AU1261788A - Amino acid derivatives - Google Patents

Amino acid derivatives

Info

Publication number
AU1261788A
AU1261788A AU12617/88A AU1261788A AU1261788A AU 1261788 A AU1261788 A AU 1261788A AU 12617/88 A AU12617/88 A AU 12617/88A AU 1261788 A AU1261788 A AU 1261788A AU 1261788 A AU1261788 A AU 1261788A
Authority
AU
Australia
Prior art keywords
amino acid
acid derivatives
derivatives
amino
acid
Prior art date
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Granted
Application number
AU12617/88A
Other versions
AU614951B2 (en
Inventor
Joachim Gante
Klaus Otto Minck
Peter Raddatz
Claus J. Schmitges
Johannes Sombroek
Current Assignee (The listed assignees may be inaccurate. Google has not performed a legal analysis and makes no representation or warranty as to the accuracy of the list.)
Merck Patent GmbH
Original Assignee
Merck Patent GmbH
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Merck Patent GmbH filed Critical Merck Patent GmbH
Publication of AU1261788A publication Critical patent/AU1261788A/en
Application granted granted Critical
Publication of AU614951B2 publication Critical patent/AU614951B2/en
Anticipated expiration legal-status Critical
Ceased legal-status Critical Current

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K5/00—Peptides containing up to four amino acids in a fully defined sequence; Derivatives thereof
    • C07K5/04—Peptides containing up to four amino acids in a fully defined sequence; Derivatives thereof containing only normal peptide links
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D403/00—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, not provided for by group C07D401/00
    • C07D403/02—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, not provided for by group C07D401/00 containing two hetero rings
    • C07D403/12—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, not provided for by group C07D401/00 containing two hetero rings linked by a chain containing hetero atoms as chain links
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P9/00—Drugs for disorders of the cardiovascular system
    • A61P9/12—Antihypertensives
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D239/00—Heterocyclic compounds containing 1,3-diazine or hydrogenated 1,3-diazine rings
    • C07D239/70—Heterocyclic compounds containing 1,3-diazine or hydrogenated 1,3-diazine rings condensed with carbocyclic rings or ring systems
    • C07D239/72—Quinazolines; Hydrogenated quinazolines
    • C07D239/86—Quinazolines; Hydrogenated quinazolines with hetero atoms directly attached in position 4
    • C07D239/88—Oxygen atoms
    • C07D239/92—Oxygen atoms with hetero atoms directly attached to nitrogen atoms of the hetero ring
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K5/00—Peptides containing up to four amino acids in a fully defined sequence; Derivatives thereof
    • C07K5/02—Peptides containing up to four amino acids in a fully defined sequence; Derivatives thereof containing at least one abnormal peptide link
    • C07K5/0227—Peptides containing up to four amino acids in a fully defined sequence; Derivatives thereof containing at least one abnormal peptide link containing the (partial) peptide sequence -Phe-His-NH-(X)2-C(=0)-, e.g. Renin-inhibitors with n = 2 - 6; for n > 6 see C07K5/06 - C07K5/10

Landscapes

  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Health & Medical Sciences (AREA)
  • Medicinal Chemistry (AREA)
  • General Health & Medical Sciences (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Proteomics, Peptides & Aminoacids (AREA)
  • Biochemistry (AREA)
  • Molecular Biology (AREA)
  • Genetics & Genomics (AREA)
  • Biophysics (AREA)
  • Cardiology (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Animal Behavior & Ethology (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Public Health (AREA)
  • Veterinary Medicine (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Heart & Thoracic Surgery (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • General Chemical & Material Sciences (AREA)
  • Engineering & Computer Science (AREA)
  • Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
  • Organic Low-Molecular-Weight Compounds And Preparation Thereof (AREA)
  • Acyclic And Carbocyclic Compounds In Medicinal Compositions (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Furan Compounds (AREA)
  • Pyridine Compounds (AREA)
  • Peptides Or Proteins (AREA)
  • Heterocyclic Compounds Containing Sulfur Atoms (AREA)
AU12617/88A 1987-03-12 1988-03-01 Amino acid derivatives Ceased AU614951B2 (en)

Applications Claiming Priority (4)

Application Number Priority Date Filing Date Title
DE3707879 1987-03-12
DE3707879 1987-03-12
DE19873721855 DE3721855A1 (en) 1987-03-12 1987-07-02 AMINO ACID DERIVATIVES
DE3721855 1987-07-02

Publications (2)

Publication Number Publication Date
AU1261788A true AU1261788A (en) 1988-09-15
AU614951B2 AU614951B2 (en) 1991-09-19

Family

ID=25853356

Family Applications (1)

Application Number Title Priority Date Filing Date
AU12617/88A Ceased AU614951B2 (en) 1987-03-12 1988-03-01 Amino acid derivatives

Country Status (6)

Country Link
EP (1) EP0286813A3 (en)
JP (1) JPS63258451A (en)
KR (1) KR880011196A (en)
AU (1) AU614951B2 (en)
DE (1) DE3721855A1 (en)
HU (1) HU204848B (en)

Cited By (3)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
AU605210B2 (en) * 1986-11-27 1991-01-10 Merck Patent Gesellschaft Mit Beschrankter Haftung Peptides which inhibit human plasma renin
US7671200B2 (en) 1999-10-27 2010-03-02 Cytokinetics, Inc. Quinazolinone KSP inhibitors
US7763628B2 (en) 1999-10-27 2010-07-27 Cytokinetics, Inc. Methods and compositions utilizing quinazolinones

Families Citing this family (16)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
DE3812328A1 (en) * 1988-04-14 1989-10-26 Merck Patent Gmbh AMINOSAEUREDERIVATE
US5268374A (en) * 1988-10-04 1993-12-07 Abbott Laboratories Non-peptide renin inhibitors
US5164388A (en) * 1988-10-19 1992-11-17 Abbott Laboratories Heterocyclic peptide renin inhibitors
US5049548A (en) * 1989-03-03 1991-09-17 Merck & Co., Inc. Renin-inhibitory di-, tri-, and tetrapeptides
DE3913290A1 (en) * 1989-04-22 1990-10-25 Hoechst Ag RENIN-INHIBITING DI- AND TRIPEPTIDES, METHOD FOR THE PRODUCTION THEREOF, THE MEANS CONTAINING THEM AND THEIR USE
US4985417A (en) * 1989-05-02 1991-01-15 Trager Seymour F Treatment of glaucoma
US5063208A (en) * 1989-07-26 1991-11-05 Abbott Laboratories Peptidyl aminodiol renin inhibitors
US5559256A (en) * 1992-07-20 1996-09-24 E. R. Squibb & Sons, Inc. Aminediol protease inhibitors
US6545004B1 (en) 1999-10-27 2003-04-08 Cytokinetics, Inc. Methods and compositions utilizing quinazolinones
AU2001252958A1 (en) 2000-03-23 2001-10-03 Elan Pharmaceuticals, Inc. Compounds and methods to treat alzheimer's disease
US6992081B2 (en) 2000-03-23 2006-01-31 Elan Pharmaceuticals, Inc. Compounds to treat Alzheimer's disease
US6846813B2 (en) 2000-06-30 2005-01-25 Pharmacia & Upjohn Company Compounds to treat alzheimer's disease
ATE302751T1 (en) 2000-06-30 2005-09-15 Elan Pharm Inc COMPOUNDS FOR THE TREATMENT OF ALZHEIMER'S DISEASE
US6689782B2 (en) * 2001-07-16 2004-02-10 Essential Therapeutics, Inc. Fungal efflux pump inhibitors
AU2002346471A1 (en) 2001-11-20 2003-06-10 Cytokinetics, Inc. Process for the racemization of chiral quinazolinones
ES2962736T3 (en) * 2018-04-11 2024-05-24 Viiv Healthcare Uk No 5 Ltd 4-oxo-3,4-dihydroquinazoline compounds as inhibitors of human immunodeficiency virus replication

Family Cites Families (8)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US4613676A (en) * 1983-11-23 1986-09-23 Ciba-Geigy Corporation Substituted 5-amino-4-hydroxyvaleryl derivatives
US4636491A (en) * 1984-03-27 1987-01-13 Merck & Co., Inc. Renin inhibitory peptides having improved solubility
PT82077B (en) * 1985-02-26 1987-09-25 Sanofi Sa PROCESS FOR OBTAINING PEPTIDE AMINOALCOHOL DERIVATIVES INHIBITORS OF RENIN AND ACIDIC PROTEASES
CA1290097C (en) * 1985-07-24 1991-10-01 Merck & Co., Inc. Peptide enzyme inhibitors
DE3601248A1 (en) * 1986-01-17 1987-07-23 Hoechst Ag SUBSTITUTED 4-AMINO-3-HYDROXYBUTTERIC ACID DERIVATIVES, METHOD FOR THE PRODUCTION THEREOF, THESE AGENTS AND THEIR USE
DE3626130A1 (en) * 1986-08-01 1988-02-11 Merck Patent Gmbh AMINO ACID DERIVATIVES
DE3635907A1 (en) * 1986-10-22 1988-04-28 Merck Patent Gmbh HYDROXY AMINO ACID DERIVATIVES
DE3733296A1 (en) * 1987-10-02 1989-04-20 Merck Patent Gmbh AMINOSAEUREDERIVATE

Cited By (5)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
AU605210B2 (en) * 1986-11-27 1991-01-10 Merck Patent Gesellschaft Mit Beschrankter Haftung Peptides which inhibit human plasma renin
US7671200B2 (en) 1999-10-27 2010-03-02 Cytokinetics, Inc. Quinazolinone KSP inhibitors
US7763628B2 (en) 1999-10-27 2010-07-27 Cytokinetics, Inc. Methods and compositions utilizing quinazolinones
US8008311B2 (en) 1999-10-27 2011-08-30 Cytokinetics, Inc. Methods and compostions utilizing quinazolinones
US8470838B2 (en) 1999-10-27 2013-06-25 Cytokinetics, Incorporated Methods and compositions utilizing quinazolinones

Also Published As

Publication number Publication date
EP0286813A3 (en) 1990-12-12
JPS63258451A (en) 1988-10-25
AU614951B2 (en) 1991-09-19
HUT49147A (en) 1989-08-28
EP0286813A2 (en) 1988-10-19
HU204848B (en) 1992-02-28
DE3721855A1 (en) 1988-09-22
KR880011196A (en) 1988-10-27

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