AU1039783A - Synthesis of oligosaccharides - Google Patents

Synthesis of oligosaccharides

Info

Publication number
AU1039783A
AU1039783A AU10397/83A AU1039783A AU1039783A AU 1039783 A AU1039783 A AU 1039783A AU 10397/83 A AU10397/83 A AU 10397/83A AU 1039783 A AU1039783 A AU 1039783A AU 1039783 A AU1039783 A AU 1039783A
Authority
AU
Australia
Prior art keywords
oligosaccharides
synthesis
Prior art date
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Granted
Application number
AU10397/83A
Other versions
AU563351C (en
AU563351B2 (en
Inventor
Jean Choay
Jean-Claude Jacquinet
Jean-Claude Lormeau
Mahmoud Nassr
Maurice Petitou
Pierre Sinay
Current Assignee (The listed assignees may be inaccurate. Google has not performed a legal analysis and makes no representation or warranty as to the accuracy of the list.)
Glaxo Group Ltd
Original Assignee
Glaxo Group Ltd
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Priority claimed from FR8200621A external-priority patent/FR2519987A1/en
Priority claimed from FR8201575A external-priority patent/FR2520744A1/en
Priority claimed from FR8202526A external-priority patent/FR2521566A1/en
Priority claimed from FR8209392A external-priority patent/FR2527614A1/en
Priority claimed from FR8210891A external-priority patent/FR2528853A1/en
Priority claimed from FR8210892A external-priority patent/FR2528854A1/en
Priority claimed from FR8211679A external-priority patent/FR2529557A1/en
Priority claimed from FR8213804A external-priority patent/FR2531436A1/en
Priority claimed from FR8215804A external-priority patent/FR2533220A1/en
Priority claimed from FR8215803A external-priority patent/FR2533219A1/en
Priority claimed from FR8218303A external-priority patent/FR2535306A1/en
Application filed by Glaxo Group Ltd filed Critical Glaxo Group Ltd
Publication of AU1039783A publication Critical patent/AU1039783A/en
Publication of AU563351B2 publication Critical patent/AU563351B2/en
Application granted granted Critical
Assigned to SANOFI-SYNTHELABO reassignment SANOFI-SYNTHELABO Request to Amend Deed and Register Assignors: CHOAY S.A.
Assigned to Societe Civile De Gestion De Propriete Industrielle Choay "Dropic" reassignment Societe Civile De Gestion De Propriete Industrielle Choay "Dropic" Alteration of Name(s) in Register under S187 Assignors: SANOFI-SYNTHELABO
Assigned to SANOFI-SYNTHELABO reassignment SANOFI-SYNTHELABO Alteration of Name(s) in Register under S187 Assignors: Societe Civile De Gestion De Propriete Industrielle Choay "Dropic"
Publication of AU563351C publication Critical patent/AU563351C/en
Assigned to GLAXO GROUP LIMITED reassignment GLAXO GROUP LIMITED Alteration of Name(s) in Register under S187 Assignors: SANOFI-SYNTHELABO
Adjusted expiration legal-status Critical
Expired legal-status Critical Current

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C08—ORGANIC MACROMOLECULAR COMPOUNDS; THEIR PREPARATION OR CHEMICAL WORKING-UP; COMPOSITIONS BASED THEREON
    • C08B—POLYSACCHARIDES; DERIVATIVES THEREOF
    • C08B37/00—Preparation of polysaccharides not provided for in groups C08B1/00 - C08B35/00; Derivatives thereof
    • C08B37/006—Heteroglycans, i.e. polysaccharides having more than one sugar residue in the main chain in either alternating or less regular sequence; Gellans; Succinoglycans; Arabinogalactans; Tragacanth or gum tragacanth or traganth from Astragalus; Gum Karaya from Sterculia urens; Gum Ghatti from Anogeissus latifolia; Derivatives thereof
    • C08B37/0063—Glycosaminoglycans or mucopolysaccharides, e.g. keratan sulfate; Derivatives thereof, e.g. fucoidan
    • C08B37/0075—Heparin; Heparan sulfate; Derivatives thereof, e.g. heparosan; Purification or extraction methods thereof
    • C08B37/0078—Degradation products
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07H—SUGARS; DERIVATIVES THEREOF; NUCLEOSIDES; NUCLEOTIDES; NUCLEIC ACIDS
    • C07H11/00—Compounds containing saccharide radicals esterified by inorganic acids; Metal salts thereof
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07H—SUGARS; DERIVATIVES THEREOF; NUCLEOSIDES; NUCLEOTIDES; NUCLEIC ACIDS
    • C07H3/00—Compounds containing only hydrogen atoms and saccharide radicals having only carbon, hydrogen, and oxygen atoms
    • C07H3/06—Oligosaccharides, i.e. having three to five saccharide radicals attached to each other by glycosidic linkages
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07H—SUGARS; DERIVATIVES THEREOF; NUCLEOSIDES; NUCLEOTIDES; NUCLEIC ACIDS
    • C07H7/00—Compounds containing non-saccharide radicals linked to saccharide radicals by a carbon-to-carbon bond
    • C07H7/02—Acyclic radicals
    • C07H7/033—Uronic acids
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07H—SUGARS; DERIVATIVES THEREOF; NUCLEOSIDES; NUCLEOTIDES; NUCLEIC ACIDS
    • C07H9/00—Compounds containing a hetero ring sharing at least two hetero atoms with a saccharide radical
    • C07H9/02—Compounds containing a hetero ring sharing at least two hetero atoms with a saccharide radical the hetero ring containing only oxygen as ring hetero atoms
    • C07H9/04—Cyclic acetals
    • Y—GENERAL TAGGING OF NEW TECHNOLOGICAL DEVELOPMENTS; GENERAL TAGGING OF CROSS-SECTIONAL TECHNOLOGIES SPANNING OVER SEVERAL SECTIONS OF THE IPC; TECHNICAL SUBJECTS COVERED BY FORMER USPC CROSS-REFERENCE ART COLLECTIONS [XRACs] AND DIGESTS
    • Y02—TECHNOLOGIES OR APPLICATIONS FOR MITIGATION OR ADAPTATION AGAINST CLIMATE CHANGE
    • Y02P—CLIMATE CHANGE MITIGATION TECHNOLOGIES IN THE PRODUCTION OR PROCESSING OF GOODS
    • Y02P20/00—Technologies relating to chemical industry
    • Y02P20/50—Improvements relating to the production of bulk chemicals
    • Y02P20/55—Design of synthesis routes, e.g. reducing the use of auxiliary or protecting groups
AU10397/83A 1982-01-15 1983-01-14 Synthesis of oligosaccharides Expired AU563351C (en)

Applications Claiming Priority (22)

Application Number Priority Date Filing Date Title
FR8200621A FR2519987A1 (en) 1982-01-15 1982-01-15 Uronic acid derivs. - useful as glycoside intermediates or hapten(s)
FR8200621 1982-01-15
FR8201575 1982-02-01
FR8201575A FR2520744A1 (en) 1982-02-01 1982-02-01 Uronic acid derivs. - useful as glycoside intermediates or hapten(s)
FR8202526A FR2521566A1 (en) 1982-02-16 1982-02-16 Antithrombotic oligosaccharide fragments of muco-polysaccharide prodn. - by reacting uronic acid and glucosamine units
FR8202526 1982-02-16
FR8209392 1982-05-28
FR8209392A FR2527614A1 (en) 1982-05-28 1982-05-28 Uronic acid derivs. - useful as glycoside intermediates or hapten(s)
FR8210892A FR2528854A1 (en) 1982-06-22 1982-06-22 Antithrombotic oligosaccharide fragments of muco-polysaccharide prodn. - by reacting uronic acid and glucosamine units
FR8210891A FR2528853A1 (en) 1982-06-22 1982-06-22 Antithrombotic oligosaccharide fragments of muco-polysaccharide prodn. - by reacting uronic acid and glucosamine units
FR8210892 1982-06-22
FR8210891 1982-06-22
FR8211679A FR2529557A1 (en) 1982-07-02 1982-07-02 New disaccharides containing an alpha -L-idopyranose unit, and their preparation
FR8211679 1982-07-02
FR8213804A FR2531436A1 (en) 1982-08-06 1982-08-06 Substituted pentasaccharides possessing biological properties, their preparation and their uses as medicaments
FR8213804 1982-08-06
FR8215803 1982-09-20
FR8215804A FR2533220A1 (en) 1982-09-20 1982-09-20 New disaccharides composed of units having a D-glucuronic acid and D-glucosamine structure and method for preparing them
FR8215803A FR2533219A1 (en) 1982-09-20 1982-09-20 New disaccharides composed of units having a D-glucosamine and L-iduronic acid structure and method for preparing them
FR8215804 1982-09-20
FR8218003 1982-10-27
FR8218303A FR2535306A1 (en) 1982-10-28 1982-10-28 Improved station for sewage purification

Related Child Applications (1)

Application Number Title Priority Date Filing Date
AU42637/85A Addition AU582362B2 (en) 1984-05-16 1985-05-16 Novel oligosaccharides,their preparation synthesis and their biological applications

Publications (3)

Publication Number Publication Date
AU1039783A true AU1039783A (en) 1983-07-21
AU563351B2 AU563351B2 (en) 1987-07-09
AU563351C AU563351C (en) 2003-06-19

Family

ID=27581615

Family Applications (1)

Application Number Title Priority Date Filing Date
AU10397/83A Expired AU563351C (en) 1982-01-15 1983-01-14 Synthesis of oligosaccharides

Country Status (4)

Country Link
EP (1) EP0084999B1 (en)
AU (1) AU563351C (en)
LU (1) LU90928I2 (en)
NL (1) NL300093I2 (en)

Cited By (4)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
AU698456B2 (en) * 1997-03-10 1998-10-29 Sanofi-Aventis Compositions containing an association of aspirin and an anti-Xa oligosaccharide and use of anti-Xa oligosaccharide optionally in combination with aspirin
WO1999011273A1 (en) * 1997-09-01 1999-03-11 The Australian National University Use of sulfated oligosaccharides as inhibitors of cardiovascular disease
WO1999018974A1 (en) * 1997-10-14 1999-04-22 The Australian National University Use of sulfated oligosaccharides in lowering blood triglyceride levels
WO2003022860A1 (en) * 2001-09-07 2003-03-20 Alchemia Pty Ltd Synthetic heparin pentasaccharides

Families Citing this family (20)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
FR2535324A1 (en) * 1982-10-27 1984-05-04 Choay Sa PERFECTED STATION FOR THE PURIFICATION OF WASTEWATER
US4801583A (en) * 1982-01-15 1989-01-31 Choay S.A. Oligosaccharides and their biological applications
FR2564468B1 (en) * 1984-05-16 1994-12-23 Choay Sa NOVEL OLIGOSACCHARIDES, THEIR SYNTHESIS PREPARATION AND THEIR BIOLOGICAL APPLICATIONS
FR2548189B1 (en) * 1983-07-01 1986-04-11 Choay Sa NEW PRODUCTS CONTAINING OLIGOSACCHARIDES, THEIR PREPARATION AND THEIR BIOLOGICAL AND BIOCHEMICAL APPLICATIONS
SE8501022L (en) * 1985-03-01 1986-09-02 Pharmacia Ab FORMAT CREATES AND PROCEDURES FOR ITS PREPARATION
GB8519416D0 (en) * 1985-08-01 1985-09-04 Unilever Plc Oligosaccharides
EP0300099A1 (en) * 1987-07-20 1989-01-25 Akzo N.V. New pentasaccharides
EP0347964A1 (en) * 1988-06-21 1989-12-27 Akzo N.V. New oligosaccharides with internal spacer
FR2636967B1 (en) * 1988-09-29 1990-12-07 Sanofi Sa METHOD FOR DETERMINING ANIONIC SULPHATE POLYOSIDES, AND CASE FOR CARRYING OUT SAID METHOD
JPH0296588A (en) * 1988-09-29 1990-04-09 Rikagaku Kenkyusho Sulfated oligosaccharide and relating substance thereof
US5476924A (en) * 1989-01-27 1995-12-19 Duke University Protecting group for acetals and methods of using the same in the activation of saccharides
US5707973A (en) * 1991-04-23 1998-01-13 Rhone-Poulenc Rorer S.A. Sulfated polysaccharids for treatment or prevention of thromboses
EP0669827B1 (en) * 1992-11-10 2001-05-23 Yeda Research And Development Co. Ltd. Compositions for the regulation of cytokine activity
AU8211398A (en) * 1997-05-27 1998-12-30 Akzo Nobel N.V. Use of oligosaccharide for preventing blood clotting in extracorporeal blood circuits
FR2800074B1 (en) * 1999-10-22 2001-12-21 Aventis Pharma Sa NOVEL OLIGOSACCHARIDES, THEIR PREPARATION AND THE PHARMACEUTICAL COMPOSITIONS CONTAINING THEM
FR2814463B1 (en) * 2000-09-22 2002-11-15 Sanofi Synthelabo NOVEL POLYSACCHARIDES WITH ANTITHROMBOTIC ACTIVITY COMPRISING AT LEAST ONE COVALENT BINDING WITH BIOTIN OR A BIOTINE DERIVATIVE
CN1317287C (en) * 2003-04-18 2007-05-23 山东大学 Oligose polysulfate and preparation process thereof
FR2874924B1 (en) 2004-09-09 2006-12-01 Sanofi Aventis Sa BIOTINYLATED HEXADECASACCHARIDES, THEIR PREPARATION AND THEIR THERAPEUTIC USE
CN102046781A (en) 2008-05-30 2011-05-04 动量制药公司 Saccharide structures and methods of making and using such structures
CN109734757B (en) * 2019-03-11 2020-09-11 淮北师范大学 Preparation method of related substance B of fondaparinux sodium injection

Family Cites Families (4)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
CA1136620A (en) * 1979-01-08 1982-11-30 Ulf P.F. Lindahl Heparin fragments having selective anticoagulation activity
IL61201A (en) * 1979-10-05 1984-09-30 Choay Sa Oligosaccharides having no more than 8 saccharide moieties,their obtention from heparin and pharmaceutical compositions containing them
CA1171375A (en) * 1980-09-15 1984-07-24 Ulf P.F. Lindahl Oligosaccharides having selective anticoagulation activity
FR2504535B1 (en) * 1981-04-28 1987-08-14 Choay Sa DISACCHARIDES DERIVED FROM URONIC ACID AND GLUCOSAMINE AND PHARMACEUTICAL COMPOSITIONS CONTAINING THEM FOR THE CONTROL OF BLOOD COAGULATION

Cited By (11)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
AU698456B2 (en) * 1997-03-10 1998-10-29 Sanofi-Aventis Compositions containing an association of aspirin and an anti-Xa oligosaccharide and use of anti-Xa oligosaccharide optionally in combination with aspirin
WO1999011273A1 (en) * 1997-09-01 1999-03-11 The Australian National University Use of sulfated oligosaccharides as inhibitors of cardiovascular disease
US6638916B1 (en) 1997-09-01 2003-10-28 The Australian National University Use of sulfated oligosaccharides as inhibitors of cardiovascular disease
WO1999018974A1 (en) * 1997-10-14 1999-04-22 The Australian National University Use of sulfated oligosaccharides in lowering blood triglyceride levels
US6670339B1 (en) 1997-10-14 2003-12-30 The Australian National University Use of sulfated oligosaccharides in lowering blood triglyceride levels
WO2003022860A1 (en) * 2001-09-07 2003-03-20 Alchemia Pty Ltd Synthetic heparin pentasaccharides
US7541445B2 (en) 2001-09-07 2009-06-02 Alchemia Limited Synthetic heparin pentasaccharides
US8114970B2 (en) 2001-09-07 2012-02-14 Alchemia Limited Synthetic heparin monosaccharides
US8404833B2 (en) 2001-09-07 2013-03-26 Alchemia Limited Synthetic heparin disaccharides
US8686131B2 (en) 2001-09-07 2014-04-01 Alchemia Limited Synthetic heparin trisaccharides
US9243018B2 (en) 2001-09-07 2016-01-26 Dr. Reddy's Laboratories, Sa Synthetic heparin pentasaccharides

Also Published As

Publication number Publication date
NL300093I2 (en) 2002-11-01
NL300093I1 (en) 2002-09-02
LU90928I2 (en) 2002-08-07
AU563351C (en) 2003-06-19
EP0084999B1 (en) 1988-04-13
EP0084999A1 (en) 1983-08-03
AU563351B2 (en) 1987-07-09

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Legal Events

Date Code Title Description
HB Alteration of name in register

Owner name: SANOFI-SYNTHELABO

Free format text: FORMER NAME WAS: CHOAY S.A.

NC Extension of term for standard patent requested (sect. 70)

Free format text: PRODUCT NAME: ARIXTRA (FONDAPARINUX SODIUM)

PC Assignment registered

Owner name: SANOFI-SYNTHELABO

Free format text: FORMER OWNER WAS: SOCIETE CIVILE DE GESTION DE PROPRIETE INDUSTRIELLE CHOAY "DROPIC"

DA2 Applications for amendment section 104

Free format text: THE NATURE OF THE PROPOSED AMENDMENT IS AS SHOWN IN THE STATEMENT(S) FILED 20020513

NDA Extension of term for standard patent accepted (sect.70)

Free format text: PRODUCT NAME: ARIXTRA (FONDAPARINUX SODIUM)

Extension date: 20080114

DA3 Amendments made section 104

Free format text: THE NATURE OF THE AMENDMENT IS AS WAS NOTIFIED IN THE OFFICIAL JOURNAL DATED 20030109

NDB Extension of term for standard patent granted (sect.76)

Free format text: PRODUCT NAME: ARIXTRA (FONDAPARINUX SODIUM)

Extension date: 20080114