ATE88094T1 - Parenteral anzuwendende 1-diphenylmethyl-4-((2-(4-methylphenyl)-5-methy -1h-imidazol-4-yl)-methyl>- piperazin enthaltende zubereitungen. - Google Patents

Parenteral anzuwendende 1-diphenylmethyl-4-((2-(4-methylphenyl)-5-methy -1h-imidazol-4-yl)-methyl>- piperazin enthaltende zubereitungen.

Info

Publication number
ATE88094T1
ATE88094T1 AT89310852T AT89310852T ATE88094T1 AT E88094 T1 ATE88094 T1 AT E88094T1 AT 89310852 T AT89310852 T AT 89310852T AT 89310852 T AT89310852 T AT 89310852T AT E88094 T1 ATE88094 T1 AT E88094T1
Authority
AT
Austria
Prior art keywords
diphenylmethyl
methylphenyl
methyl
salt
acid
Prior art date
Application number
AT89310852T
Other languages
English (en)
Inventor
Alastair B Selkirk
Michael J Dey
Original Assignee
Syntex Pharma Ltd
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Syntex Pharma Ltd filed Critical Syntex Pharma Ltd
Application granted granted Critical
Publication of ATE88094T1 publication Critical patent/ATE88094T1/de

Links

Classifications

    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K9/00—Medicinal preparations characterised by special physical form
    • A61K9/08—Solutions
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K47/00—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient
    • A61K47/06—Organic compounds, e.g. natural or synthetic hydrocarbons, polyolefins, mineral oil, petrolatum or ozokerite
    • A61K47/08—Organic compounds, e.g. natural or synthetic hydrocarbons, polyolefins, mineral oil, petrolatum or ozokerite containing oxygen, e.g. ethers, acetals, ketones, quinones, aldehydes, peroxides
    • A61K47/12—Carboxylic acids; Salts or anhydrides thereof
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/33—Heterocyclic compounds
    • A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
    • A61K31/495—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with two or more nitrogen atoms as the only ring heteroatoms, e.g. piperazine or tetrazines
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K47/00—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient
    • A61K47/06—Organic compounds, e.g. natural or synthetic hydrocarbons, polyolefins, mineral oil, petrolatum or ozokerite
    • A61K47/26—Carbohydrates, e.g. sugar alcohols, amino sugars, nucleic acids, mono-, di- or oligo-saccharides; Derivatives thereof, e.g. polysorbates, sorbitan fatty acid esters or glycyrrhizin
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K9/00—Medicinal preparations characterised by special physical form
    • A61K9/0012—Galenical forms characterised by the site of application
    • A61K9/0019—Injectable compositions; Intramuscular, intravenous, arterial, subcutaneous administration; Compositions to be administered through the skin in an invasive manner
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P13/00—Drugs for disorders of the urinary system
    • A61P13/02—Drugs for disorders of the urinary system of urine or of the urinary tract, e.g. urine acidifiers
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P15/00—Drugs for genital or sexual disorders; Contraceptives
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00—Drugs for disorders of the nervous system
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P9/00—Drugs for disorders of the cardiovascular system
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P9/00—Drugs for disorders of the cardiovascular system
    • A61P9/10—Drugs for disorders of the cardiovascular system for treating ischaemic or atherosclerotic diseases, e.g. antianginal drugs, coronary vasodilators, drugs for myocardial infarction, retinopathy, cerebrovascula insufficiency, renal arteriosclerosis

Landscapes

  • Health & Medical Sciences (AREA)
  • Chemical & Material Sciences (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Medicinal Chemistry (AREA)
  • Veterinary Medicine (AREA)
  • Public Health (AREA)
  • General Health & Medical Sciences (AREA)
  • Animal Behavior & Ethology (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Engineering & Computer Science (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • General Chemical & Material Sciences (AREA)
  • Epidemiology (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Organic Chemistry (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Oil, Petroleum & Natural Gas (AREA)
  • Heart & Thoracic Surgery (AREA)
  • Cardiology (AREA)
  • Urology & Nephrology (AREA)
  • Molecular Biology (AREA)
  • Biochemistry (AREA)
  • Dermatology (AREA)
  • Vascular Medicine (AREA)
  • Reproductive Health (AREA)
  • Endocrinology (AREA)
  • Neurosurgery (AREA)
  • Neurology (AREA)
  • Biomedical Technology (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
  • Plural Heterocyclic Compounds (AREA)
  • Medicinal Preparation (AREA)
  • Materials For Medical Uses (AREA)
AT89310852T 1988-10-21 1989-10-20 Parenteral anzuwendende 1-diphenylmethyl-4-((2-(4-methylphenyl)-5-methy -1h-imidazol-4-yl)-methyl>- piperazin enthaltende zubereitungen. ATE88094T1 (de)

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
US07/260,628 US4973591A (en) 1988-10-21 1988-10-21 Parenteral formulations of 1-diphenylmethyl-4-((2-(4-methylphenyl)-5-methyl-1H-imidazol-4-yl)methyl)piperazine
EP89310852A EP0365363B1 (de) 1988-10-21 1989-10-20 Parenteral anzuwendende 1-Diphenylmethyl-4-[(2-(4-methylphenyl)-5-methyl-1H-imidazol-4-yl)-methyl]-piperazin enthaltende Zubereitungen

Publications (1)

Publication Number Publication Date
ATE88094T1 true ATE88094T1 (de) 1993-04-15

Family

ID=22989940

Family Applications (1)

Application Number Title Priority Date Filing Date
AT89310852T ATE88094T1 (de) 1988-10-21 1989-10-20 Parenteral anzuwendende 1-diphenylmethyl-4-((2-(4-methylphenyl)-5-methy -1h-imidazol-4-yl)-methyl>- piperazin enthaltende zubereitungen.

Country Status (14)

Country Link
US (1) US4973591A (de)
EP (1) EP0365363B1 (de)
JP (1) JPH02157224A (de)
KR (1) KR900005962A (de)
AT (1) ATE88094T1 (de)
AU (1) AU636581B2 (de)
CA (1) CA2001170A1 (de)
DE (1) DE68905995T2 (de)
DK (1) DK523389A (de)
ES (1) ES2057145T3 (de)
GR (1) GR3007663T3 (de)
IE (1) IE63292B1 (de)
NZ (1) NZ231094A (de)
ZA (1) ZA897975B (de)

Families Citing this family (5)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
DK178590D0 (da) * 1990-07-26 1990-07-26 Novo Nordisk As 1,4-disubstituerede piperaziner
US5276035A (en) * 1990-07-26 1994-01-04 Novo Nordisk A/S 1,4-disubstituted piperazines
SE469717B (sv) * 1992-02-20 1993-08-30 Ingemar Naeslund Klaemma, speciellt foer tillslutning av paasar
WO1994027603A1 (en) * 1993-06-01 1994-12-08 Cortex Pharmaceuticals, Inc. Alkaline and acid phosphatase inhibitors in treatment of neurological disorders
US20070082949A1 (en) * 2003-11-14 2007-04-12 Hiroaki Ootani Agent for preventing and treating language disorders

Family Cites Families (13)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US3362956A (en) * 1965-08-19 1968-01-09 Sterling Drug Inc 1-[(heterocyclyl)-lower-alkyl]-4-substituted-piperazines
GB1184714A (en) * 1965-12-16 1970-03-18 Science Union & Cie Di- and Tri-Phenylpropyl Piperazine Derivatives
US3491098A (en) * 1967-05-29 1970-01-20 Sterling Drug Inc 1-((imidazolyl)-lower-alkyl)-4-substituted-piperazines
DE1795314A1 (de) * 1968-09-11 1972-01-05 Merck Patent Gmbh N-(Thiazolyl-2)-piperazine
US3927011A (en) * 1973-05-10 1975-12-16 Yoshitomi Pharmaceutical 2-Aminoalkyl-1-(pyridylcarbonylphenyl)imidazole compounds
US4022783A (en) * 1975-10-29 1977-05-10 Usv Pharmaceutical Corporation Piperazinyl-imidazolines
GB1551993A (en) * 1976-09-21 1979-09-05 Malesci Sas Pharmacologiclly active derivatives of 1 alkyl 4-phenylpiperazines and the preparation thereof
IT1159698B (it) * 1978-05-29 1987-03-04 Rotta Research Lab Derivati 5-nitro-imidazolici della piperazina ad attivita' antiprotozoica
US4243806A (en) * 1979-06-13 1981-01-06 Janssen Pharmaceutica N.V. 5-[4-(Diarylmethyl)-1-piperazinylalkyl]benzimidazole derivatives
US4404382A (en) * 1980-09-17 1983-09-13 The Upjohn Company Piperazinyl-substituted imidazoles
HU187399B (en) * 1980-12-24 1985-12-28 Sumitomo Chemical Co Process for preparing imidazolyl-propanol derivatives
US4435399A (en) * 1981-07-18 1984-03-06 Pfizer Inc. 2-Aryl-1-(imidazol-1-yl)-8-(4-piperazin-1-ylphenoxy) octan-2-ol antifungal agents
US4829065A (en) * 1987-04-24 1989-05-09 Syntex Pharmaceuticals, Ltd. Substituted imidazolyl-alkyl-piperazine and -diazepine derivatives

Also Published As

Publication number Publication date
IE63292B1 (en) 1995-04-05
AU636581B2 (en) 1993-05-06
US4973591A (en) 1990-11-27
NZ231094A (en) 1991-12-23
DK523389D0 (da) 1989-10-20
EP0365363A1 (de) 1990-04-25
AU4356989A (en) 1990-04-26
DE68905995D1 (de) 1993-05-19
CA2001170A1 (en) 1990-04-21
EP0365363B1 (de) 1993-04-14
GR3007663T3 (de) 1993-08-31
ES2057145T3 (es) 1994-10-16
DK523389A (da) 1990-04-22
DE68905995T2 (de) 1993-09-16
IE893382L (en) 1990-04-21
ZA897975B (en) 1991-06-26
JPH02157224A (ja) 1990-06-18
KR900005962A (ko) 1990-05-07

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Legal Events

Date Code Title Description
UEP Publication of translation of european patent specification
REN Ceased due to non-payment of the annual fee