ATE92326T1 - Adenosin-deaminase-stabile anti-retroviralnukleoside. - Google Patents

Adenosin-deaminase-stabile anti-retroviralnukleoside.

Info

Publication number
ATE92326T1
ATE92326T1 AT89900509T AT89900509T ATE92326T1 AT E92326 T1 ATE92326 T1 AT E92326T1 AT 89900509 T AT89900509 T AT 89900509T AT 89900509 T AT89900509 T AT 89900509T AT E92326 T1 ATE92326 T1 AT E92326T1
Authority
AT
Austria
Prior art keywords
deeaminase
adenosin
nucleosides
retroviral
stable anti
Prior art date
Application number
AT89900509T
Other languages
English (en)
Inventor
Thomasz Haertle
Dennis A Carson
Original Assignee
Scripps Clinic Res
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Scripps Clinic Res filed Critical Scripps Clinic Res
Application granted granted Critical
Publication of ATE92326T1 publication Critical patent/ATE92326T1/de

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07H—SUGARS; DERIVATIVES THEREOF; NUCLEOSIDES; NUCLEOTIDES; NUCLEIC ACIDS
    • C07H19/00—Compounds containing a hetero ring sharing one ring hetero atom with a saccharide radical; Nucleosides; Mononucleotides; Anhydro-derivatives thereof
    • C07H19/02—Compounds containing a hetero ring sharing one ring hetero atom with a saccharide radical; Nucleosides; Mononucleotides; Anhydro-derivatives thereof sharing nitrogen
    • C07H19/04—Heterocyclic radicals containing only nitrogen atoms as ring hetero atom
    • C07H19/16—Purine radicals

Landscapes

  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Health & Medical Sciences (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Engineering & Computer Science (AREA)
  • Biochemistry (AREA)
  • Biotechnology (AREA)
  • General Health & Medical Sciences (AREA)
  • Genetics & Genomics (AREA)
  • Molecular Biology (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
AT89900509T 1987-11-18 1988-11-17 Adenosin-deaminase-stabile anti-retroviralnukleoside. ATE92326T1 (de)

Applications Claiming Priority (3)

Application Number Priority Date Filing Date Title
US07/121,950 US4997926A (en) 1987-11-18 1987-11-18 Deaminase-stable anti-retroviral 2-halo-2',3'-dideoxy
EP89900509A EP0355135B1 (de) 1987-11-18 1988-11-17 Adenosin-deaminase-stabile anti-retroviral-nukleoside
PCT/US1988/004104 WO1989004662A1 (en) 1987-11-18 1988-11-17 Adenosine deaminase-stable anti-retroviral nucleosides

Publications (1)

Publication Number Publication Date
ATE92326T1 true ATE92326T1 (de) 1993-08-15

Family

ID=22399710

Family Applications (1)

Application Number Title Priority Date Filing Date
AT89900509T ATE92326T1 (de) 1987-11-18 1988-11-17 Adenosin-deaminase-stabile anti-retroviralnukleoside.

Country Status (7)

Country Link
US (1) US4997926A (de)
EP (1) EP0355135B1 (de)
AT (1) ATE92326T1 (de)
AU (2) AU615705B2 (de)
CA (1) CA1322748C (de)
DE (1) DE3882985T2 (de)
WO (1) WO1989004662A1 (de)

Families Citing this family (35)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US5495010A (en) * 1987-04-17 1996-02-27 The United States Of America As Represented By The Department Of Health And Human Services Acid stable purine dideoxynucleosides
US7119202B1 (en) 1989-02-08 2006-10-10 Glaxo Wellcome Inc. Substituted-1,3-oxathiolanes and substituted-1,3-dioxolanes with antiviral properties
US6350753B1 (en) 1988-04-11 2002-02-26 Biochem Pharma Inc. 2-Substituted-4-substituted-1,3-dioxolanes and use thereof
US6903224B2 (en) 1988-04-11 2005-06-07 Biochem Pharma Inc. Substituted 1,3-oxathiolanes
US5270315A (en) * 1988-04-11 1993-12-14 Biochem Pharma Inc. 4-(purinyl bases)-substituted-1,3-dioxlanes
US5817638A (en) * 1988-07-07 1998-10-06 Nexstar Pharmaceuticals, Inc. Antiviral liponucleosides: treatment of hepatitis B
US6599887B2 (en) 1988-07-07 2003-07-29 Chimerix, Inc. Methods of treating viral infections using antiviral liponucleotides
US6252060B1 (en) 1988-07-07 2001-06-26 Nexstar Pharmaceuticals, Inc. Antiviral liponucleosides: treatment of hepatitis B
UA45942A (uk) * 1989-02-08 2002-05-15 Біокем Фарма, Інк. 1,3-оксатіолан, його похідні, спосіб (варіанти) його одержання та фармацевтична композиція
JP2619710B2 (ja) * 1989-02-27 1997-06-11 日本製紙 株式会社 ２′，３′−ジデオキシプリンヌクレオシド類の製造方法
DD293498A5 (de) * 1989-07-20 1991-09-05 Zi Fuer Molekularbiologie Der Adw,De Verfahren zur herstellung eines mittels fuer die behandlung oder prophylaxe von hepatits-infektionen bei mensch und tier
CA2027023C (en) * 1989-10-11 2001-12-25 Esa T. Jarvi Inosine/guanosine derivatives
US5128458A (en) * 1990-04-20 1992-07-07 Southern Research Institute 2',3'-dideoxy-4'-thioribonucleosides as antiviral agents
GB9009861D0 (en) 1990-05-02 1990-06-27 Glaxo Group Ltd Chemical compounds
US6369066B1 (en) 1990-11-13 2002-04-09 Biochem Pharma, Inc. Substituted 1,3-oxathiolanes with antiviral properties
US5587480A (en) * 1990-11-13 1996-12-24 Biochem Pharma, Inc. Substituted 1,3-oxathiolanes and substituted 1,3-dithiolanes with antiviral properties
US6228860B1 (en) 1990-11-13 2001-05-08 Biochem Pharma Inc. Substituted 1,3-oxathiolanes with antiviral properties
IL100502A (en) * 1991-01-03 1995-12-08 Iaf Biochem Int PHARMACEUTICAL PREPARATIONS CONTAINING CIS-4-AMINO-1-) 2-HYDROXIMETHIL-1,3-OXETYOLEN-5-IL (-
GB9110874D0 (en) * 1991-05-20 1991-07-10 Iaf Biochem Int Medicaments
ZA923640B (en) * 1991-05-21 1993-02-24 Iaf Biochem Int Processes for the diastereoselective synthesis of nucleosides
NL9300058A (nl) * 1992-06-18 1994-01-17 Stichting Rega V Z W 1,5-anhydrohexitol nucleoside analoga en farmaceutisch gebruik daarvan.
US5451671A (en) * 1992-07-27 1995-09-19 Ajinomoto Co., Inc. Method of purifying 2',3'-dideoxynucleosides
US5360714A (en) * 1992-08-28 1994-11-01 Fox Chase Cancer Center Hepadnavirus polymerase gene product having RNA-dependent DNA priming and reverse transcriptase activities and methods of measuring the activities thereof
US5334525A (en) * 1992-08-28 1994-08-02 Fox Chase Cancer Center Hepadnavirus polymerase gene product having RNA-dependent DNA priming and reverse transcriptase activities and methods of measuring the activities thereof
TW374087B (en) * 1993-05-25 1999-11-11 Univ Yale L-2',3'-dideoxy nucleotide analogs as anti-hepatitis B(HBV) and anti-HIV agents
US5627160A (en) * 1993-05-25 1997-05-06 Yale University L-2',3'-dideoxy nucleoside analogs as anti-hepatitis B (HBV) and anti-HIV agents
WO1996003134A1 (en) * 1994-07-21 1996-02-08 Thomas Jefferson University Treatment of diarrhea with 2-substituted adenosine derivatives
US6015576A (en) * 1997-08-29 2000-01-18 Bio-Sphere Technology, Inc. Method for inducing a systemic immune response to an antigen
US6117449A (en) * 1996-03-22 2000-09-12 Bio-Sphere Technology, Inc. Method for inducing a systemic immune response to a hepatitis antigen
US6207185B1 (en) 1996-03-22 2001-03-27 Bio-Sphere Technology Method for inducing a systemic immune response to an HIV antigen
US6316228B1 (en) * 1996-10-21 2001-11-13 The University Of Iowa Research Foundation Efficient synthesis of nucleosides
AU8167498A (en) * 1997-06-26 1999-01-19 Biosphere Technologies Inc. Method for inducing a systemic immune response to a hepatitis or hiv antigen
US6274725B1 (en) * 1998-06-02 2001-08-14 Isis Pharmaceuticals, Inc. Activators for oligonucleotide synthesis
WO2000064918A1 (en) * 1999-04-28 2000-11-02 Sterrenbeld Biotechnologie North America, Inc. METHOD FOR THE PRODUCTION OF 2-CHLORO-2'-DEOXYADENOSINE (CLADRIBINE) AND ITS 3,5-DI-O-p-TOLUOYL DERIVATIVE
CA2535510C (en) * 2003-08-11 2013-10-15 Monogram Biosciences, Inc. Detecting and profiling molecular complexes

Family Cites Families (2)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
DD279407A1 (de) * 1986-07-24 1990-06-06 Akad Wissenschaften Ddr Verfahren zur herstellung eines mittels gegen aids
EP0314011A3 (de) * 1987-10-30 1990-04-11 F. Hoffmann-La Roche Ag Purinderivate

Also Published As

Publication number Publication date
AU2813189A (en) 1989-06-14
AU615705B2 (en) 1991-10-10
AU7944491A (en) 1991-09-26
WO1989004662A1 (en) 1989-06-01
EP0355135A4 (de) 1990-04-09
DE3882985D1 (de) 1993-09-09
EP0355135B1 (de) 1993-08-04
DE3882985T2 (de) 1994-03-03
US4997926A (en) 1991-03-05
EP0355135A1 (de) 1990-02-28
CA1322748C (en) 1993-10-05

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Legal Events

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UEP Publication of translation of european patent specification
REN Ceased due to non-payment of the annual fee