ATE836T1 - CONTROL REAGENTS FOR THE DETERMINATION OF HEPARIN ACTIVITY. - Google Patents
CONTROL REAGENTS FOR THE DETERMINATION OF HEPARIN ACTIVITY.Info
- Publication number
- ATE836T1 ATE836T1 AT80100222T AT80100222T ATE836T1 AT E836 T1 ATE836 T1 AT E836T1 AT 80100222 T AT80100222 T AT 80100222T AT 80100222 T AT80100222 T AT 80100222T AT E836 T1 ATE836 T1 AT E836T1
- Authority
- AT
- Austria
- Prior art keywords
- determination
- heparin activity
- control reagents
- heparin
- mole
- Prior art date
Links
- HTTJABKRGRZYRN-UHFFFAOYSA-N Heparin Chemical compound OC1C(NC(=O)C)C(O)OC(COS(O)(=O)=O)C1OC1C(OS(O)(=O)=O)C(O)C(OC2C(C(OS(O)(=O)=O)C(OC3C(C(O)C(O)C(O3)C(O)=O)OS(O)(=O)=O)C(CO)O2)NS(O)(=O)=O)C(C(O)=O)O1 HTTJABKRGRZYRN-UHFFFAOYSA-N 0.000 title abstract 3
- 239000003153 chemical reaction reagent Substances 0.000 title abstract 3
- 229960002897 heparin Drugs 0.000 title abstract 3
- 229920000669 heparin Polymers 0.000 title abstract 3
- 102000004411 Antithrombin III Human genes 0.000 abstract 1
- 108090000935 Antithrombin III Proteins 0.000 abstract 1
- 108010039627 Aprotinin Proteins 0.000 abstract 1
- 102000007562 Serum Albumin Human genes 0.000 abstract 1
- 108010071390 Serum Albumin Proteins 0.000 abstract 1
- CZMRCDWAGMRECN-UGDNZRGBSA-N Sucrose Chemical compound O[C@H]1[C@H](O)[C@@H](CO)O[C@@]1(CO)O[C@@H]1[C@H](O)[C@@H](O)[C@H](O)[C@@H](CO)O1 CZMRCDWAGMRECN-UGDNZRGBSA-N 0.000 abstract 1
- 229930006000 Sucrose Natural products 0.000 abstract 1
- 229960005348 antithrombin iii Drugs 0.000 abstract 1
- 229960004405 aprotinin Drugs 0.000 abstract 1
- 239000012928 buffer substance Substances 0.000 abstract 1
- 235000013681 dietary sucrose Nutrition 0.000 abstract 1
- ZPNFWUPYTFPOJU-LPYSRVMUSA-N iniprol Chemical compound C([C@H]1C(=O)NCC(=O)NCC(=O)N[C@H]2CSSC[C@H]3C(=O)N[C@@H](CCCCN)C(=O)N[C@@H](C)C(=O)N[C@@H](CCCNC(N)=N)C(=O)N[C@H](C(N[C@H](C(=O)N[C@@H](CCCNC(N)=N)C(=O)N[C@@H](CC=4C=CC(O)=CC=4)C(=O)N[C@@H](CC=4C=CC=CC=4)C(=O)N[C@@H](CC=4C=CC(O)=CC=4)C(=O)N[C@@H](CC(N)=O)C(=O)N[C@@H](C)C(=O)N[C@@H](CCCCN)C(=O)N[C@@H](C)C(=O)NCC(=O)N[C@@H](CC(C)C)C(=O)N[C@@H](CSSC[C@H](NC(=O)[C@H](CC(O)=O)NC(=O)[C@H](CCC(O)=O)NC(=O)[C@H](C)NC(=O)[C@H](CO)NC(=O)[C@H](CCCCN)NC(=O)[C@H](CC=4C=CC=CC=4)NC(=O)[C@H](CC(N)=O)NC(=O)[C@H](CC(N)=O)NC(=O)[C@H](CCCNC(N)=N)NC(=O)[C@H](CCCCN)NC(=O)[C@H](C)NC(=O)[C@H](CCCNC(N)=N)NC2=O)C(=O)N[C@@H](CCSC)C(=O)N[C@@H](CCCNC(N)=N)C(=O)N[C@@H]([C@@H](C)O)C(=O)N[C@@H](CSSC[C@H](NC(=O)[C@H](CC=2C=CC=CC=2)NC(=O)[C@H](CC(O)=O)NC(=O)[C@H]2N(CCC2)C(=O)[C@@H](N)CCCNC(N)=N)C(=O)N[C@@H](CC(C)C)C(=O)N[C@@H](CCC(O)=O)C(=O)N2[C@@H](CCC2)C(=O)N2[C@@H](CCC2)C(=O)N[C@@H](CC=2C=CC(O)=CC=2)C(=O)N[C@@H]([C@@H](C)O)C(=O)NCC(=O)N2[C@@H](CCC2)C(=O)N3)C(=O)NCC(=O)NCC(=O)N[C@@H](C)C(O)=O)C(=O)N[C@@H](CCC(N)=O)C(=O)N[C@H](C(=O)N[C@@H](CC=2C=CC=CC=2)C(=O)N[C@H](C(=O)N1)C(C)C)[C@@H](C)O)[C@@H](C)CC)=O)[C@@H](C)CC)C1=CC=C(O)C=C1 ZPNFWUPYTFPOJU-LPYSRVMUSA-N 0.000 abstract 1
- HLWRUJAIJJEZDL-UHFFFAOYSA-M sodium;2-[2-[bis(carboxymethyl)amino]ethyl-(carboxymethyl)amino]acetate Chemical compound [Na+].OC(=O)CN(CC(O)=O)CCN(CC(O)=O)CC([O-])=O HLWRUJAIJJEZDL-UHFFFAOYSA-M 0.000 abstract 1
- 229960004793 sucrose Drugs 0.000 abstract 1
Classifications
-
- G—PHYSICS
- G01—MEASURING; TESTING
- G01N—INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
- G01N33/00—Investigating or analysing materials by specific methods not covered by groups G01N1/00 - G01N31/00
- G01N33/48—Biological material, e.g. blood, urine; Haemocytometers
- G01N33/50—Chemical analysis of biological material, e.g. blood, urine; Testing involving biospecific ligand binding methods; Immunological testing
- G01N33/96—Chemical analysis of biological material, e.g. blood, urine; Testing involving biospecific ligand binding methods; Immunological testing involving blood or serum control standard
-
- G—PHYSICS
- G01—MEASURING; TESTING
- G01N—INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
- G01N2400/00—Assays, e.g. immunoassays or enzyme assays, involving carbohydrates
- G01N2400/10—Polysaccharides, i.e. having more than five saccharide radicals attached to each other by glycosidic linkages; Derivatives thereof, e.g. ethers, esters
- G01N2400/38—Heteroglycans, i.e. polysaccharides having more than one sugar residue in the main chain in either alternating or less regular sequence, e.g. gluco- or galactomannans, Konjac gum, Locust bean gum or Guar gum
- G01N2400/40—Glycosaminoglycans, i.e. GAG or mucopolysaccharides, e.g. chondroitin sulfate, dermatan sulfate, hyaluronic acid, heparin, heparan sulfate, and related sulfated polysaccharides
-
- G—PHYSICS
- G01—MEASURING; TESTING
- G01N—INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
- G01N33/00—Investigating or analysing materials by specific methods not covered by groups G01N1/00 - G01N31/00
- G01N33/48—Biological material, e.g. blood, urine; Haemocytometers
- G01N33/50—Chemical analysis of biological material, e.g. blood, urine; Testing involving biospecific ligand binding methods; Immunological testing
- G01N33/86—Chemical analysis of biological material, e.g. blood, urine; Testing involving biospecific ligand binding methods; Immunological testing involving blood coagulating time or factors, or their receptors
-
- Y—GENERAL TAGGING OF NEW TECHNOLOGICAL DEVELOPMENTS; GENERAL TAGGING OF CROSS-SECTIONAL TECHNOLOGIES SPANNING OVER SEVERAL SECTIONS OF THE IPC; TECHNICAL SUBJECTS COVERED BY FORMER USPC CROSS-REFERENCE ART COLLECTIONS [XRACs] AND DIGESTS
- Y10—TECHNICAL SUBJECTS COVERED BY FORMER USPC
- Y10T—TECHNICAL SUBJECTS COVERED BY FORMER US CLASSIFICATION
- Y10T436/00—Chemistry: analytical and immunological testing
- Y10T436/10—Composition for standardization, calibration, simulation, stabilization, preparation or preservation; processes of use in preparation for chemical testing
-
- Y—GENERAL TAGGING OF NEW TECHNOLOGICAL DEVELOPMENTS; GENERAL TAGGING OF CROSS-SECTIONAL TECHNOLOGIES SPANNING OVER SEVERAL SECTIONS OF THE IPC; TECHNICAL SUBJECTS COVERED BY FORMER USPC CROSS-REFERENCE ART COLLECTIONS [XRACs] AND DIGESTS
- Y10—TECHNICAL SUBJECTS COVERED BY FORMER USPC
- Y10T—TECHNICAL SUBJECTS COVERED BY FORMER US CLASSIFICATION
- Y10T436/00—Chemistry: analytical and immunological testing
- Y10T436/10—Composition for standardization, calibration, simulation, stabilization, preparation or preservation; processes of use in preparation for chemical testing
- Y10T436/106664—Blood serum or blood plasma standard or control
Landscapes
- Health & Medical Sciences (AREA)
- Life Sciences & Earth Sciences (AREA)
- Hematology (AREA)
- Engineering & Computer Science (AREA)
- Molecular Biology (AREA)
- Biomedical Technology (AREA)
- Chemical & Material Sciences (AREA)
- Immunology (AREA)
- Urology & Nephrology (AREA)
- Food Science & Technology (AREA)
- Biochemistry (AREA)
- Cell Biology (AREA)
- Biotechnology (AREA)
- Medicinal Chemistry (AREA)
- Physics & Mathematics (AREA)
- Analytical Chemistry (AREA)
- Microbiology (AREA)
- General Health & Medical Sciences (AREA)
- General Physics & Mathematics (AREA)
- Pathology (AREA)
- Investigating Or Analysing Biological Materials (AREA)
- Measuring Or Testing Involving Enzymes Or Micro-Organisms (AREA)
- Polysaccharides And Polysaccharide Derivatives (AREA)
- Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
Abstract
A control reagent for heparin activity determination comprising 20 to 1500 USP heparin, 2000 to 30000 IU antithrombin III, 0.15 to 1.5 millimoles serum albumin, 0.005 to 0.05 mole ethylenediaminetetraacetic acid sodium salt, 0 to 0.4 mole saccharose, 2000 to 20000 U aprotinin, and buffer substance, pH 6.5 to 7.5, per liter of control reagent solution.
Applications Claiming Priority (2)
Application Number | Priority Date | Filing Date | Title |
---|---|---|---|
DE2903701A DE2903701C2 (en) | 1979-01-31 | 1979-01-31 | Control reagent for the determination of the heparin activity |
EP80100222A EP0014349B1 (en) | 1979-01-31 | 1980-01-17 | Control reagent for the determination of the activity of heparin |
Publications (1)
Publication Number | Publication Date |
---|---|
ATE836T1 true ATE836T1 (en) | 1982-04-15 |
Family
ID=6061834
Family Applications (1)
Application Number | Title | Priority Date | Filing Date |
---|---|---|---|
AT80100222T ATE836T1 (en) | 1979-01-31 | 1980-01-17 | CONTROL REAGENTS FOR THE DETERMINATION OF HEPARIN ACTIVITY. |
Country Status (5)
Country | Link |
---|---|
US (1) | US4301028A (en) |
EP (1) | EP0014349B1 (en) |
JP (1) | JPS55103463A (en) |
AT (1) | ATE836T1 (en) |
DE (2) | DE2903701C2 (en) |
Families Citing this family (14)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
DE3019612A1 (en) * | 1980-05-22 | 1981-11-26 | Boehringer Mannheim Gmbh, 6800 Mannheim | STABILIZED THROMBINE PREPARATION |
EP0066908B1 (en) | 1981-05-21 | 1985-08-28 | Akzo N.V. | New anti-thromboticum based on polysacharides, method for its preparation and pharmaceutical compositions |
JPS58220697A (en) * | 1982-06-15 | 1983-12-22 | Green Cross Corp:The | Activity measurement method of antithrombin-3 and kit using it |
SE8702556D0 (en) * | 1987-06-18 | 1987-06-18 | Kabivitrum Ab | DETERMINATION OF PROTEOLYS ACTIVE COMPONENTS |
US5312745A (en) * | 1987-06-18 | 1994-05-17 | Chromogenix Ab | Determination of components active in proteolysis |
DE69033033T2 (en) * | 1989-07-20 | 1999-10-28 | Analytical Control Systems, Inc. | IMPROVED CONTROL PROCEDURE FOR STABLE BLOOD COAGULATION |
US5939325A (en) * | 1989-07-20 | 1999-08-17 | Analytical Control Systems, Inc. | Stable whole blood coagulation controls |
US5296377A (en) * | 1992-12-15 | 1994-03-22 | Boehringer Mannheim Corporation | Control reagent containing a hydroxylamine or an antioxidant |
US5385825A (en) * | 1993-07-20 | 1995-01-31 | Emerald Biomedical Sciences, Inc. | Composition for processing bodyfluids, method of processing bodyfluids and products made from bodyfluids |
US6194394B1 (en) | 1998-07-01 | 2001-02-27 | Sigma-Aldrich Co. | Coagulation controls for prothrombin time (PT) and activated partial thromboplastin time (APTT) assays |
DE19855819C2 (en) * | 1998-12-03 | 2001-02-15 | Roche Diagnostics Gmbh | Stabilization of calibrators containing cytokeratin |
DE102005028018A1 (en) * | 2005-06-16 | 2006-12-21 | Dade Behring Marburg Gmbh | Method for the standardization of coagulation tests |
DE102006035580A1 (en) * | 2006-07-27 | 2008-02-14 | Csl Behring Gmbh | Determination of the biological activity of heparin in AT III-containing preparations |
CN114813287A (en) * | 2022-06-29 | 2022-07-29 | 深圳市帝迈生物技术有限公司 | Calibrator for heparin anticoagulation detection and preparation method thereof |
Family Cites Families (11)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
US3030272A (en) * | 1960-05-26 | 1962-04-17 | Abbott Lab | Stable heaparin solution |
DE2461969A1 (en) * | 1974-12-31 | 1976-07-08 | Behringwerke Ag | STABLE BLOOD PLASMA, THE PROCESS FOR PRODUCING IT AND ITS USE AS A COMPARATIVE PLASMA IN COOLAGE EXAMINATIONS |
US3985618A (en) * | 1975-05-02 | 1976-10-12 | Irving Innerfield | Method for detection of thrombosis and prethrombosis |
DE2601372C3 (en) * | 1976-01-15 | 1980-03-27 | Behringwerke Ag, 3550 Marburg | Method for the determination of antithrombin III |
US4067777A (en) * | 1976-05-13 | 1978-01-10 | Innerfield Irving | Determination of heparin in the blood |
CH634662A5 (en) * | 1976-05-28 | 1983-02-15 | Pentapharm Ag | USE OF TRIPEPTIDE DERIVATIVES FOR THE QUANTITATIVE DETERMINATION OF PLASMINOGEN ACTIVATORS. |
US4090977A (en) * | 1976-11-22 | 1978-05-23 | Research Corporation | Osmotically balanced anticoaglant |
US4127502A (en) * | 1977-06-10 | 1978-11-28 | Eastman Kodak Company | Stabilizers for reconstituted, lyophilized samples |
DE2812943C3 (en) * | 1978-03-23 | 1981-05-14 | Boehringer Mannheim Gmbh, 6800 Mannheim | Method and reagent for determining the biological activity of heparin in plasma |
US4216117A (en) * | 1978-05-15 | 1980-08-05 | Bonderman Dean P | Lipoprotein diluent or solution and method useful in the preparation of assay reference materials |
US4195072A (en) * | 1978-07-05 | 1980-03-25 | Abbott Laboratories | Stabilized platelet factor 4 immunoassay standards |
-
1979
- 1979-01-31 DE DE2903701A patent/DE2903701C2/en not_active Expired
-
1980
- 1980-01-09 US US06/110,581 patent/US4301028A/en not_active Expired - Lifetime
- 1980-01-17 AT AT80100222T patent/ATE836T1/en not_active IP Right Cessation
- 1980-01-17 EP EP80100222A patent/EP0014349B1/en not_active Expired
- 1980-01-17 DE DE8080100222T patent/DE3060262D1/en not_active Expired
- 1980-01-30 JP JP885980A patent/JPS55103463A/en active Granted
Also Published As
Publication number | Publication date |
---|---|
DE2903701B1 (en) | 1980-02-28 |
JPS55103463A (en) | 1980-08-07 |
EP0014349A1 (en) | 1980-08-20 |
DE2903701C2 (en) | 1980-10-16 |
US4301028A (en) | 1981-11-17 |
EP0014349B1 (en) | 1982-04-07 |
DE3060262D1 (en) | 1982-05-19 |
JPS6342228B2 (en) | 1988-08-22 |
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Legal Events
Date | Code | Title | Description |
---|---|---|---|
EELA | Cancelled due to lapse of time |