18 2024-03-26 Natera, Inc. Methods for simultaneous amplification of target loci
US11332793B2 (en) 2010-05-18 2022-05-17 Natera, Inc. Methods for simultaneous amplification of target loci
US11322224B2 (en) 2010-05-18 2022-05-03 Natera, Inc. Methods for non-invasive prenatal ploidy calling
US9677118B2 (en) 2014-04-21 2017-06-13 Natera, Inc. Methods for simultaneous amplification of target loci
US11326208B2 (en) 2010-05-18 2022-05-10 Natera, Inc. Methods for nested PCR amplification of cell-free DNA
US11339429B2 (en) 2010-05-18 2022-05-24 Natera, Inc. Methods for non-invasive prenatal ploidy calling
US10316362B2 (en) 2010-05-18 2019-06-11 Natera, Inc. Methods for simultaneous amplification of target loci
US11332785B2 (en) 2010-05-18 2022-05-17 Natera, Inc. Methods for non-invasive prenatal ploidy calling
US20190010543A1 (en) 2010-05-18 2019-01-10 Natera, Inc. Methods for simultaneous amplification of target loci
US8828211B2 (en) 2010-06-08 2014-09-09 President And Fellows Of Harvard College Nanopore device with graphene supported artificial lipid membrane
JP6328934B2 (en) 2010-12-22 2018-05-23 ナテラ， インコーポレイテッド Noninvasive prenatal testing
CN102181443B (en) * 2011-03-21 2013-10-23 中国科学院植物研究所 Multiple detection method for DNA polymorphism of genome and special probe thereof
EP2980226A1 (en) 2011-07-08 2016-02-03 Keygene N.V. Sequence based genotyping based on oligonucleotide ligation assays
EP3620533B1 (en) 2011-09-06 2023-01-18 Gen-Probe Incorporated Closed nucleic acid structures
WO2013059044A1 (en) * 2011-10-18 2013-04-25 Celedon Alfredo Andres Detection units and methods for detecting a target analyte
WO2013119827A1 (en) * 2012-02-07 2013-08-15 Pathogenica, Inc. Direct rna capture with molecular inversion probes
WO2013119888A1 (en) * 2012-02-09 2013-08-15 President And Fellows Of Harvard College Selective nucleic acid amplification from nucleic acid pools
CN113774132A (en) 2014-04-21 2021-12-10 纳特拉公司 Detection of mutations and ploidy in chromosomal segments
US10870845B2 (en) 2014-07-01 2020-12-22 Global Life Sciences Solutions Operations UK Ltd Methods for capturing nucleic acids
US9593368B2 (en) 2014-07-01 2017-03-14 General Electric Company Methods for amplifying nucleic acids on substrates
US10472620B2 (en) 2014-07-01 2019-11-12 General Electric Company Method, substrate and device for separating nucleic acids
CA3010579A1 (en) * 2015-01-06 2016-07-14 Good Start Genetics, Inc. Screening for structural variants
US10808278B2 (en) * 2015-03-03 2020-10-20 University Of Miami Kits and methods for pathogen detection
US11479812B2 (en) 2015-05-11 2022-10-25 Natera, Inc. Methods and compositions for determining ploidy
WO2018067517A1 (en) 2016-10-04 2018-04-12 Natera, Inc. Methods for characterizing copy number variation using proximity-litigation sequencing
US10011870B2 (en) 2016-12-07 2018-07-03 Natera, Inc. Compositions and methods for identifying nucleic acid molecules
WO2019238765A1 (en) 2018-06-12 2019-12-19 Keygene N.V. Nucleic acid amplification method
US11525159B2 (en) 2018-07-03 2022-12-13 Natera, Inc. Methods for detection of donor-derived cell-free DNA
EP3836967A4 (en) * 2018-07-30 2022-06-15 ReadCoor, LLC Methods and systems for sample processing or analysis
US10704094B1 (en) * 2018-11-14 2020-07-07 Element Biosciences, Inc. Multipart reagents having increased avidity for polymerase binding
US10876148B2 (en) 2018-11-14 2020-12-29 Element Biosciences, Inc. De novo surface preparation and uses thereof
CN113474466A (en) 2019-02-21 2021-10-01 主基因有限公司 Polyploid genotyping
JP2023524117A (en) 2020-04-30 2023-06-08 スタブ ヴィーダ － インヴェスティガサォン エ セルヴィソス エム シエンシアス バイオロジカス エルディーエー Method and portable device for detecting nucleic acid sequences in suspected coronavirus samples
CN115873927B (en) * 2022-08-04 2023-12-26 迈杰转化医学研究(苏州)有限公司 Connection-independent nucleic acid constant-temperature rolling circle amplification method and application thereof

Family Cites Families (9)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
EP0542874A4 (en) * 1990-07-25 1994-05-11 Syngene Inc Circular extension for generating multiple nucleic acid complements
US6077668A (en) 1993-04-15 2000-06-20 University Of Rochester Highly sensitive multimeric nucleic acid probes
US5714320A (en) 1993-04-15 1998-02-03 University Of Rochester Rolling circle synthesis of oligonucleotides and amplification of select randomized circular oligonucleotides
SE9400522D0 (en) 1994-02-16 1994-02-16 Ulf Landegren Method and reagent for detecting specific nucleotide sequences
US5866337A (en) 1995-03-24 1999-02-02 The Trustees Of Columbia University In The City Of New York Method to detect mutations in a nucleic acid using a hybridization-ligation procedure
US5648245A (en) 1995-05-09 1997-07-15 Carnegie Institution Of Washington Method for constructing an oligonucleotide concatamer library by rolling circle replication
US5854033A (en) 1995-11-21 1998-12-29 Yale University Rolling circle replication reporter systems
US5846726A (en) 1997-05-13 1998-12-08 Becton, Dickinson And Company Detection of nucleic acids by fluorescence quenching
WO2000004193A1 (en) * 1998-07-20 2000-01-27 Yale University Method for detecting nucleic acids using target-mediated ligation of bipartite primers

Also Published As

Publication number Publication date
WO2001057256A2 (en) 2001-08-09
EP1252334A2 (en) 2002-10-30
US6221603B1 (en) 2001-04-24
WO2001057256A3 (en) 2002-07-25

Similar Documents

Publication Publication Date Title
AU2001234760A1 (en) Rolling circle amplification assay for nucleic acid analysis
AU2002245184A1 (en) Nucleic acid amplification
AU2001276843A1 (en) Nucleic acid enzyme biosensor for ions
AU2002325538A1 (en) Nucleic acid amplification methods
AU2002314693A1 (en) Nucleic acid amplification method
AU2002307152A1 (en) Nucleic acid amplification utilizing microfluidic devices
AU2013202A (en) Nucleic acid amplification methods
AU2001278783A1 (en) Method of amplifying nucleic acid
AU2001235479A1 (en) Container for nucleic acid analysis
AU2002347981A1 (en) Universal nucleotides for nucleic acid analysis
AU2001240040A1 (en) Combinatorial array for nucleic acid analysis
AU2002356502A1 (en) Automated nucleic acid assay system
AU2003206095A1 (en) Methods and means for amplifying nucleic acid
AU2003299541A1 (en) Microfluidic nucleic acid analysis
AU2002230689A1 (en) Methods for detection of a nucleic acid by sequential amplification
IL130477A0 (en) Processes for amplifying nucleic acid
AU2002313683A1 (en) Nucleic acid amplification using nicking agents
AU7878301A (en) Method of amplifying nucleic acid
AU2002311897A1 (en) Nucleic acid detection in pooled samples
AU2002239679A1 (en) Rolling circle amplification detection of rna and dna
AU2001293336A1 (en) Nucleic acid detection medium
AUPS076802A0 (en) Selective nucleic acid amplification
AU2003220249A1 (en) Improved nucleic acid amplification
AU1908100A (en) Isothermal nucleic acid amplification methods
AU2002367750A1 (en) Isothermal amplification in nucleic acid analysis