AU1142800A - The use of excitatory amino acid transporter inhibitors to reduce cns white matter injury - Google Patents

The use of excitatory amino acid transporter inhibitors to reduce cns white matter injury

Info

Publication number
AU1142800A
AU1142800A AU11428/00A AU1142800A AU1142800A AU 1142800 A AU1142800 A AU 1142800A AU 11428/00 A AU11428/00 A AU 11428/00A AU 1142800 A AU1142800 A AU 1142800A AU 1142800 A AU1142800 A AU 1142800A
Authority
AU
Australia
Prior art keywords
amino acid
white matter
acid transporter
excitatory amino
transporter inhibitors
Prior art date
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Abandoned
Application number
AU11428/00A
Other languages
English (en)
Inventor
Peter Stys
Current Assignee (The listed assignees may be inaccurate. Google has not performed a legal analysis and makes no representation or warranty as to the accuracy of the list.)
LOEB HEALTH INSTITUTE AT OTTAWA HOSPITAL
Original Assignee
LOEB HEALTH INST AT OTTAWA
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by LOEB HEALTH INST AT OTTAWA filed Critical LOEB HEALTH INST AT OTTAWA
Publication of AU1142800A publication Critical patent/AU1142800A/en
Abandoned legal-status Critical Current

Links

Classifications

    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/33—Heterocyclic compounds
    • A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
    • A61K31/55—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having seven-membered rings, e.g. azelastine, pentylenetetrazole
    • A61K31/551—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having seven-membered rings, e.g. azelastine, pentylenetetrazole having two nitrogen atoms, e.g. dilazep
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/185—Acids; Anhydrides, halides or salts thereof, e.g. sulfur acids, imidic, hydrazonic or hydroximic acids
    • A61K31/19—Carboxylic acids, e.g. valproic acid
    • A61K31/195—Carboxylic acids, e.g. valproic acid having an amino group
    • A61K31/197—Carboxylic acids, e.g. valproic acid having an amino group the amino and the carboxyl groups being attached to the same acyclic carbon chain, e.g. gamma-aminobutyric acid [GABA], beta-alanine, epsilon-aminocaproic acid or pantothenic acid
    • A61K31/198—Alpha-amino acids, e.g. alanine or edetic acid [EDTA]
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/33—Heterocyclic compounds
    • A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
    • A61K31/40—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having five-membered rings with one nitrogen as the only ring hetero atom, e.g. sulpiride, succinimide, tolmetin, buflomedil
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/33—Heterocyclic compounds
    • A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
    • A61K31/40—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having five-membered rings with one nitrogen as the only ring hetero atom, e.g. sulpiride, succinimide, tolmetin, buflomedil
    • A61K31/401—Proline; Derivatives thereof, e.g. captopril
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/33—Heterocyclic compounds
    • A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
    • A61K31/40—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having five-membered rings with one nitrogen as the only ring hetero atom, e.g. sulpiride, succinimide, tolmetin, buflomedil
    • A61K31/403—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having five-membered rings with one nitrogen as the only ring hetero atom, e.g. sulpiride, succinimide, tolmetin, buflomedil condensed with carbocyclic rings, e.g. carbazole
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00—Drugs for disorders of the nervous system

Landscapes

  • Health & Medical Sciences (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Veterinary Medicine (AREA)
  • Public Health (AREA)
  • General Health & Medical Sciences (AREA)
  • Chemical & Material Sciences (AREA)
  • Animal Behavior & Ethology (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Medicinal Chemistry (AREA)
  • Epidemiology (AREA)
  • Neurosurgery (AREA)
  • Organic Chemistry (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • General Chemical & Material Sciences (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Neurology (AREA)
  • Biomedical Technology (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Engineering & Computer Science (AREA)
  • Acyclic And Carbocyclic Compounds In Medicinal Compositions (AREA)
  • Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
AU11428/00A 1998-11-06 1999-11-08 The use of excitatory amino acid transporter inhibitors to reduce cns white matter injury Abandoned AU1142800A (en)

Applications Claiming Priority (5)

Application Number Priority Date Filing Date Title
CA2252996 1998-11-06
CA2252996 1998-11-06
CA002282236A CA2282236A1 (fr) 1998-11-06 1999-09-16 L'utilisation des acides aminés transporteurs inhibiteurs pour prévenir des blessures a la substance blanche du snc
CA2282236 1999-09-16
PCT/CA1999/001037 WO2000027374A2 (fr) 1998-11-06 1999-11-08 Utilisation d'inhibiteurs des transporteurs d'acides amines excitateurs pour reduire les lesions de la substance blanche du systeme nerveux central

Publications (1)

Publication Number Publication Date
AU1142800A true AU1142800A (en) 2000-05-29

Family

ID=25680622

Family Applications (1)

Application Number Title Priority Date Filing Date
AU11428/00A Abandoned AU1142800A (en) 1998-11-06 1999-11-08 The use of excitatory amino acid transporter inhibitors to reduce cns white matter injury

Country Status (3)

Country Link
AU (1) AU1142800A (fr)
CA (1) CA2282236A1 (fr)
WO (1) WO2000027374A2 (fr)

Families Citing this family (3)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
CA2427819A1 (fr) * 2000-10-30 2002-05-23 Xue-Feng Pei Procede de modulation, de stimulation et d'inhibition de la reabsorption du glutamate
CN109111391A (zh) * 2018-07-03 2019-01-01 杭州师范大学 一种含三元环骨架的手性吡咯烷衍生物及其合成方法与应用
KR20210072770A (ko) * 2018-10-02 2021-06-17 조지타운 유니버시티 염증성 신경계 장애를 치료하기 위한 조성물 및 방법

Family Cites Families (2)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
CA2069912A1 (fr) * 1989-10-25 1991-04-26 A. Richard Chamberlin Methode d'inhibition du transport du l-glutamate
US5711316A (en) * 1996-04-30 1998-01-27 Medtronic, Inc. Method of treating movement disorders by brain infusion

Also Published As

Publication number Publication date
WO2000027374B1 (fr) 2001-06-21
WO2000027374A2 (fr) 2000-05-18
WO2000027374A3 (fr) 2000-12-21
CA2282236A1 (fr) 2000-05-06

Similar Documents

Publication Publication Date Title
GB9623908D0 (en) Amino acid derivatives
GB9806815D0 (en) Amino acid derivatives
PL330482A1 (en) Novel amino acid derivatives and their application as thrombosin inhibitors
GR3036341T3 (en) Aminothiophene carboxylic acid amides and the use thereof as phosphodiesterase inhibitors
HUP0103601A3 (en) Hybrid protein for inhibiting the degranulation of mastocytes and the use thereof
PT900270E (pt) Composicao acida espessada
GB9926057D0 (en) Excitatory amino acid derivatives
ZA9711207B (en) Sulfonic acid or sulfonylamino n-(heteroaralkyl)-azahetero-cyclylamide compounds
PL339559A1 (en) Mcp-2 trimmed at their amino end as antagosists of chemokin
AU4077193A (en) Alpha-aminoboronic acid peptides and their use as elastase inhibitors
NZ323205A (en) Excitatory amino acid derivatives
AU4451797A (en) 3-alkoxyisoxazol-4-yl-substituted 2-amino carboxylic acid compounds
AU1142800A (en) The use of excitatory amino acid transporter inhibitors to reduce cns white matter injury
HUP0001661A3 (en) Quinoline-2-carboxylic acid derivative and its use as excitatory amino acids antagonist
IL125381A0 (en) Hydroxamic acid based collagenase inhibitors
IL130014A0 (en) Genetically modified plants having modified amino acid content
AU3494093A (en) S-lipophilic aliphatic carbonyl {n-mercaptoacyl-(amino acid or peptide)} compounds as antihypertensive agents
GB9602117D0 (en) Amino acid compositions
IL129273A0 (en) Antibodies to placental protein 13
DE59206226D1 (de) Aminosäurederivate zur Peptidsynthese
IL112913A0 (en) Amino acid inhibitors of kynureninase
AU2739400A (en) Inhibition of cationic amino acid transporter protein and uses thereof
HUP0100056A3 (en) Carboxyl acid substituted heterocycles as metalloproteinase inhibitors, use of them for producing pharmaceutical compositions and pharmaceutical compositions containing them
AU1898200A (en) Process for the preparation of amino acid amides or derivatives thereof
AU2002227145A1 (en) Assays for inhibitors of neuronal transport of alzheimer's amyloid precursor protein

Legal Events

Date Code Title Description
MK6 Application lapsed section 142(2)(f)/reg. 8.3(3) - pct applic. not entering national phase