AU1429788A - Renin inhibitors containing a cyclopropyl amino acid and/or a cycloalkyl transition-state analogue - Google Patents

Renin inhibitors containing a cyclopropyl amino acid and/or a cycloalkyl transition-state analogue

Info

Publication number
AU1429788A
AU1429788A AU14297/88A AU1429788A AU1429788A AU 1429788 A AU1429788 A AU 1429788A AU 14297/88 A AU14297/88 A AU 14297/88A AU 1429788 A AU1429788 A AU 1429788A AU 1429788 A AU1429788 A AU 1429788A
Authority
AU
Australia
Prior art keywords
cycloalkyl
transition
amino acid
renin inhibitors
cyclopropyl amino
Prior art date
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Abandoned
Application number
AU14297/88A
Inventor
Ronald Bruce Gammill
Jackson B. Hester Jr.
Current Assignee (The listed assignees may be inaccurate. Google has not performed a legal analysis and makes no representation or warranty as to the accuracy of the list.)
Pharmacia and Upjohn Co
Original Assignee
Upjohn Co
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Upjohn Co filed Critical Upjohn Co
Publication of AU1429788A publication Critical patent/AU1429788A/en
Abandoned legal-status Critical Current

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D233/00—Heterocyclic compounds containing 1,3-diazole or hydrogenated 1,3-diazole rings, not condensed with other rings
    • C07D233/54—Heterocyclic compounds containing 1,3-diazole or hydrogenated 1,3-diazole rings, not condensed with other rings having two double bonds between ring members or between ring members and non-ring members
    • C07D233/64—Heterocyclic compounds containing 1,3-diazole or hydrogenated 1,3-diazole rings, not condensed with other rings having two double bonds between ring members or between ring members and non-ring members with substituted hydrocarbon radicals attached to ring carbon atoms, e.g. histidine
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P9/00—Drugs for disorders of the cardiovascular system
    • A61P9/12—Antihypertensives
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D401/00—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom
    • C07D401/02—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom containing two hetero rings
    • C07D401/12—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom containing two hetero rings linked by a chain containing hetero atoms as chain links
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K5/00—Peptides containing up to four amino acids in a fully defined sequence; Derivatives thereof
    • C07K5/02—Peptides containing up to four amino acids in a fully defined sequence; Derivatives thereof containing at least one abnormal peptide link
    • C07K5/0227—Peptides containing up to four amino acids in a fully defined sequence; Derivatives thereof containing at least one abnormal peptide link containing the (partial) peptide sequence -Phe-His-NH-(X)2-C(=0)-, e.g. Renin-inhibitors with n = 2 - 6; for n > 6 see C07K5/06 - C07K5/10

Landscapes

  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Health & Medical Sciences (AREA)
  • General Health & Medical Sciences (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Medicinal Chemistry (AREA)
  • Heart & Thoracic Surgery (AREA)
  • Public Health (AREA)
  • General Chemical & Material Sciences (AREA)
  • Cardiology (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Animal Behavior & Ethology (AREA)
  • Engineering & Computer Science (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Veterinary Medicine (AREA)
  • Biochemistry (AREA)
  • Biophysics (AREA)
  • Genetics & Genomics (AREA)
  • Molecular Biology (AREA)
  • Proteomics, Peptides & Aminoacids (AREA)
  • Peptides Or Proteins (AREA)
  • Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
AU14297/88A 1987-03-09 1988-03-02 Renin inhibitors containing a cyclopropyl amino acid and/or a cycloalkyl transition-state analogue Abandoned AU1429788A (en)

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
US023404 1979-03-23
US2340487A 1987-03-09 1987-03-09

Publications (1)

Publication Number Publication Date
AU1429788A true AU1429788A (en) 1988-10-10

Family

ID=21814881

Family Applications (1)

Application Number Title Priority Date Filing Date
AU14297/88A Abandoned AU1429788A (en) 1987-03-09 1988-03-02 Renin inhibitors containing a cyclopropyl amino acid and/or a cycloalkyl transition-state analogue

Country Status (4)

Country Link
EP (1) EP0349570A1 (en)
JP (1) JPH02502457A (en)
AU (1) AU1429788A (en)
WO (1) WO1988007053A1 (en)

Families Citing this family (3)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
EP0361341A3 (en) * 1988-09-28 1991-07-03 Miles Inc. Therapeutics for aids based on inhibitors of hiv protease
US5098924A (en) * 1989-09-15 1992-03-24 E. R. Squibb & Sons, Inc. Diol sulfonamide and sulfinyl renin inhibitors
WO1992000972A1 (en) * 1990-07-11 1992-01-23 Abbott Laboratories Renin inhibiting compounds

Family Cites Families (2)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
DE3485587D1 (en) * 1983-08-16 1992-04-23 Univ Georgia Res Found PRODUCTION OF AMINOCYCLOPROPANCARBONIC ACIDS AND PEPTIDES.
FI88400C (en) * 1984-08-06 1993-05-10 Upjohn Co FRAMEWORK FOR THE FRAME STATION INHIBITION OF PEPTIDER

Also Published As

Publication number Publication date
EP0349570A1 (en) 1990-01-10
WO1988007053A1 (en) 1988-09-22
JPH02502457A (en) 1990-08-09

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