AU2001227903A1 - Everninomicin biosynthetic genes - Google Patents

Everninomicin biosynthetic genes

Info

Publication number
AU2001227903A1
AU2001227903A1 AU2001227903A AU2790301A AU2001227903A1 AU 2001227903 A1 AU2001227903 A1 AU 2001227903A1 AU 2001227903 A AU2001227903 A AU 2001227903A AU 2790301 A AU2790301 A AU 2790301A AU 2001227903 A1 AU2001227903 A1 AU 2001227903A1
Authority
AU
Australia
Prior art keywords
biosynthetic genes
everninomicin biosynthetic
everninomicin
genes
biosynthetic
Prior art date
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Abandoned
Application number
AU2001227903A
Inventor
Ann C. Horan
Thomas J. Hosted
Tim X. Wang
Current Assignee (The listed assignees may be inaccurate. Google has not performed a legal analysis and makes no representation or warranty as to the accuracy of the list.)
Merck Sharp and Dohme Corp
Original Assignee
Schering Corp
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Schering Corp filed Critical Schering Corp
Publication of AU2001227903A1 publication Critical patent/AU2001227903A1/en
Abandoned legal-status Critical Current

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
    • C12N9/00—Enzymes; Proenzymes; Compositions thereof; Processes for preparing, activating, inhibiting, separating or purifying enzymes
    • C12N9/14—Hydrolases (3)
    • C12N9/16—Hydrolases (3) acting on ester bonds (3.1)
    • C12N9/22—Ribonucleases RNAses, DNAses
    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
    • C12N15/00—Mutation or genetic engineering; DNA or RNA concerning genetic engineering, vectors, e.g. plasmids, or their isolation, preparation or purification; Use of hosts therefor
    • C12N15/09—Recombinant DNA-technology
    • C12N15/11—DNA or RNA fragments; Modified forms thereof; Non-coding nucleic acids having a biological activity
    • C12N15/52—Genes encoding for enzymes or proenzymes
    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
    • C12N15/00—Mutation or genetic engineering; DNA or RNA concerning genetic engineering, vectors, e.g. plasmids, or their isolation, preparation or purification; Use of hosts therefor
    • C12N15/09—Recombinant DNA-technology
    • C12N15/63—Introduction of foreign genetic material using vectors; Vectors; Use of hosts therefor; Regulation of expression
    • C12N15/74—Vectors or expression systems specially adapted for prokaryotic hosts other than E. coli, e.g. Lactobacillus, Micromonospora
    • C12N15/76—Vectors or expression systems specially adapted for prokaryotic hosts other than E. coli, e.g. Lactobacillus, Micromonospora for Actinomyces; for Streptomyces
    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
    • C12N15/00—Mutation or genetic engineering; DNA or RNA concerning genetic engineering, vectors, e.g. plasmids, or their isolation, preparation or purification; Use of hosts therefor
    • C12N15/09—Recombinant DNA-technology
    • C12N15/87—Introduction of foreign genetic material using processes not otherwise provided for, e.g. co-transformation
    • C12N15/90—Stable introduction of foreign DNA into chromosome
    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12P—FERMENTATION OR ENZYME-USING PROCESSES TO SYNTHESISE A DESIRED CHEMICAL COMPOUND OR COMPOSITION OR TO SEPARATE OPTICAL ISOMERS FROM A RACEMIC MIXTURE
    • C12P19/00—Preparation of compounds containing saccharide radicals
    • C12P19/04—Polysaccharides, i.e. compounds containing more than five saccharide radicals attached to each other by glycosidic bonds
    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12P—FERMENTATION OR ENZYME-USING PROCESSES TO SYNTHESISE A DESIRED CHEMICAL COMPOUND OR COMPOSITION OR TO SEPARATE OPTICAL ISOMERS FROM A RACEMIC MIXTURE
    • C12P19/00—Preparation of compounds containing saccharide radicals
    • C12P19/44—Preparation of O-glycosides, e.g. glucosides
    • C12P19/60—Preparation of O-glycosides, e.g. glucosides having an oxygen of the saccharide radical directly bound to a non-saccharide heterocyclic ring or a condensed ring system containing a non-saccharide heterocyclic ring, e.g. coumermycin, novobiocin
    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
    • C12N2800/00—Nucleic acids vectors
    • C12N2800/30—Vector systems comprising sequences for excision in presence of a recombinase, e.g. loxP or FRT
AU2001227903A 2000-01-12 2001-01-12 Everninomicin biosynthetic genes Abandoned AU2001227903A1 (en)

Applications Claiming Priority (3)

Application Number Priority Date Filing Date Title
US17575100P 2000-01-12 2000-01-12
US60175751 2000-01-12
PCT/US2001/001187 WO2001051639A2 (en) 2000-01-12 2001-01-12 Everninomicin biosynthetic genes

Publications (1)

Publication Number Publication Date
AU2001227903A1 true AU2001227903A1 (en) 2001-07-24

Family

ID=22641488

Family Applications (1)

Application Number Title Priority Date Filing Date
AU2001227903A Abandoned AU2001227903A1 (en) 2000-01-12 2001-01-12 Everninomicin biosynthetic genes

Country Status (3)

Country Link
US (5) US6861513B2 (en)
AU (1) AU2001227903A1 (en)
WO (1) WO2001051639A2 (en)

Families Citing this family (13)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US6861513B2 (en) * 2000-01-12 2005-03-01 Schering Corporation Everninomicin biosynthetic genes
WO2001087936A2 (en) * 2000-05-17 2001-11-22 Schering Corporation Isolation of micromonospora carbonacea var africana pmlp1 integrase and use of integrating function for site-specific integration into micromonospora halophitica and micromonospora carbonacea chromosome
JP2004532021A (en) * 2001-03-28 2004-10-21 エコピア バイオサイエンシーズ インク Compositions for identification and identification of orthosomycin biosynthetic loci and methods of identification and identification
US20030180766A1 (en) * 2002-01-24 2003-09-25 Ecopia Biosciences, Inc. Method, system and knowledge repository for identifying a secondary metabolite from a microorganism
EP2397852B1 (en) 2006-03-14 2013-12-04 Oregon Health and Science University Methods for detecting a mycobacterium tuberculosis infection
CZ299789B6 (en) * 2006-05-10 2008-11-26 Mikrobiologický ústav AV CR, v.v.i. Method of detecting microorganisms producing metabolites comprising C5N unit
CZ299943B6 (en) * 2006-05-10 2008-12-29 Mikrobiologický ústav AV CR, v.v.i. Nucleic acid for preparing manumycin-producing strain
US20110170060A1 (en) * 2010-01-08 2011-07-14 Gordon Gary B Gaze Tracking Using Polarized Light
CN103215282B (en) * 2013-04-09 2016-08-03 中国科学院上海有机化学研究所 The biological synthesis gene cluster of cross-country statin and application thereof
MX2018006790A (en) 2015-12-03 2019-05-02 Epidestiny Inc Compositions containing decitabine, 5azacytidine and tetrahydrouridine and uses thereof.
CN107541481B (en) * 2016-06-23 2021-07-02 上海医药工业研究院 Genetic engineering bacterium for producing epirubicin and application thereof
CN108929860B (en) * 2017-05-23 2023-08-22 上海来益生物药物研究开发中心有限责任公司 Gene engineering bacterium for producing chloroeremomycin as well as preparation method and application thereof
CN110914425A (en) 2017-06-06 2020-03-24 齐默尔根公司 High Throughput (HTP) genome engineering platform for improving saccharopolyspora spinosa

Family Cites Families (17)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US2232406A (en) * 1938-10-26 1941-02-18 Gen Aniline & Film Corp Process and preparation for the manufacture of azo dyestuffs
US2418608A (en) * 1939-05-22 1947-04-08 Parker Rust Proof Co Corrosion-resistant metallic article and method of making the same
US2262067A (en) * 1940-04-27 1941-11-11 Bulldog Electric Prod Co Electrical distribution system
US4735903A (en) * 1984-06-21 1988-04-05 Schering Corporation Micromonospora carbonacea var africana
FR2631634B1 (en) 1988-05-18 1991-06-14 Centre Nat Rech Scient CLONING AND EXPRESSION VECTORS IN AN ACTINOMYCETE STRAIN, PROCESS FOR CONVERTING THE SAME, ACTINOMYCETE STRAIN OBTAINED AND PREPARATION OF PROTEINS
US5190870A (en) 1989-05-16 1993-03-02 Amoco Corporation Method for oxidizing hydrocarbons with a hydroxylase from a methane monooxygenase
US5190871A (en) 1989-06-12 1993-03-02 Eli Lilly And Company Use of the site-specific integrating function of phage φC31
JP2912423B2 (en) 1989-07-11 1999-06-28 旭化成工業株式会社 Novel gene conferring macrolide antibiotic resistance
WO1993013663A1 (en) 1992-01-17 1993-07-22 Abbott Laboratories Method of directing biosynthesis of specific polyketides
ZA927923B (en) 1991-10-16 1993-04-26 Schering Corp Lipophilic oligosaccharide antibiotic salt compositions.
FR2713658B1 (en) 1993-12-08 1996-04-12 Rhone Poulenc Rorer Sa Regulatory nucleic acid sequences and uses.
WO1997013777A1 (en) 1995-10-10 1997-04-17 Schering Corporation Novel orthosomycins from micromonospora carbonacea
EP0934421A1 (en) * 1997-08-06 1999-08-11 Laboratorio Medinfar-Produtos Farmaceuticos LDA. DNA INTEGRATION INTO "MYCOBACTERIUM spp." GENOME BY TRANS-COMPLEMENTATION USING A SITE-SPECIFIC INTEGRATION SYSTEM
US5978989A (en) * 1998-01-28 1999-11-09 Chavez; Manuel Garcia Flexible patient transporter with foot pocket
US6861513B2 (en) * 2000-01-12 2005-03-01 Schering Corporation Everninomicin biosynthetic genes
US20030143666A1 (en) * 2000-01-27 2003-07-31 Alfredo Staffa Genetic locus for everninomicin biosynthesis
WO2001087936A2 (en) * 2000-05-17 2001-11-22 Schering Corporation Isolation of micromonospora carbonacea var africana pmlp1 integrase and use of integrating function for site-specific integration into micromonospora halophitica and micromonospora carbonacea chromosome

Also Published As

Publication number Publication date
US20090004649A1 (en) 2009-01-01
US20050233414A1 (en) 2005-10-20
US7947480B2 (en) 2011-05-24
US6861513B2 (en) 2005-03-01
US20110269216A1 (en) 2011-11-03
US20040101832A1 (en) 2004-05-27
WO2001051639A2 (en) 2001-07-19
US7790411B2 (en) 2010-09-07
US20110027865A1 (en) 2011-02-03
US7229813B2 (en) 2007-06-12
WO2001051639A3 (en) 2002-02-28

Similar Documents

Publication Publication Date Title
AU2002313559A1 (en) Genes
AU2001262847A1 (en) Language-understanding
AU2001254546A1 (en) Aminopiperidines
AU2000267458A1 (en) Hypercomputer
AU2001278918A1 (en) Novel lipase genes
AU2001220246A1 (en) Neckphone
AU2001265089A1 (en) Rc-timer scheme
AU2001258349A1 (en) Bisacylguanidine
AU2002220553A1 (en) Bioreactor
AU2001295795A1 (en) Streptococcal genes
AU2001227903A1 (en) Everninomicin biosynthetic genes
AU2001258924A1 (en) Microsatellite-aflp
AU2001250428A1 (en) Genes of the 1-desoxy-d-xylulose biosynthesis path
AU2001242625A1 (en) Gene sequence
AU2001240103A1 (en) Reproduction-specific genes
AU2001264247A1 (en) GASC1 gene
AU2001244358A1 (en) Schizophrenia related genes
EP1144631A3 (en) Insulin-synthesis genes
AU2001246864A1 (en) Hypotensors
AU2001247444A1 (en) Erbeta-mediated gene expression
AUPQ749100A0 (en) New epilespy gene
AU2001285743A1 (en) Adipose-related gene
AU7567101A (en) Gene expression system
AU2001226668A1 (en) Crankshaft-starter-generator
AU2001262711A1 (en) Cytoprotectors