ATE836T1 - CONTROL REAGENTS FOR THE DETERMINATION OF HEPARIN ACTIVITY. - Google Patents

CONTROL REAGENTS FOR THE DETERMINATION OF HEPARIN ACTIVITY.

Info

Publication number
ATE836T1
ATE836T1 AT80100222T AT80100222T ATE836T1 AT E836 T1 ATE836 T1 AT E836T1 AT 80100222 T AT80100222 T AT 80100222T AT 80100222 T AT80100222 T AT 80100222T AT E836 T1 ATE836 T1 AT E836T1
Authority
AT
Austria
Prior art keywords
determination
heparin activity
control reagents
heparin
mole
Prior art date
Application number
AT80100222T
Other languages
German (de)
Inventor
Knut Dr. Bartl
Joachim Dr. Ziegenhorn
Peter Dr. Wunderwald
Klaus Dr. Beaucamp
Helmut Dr. Lill
Original Assignee
Boehringer Mannheim Gmbh
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Boehringer Mannheim Gmbh filed Critical Boehringer Mannheim Gmbh
Application granted granted Critical
Publication of ATE836T1 publication Critical patent/ATE836T1/en

Links

Classifications

    • G—PHYSICS
    • G01—MEASURING; TESTING
    • G01N—INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
    • G01N33/00—Investigating or analysing materials by specific methods not covered by groups G01N1/00 - G01N31/00
    • G01N33/48—Biological material, e.g. blood, urine; Haemocytometers
    • G01N33/50—Chemical analysis of biological material, e.g. blood, urine; Testing involving biospecific ligand binding methods; Immunological testing
    • G01N33/96—Chemical analysis of biological material, e.g. blood, urine; Testing involving biospecific ligand binding methods; Immunological testing involving blood or serum control standard
    • G—PHYSICS
    • G01—MEASURING; TESTING
    • G01N—INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
    • G01N2400/00—Assays, e.g. immunoassays or enzyme assays, involving carbohydrates
    • G01N2400/10—Polysaccharides, i.e. having more than five saccharide radicals attached to each other by glycosidic linkages; Derivatives thereof, e.g. ethers, esters
    • G01N2400/38—Heteroglycans, i.e. polysaccharides having more than one sugar residue in the main chain in either alternating or less regular sequence, e.g. gluco- or galactomannans, Konjac gum, Locust bean gum or Guar gum
    • G01N2400/40—Glycosaminoglycans, i.e. GAG or mucopolysaccharides, e.g. chondroitin sulfate, dermatan sulfate, hyaluronic acid, heparin, heparan sulfate, and related sulfated polysaccharides
    • G—PHYSICS
    • G01—MEASURING; TESTING
    • G01N—INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
    • G01N33/00—Investigating or analysing materials by specific methods not covered by groups G01N1/00 - G01N31/00
    • G01N33/48—Biological material, e.g. blood, urine; Haemocytometers
    • G01N33/50—Chemical analysis of biological material, e.g. blood, urine; Testing involving biospecific ligand binding methods; Immunological testing
    • G01N33/86—Chemical analysis of biological material, e.g. blood, urine; Testing involving biospecific ligand binding methods; Immunological testing involving blood coagulating time or factors, or their receptors
    • Y—GENERAL TAGGING OF NEW TECHNOLOGICAL DEVELOPMENTS; GENERAL TAGGING OF CROSS-SECTIONAL TECHNOLOGIES SPANNING OVER SEVERAL SECTIONS OF THE IPC; TECHNICAL SUBJECTS COVERED BY FORMER USPC CROSS-REFERENCE ART COLLECTIONS [XRACs] AND DIGESTS
    • Y10—TECHNICAL SUBJECTS COVERED BY FORMER USPC
    • Y10T—TECHNICAL SUBJECTS COVERED BY FORMER US CLASSIFICATION
    • Y10T436/00—Chemistry: analytical and immunological testing
    • Y10T436/10—Composition for standardization, calibration, simulation, stabilization, preparation or preservation; processes of use in preparation for chemical testing
    • Y—GENERAL TAGGING OF NEW TECHNOLOGICAL DEVELOPMENTS; GENERAL TAGGING OF CROSS-SECTIONAL TECHNOLOGIES SPANNING OVER SEVERAL SECTIONS OF THE IPC; TECHNICAL SUBJECTS COVERED BY FORMER USPC CROSS-REFERENCE ART COLLECTIONS [XRACs] AND DIGESTS
    • Y10—TECHNICAL SUBJECTS COVERED BY FORMER USPC
    • Y10T—TECHNICAL SUBJECTS COVERED BY FORMER US CLASSIFICATION
    • Y10T436/00—Chemistry: analytical and immunological testing
    • Y10T436/10—Composition for standardization, calibration, simulation, stabilization, preparation or preservation; processes of use in preparation for chemical testing
    • Y10T436/106664—Blood serum or blood plasma standard or control

Landscapes

  • Health & Medical Sciences (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Hematology (AREA)
  • Engineering & Computer Science (AREA)
  • Molecular Biology (AREA)
  • Biomedical Technology (AREA)
  • Chemical & Material Sciences (AREA)
  • Immunology (AREA)
  • Urology & Nephrology (AREA)
  • Food Science & Technology (AREA)
  • Biochemistry (AREA)
  • Cell Biology (AREA)
  • Biotechnology (AREA)
  • Medicinal Chemistry (AREA)
  • Physics & Mathematics (AREA)
  • Analytical Chemistry (AREA)
  • Microbiology (AREA)
  • General Health & Medical Sciences (AREA)
  • General Physics & Mathematics (AREA)
  • Pathology (AREA)
  • Investigating Or Analysing Biological Materials (AREA)
  • Measuring Or Testing Involving Enzymes Or Micro-Organisms (AREA)
  • Polysaccharides And Polysaccharide Derivatives (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)

Abstract

A control reagent for heparin activity determination comprising 20 to 1500 USP heparin, 2000 to 30000 IU antithrombin III, 0.15 to 1.5 millimoles serum albumin, 0.005 to 0.05 mole ethylenediaminetetraacetic acid sodium salt, 0 to 0.4 mole saccharose, 2000 to 20000 U aprotinin, and buffer substance, pH 6.5 to 7.5, per liter of control reagent solution.
AT80100222T 1979-01-31 1980-01-17 CONTROL REAGENTS FOR THE DETERMINATION OF HEPARIN ACTIVITY. ATE836T1 (en)

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
DE2903701A DE2903701C2 (en) 1979-01-31 1979-01-31 Control reagent for the determination of the heparin activity
EP80100222A EP0014349B1 (en) 1979-01-31 1980-01-17 Control reagent for the determination of the activity of heparin

Publications (1)

Publication Number Publication Date
ATE836T1 true ATE836T1 (en) 1982-04-15

Family

ID=6061834

Family Applications (1)

Application Number Title Priority Date Filing Date
AT80100222T ATE836T1 (en) 1979-01-31 1980-01-17 CONTROL REAGENTS FOR THE DETERMINATION OF HEPARIN ACTIVITY.

Country Status (5)

Country Link
US (1) US4301028A (en)
EP (1) EP0014349B1 (en)
JP (1) JPS55103463A (en)
AT (1) ATE836T1 (en)
DE (2) DE2903701C2 (en)

Families Citing this family (14)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
DE3019612A1 (en) * 1980-05-22 1981-11-26 Boehringer Mannheim Gmbh, 6800 Mannheim STABILIZED THROMBINE PREPARATION
EP0066908B1 (en) 1981-05-21 1985-08-28 Akzo N.V. New anti-thromboticum based on polysacharides, method for its preparation and pharmaceutical compositions
JPS58220697A (en) * 1982-06-15 1983-12-22 Green Cross Corp:The Activity measurement method of antithrombin-3 and kit using it
SE8702556D0 (en) * 1987-06-18 1987-06-18 Kabivitrum Ab DETERMINATION OF PROTEOLYS ACTIVE COMPONENTS
US5312745A (en) * 1987-06-18 1994-05-17 Chromogenix Ab Determination of components active in proteolysis
DE69033033T2 (en) * 1989-07-20 1999-10-28 Analytical Control Systems, Inc. IMPROVED CONTROL PROCEDURE FOR STABLE BLOOD COAGULATION
US5939325A (en) * 1989-07-20 1999-08-17 Analytical Control Systems, Inc. Stable whole blood coagulation controls
US5296377A (en) * 1992-12-15 1994-03-22 Boehringer Mannheim Corporation Control reagent containing a hydroxylamine or an antioxidant
US5385825A (en) * 1993-07-20 1995-01-31 Emerald Biomedical Sciences, Inc. Composition for processing bodyfluids, method of processing bodyfluids and products made from bodyfluids
US6194394B1 (en) 1998-07-01 2001-02-27 Sigma-Aldrich Co. Coagulation controls for prothrombin time (PT) and activated partial thromboplastin time (APTT) assays
DE19855819C2 (en) * 1998-12-03 2001-02-15 Roche Diagnostics Gmbh Stabilization of calibrators containing cytokeratin
DE102005028018A1 (en) * 2005-06-16 2006-12-21 Dade Behring Marburg Gmbh Method for the standardization of coagulation tests
DE102006035580A1 (en) * 2006-07-27 2008-02-14 Csl Behring Gmbh Determination of the biological activity of heparin in AT III-containing preparations
CN114813287A (en) * 2022-06-29 2022-07-29 深圳市帝迈生物技术有限公司 Calibrator for heparin anticoagulation detection and preparation method thereof

Family Cites Families (11)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US3030272A (en) * 1960-05-26 1962-04-17 Abbott Lab Stable heaparin solution
DE2461969A1 (en) * 1974-12-31 1976-07-08 Behringwerke Ag STABLE BLOOD PLASMA, THE PROCESS FOR PRODUCING IT AND ITS USE AS A COMPARATIVE PLASMA IN COOLAGE EXAMINATIONS
US3985618A (en) * 1975-05-02 1976-10-12 Irving Innerfield Method for detection of thrombosis and prethrombosis
DE2601372C3 (en) * 1976-01-15 1980-03-27 Behringwerke Ag, 3550 Marburg Method for the determination of antithrombin III
US4067777A (en) * 1976-05-13 1978-01-10 Innerfield Irving Determination of heparin in the blood
CH634662A5 (en) * 1976-05-28 1983-02-15 Pentapharm Ag USE OF TRIPEPTIDE DERIVATIVES FOR THE QUANTITATIVE DETERMINATION OF PLASMINOGEN ACTIVATORS.
US4090977A (en) * 1976-11-22 1978-05-23 Research Corporation Osmotically balanced anticoaglant
US4127502A (en) * 1977-06-10 1978-11-28 Eastman Kodak Company Stabilizers for reconstituted, lyophilized samples
DE2812943C3 (en) * 1978-03-23 1981-05-14 Boehringer Mannheim Gmbh, 6800 Mannheim Method and reagent for determining the biological activity of heparin in plasma
US4216117A (en) * 1978-05-15 1980-08-05 Bonderman Dean P Lipoprotein diluent or solution and method useful in the preparation of assay reference materials
US4195072A (en) * 1978-07-05 1980-03-25 Abbott Laboratories Stabilized platelet factor 4 immunoassay standards

Also Published As

Publication number Publication date
DE2903701B1 (en) 1980-02-28
JPS55103463A (en) 1980-08-07
EP0014349A1 (en) 1980-08-20
DE2903701C2 (en) 1980-10-16
US4301028A (en) 1981-11-17
EP0014349B1 (en) 1982-04-07
DE3060262D1 (en) 1982-05-19
JPS6342228B2 (en) 1988-08-22

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Legal Events

Date Code Title Description
EELA Cancelled due to lapse of time