ATE94411T1 - Kationische komplexe von technetium-99m und liganden dafuer. - Google Patents
Kationische komplexe von technetium-99m und liganden dafuer.Info
- Publication number
- ATE94411T1 ATE94411T1 AT90300630T AT90300630T ATE94411T1 AT E94411 T1 ATE94411 T1 AT E94411T1 AT 90300630 T AT90300630 T AT 90300630T AT 90300630 T AT90300630 T AT 90300630T AT E94411 T1 ATE94411 T1 AT E94411T1
- Authority
- AT
- Austria
- Prior art keywords
- alkyl
- technetium
- alkoxy
- ligands
- cationic complexes
- Prior art date
Links
- 239000003446 ligand Substances 0.000 title abstract 3
- GKLVYJBZJHMRIY-OUBTZVSYSA-N Technetium-99 Chemical compound [99Tc] GKLVYJBZJHMRIY-OUBTZVSYSA-N 0.000 title abstract 2
- 229940056501 technetium 99m Drugs 0.000 title abstract 2
- RMVRSNDYEFQCLF-UHFFFAOYSA-N thiophenol Chemical compound SC1=CC=CC=C1 RMVRSNDYEFQCLF-UHFFFAOYSA-N 0.000 abstract 3
- 125000004183 alkoxy alkyl group Chemical group 0.000 abstract 2
- 125000003545 alkoxy group Chemical group 0.000 abstract 2
- 125000004178 (C1-C4) alkyl group Chemical group 0.000 abstract 1
- 239000004215 Carbon black (E152) Substances 0.000 abstract 1
- DHXVGJBLRPWPCS-UHFFFAOYSA-N Tetrahydropyran Chemical group C1CCOCC1 DHXVGJBLRPWPCS-UHFFFAOYSA-N 0.000 abstract 1
- 125000005081 alkoxyalkoxyalkyl group Chemical group 0.000 abstract 1
- 125000000217 alkyl group Chemical group 0.000 abstract 1
- 125000004432 carbon atom Chemical group C* 0.000 abstract 1
- 125000002091 cationic group Chemical group 0.000 abstract 1
- 229930195733 hydrocarbon Natural products 0.000 abstract 1
- 238000003384 imaging method Methods 0.000 abstract 1
- ISWSIDIOOBJBQZ-UHFFFAOYSA-N phenol group Chemical group C1(=CC=CC=C1)O ISWSIDIOOBJBQZ-UHFFFAOYSA-N 0.000 abstract 1
- 125000001997 phenyl group Chemical group [H]C1=C([H])C([H])=C(*)C([H])=C1[H] 0.000 abstract 1
- 150000003573 thiols Chemical class 0.000 abstract 1
Classifications
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07F—ACYCLIC, CARBOCYCLIC OR HETEROCYCLIC COMPOUNDS CONTAINING ELEMENTS OTHER THAN CARBON, HYDROGEN, HALOGEN, OXYGEN, NITROGEN, SULFUR, SELENIUM OR TELLURIUM
- C07F13/00—Compounds containing elements of Groups 7 or 17 of the Periodic Table
- C07F13/005—Compounds without a metal-carbon linkage
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K51/00—Preparations containing radioactive substances for use in therapy or testing in vivo
- A61K51/02—Preparations containing radioactive substances for use in therapy or testing in vivo characterised by the carrier, i.e. characterised by the agent or material covalently linked or complexing the radioactive nucleus
- A61K51/04—Organic compounds
- A61K51/0474—Organic compounds complexes or complex-forming compounds, i.e. wherein a radioactive metal (e.g. 111In3+) is complexed or chelated by, e.g. a N2S2, N3S, NS3, N4 chelating group
- A61K51/0478—Organic compounds complexes or complex-forming compounds, i.e. wherein a radioactive metal (e.g. 111In3+) is complexed or chelated by, e.g. a N2S2, N3S, NS3, N4 chelating group complexes from non-cyclic ligands, e.g. EDTA, MAG3
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K2123/00—Preparations for testing in vivo
Landscapes
- Chemical & Material Sciences (AREA)
- Health & Medical Sciences (AREA)
- Organic Chemistry (AREA)
- Life Sciences & Earth Sciences (AREA)
- Optics & Photonics (AREA)
- Medicinal Chemistry (AREA)
- Physics & Mathematics (AREA)
- Pharmacology & Pharmacy (AREA)
- Epidemiology (AREA)
- Animal Behavior & Ethology (AREA)
- General Health & Medical Sciences (AREA)
- Public Health (AREA)
- Veterinary Medicine (AREA)
- Proteomics, Peptides & Aminoacids (AREA)
- Medicines Containing Antibodies Or Antigens For Use As Internal Diagnostic Agents (AREA)
Applications Claiming Priority (2)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| GB898902362A GB8902362D0 (en) | 1989-02-03 | 1989-02-03 | Cationic complexes of technetium-99m |
| EP90300630A EP0386873B1 (de) | 1989-02-03 | 1990-01-22 | Kationische Komplexe von Technetium-99m und Liganden dafür |
Publications (1)
| Publication Number | Publication Date |
|---|---|
| ATE94411T1 true ATE94411T1 (de) | 1993-10-15 |
Family
ID=10651048
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| AT90300630T ATE94411T1 (de) | 1989-02-03 | 1990-01-22 | Kationische komplexe von technetium-99m und liganden dafuer. |
Country Status (7)
| Country | Link |
|---|---|
| US (1) | US5312904A (de) |
| EP (1) | EP0386873B1 (de) |
| JP (1) | JP2894767B2 (de) |
| AT (1) | ATE94411T1 (de) |
| CA (1) | CA2008893A1 (de) |
| DE (1) | DE69003277T2 (de) |
| GB (1) | GB8902362D0 (de) |
Families Citing this family (8)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| DE4025788C2 (de) * | 1990-08-10 | 1994-04-14 | Diagnostikforschung Inst | Technetium- und Rhenium-Komplexe, Verfahren zu ihrer Herstellung sowie deren Verwendung in Diagnostik und Therapie |
| US5879657A (en) * | 1993-03-30 | 1999-03-09 | The Dupont Merck Pharmaceutical Company | Radiolabeled platelet GPIIb/IIIa receptor antagonists as imaging agents for the diagnosis of thromboembolic disorders |
| US5744120A (en) * | 1993-03-30 | 1998-04-28 | The Dupont Merick Pharmaceutical Company | Ternary radiopharmaceutical complexes |
| US5750088A (en) * | 1993-03-30 | 1998-05-12 | The Dupont Merck Pharmaceutical Company | Stable hydrazones linked to a peptide moiety as reagents for the preparation of radiopharmaceuticals |
| US5541289A (en) * | 1994-03-30 | 1996-07-30 | Washington University | Phosphine containing amino acids and peptides and methods of preparing and using same |
| JP2002509960A (ja) * | 1998-03-31 | 2002-04-02 | チバ スペシャルティ ケミカルズ ホールディング インコーポレーテッド | ルテニウムおよびオスミウムカルベンカルボニル触媒 |
| CN1606539A (zh) * | 2001-12-20 | 2005-04-13 | Sasol技术股份有限公司 | 使用铬基催化剂的烯烃寡聚和三聚 |
| GB0804406D0 (en) * | 2008-03-10 | 2008-04-16 | Univ Zuerich | Metal complexes |
Family Cites Families (14)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| US4387087A (en) * | 1980-04-18 | 1983-06-07 | Research Corporation | Cationic lipophilic complexes of 99m Tc and their use for myocardial and hepatobiliary imaging |
| US4489054A (en) * | 1980-04-18 | 1984-12-18 | Research Corporation | Cationic lipophilic complexes of 99m Tc and their use for myocardial and hepatobiliary imaging |
| US4451450A (en) * | 1981-10-15 | 1984-05-29 | New England Nuclear Corporation | Cationic compounds useful for making radiodiagnostic agents |
| JPS5896031A (ja) * | 1981-12-03 | 1983-06-07 | Nippon Mejifuijitsukusu Kk | 放射性診断剤およびその製造用組成物 |
| US4455291A (en) * | 1982-01-22 | 1984-06-19 | New England Nuclear Corporation | Accelerators for forming cationic technetium complexes useful as radiodiagnostic agents |
| US4430319A (en) * | 1982-05-21 | 1984-02-07 | State University Of New York | Radioactive iodine labeled phenolic amines |
| US4497790A (en) * | 1982-09-03 | 1985-02-05 | E. I. Du Pont De Nemours And Company, Inc. | Method for forming cationic technetium complexes useful as radiodiagnostic agents |
| US4481184A (en) * | 1983-02-14 | 1984-11-06 | E. R. Squibb & Sons, Inc. | Cationic technetium (I) complexes |
| US4526776A (en) * | 1983-04-15 | 1985-07-02 | E. I. Du Pont De Nemours & Company | Cationic cyanato and thiocyanato complexes useful as radiodiagnostic agents |
| US4746505A (en) * | 1985-04-26 | 1988-05-24 | President And Fellows Of Harvard College | Technetium radiodiagnostic fatty acids derived from bisamide bisthiol ligands |
| US4795626A (en) * | 1985-05-10 | 1989-01-03 | University Of Cincinnati | 99m Tc.sup.(III) myocardial imaging agents which are non-reducable in vivo |
| CA1300608C (en) * | 1985-05-10 | 1992-05-12 | Edward A. Deutsch | 99 mtc (iii) myocardial imaging agents which are non-reducable in vivo |
| GB8723438D0 (en) * | 1987-10-06 | 1987-11-11 | Amersham Int Plc | Cationic complexes of technetium-99m |
| US5112595A (en) * | 1990-12-21 | 1992-05-12 | Mallinckrodt Medical, Inc. | 99MTC(III) myocardial imaging agents and method of use |
-
1989
- 1989-02-03 GB GB898902362A patent/GB8902362D0/en active Pending
-
1990
- 1990-01-22 DE DE90300630T patent/DE69003277T2/de not_active Expired - Fee Related
- 1990-01-22 AT AT90300630T patent/ATE94411T1/de not_active IP Right Cessation
- 1990-01-22 EP EP90300630A patent/EP0386873B1/de not_active Expired - Lifetime
- 1990-01-30 CA CA002008893A patent/CA2008893A1/en not_active Abandoned
- 1990-02-03 JP JP2025006A patent/JP2894767B2/ja not_active Expired - Lifetime
-
1992
- 1992-05-04 US US07/879,098 patent/US5312904A/en not_active Expired - Lifetime
Also Published As
| Publication number | Publication date |
|---|---|
| US5312904A (en) | 1994-05-17 |
| GB8902362D0 (en) | 1989-03-22 |
| JP2894767B2 (ja) | 1999-05-24 |
| EP0386873B1 (de) | 1993-09-15 |
| JPH03197487A (ja) | 1991-08-28 |
| DE69003277T2 (de) | 1994-01-13 |
| CA2008893A1 (en) | 1990-08-03 |
| EP0386873A1 (de) | 1990-09-12 |
| DE69003277D1 (de) | 1993-10-21 |
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Legal Events
| Date | Code | Title | Description |
|---|---|---|---|
| UEP | Publication of translation of european patent specification | ||
| REN | Ceased due to non-payment of the annual fee |