ATE98468T1 - 2-aminopyrimidin-3-oxid-derivate enthaltende zusammensetzungen zur verwendung zum vermindern des haarausfalles und zum induzieren und stimulieren des haarwuchses und neue von 2aminopyrimidin-3-oxid abgeleitete verbindungen. - Google Patents
2-aminopyrimidin-3-oxid-derivate enthaltende zusammensetzungen zur verwendung zum vermindern des haarausfalles und zum induzieren und stimulieren des haarwuchses und neue von 2aminopyrimidin-3-oxid abgeleitete verbindungen.Info
- Publication number
- ATE98468T1 ATE98468T1 AT90402361T AT90402361T ATE98468T1 AT E98468 T1 ATE98468 T1 AT E98468T1 AT 90402361 T AT90402361 T AT 90402361T AT 90402361 T AT90402361 T AT 90402361T AT E98468 T1 ATE98468 T1 AT E98468T1
- Authority
- AT
- Austria
- Prior art keywords
- oxide
- alkyl
- inducing
- aminopyrimidine
- novel
- Prior art date
Links
Classifications
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D239/00—Heterocyclic compounds containing 1,3-diazine or hydrogenated 1,3-diazine rings
- C07D239/02—Heterocyclic compounds containing 1,3-diazine or hydrogenated 1,3-diazine rings not condensed with other rings
- C07D239/24—Heterocyclic compounds containing 1,3-diazine or hydrogenated 1,3-diazine rings not condensed with other rings having three or more double bonds between ring members or between ring members and non-ring members
- C07D239/28—Heterocyclic compounds containing 1,3-diazine or hydrogenated 1,3-diazine rings not condensed with other rings having three or more double bonds between ring members or between ring members and non-ring members with hetero atoms or with carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, directly attached to ring carbon atoms
- C07D239/32—One oxygen, sulfur or nitrogen atom
- C07D239/42—One nitrogen atom
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K8/00—Cosmetics or similar toiletry preparations
- A61K8/18—Cosmetics or similar toiletry preparations characterised by the composition
- A61K8/30—Cosmetics or similar toiletry preparations characterised by the composition containing organic compounds
- A61K8/49—Cosmetics or similar toiletry preparations characterised by the composition containing organic compounds containing heterocyclic compounds
- A61K8/494—Cosmetics or similar toiletry preparations characterised by the composition containing organic compounds containing heterocyclic compounds with more than one nitrogen as the only hetero atom
- A61K8/4953—Cosmetics or similar toiletry preparations characterised by the composition containing organic compounds containing heterocyclic compounds with more than one nitrogen as the only hetero atom containing pyrimidine ring derivatives, e.g. minoxidil
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P17/00—Drugs for dermatological disorders
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P17/00—Drugs for dermatological disorders
- A61P17/14—Drugs for dermatological disorders for baldness or alopecia
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61Q—SPECIFIC USE OF COSMETICS OR SIMILAR TOILETRY PREPARATIONS
- A61Q7/00—Preparations for affecting hair growth
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D239/00—Heterocyclic compounds containing 1,3-diazine or hydrogenated 1,3-diazine rings
- C07D239/02—Heterocyclic compounds containing 1,3-diazine or hydrogenated 1,3-diazine rings not condensed with other rings
- C07D239/24—Heterocyclic compounds containing 1,3-diazine or hydrogenated 1,3-diazine rings not condensed with other rings having three or more double bonds between ring members or between ring members and non-ring members
- C07D239/28—Heterocyclic compounds containing 1,3-diazine or hydrogenated 1,3-diazine rings not condensed with other rings having three or more double bonds between ring members or between ring members and non-ring members with hetero atoms or with carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, directly attached to ring carbon atoms
- C07D239/46—Two or more oxygen, sulphur or nitrogen atoms
- C07D239/47—One nitrogen atom and one oxygen or sulfur atom, e.g. cytosine
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D239/00—Heterocyclic compounds containing 1,3-diazine or hydrogenated 1,3-diazine rings
- C07D239/02—Heterocyclic compounds containing 1,3-diazine or hydrogenated 1,3-diazine rings not condensed with other rings
- C07D239/24—Heterocyclic compounds containing 1,3-diazine or hydrogenated 1,3-diazine rings not condensed with other rings having three or more double bonds between ring members or between ring members and non-ring members
- C07D239/28—Heterocyclic compounds containing 1,3-diazine or hydrogenated 1,3-diazine rings not condensed with other rings having three or more double bonds between ring members or between ring members and non-ring members with hetero atoms or with carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, directly attached to ring carbon atoms
- C07D239/46—Two or more oxygen, sulphur or nitrogen atoms
- C07D239/48—Two nitrogen atoms
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D239/00—Heterocyclic compounds containing 1,3-diazine or hydrogenated 1,3-diazine rings
- C07D239/70—Heterocyclic compounds containing 1,3-diazine or hydrogenated 1,3-diazine rings condensed with carbocyclic rings or ring systems
- C07D239/72—Quinazolines; Hydrogenated quinazolines
- C07D239/95—Quinazolines; Hydrogenated quinazolines with hetero atoms directly attached in positions 2 and 4
Landscapes
- Organic Chemistry (AREA)
- Chemical & Material Sciences (AREA)
- Health & Medical Sciences (AREA)
- Life Sciences & Earth Sciences (AREA)
- Veterinary Medicine (AREA)
- Public Health (AREA)
- General Health & Medical Sciences (AREA)
- Animal Behavior & Ethology (AREA)
- Dermatology (AREA)
- Chemical Kinetics & Catalysis (AREA)
- Pharmacology & Pharmacy (AREA)
- Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
- Medicinal Chemistry (AREA)
- General Chemical & Material Sciences (AREA)
- Bioinformatics & Cheminformatics (AREA)
- Engineering & Computer Science (AREA)
- Birds (AREA)
- Epidemiology (AREA)
- Cosmetics (AREA)
- Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
- Nitrogen And Oxygen Or Sulfur-Condensed Heterocyclic Ring Systems (AREA)
Applications Claiming Priority (2)
Application Number | Priority Date | Filing Date | Title |
---|---|---|---|
FR8911352A FR2651122B1 (fr) | 1989-08-29 | 1989-08-29 | Compositions destinees a etre utilisees pour freiner la chute des cheveux et pour induire et stimuler leur croissance, contenant des derives de l'amino-2 pyrimidine oxyde-3 et nouveaux composes derives de l'amino-2 pyrimidine oxyde-3. |
EP90402361A EP0420707B1 (de) | 1989-08-29 | 1990-08-24 | 2-Aminopyrimidin-3-oxid-Derivate enthaltende Zusammensetzungen zur Verwendung zum Vermindern des Haarausfalles und zum Induzieren und Stimulieren des Haarwuchses und neue von 2-Aminopyrimidin-3-oxid abgeleitete Verbindungen |
Publications (1)
Publication Number | Publication Date |
---|---|
ATE98468T1 true ATE98468T1 (de) | 1994-01-15 |
Family
ID=9384977
Family Applications (1)
Application Number | Title | Priority Date | Filing Date |
---|---|---|---|
AT90402361T ATE98468T1 (de) | 1989-08-29 | 1990-08-24 | 2-aminopyrimidin-3-oxid-derivate enthaltende zusammensetzungen zur verwendung zum vermindern des haarausfalles und zum induzieren und stimulieren des haarwuchses und neue von 2aminopyrimidin-3-oxid abgeleitete verbindungen. |
Country Status (7)
Country | Link |
---|---|
US (2) | US5610302A (de) |
EP (1) | EP0420707B1 (de) |
JP (1) | JP3053200B2 (de) |
AT (1) | ATE98468T1 (de) |
CA (1) | CA2024156C (de) |
DE (1) | DE69005248T2 (de) |
FR (1) | FR2651122B1 (de) |
Families Citing this family (39)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
FR2671082B1 (fr) * | 1990-12-28 | 1993-04-16 | Oreal | Agent a plusieurs composants ou kit de preparation de la forme sulfo-conjuguee de composes pyrimidino- ou triazino-n-oxyde et procede de mise en óoeuvre. |
FR2677884B1 (fr) * | 1991-06-20 | 1993-07-09 | Oreal | Composition pour freiner la chute des cheveux a base de pyrimidines n-oxyde trisubstitues ou leurs derives sulfoconjugues, nouveaux composes pyrimidines n-oxyde ou leurs derives sulfoconjugues. |
US6274602B1 (en) | 1998-06-03 | 2001-08-14 | Gpi Nil Holdings, Inc. | Heterocyclic thioester and ketone hair growth compositions and uses |
US6187784B1 (en) | 1998-06-03 | 2001-02-13 | Gpi Nil Holdings, Inc. | Pipecolic acid derivative hair growth compositions and uses |
US5945441A (en) | 1997-06-04 | 1999-08-31 | Gpi Nil Holdings, Inc. | Pyrrolidine carboxylate hair revitalizing agents |
US6187796B1 (en) | 1998-06-03 | 2001-02-13 | Gpi Nil Holdings, Inc. | Sulfone hair growth compositions and uses |
US20010049381A1 (en) | 1997-06-04 | 2001-12-06 | Gpl Nil Holdings, Inc., | Pyrrolidine derivative hair growth compositions and uses |
US6271244B1 (en) | 1998-06-03 | 2001-08-07 | Gpi Nil Holdings, Inc. | N-linked urea or carbamate of heterocyclic thioester hair growth compositions and uses |
US6099870A (en) * | 1997-12-18 | 2000-08-08 | Johnson & Johnson Consumer Companies, Inc. | Methods for improving the health of hair and scalp |
US6034388A (en) * | 1998-05-15 | 2000-03-07 | International Business Machines Corporation | Depleted polysilicon circuit element and method for producing the same |
US6172087B1 (en) | 1998-06-03 | 2001-01-09 | Gpi Nil Holding, Inc. | N-oxide of heterocyclic ester, amide, thioester, or ketone hair growth compositions and uses |
CA2334204A1 (en) | 1998-06-03 | 1999-12-09 | Gpi Nil Holdings, Inc. | Heterocyclic ester and amide hair growth compositions and uses |
US6429215B1 (en) | 1998-06-03 | 2002-08-06 | Gpi Nil Holdings, Inc. | N-oxide of heterocyclic ester, amide, thioester, or ketone hair growth compositions and uses |
AU761737B2 (en) * | 1998-06-03 | 2003-06-12 | Gpi Nil Holdings, Inc. | N-oxide of heterocyclic ester, amide, thioester, or ketone hair growth compositions and uses |
FR2781481B1 (fr) | 1998-07-24 | 2000-09-15 | Oreal | Nouveaux 2-amino, 4-alkylamino pyrimidine 3-oxydes et composition les comprenant |
US6159950A (en) * | 1998-10-16 | 2000-12-12 | Cornell Research Foundation, Inc. | Method of modulating hair growth |
FR2791671B1 (fr) | 1999-04-01 | 2001-05-11 | Oreal | Nouveaux composes derives d'esters d'acide benzoique, composition les comprenant et utilisation |
EP1515712B1 (de) | 2002-06-21 | 2019-12-25 | L'Oréal | Verwendung von taurin oder dessen derivaten zur behandlung von haarausfall |
EP1437348A1 (de) * | 2003-01-13 | 2004-07-14 | L'oreal | 6-Methyl-2,4-diamino-Pyrimidin-Derivate, Verfahren zu Herstellung, diese enthaltende Zusammenstellungen, und Verwendungen als basische Neutralisierungsmittel |
US7326717B2 (en) * | 2003-05-06 | 2008-02-05 | L'oreal | Pyrimidine n-oxide compounds for stimulating the growth of keratin fibers and/or reducing loss thereof |
US20050180940A1 (en) * | 2004-02-17 | 2005-08-18 | Puma Jeffrey P. | Protect against hair loss |
US20060193804A1 (en) * | 2005-02-24 | 2006-08-31 | L'oreal | Haircare use of cyclic amine derivatives |
TW200904437A (en) | 2007-02-14 | 2009-02-01 | Janssen Pharmaceutica Nv | 2-aminopyrimidine modulators of the histamine H4 receptor |
FR2920309B1 (fr) | 2007-08-28 | 2010-05-28 | Galderma Res & Dev | Utilisation de travoprost pour traiter la chute des cheveux |
US8067470B2 (en) * | 2008-02-01 | 2011-11-29 | Mcdaniel William Robert | Linoleic acid preparations for the topical treatment of male and female pattern androgenetic alopecia, age-related alopecia, and keratosis pilaris |
FR2949052B1 (fr) | 2009-08-13 | 2015-03-27 | Oreal | Procede de traitement cosmetique du cuir chevelu. |
FR2953722B1 (fr) | 2009-12-16 | 2012-03-09 | Expanscience Lab | Composition comprenant au moins un sucre en c7 pour le traitement de l'alopecie, pour le traitement cosmetique des phaneres, et pour le soin des cheveux, cils ou ongles |
FI20105626A0 (fi) | 2010-06-03 | 2010-06-03 | Hs Foils Oy | Erittäin ohut berylliumikkuna ja menetelmä sen valmistamiseksi |
US9564252B2 (en) | 2012-02-15 | 2017-02-07 | Hs Foils Oy | Method and arrangement for manufacturing a radiation window |
EP2838533B1 (de) | 2012-04-16 | 2017-10-04 | Case Western Reserve University | Zusammensetzungen und verfahren zur modulation der 15-pgdh-aktivität |
CA2927730A1 (en) | 2013-10-15 | 2015-05-07 | Case Western Reserve University | Compositions and methods of modulating short-chain dehydrogenase activity |
JP6698019B2 (ja) | 2013-12-12 | 2020-05-27 | セルミド リミテッドCellmid Limited | 同種異系脱毛症の治療方法および治療用化合物 |
WO2016025640A1 (en) * | 2014-08-13 | 2016-02-18 | Celgene Avilomics Research, Inc. | Heteroaryl compounds and uses thereof |
EP3548035A4 (de) | 2016-11-30 | 2020-07-22 | Case Western Reserve University | Kombinationen von 15-pgdh-inhibitoren mit corticosteroiden und/oder tnf-inhibitoren und verwendungen davon |
WO2018145080A1 (en) | 2017-02-06 | 2018-08-09 | Case Western Reserve University | Compositions and methods of modulating short-chain dehydrogenase activity |
KR20210119954A (ko) | 2018-11-21 | 2021-10-06 | 케이스 웨스턴 리저브 유니버시티 | 단쇄 데히드로게나아제 활성을 조절하는 조성물 및 방법 |
EP3895686A1 (de) | 2020-04-14 | 2021-10-20 | FRAUNHOFER-GESELLSCHAFT zur Förderung der angewandten Forschung e.V. | Natürliche zusammensetzung zur stimulierung des haarwuchses und zur vorbeugung und behandlung von haarausfall |
EP3895685A1 (de) | 2020-04-14 | 2021-10-20 | Fraunhofer-Gesellschaft zur Förderung der angewandten Forschung e.V. | Natürliche zusammensetzung zur haarwachstumsstimulation und haarverlustverhinderung und behandlung ohne konservierungsmittel |
US20230192717A1 (en) | 2020-05-20 | 2023-06-22 | Rodeo Therapeutics Corporation | Compositions and methods of modulating short-chain dehydrogenase activity |
Family Cites Families (12)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
US3357981A (en) * | 1965-12-27 | 1967-12-12 | Upjohn Co | 1, 2-dihydro-1-hydroxy-5, 6-tri-and 5, 6-tetramethylene pyrimidines |
US3464987A (en) * | 1966-02-21 | 1969-09-02 | Upjohn Co | 1,2-dihydro-1-hydroxy-2-imino-6-(lower alkyl)pyrimidines |
US3644364A (en) * | 1970-03-31 | 1972-02-22 | Upjohn Co | Compounds and process |
US4013778A (en) * | 1974-08-05 | 1977-03-22 | Warner-Lambert Company | Method for reducing blood pressure |
US4287338A (en) * | 1980-03-10 | 1981-09-01 | The Upjohn Company | Sulfooxy-pyrimidinium, -pyridinium, and -triazinium hydroxide inner salts |
EP0042669A3 (de) * | 1980-06-23 | 1982-03-24 | The Upjohn Company | In Tierfutter verwendbare Verbindungen und Zusammensetzungen |
US4411690A (en) * | 1981-01-26 | 1983-10-25 | E. I. Du Pont De Nemours & Co. | Fused [1,2,4]oxadiazolylidenebenzenesulfonamides and their use as herbicides and plant growth regulants |
DE3670765D1 (en) * | 1985-01-25 | 1990-06-07 | Upjohn Co | Pyrimidinsulfate fuer haarwuchs. |
FR2590897B1 (fr) * | 1985-12-06 | 1988-02-19 | Kemyos Bio Medical Research Sr | Nouveaux derives de 6 amino 1,2-dihydro-1-hydroxy-2-imino-pyrimidine, leur procede de preparation et compositions cosmetiques les renfermant |
NZ223237A (en) * | 1987-01-22 | 1991-03-26 | Shiseido Co Ltd | Hair growth promoting agent and compositions |
LU86959A1 (fr) * | 1987-07-31 | 1989-03-08 | Oreal | Nouveaux derives d'ureylene triamino-2,4,6 pyrimidine oxyde-3,leur preparation et leur utilisation en cosmetique et dermopharmacie |
JP2814090B2 (ja) * | 1988-12-14 | 1998-10-22 | 株式会社資生堂 | 養毛料 |
-
1989
- 1989-08-29 FR FR8911352A patent/FR2651122B1/fr not_active Expired - Fee Related
-
1990
- 1990-08-24 DE DE90402361T patent/DE69005248T2/de not_active Expired - Fee Related
- 1990-08-24 EP EP90402361A patent/EP0420707B1/de not_active Expired - Lifetime
- 1990-08-24 AT AT90402361T patent/ATE98468T1/de not_active IP Right Cessation
- 1990-08-28 CA CA002024156A patent/CA2024156C/fr not_active Expired - Fee Related
- 1990-08-28 JP JP2224531A patent/JP3053200B2/ja not_active Expired - Fee Related
-
1995
- 1995-06-05 US US08/461,848 patent/US5610302A/en not_active Expired - Fee Related
-
1996
- 1996-12-18 US US08/768,533 patent/US5760043A/en not_active Expired - Fee Related
Also Published As
Publication number | Publication date |
---|---|
DE69005248D1 (de) | 1994-01-27 |
EP0420707B1 (de) | 1993-12-15 |
US5610302A (en) | 1997-03-11 |
FR2651122B1 (fr) | 1994-10-28 |
US5760043A (en) | 1998-06-02 |
JPH03118372A (ja) | 1991-05-20 |
FR2651122A1 (fr) | 1991-03-01 |
DE69005248T2 (de) | 1994-04-14 |
EP0420707A1 (de) | 1991-04-03 |
CA2024156C (fr) | 2002-01-01 |
JP3053200B2 (ja) | 2000-06-19 |
CA2024156A1 (fr) | 1991-03-01 |
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Legal Events
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RER | Ceased as to paragraph 5 lit. 3 law introducing patent treaties |