AU2001227100A1 - Process for the preparation of quinolylpropenal - Google Patents

Process for the preparation of quinolylpropenal

Info

Publication number
AU2001227100A1
AU2001227100A1 AU2001227100A AU2710001A AU2001227100A1 AU 2001227100 A1 AU2001227100 A1 AU 2001227100A1 AU 2001227100 A AU2001227100 A AU 2001227100A AU 2710001 A AU2710001 A AU 2710001A AU 2001227100 A1 AU2001227100 A1 AU 2001227100A1
Authority
AU
Australia
Prior art keywords
formic acid
quinolylpropenal
preparation
fluorophenyl
cyclopropyl
Prior art date
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Abandoned
Application number
AU2001227100A
Inventor
Katsumasa Harada
Takashi Harada
Shigeyoshi Nishino
Naoko Okada
Hidetaka Shima
Current Assignee (The listed assignees may be inaccurate. Google has not performed a legal analysis and makes no representation or warranty as to the accuracy of the list.)
Nissan Chemical Corp
Ube Corp
Original Assignee
Nissan Chemical Corp
Ube Industries Ltd
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Priority claimed from JP2000014849A external-priority patent/JP4496585B2/en
Priority claimed from JP2000014848A external-priority patent/JP4496584B2/en
Application filed by Nissan Chemical Corp, Ube Industries Ltd filed Critical Nissan Chemical Corp
Publication of AU2001227100A1 publication Critical patent/AU2001227100A1/en
Abandoned legal-status Critical Current

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D215/00—Heterocyclic compounds containing quinoline or hydrogenated quinoline ring systems
    • C07D215/02—Heterocyclic compounds containing quinoline or hydrogenated quinoline ring systems having no bond between the ring nitrogen atom and a non-ring member or having only hydrogen atoms or carbon atoms directly attached to the ring nitrogen atom
    • C07D215/12—Heterocyclic compounds containing quinoline or hydrogenated quinoline ring systems having no bond between the ring nitrogen atom and a non-ring member or having only hydrogen atoms or carbon atoms directly attached to the ring nitrogen atom with substituted hydrocarbon radicals attached to ring carbon atoms
    • C07D215/14—Radicals substituted by oxygen atoms

Abstract

3-Ä2-Cyclopropyl-4-(4-fluorophenyl)-3-quinolylÜprop-2-enal is prepared in a high yield by reducing 3-Ä2-cyclopropyl-4-(4-fluorophenyl)-3-quinolyl)prop-2-enenitrite with Raney nickel either in the presence of formic acid and 0.25 to 1 part by volume of water per part by volume of formic acid or in the presence of both an amine salt of formic acid and an organic acid.
AU2001227100A 2000-01-24 2001-01-24 Process for the preparation of quinolylpropenal Abandoned AU2001227100A1 (en)

Applications Claiming Priority (5)

Application Number Priority Date Filing Date Title
JP2000-14848 2000-01-24
JP2000014849A JP4496585B2 (en) 2000-01-24 2000-01-24 Process for producing quinolylpropenal
JP2000014848A JP4496584B2 (en) 2000-01-24 2000-01-24 Process for producing quinolylpropenal
JP2000-14849 2000-01-24
PCT/JP2001/000452 WO2001053265A1 (en) 2000-01-24 2001-01-24 Process for the preparation of quinolylpropenal

Publications (1)

Publication Number Publication Date
AU2001227100A1 true AU2001227100A1 (en) 2001-07-31

Family

ID=26584043

Family Applications (1)

Application Number Title Priority Date Filing Date
AU2001227100A Abandoned AU2001227100A1 (en) 2000-01-24 2001-01-24 Process for the preparation of quinolylpropenal

Country Status (8)

Country Link
US (1) US6630591B2 (en)
EP (1) EP1251124B1 (en)
CN (1) CN1222512C (en)
AT (1) ATE366239T1 (en)
AU (1) AU2001227100A1 (en)
CA (1) CA2398138C (en)
DE (1) DE60129203T2 (en)
WO (1) WO2001053265A1 (en)

Families Citing this family (1)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
EP2423195A1 (en) * 2010-07-26 2012-02-29 LEK Pharmaceuticals d.d. Process for the preparation of key intermediates for the synthesis of statins or pharmaceutically acceptable salts thereof

Family Cites Families (3)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
JP2569746B2 (en) * 1987-08-20 1997-01-08 日産化学工業株式会社 Quinoline mevalonolactones
JP3130342B2 (en) * 1991-10-04 2001-01-31 日産化学工業株式会社 Atherosclerotic intimal thickening inhibitor
MXPA01000890A (en) * 1998-07-23 2002-06-04 Nissan Chemical Ind Ltd Process for the preparation of quinoline derivative and intermediate therefor.

Also Published As

Publication number Publication date
US6630591B2 (en) 2003-10-07
CA2398138A1 (en) 2001-07-26
US20030114680A1 (en) 2003-06-19
EP1251124A1 (en) 2002-10-23
CN1419544A (en) 2003-05-21
DE60129203D1 (en) 2007-08-16
DE60129203T2 (en) 2008-03-13
ATE366239T1 (en) 2007-07-15
WO2001053265A1 (en) 2001-07-26
CN1222512C (en) 2005-10-12
EP1251124B1 (en) 2007-07-04
CA2398138C (en) 2009-12-22
EP1251124A4 (en) 2004-09-01

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