AU1429788A - Renin inhibitors containing a cyclopropyl amino acid and/or a cycloalkyl transition-state analogue - Google Patents
Renin inhibitors containing a cyclopropyl amino acid and/or a cycloalkyl transition-state analogueInfo
- Publication number
- AU1429788A AU1429788A AU14297/88A AU1429788A AU1429788A AU 1429788 A AU1429788 A AU 1429788A AU 14297/88 A AU14297/88 A AU 14297/88A AU 1429788 A AU1429788 A AU 1429788A AU 1429788 A AU1429788 A AU 1429788A
- Authority
- AU
- Australia
- Prior art keywords
- cycloalkyl
- transition
- amino acid
- renin inhibitors
- cyclopropyl amino
- Prior art date
- Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
- Abandoned
Links
Classifications
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D233/00—Heterocyclic compounds containing 1,3-diazole or hydrogenated 1,3-diazole rings, not condensed with other rings
- C07D233/54—Heterocyclic compounds containing 1,3-diazole or hydrogenated 1,3-diazole rings, not condensed with other rings having two double bonds between ring members or between ring members and non-ring members
- C07D233/64—Heterocyclic compounds containing 1,3-diazole or hydrogenated 1,3-diazole rings, not condensed with other rings having two double bonds between ring members or between ring members and non-ring members with substituted hydrocarbon radicals attached to ring carbon atoms, e.g. histidine
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P9/00—Drugs for disorders of the cardiovascular system
- A61P9/12—Antihypertensives
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D401/00—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom
- C07D401/02—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom containing two hetero rings
- C07D401/12—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom containing two hetero rings linked by a chain containing hetero atoms as chain links
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K5/00—Peptides containing up to four amino acids in a fully defined sequence; Derivatives thereof
- C07K5/02—Peptides containing up to four amino acids in a fully defined sequence; Derivatives thereof containing at least one abnormal peptide link
- C07K5/0227—Peptides containing up to four amino acids in a fully defined sequence; Derivatives thereof containing at least one abnormal peptide link containing the (partial) peptide sequence -Phe-His-NH-(X)2-C(=0)-, e.g. Renin-inhibitors with n = 2 - 6; for n > 6 see C07K5/06 - C07K5/10
Landscapes
- Chemical & Material Sciences (AREA)
- Organic Chemistry (AREA)
- Health & Medical Sciences (AREA)
- General Health & Medical Sciences (AREA)
- Life Sciences & Earth Sciences (AREA)
- Medicinal Chemistry (AREA)
- Heart & Thoracic Surgery (AREA)
- Public Health (AREA)
- General Chemical & Material Sciences (AREA)
- Cardiology (AREA)
- Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
- Pharmacology & Pharmacy (AREA)
- Bioinformatics & Cheminformatics (AREA)
- Animal Behavior & Ethology (AREA)
- Engineering & Computer Science (AREA)
- Chemical Kinetics & Catalysis (AREA)
- Veterinary Medicine (AREA)
- Biochemistry (AREA)
- Biophysics (AREA)
- Genetics & Genomics (AREA)
- Molecular Biology (AREA)
- Proteomics, Peptides & Aminoacids (AREA)
- Peptides Or Proteins (AREA)
- Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
Applications Claiming Priority (2)
Application Number | Priority Date | Filing Date | Title |
---|---|---|---|
US023404 | 1979-03-23 | ||
US2340487A | 1987-03-09 | 1987-03-09 |
Publications (1)
Publication Number | Publication Date |
---|---|
AU1429788A true AU1429788A (en) | 1988-10-10 |
Family
ID=21814881
Family Applications (1)
Application Number | Title | Priority Date | Filing Date |
---|---|---|---|
AU14297/88A Abandoned AU1429788A (en) | 1987-03-09 | 1988-03-02 | Renin inhibitors containing a cyclopropyl amino acid and/or a cycloalkyl transition-state analogue |
Country Status (4)
Country | Link |
---|---|
EP (1) | EP0349570A1 (en) |
JP (1) | JPH02502457A (en) |
AU (1) | AU1429788A (en) |
WO (1) | WO1988007053A1 (en) |
Families Citing this family (3)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
EP0361341A3 (en) * | 1988-09-28 | 1991-07-03 | Miles Inc. | Therapeutics for aids based on inhibitors of hiv protease |
US5098924A (en) * | 1989-09-15 | 1992-03-24 | E. R. Squibb & Sons, Inc. | Diol sulfonamide and sulfinyl renin inhibitors |
WO1992000972A1 (en) * | 1990-07-11 | 1992-01-23 | Abbott Laboratories | Renin inhibiting compounds |
Family Cites Families (2)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
DE3485587D1 (en) * | 1983-08-16 | 1992-04-23 | Univ Georgia Res Found | PRODUCTION OF AMINOCYCLOPROPANCARBONIC ACIDS AND PEPTIDES. |
FI88400C (en) * | 1984-08-06 | 1993-05-10 | Upjohn Co | FRAMEWORK FOR THE FRAME STATION INHIBITION OF PEPTIDER |
-
1988
- 1988-03-02 JP JP63502520A patent/JPH02502457A/en active Pending
- 1988-03-02 EP EP88902695A patent/EP0349570A1/en not_active Withdrawn
- 1988-03-02 WO PCT/US1988/000547 patent/WO1988007053A1/en not_active Application Discontinuation
- 1988-03-02 AU AU14297/88A patent/AU1429788A/en not_active Abandoned
Also Published As
Publication number | Publication date |
---|---|
EP0349570A1 (en) | 1990-01-10 |
WO1988007053A1 (en) | 1988-09-22 |
JPH02502457A (en) | 1990-08-09 |
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