ATE852T1 - ANTI-SECRETION OXADIAZOLE DERIVATIVES, PROCESS FOR THEIR PREPARATION AND PHARMACEUTICAL COMPOSITIONS CONTAINING THEM. - Google Patents

ANTI-SECRETION OXADIAZOLE DERIVATIVES, PROCESS FOR THEIR PREPARATION AND PHARMACEUTICAL COMPOSITIONS CONTAINING THEM.

Info

Publication number
ATE852T1
ATE852T1 AT79300755T AT79300755T ATE852T1 AT E852 T1 ATE852 T1 AT E852T1 AT 79300755 T AT79300755 T AT 79300755T AT 79300755 T AT79300755 T AT 79300755T AT E852 T1 ATE852 T1 AT E852T1
Authority
AT
Austria
Prior art keywords
sup
sub
oxadiazole derivatives
secretion
pharmaceutical compositions
Prior art date
Application number
AT79300755T
Other languages
German (de)
Inventor
Tobias Oregon Yellin
Derrick Michael Mant
Original Assignee
Imperial Chemical Industries Plc
Ici Americas Inc
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Imperial Chemical Industries Plc, Ici Americas Inc filed Critical Imperial Chemical Industries Plc
Application granted granted Critical
Publication of ATE852T1 publication Critical patent/ATE852T1/en

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D271/00—Heterocyclic compounds containing five-membered rings having two nitrogen atoms and one oxygen atom as the only ring hetero atoms
    • C07D271/02—Heterocyclic compounds containing five-membered rings having two nitrogen atoms and one oxygen atom as the only ring hetero atoms not condensed with other rings
    • C07D271/06—1,2,4-Oxadiazoles; Hydrogenated 1,2,4-oxadiazoles
    • C07D271/07—1,2,4-Oxadiazoles; Hydrogenated 1,2,4-oxadiazoles with oxygen, sulfur or nitrogen atoms, directly attached to ring carbon atoms, the nitrogen atoms not forming part of a nitro radical
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P1/00—Drugs for disorders of the alimentary tract or the digestive system
    • A61P1/04—Drugs for disorders of the alimentary tract or the digestive system for ulcers, gastritis or reflux esophagitis, e.g. antacids, inhibitors of acid secretion, mucosal protectants

Landscapes

  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Health & Medical Sciences (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • General Chemical & Material Sciences (AREA)
  • Medicinal Chemistry (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Engineering & Computer Science (AREA)
  • Animal Behavior & Ethology (AREA)
  • General Health & Medical Sciences (AREA)
  • Public Health (AREA)
  • Veterinary Medicine (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Heterocyclic Carbon Compounds Containing A Hetero Ring Having Nitrogen And Oxygen As The Only Ring Hetero Atoms (AREA)
  • Plural Heterocyclic Compounds (AREA)

Abstract

The invention relates to oxadiazole derivatives which are histamine H-2 antagonists and which inhibit the secretion of gastric acid, to methods for their manufacture and to pharmaceutical compositions containing them. The oxadiazole derivatives are of the formula:in which Y is O, S, CH<sub>2</sub> or a direct bond; m is 0 to 4 and n is 1 to 4, provided that when Y is S or O m is 1 to 4 and when Y is O n is 2 to 4; A is a 3,4-dioxocyclobuten-1,2-diyl radical or C=Z in which Z is O, S, NCN, NNO<sub>2</sub>, CHNO<sub>2</sub>,NCONH<sub>2</sub>, C(CN)<sub>2</sub>, NCOR<sup>1</sup>, NCO<sub>2</sub>R<sup>1</sup>, NSO<sub>2</sub>R<sup>1</sup> or NR<sup>2</sup> in which R<sup>1</sup> is alkyl or aryl and R<sup>2</sup> is H or alkyl; B is alkoxy or alkylthio or NHR<sup>3</sup> in which R<sup>3</sup> is H or alkyl: and the salts thereof.
AT79300755T 1978-05-24 1979-05-02 ANTI-SECRETION OXADIAZOLE DERIVATIVES, PROCESS FOR THEIR PREPARATION AND PHARMACEUTICAL COMPOSITIONS CONTAINING THEM. ATE852T1 (en)

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
GB2173878 1978-05-24
EP79300755A EP0006286B1 (en) 1978-05-24 1979-05-02 Antisecretory oxadiazole derivatives, processes for their manufacture and pharmaceutical compositions containing them

Publications (1)

Publication Number Publication Date
ATE852T1 true ATE852T1 (en) 1982-04-15

Family

ID=10167976

Family Applications (1)

Application Number Title Priority Date Filing Date
AT79300755T ATE852T1 (en) 1978-05-24 1979-05-02 ANTI-SECRETION OXADIAZOLE DERIVATIVES, PROCESS FOR THEIR PREPARATION AND PHARMACEUTICAL COMPOSITIONS CONTAINING THEM.

Country Status (6)

Country Link
US (2) US4338447A (en)
EP (1) EP0006286B1 (en)
JP (1) JPS54160377A (en)
AT (1) ATE852T1 (en)
CA (1) CA1125296A (en)
DE (1) DE2962500D1 (en)

Families Citing this family (9)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
EP0014057B1 (en) * 1979-01-18 1985-01-02 Imperial Chemical Industries Plc Guanidine derivatives, processes for their manufacture and pharmaceutical compositions containing them
DE3270716D1 (en) * 1981-02-27 1986-05-28 Ici Plc Guanidino-substituted heterocyclic derivatives having histamine h-2 antagonist activity
EP0065823A1 (en) * 1981-05-13 1982-12-01 Imperial Chemical Industries Plc Heterocyclic guanidines as histamine H-2 antagonists
US4526973A (en) * 1981-05-18 1985-07-02 Bristol-Myers Company Chemical compounds
US4522943A (en) * 1981-05-18 1985-06-11 Bristol-Myers Company Chemical compounds
US4772622A (en) * 1983-03-25 1988-09-20 Merck & Co., Inc. 3,5-diamino-1,2,4-oxidiazoles as gastric secretion inhibitors
JPH0225908U (en) * 1988-08-01 1990-02-20
US5725756A (en) * 1995-04-18 1998-03-10 Center For Research, Inc. In situ mitigation of coke buildup in porous catalysts with supercritical reaction media
US20230349922A1 (en) 2020-08-11 2023-11-02 Université De Strasbourg H2 Blockers Targeting Liver Macrophages for the Prevention and Treatment of Liver Disease and Cancer

Family Cites Families (3)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
GB1010231A (en) * 1961-07-11 1965-11-17 Jan Marcel Didier Aron Samuel Substituted 3-phenyl-5-imino-4,5 dihydro-1,2,4-oxadiazoles, process for their manufacture and therapeutic compositions containing same
FR1575544A (en) * 1967-11-09 1969-07-25
GB1351025A (en) * 1971-08-20 1974-04-24 Aron Md Samuel J Oxadiazol-5-yl biguanide derivatives method for their preparation and pharmaceutical compositions containing them

Also Published As

Publication number Publication date
CA1125296A (en) 1982-06-08
EP0006286B1 (en) 1982-04-14
JPS54160377A (en) 1979-12-19
EP0006286A1 (en) 1980-01-09
JPS6330903B2 (en) 1988-06-21
US4338447A (en) 1982-07-06
US4338448A (en) 1982-07-06
DE2962500D1 (en) 1982-05-27

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Legal Events

Date Code Title Description
UEP Publication of translation of european patent specification
REN Ceased due to non-payment of the annual fee