AU1974592A - Monoclonal antibodies against human tnf-binding protein i (tnf-bp i) - Google Patents

Monoclonal antibodies against human tnf-binding protein i (tnf-bp i)

Info

Publication number
AU1974592A
AU1974592A AU19745/92A AU1974592A AU1974592A AU 1974592 A AU1974592 A AU 1974592A AU 19745/92 A AU19745/92 A AU 19745/92A AU 1974592 A AU1974592 A AU 1974592A AU 1974592 A AU1974592 A AU 1974592A
Authority
AU
Australia
Prior art keywords
tnf
tbp
monoclonal antibodies
concentration
binding protein
Prior art date
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Granted
Application number
AU19745/92A
Other versions
AU668351B2 (en
Inventor
Gunther Adolf
Current Assignee (The listed assignees may be inaccurate. Google has not performed a legal analysis and makes no representation or warranty as to the accuracy of the list.)
Boehringer Ingelheim International GmbH
Original Assignee
Boehringer Ingelheim International GmbH
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Priority claimed from DE4120213A external-priority patent/DE4120213C2/en
Priority claimed from DE4200049A external-priority patent/DE4200049A1/en
Application filed by Boehringer Ingelheim International GmbH filed Critical Boehringer Ingelheim International GmbH
Publication of AU1974592A publication Critical patent/AU1974592A/en
Application granted granted Critical
Publication of AU668351B2 publication Critical patent/AU668351B2/en
Anticipated expiration legal-status Critical
Expired legal-status Critical Current

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K16/00—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies
    • C07K16/18—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies against material from animals or humans
    • C07K16/28—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies against material from animals or humans against receptors, cell surface antigens or cell surface determinants
    • C07K16/2866—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies against material from animals or humans against receptors, cell surface antigens or cell surface determinants against receptors for cytokines, lymphokines, interferons
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K38/00—Medicinal preparations containing peptides

Landscapes

  • Health & Medical Sciences (AREA)
  • Chemical & Material Sciences (AREA)
  • Immunology (AREA)
  • Organic Chemistry (AREA)
  • Medicinal Chemistry (AREA)
  • Biophysics (AREA)
  • General Health & Medical Sciences (AREA)
  • Genetics & Genomics (AREA)
  • Biochemistry (AREA)
  • Molecular Biology (AREA)
  • Proteomics, Peptides & Aminoacids (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Preparation Of Compounds By Using Micro-Organisms (AREA)
  • Peptides Or Proteins (AREA)
  • Medicines Containing Antibodies Or Antigens For Use As Internal Diagnostic Agents (AREA)
  • Micro-Organisms Or Cultivation Processes Thereof (AREA)

Abstract

The invention concerns monoclonal antibodies, designated tbp-1, tbp-2 and tbp-6, against the extracellular part of the human 60 kD TN tumour necrosis factor receptor (TNF-BP I). These antibodies are suitable for use in highly sensitive immuno-assays for demonstrating the presence of TNF-BP I in body fluids, including urine, and in cell-culture residues. The determination of the TNF-BP I concentration as the basis for a diagnosis of pathological conditions associated with activation of the TNF receptor system is thus particularly useful if the alpha -TNF concentration in the organism falls more rapidly than the TNF-BP I concentration. In addition, tbp-1 and tbp-6 can be used to strengthen the protective action of TNF-BP I against alpha -TNF and/or beta -TNF.
AU19745/92A 1991-06-19 1992-06-13 Monoclonal antibodies against human TNF-binding protein I (TNF-BP I) Expired AU668351B2 (en)

Applications Claiming Priority (5)

Application Number Priority Date Filing Date Title
DE4120213 1991-06-19
DE4120213A DE4120213C2 (en) 1991-06-19 1991-06-19 Monoclonal antibodies against TNF-binding protein I (TNF-BP I)
DE4200049 1992-01-03
DE4200049A DE4200049A1 (en) 1992-01-03 1992-01-03 New monoclonal antibodies specific for tumour necrosis factor binding protein
PCT/EP1992/001335 WO1992022666A1 (en) 1991-06-19 1992-06-13 Monoclonal antibodies against human tnf-binding protein i (tnf-bp i)

Publications (2)

Publication Number Publication Date
AU1974592A true AU1974592A (en) 1993-01-12
AU668351B2 AU668351B2 (en) 1996-05-02

Family

ID=25904672

Family Applications (1)

Application Number Title Priority Date Filing Date
AU19745/92A Expired AU668351B2 (en) 1991-06-19 1992-06-13 Monoclonal antibodies against human TNF-binding protein I (TNF-BP I)

Country Status (6)

Country Link
EP (1) EP0589982B1 (en)
AT (1) ATE198770T1 (en)
AU (1) AU668351B2 (en)
CA (1) CA2107340C (en)
DE (1) DE59209888D1 (en)
WO (1) WO1992022666A1 (en)

Families Citing this family (6)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
IT1270943B (en) * 1993-05-14 1997-05-26 Mini Ricerca Scient Tecnolog TYPE I TNF ALFA ANTI-RECEPTOR ANTI-RECEPTOR ANTI-PRODUCTION PROCEDURES AND THEIR USES
EP0846169B1 (en) * 1995-08-04 2003-03-19 Lek, Tovarna Farmacevtskih in Kemicnih Izdelkov, D.D. MONOCLONAL ANTIBODIES AGAINST SOLUBLE TNF-ALPHA RECEPTORS p55 and p75 AS WELL AS AGAINST TNF-ALPHA AND ITS ANALOGUES
US6620382B1 (en) 1998-05-22 2003-09-16 Biopheresis Technologies, Llc. Method and compositions for treatment of cancers
US8197430B1 (en) 1998-05-22 2012-06-12 Biopheresis Technologies, Inc. Method and system to remove cytokine inhibitor in patients
US6598597B1 (en) 1999-03-30 2003-07-29 Geo S.R.L. Method for cutting blocks of stone and frame cutting machine for carrying out said method
US9028822B2 (en) 2002-06-28 2015-05-12 Domantis Limited Antagonists against TNFR1 and methods of use therefor

Family Cites Families (6)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
GB8806339D0 (en) * 1988-03-17 1988-04-13 Hoffmann La Roche Monoclonal antibodies
IL94039A (en) * 1989-08-06 2006-09-05 Yeda Res & Dev Antibodies to tbp - 1 and their use
DK0393438T3 (en) * 1989-04-21 2005-05-30 Amgen Inc TNF receptor, TNF binding proteins and DNAs encoding it
DE4006269A1 (en) * 1990-02-28 1991-08-29 Max Planck Gesellschaft Antibody which binds to tumour necrosis factor receptors
US5224919A (en) * 1990-09-07 1993-07-06 Graphic Packaging Corporation Method and apparatus for attaching insert panels to carton blanks
JPH08509203A (en) * 1992-10-15 1996-10-01 ダナ−ファーバー キャンサー インステテュート インコーポレイテッド Treatment of obesity-related diabetes type II insulin resistance with antagonists of TNF-α action

Also Published As

Publication number Publication date
ATE198770T1 (en) 2001-02-15
EP0589982A1 (en) 1994-04-06
EP0589982B1 (en) 2001-01-17
AU668351B2 (en) 1996-05-02
WO1992022666A1 (en) 1992-12-23
CA2107340A1 (en) 1992-12-20
DE59209888D1 (en) 2001-02-22
CA2107340C (en) 2003-06-10

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