AU1145088A - Pyridine-2,4- and -2,5-dicarboxylic acid derivatives, processes for their preparation, the use thereof and medicaments based on these compounds - Google Patents

Pyridine-2,4- and -2,5-dicarboxylic acid derivatives, processes for their preparation, the use thereof and medicaments based on these compounds

Info

Publication number
AU1145088A
AU1145088A AU11450/88A AU1145088A AU1145088A AU 1145088 A AU1145088 A AU 1145088A AU 11450/88 A AU11450/88 A AU 11450/88A AU 1145088 A AU1145088 A AU 1145088A AU 1145088 A AU1145088 A AU 1145088A
Authority
AU
Australia
Prior art keywords
pyridine
compounds
processes
preparation
dicarboxylic acid
Prior art date
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Granted
Application number
AU11450/88A
Other versions
AU600084B2 (en
Inventor
Martin Bickel
Dietrich Brocks
Harald Burghard
Volkmar Gunzler
Hartmut Hanauske-Abel
Stephan Henke
Current Assignee (The listed assignees may be inaccurate. Google has not performed a legal analysis and makes no representation or warranty as to the accuracy of the list.)
Hoechst AG
Original Assignee
Hoechst AG
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Hoechst AG filed Critical Hoechst AG
Publication of AU1145088A publication Critical patent/AU1145088A/en
Application granted granted Critical
Publication of AU600084B2 publication Critical patent/AU600084B2/en
Anticipated expiration legal-status Critical
Ceased legal-status Critical Current

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D213/00—Heterocyclic compounds containing six-membered rings, not condensed with other rings, with one nitrogen atom as the only ring hetero atom and three or more double bonds between ring members or between ring members and non-ring members
    • C07D213/02—Heterocyclic compounds containing six-membered rings, not condensed with other rings, with one nitrogen atom as the only ring hetero atom and three or more double bonds between ring members or between ring members and non-ring members having three double bonds between ring members or between ring members and non-ring members
    • C07D213/04—Heterocyclic compounds containing six-membered rings, not condensed with other rings, with one nitrogen atom as the only ring hetero atom and three or more double bonds between ring members or between ring members and non-ring members having three double bonds between ring members or between ring members and non-ring members having no bond between the ring nitrogen atom and a non-ring member or having only hydrogen or carbon atoms directly attached to the ring nitrogen atom
    • C07D213/60—Heterocyclic compounds containing six-membered rings, not condensed with other rings, with one nitrogen atom as the only ring hetero atom and three or more double bonds between ring members or between ring members and non-ring members having three double bonds between ring members or between ring members and non-ring members having no bond between the ring nitrogen atom and a non-ring member or having only hydrogen or carbon atoms directly attached to the ring nitrogen atom with hetero atoms or with carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals, directly attached to ring carbon atoms
    • C07D213/78—Carbon atoms having three bonds to hetero atoms, with at the most one bond to halogen, e.g. ester or nitrile radicals
    • C07D213/79—Acids; Esters
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P3/00—Drugs for disorders of the metabolism
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P37/00—Drugs for immunological or allergic disorders
    • A61P37/02—Immunomodulators
    • A61P37/06—Immunosuppressants, e.g. drugs for graft rejection
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D213/00—Heterocyclic compounds containing six-membered rings, not condensed with other rings, with one nitrogen atom as the only ring hetero atom and three or more double bonds between ring members or between ring members and non-ring members
    • C07D213/02—Heterocyclic compounds containing six-membered rings, not condensed with other rings, with one nitrogen atom as the only ring hetero atom and three or more double bonds between ring members or between ring members and non-ring members having three double bonds between ring members or between ring members and non-ring members
    • C07D213/04—Heterocyclic compounds containing six-membered rings, not condensed with other rings, with one nitrogen atom as the only ring hetero atom and three or more double bonds between ring members or between ring members and non-ring members having three double bonds between ring members or between ring members and non-ring members having no bond between the ring nitrogen atom and a non-ring member or having only hydrogen or carbon atoms directly attached to the ring nitrogen atom
    • C07D213/60—Heterocyclic compounds containing six-membered rings, not condensed with other rings, with one nitrogen atom as the only ring hetero atom and three or more double bonds between ring members or between ring members and non-ring members having three double bonds between ring members or between ring members and non-ring members having no bond between the ring nitrogen atom and a non-ring member or having only hydrogen or carbon atoms directly attached to the ring nitrogen atom with hetero atoms or with carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals, directly attached to ring carbon atoms
    • C07D213/78—Carbon atoms having three bonds to hetero atoms, with at the most one bond to halogen, e.g. ester or nitrile radicals
    • C07D213/79—Acids; Esters
    • C07D213/80—Acids; Esters in position 3
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D213/00—Heterocyclic compounds containing six-membered rings, not condensed with other rings, with one nitrogen atom as the only ring hetero atom and three or more double bonds between ring members or between ring members and non-ring members
    • C07D213/02—Heterocyclic compounds containing six-membered rings, not condensed with other rings, with one nitrogen atom as the only ring hetero atom and three or more double bonds between ring members or between ring members and non-ring members having three double bonds between ring members or between ring members and non-ring members
    • C07D213/04—Heterocyclic compounds containing six-membered rings, not condensed with other rings, with one nitrogen atom as the only ring hetero atom and three or more double bonds between ring members or between ring members and non-ring members having three double bonds between ring members or between ring members and non-ring members having no bond between the ring nitrogen atom and a non-ring member or having only hydrogen or carbon atoms directly attached to the ring nitrogen atom
    • C07D213/60—Heterocyclic compounds containing six-membered rings, not condensed with other rings, with one nitrogen atom as the only ring hetero atom and three or more double bonds between ring members or between ring members and non-ring members having three double bonds between ring members or between ring members and non-ring members having no bond between the ring nitrogen atom and a non-ring member or having only hydrogen or carbon atoms directly attached to the ring nitrogen atom with hetero atoms or with carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals, directly attached to ring carbon atoms
    • C07D213/78—Carbon atoms having three bonds to hetero atoms, with at the most one bond to halogen, e.g. ester or nitrile radicals
    • C07D213/81—Amides; Imides
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D405/00—Heterocyclic compounds containing both one or more hetero rings having oxygen atoms as the only ring hetero atoms, and one or more rings having nitrogen as the only ring hetero atom
    • C07D405/14—Heterocyclic compounds containing both one or more hetero rings having oxygen atoms as the only ring hetero atoms, and one or more rings having nitrogen as the only ring hetero atom containing three or more hetero rings

Landscapes

  • Organic Chemistry (AREA)
  • Chemical & Material Sciences (AREA)
  • Health & Medical Sciences (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Immunology (AREA)
  • Engineering & Computer Science (AREA)
  • Veterinary Medicine (AREA)
  • General Chemical & Material Sciences (AREA)
  • Medicinal Chemistry (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Animal Behavior & Ethology (AREA)
  • General Health & Medical Sciences (AREA)
  • Public Health (AREA)
  • Obesity (AREA)
  • Diabetes (AREA)
  • Hematology (AREA)
  • Transplantation (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Pyridine Compounds (AREA)
  • Plural Heterocyclic Compounds (AREA)
AU11450/88A 1987-02-10 1988-02-09 Pyridine-2,4- and -2,5-dicarboxylic acid derivatives, processes for their preparation, the use thereof and medicaments based on these compounds Ceased AU600084B2 (en)

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
DE3703963 1987-02-10
DE19873703963 DE3703963A1 (en) 1987-02-10 1987-02-10 PYRIDINE-2,4- AND 2,, 5-DICARBONIC ACID DERIVATIVES, METHOD FOR THE PRODUCTION THEREOF, USE THEREOF, AND MEDICINAL PRODUCTS BASED ON THESE COMPOUNDS

Publications (2)

Publication Number Publication Date
AU1145088A true AU1145088A (en) 1988-08-11
AU600084B2 AU600084B2 (en) 1990-08-02

Family

ID=6320593

Family Applications (1)

Application Number Title Priority Date Filing Date
AU11450/88A Ceased AU600084B2 (en) 1987-02-10 1988-02-09 Pyridine-2,4- and -2,5-dicarboxylic acid derivatives, processes for their preparation, the use thereof and medicaments based on these compounds

Country Status (17)

Country Link
EP (1) EP0278452B1 (en)
JP (1) JPS63216870A (en)
KR (1) KR960011371B1 (en)
AR (1) AR247816A1 (en)
AT (1) ATE123022T1 (en)
AU (1) AU600084B2 (en)
DE (2) DE3703963A1 (en)
DK (2) DK168379B1 (en)
ES (1) ES2073393T3 (en)
FI (1) FI91524C (en)
HU (1) HU207295B (en)
IE (1) IE67446B1 (en)
IL (1) IL85361A (en)
NO (1) NO173184C (en)
NZ (1) NZ223431A (en)
PT (1) PT86734B (en)
ZA (1) ZA88897B (en)

Cited By (2)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
AU607811B2 (en) * 1987-10-02 1991-03-14 Egis Gyogyszergyar (2-thienyl-methyl)-thiourea derivatives
US5482953A (en) * 1991-02-05 1996-01-09 Hoechst Aktiengesellschaft 2,4-and 2,5-bistetrazolylpyridines and the use thereof as pharmaceuticals

Families Citing this family (10)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
DE3707429A1 (en) * 1987-03-07 1988-09-15 Hoechst Ag SUBSTITUTED PYRIDINE-2,4-DICARBONIC ACID DERIVATIVES, METHOD FOR THE PRODUCTION THEREOF, USE OF THE SAME AND MEDICINAL PRODUCTS BASED ON THESE COMPOUNDS
DE3924093A1 (en) 1989-07-20 1991-02-07 Hoechst Ag N, N'-BIS (ALKOXY-ALKYL) -PYRIDINE-2,4-DICARBONESAUREDIAMIDES, METHOD FOR THE PRODUCTION AND USE THEREOF
DE3938805A1 (en) * 1989-11-23 1991-05-29 Hoechst Ag PYRIDINE-2,4- AND 2,5-DICARBONIC ACID DIAMOND, METHOD FOR THE PRODUCTION AND USE THEREOF
DE4020570A1 (en) 1990-06-28 1992-01-02 Hoechst Ag 2,4- AND 2,5-SUBSTITUTED PYRIDINE-N-OXIDES, METHOD FOR THE PRODUCTION AND USE THEREOF
US5260323A (en) * 1990-06-28 1993-11-09 Hoechst Aktiengesellschaft 2,4- and 2,5-substituted pyridine-N-oxides, processes for their preparation and their use
DE4030999A1 (en) * 1990-10-01 1992-04-09 Hoechst Ag 4- OR 5-SUBSTITUTED PYRIDINE-2-CARBONIC ACIDS, METHOD FOR THE PRODUCTION THEREOF AND THEIR USE AS A MEDICINAL PRODUCT
CA2085954A1 (en) * 1991-12-24 1993-06-25 Klaus Weidmann Substituted pyridine n-oxides, processes for their preparation, and their use
DE4233124A1 (en) * 1992-10-02 1994-04-07 Hoechst Ag Acylsulfonamido and sulfonamidopyridine-2-carboxylic acid esters and their pyridine N-oxides, processes for their preparation and their use as medicaments
ATE255581T1 (en) * 1997-10-24 2003-12-15 Fibrogen Inc PHENANTHROLINE DERIVATIVES
KR100579792B1 (en) * 1998-05-13 2006-05-12 동화약품공업주식회사 Novel 2,5-pyridinedicarboxylic acid derivatives

Family Cites Families (7)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US4093622A (en) * 1975-05-19 1978-06-06 Zoecon Corporation Pyridine esters of cyclopropane-carboxylic acid
EP0123700A1 (en) * 1983-04-27 1984-11-07 Byk Gulden Lomberg Chemische Fabrik GmbH Substituted picolinic acids, processes for their preparation, their use, and pharmaceutical preparations containing them
DE3432094A1 (en) * 1984-08-31 1986-03-06 Hoechst Ag, 6230 Frankfurt ESTER OF PYRIDINE-2,4- AND -2,5-DICARBONIC ACID AS A MEDICINAL PRODUCT FOR INHIBITING PROLIN AND LYSINE HYDROXYLASE
US4757071A (en) * 1984-12-14 1988-07-12 Nisshin Flour Milling Co., Ltd. 1,4-dihydropyridine derivatives, and pharmaceutical compositions containing same, useful for treating cardiovascular diseases
US4691018A (en) * 1985-05-23 1987-09-01 Chugai Seiyaku Kabushiki Kaisha Pyridine derivatives and their use as anti-allergic agents
GB8702890D0 (en) * 1987-02-10 1987-03-18 Zyma Sa Heterocyclic compounds
ATE113036T1 (en) * 1988-08-04 1994-11-15 Hoechst Ag IMPROVED PROCESS FOR THE PRODUCTION OF N,N-BIS(ALKOXYALKYL)-PYRIDINE-2,4-DICARBONIC DIAMIDES.

Cited By (3)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
AU607811B2 (en) * 1987-10-02 1991-03-14 Egis Gyogyszergyar (2-thienyl-methyl)-thiourea derivatives
US5482953A (en) * 1991-02-05 1996-01-09 Hoechst Aktiengesellschaft 2,4-and 2,5-bistetrazolylpyridines and the use thereof as pharmaceuticals
US5614537A (en) * 1991-02-05 1997-03-25 Hoechst Aktiengesellschaft 2,4-and 2,5-bistetrazolylpyridines, a process for the preparation thereof and the use thereof as pharmaceuticals

Also Published As

Publication number Publication date
FI880554A0 (en) 1988-02-08
DE3703963A1 (en) 1988-08-18
IE880350L (en) 1988-08-10
NO173184C (en) 1993-11-10
FI91524B (en) 1994-03-31
PT86734B (en) 1992-05-29
FI91524C (en) 1994-07-11
DE3853839D1 (en) 1995-06-29
KR880009935A (en) 1988-10-05
NO173184B (en) 1993-08-02
EP0278452A2 (en) 1988-08-17
KR960011371B1 (en) 1996-08-22
HUT47249A (en) 1989-02-28
DK66088D0 (en) 1988-02-09
DK90992D0 (en) 1992-07-10
IL85361A (en) 1993-01-31
IE67446B1 (en) 1996-04-03
NZ223431A (en) 1990-07-26
AU600084B2 (en) 1990-08-02
ATE123022T1 (en) 1995-06-15
HU207295B (en) 1993-03-29
DK66088A (en) 1988-08-11
AR247816A1 (en) 1995-04-28
IL85361A0 (en) 1988-07-31
NO880556D0 (en) 1988-02-09
DK170245B1 (en) 1995-07-17
DK168379B1 (en) 1994-03-21
ES2073393T3 (en) 1995-08-16
NO880556L (en) 1988-08-11
FI880554A (en) 1988-08-11
JPS63216870A (en) 1988-09-09
DK90992A (en) 1992-07-10
ZA88897B (en) 1988-08-09
EP0278452A3 (en) 1989-10-18
PT86734A (en) 1988-03-01
EP0278452B1 (en) 1995-05-24

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