ATE645T1 - NEW ARYLETHERS, PROCESSES FOR THEIR PREPARATION AND MEDICATIONS CONTAINING THESE COMPOUNDS. - Google Patents

NEW ARYLETHERS, PROCESSES FOR THEIR PREPARATION AND MEDICATIONS CONTAINING THESE COMPOUNDS.

Info

Publication number
ATE645T1
ATE645T1 AT80100071T AT80100071T ATE645T1 AT E645 T1 ATE645 T1 AT E645T1 AT 80100071 T AT80100071 T AT 80100071T AT 80100071 T AT80100071 T AT 80100071T AT E645 T1 ATE645 T1 AT E645T1
Authority
AT
Austria
Prior art keywords
hydrogen atom
compounds
lower alkyl
radical
preparation
Prior art date
Application number
AT80100071T
Other languages
German (de)
Inventor
Walter-Gunar Dr. Rer. Nat. Friebe
Werner Dr. Rer. Nat. Winter
Max Dr. Rer. Nat. Thiel
Androniki Dr. Med. Roesch
Otto-Henning Dr. Rer. Nar. Wilhelms
Original Assignee
Boehringer Mannheim Gmbh
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Boehringer Mannheim Gmbh filed Critical Boehringer Mannheim Gmbh
Application granted granted Critical
Publication of ATE645T1 publication Critical patent/ATE645T1/en

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D401/00—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom
    • C07D401/02—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom containing two hetero rings
    • C07D401/12—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom containing two hetero rings linked by a chain containing hetero atoms as chain links
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P37/00—Drugs for immunological or allergic disorders
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P37/00—Drugs for immunological or allergic disorders
    • A61P37/08—Antiallergic agents
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P9/00—Drugs for disorders of the cardiovascular system
    • A61P9/12—Antihypertensives

Landscapes

  • Health & Medical Sciences (AREA)
  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • General Health & Medical Sciences (AREA)
  • Veterinary Medicine (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • General Chemical & Material Sciences (AREA)
  • Medicinal Chemistry (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Engineering & Computer Science (AREA)
  • Animal Behavior & Ethology (AREA)
  • Public Health (AREA)
  • Immunology (AREA)
  • Heart & Thoracic Surgery (AREA)
  • Cardiology (AREA)
  • Pulmonology (AREA)
  • Plural Heterocyclic Compounds (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Nitrogen Condensed Heterocyclic Rings (AREA)
  • Acyclic And Carbocyclic Compounds In Medicinal Compositions (AREA)
  • Steroid Compounds (AREA)
  • Medicinal Preparation (AREA)
  • Hydrogenated Pyridines (AREA)
  • Organic Low-Molecular-Weight Compounds And Preparation Thereof (AREA)

Abstract

The present invention provides aryl ether derivatives of the general formula: <IMAGE> +TR <IMAGE> wherein A is an oxygen atom or the group >N-R1, R1 being a hydrogen atom or a lower alkyl radical, R2 and R3, which can be the same or different, are hydrogen atoms or lower alkyl radicals, R4 is a hydrogen atom or a hydroxyl group, R5 is a hydrogen atom or an acyl radical, R7 is a hydrogen atom, a lower alkyl radical or a lower alkanoyl radical and R8 is a hydrogen atom, a lower alkyl radical, a lower alkoxy radical or a hydroxyl group; and the pharmacologically acceptable salts thereof. The present invention also provides a process for the preparation of these compounds and pharmaceutical compositions containing them. It is also concerned with the use of these compounds for combating allergic diseases.
AT80100071T 1979-01-15 1980-01-08 NEW ARYLETHERS, PROCESSES FOR THEIR PREPARATION AND MEDICATIONS CONTAINING THESE COMPOUNDS. ATE645T1 (en)

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
DE19792901336 DE2901336A1 (en) 1979-01-15 1979-01-15 NEW ARYLETHERS, METHOD FOR THE PRODUCTION THEREOF AND MEDICINAL PRODUCTS CONTAINING THESE COMPOUNDS
EP80100071A EP0013894B1 (en) 1979-01-15 1980-01-08 Arylethers, process for their preparation and medicines containing them

Publications (1)

Publication Number Publication Date
ATE645T1 true ATE645T1 (en) 1982-02-15

Family

ID=6060592

Family Applications (1)

Application Number Title Priority Date Filing Date
AT80100071T ATE645T1 (en) 1979-01-15 1980-01-08 NEW ARYLETHERS, PROCESSES FOR THEIR PREPARATION AND MEDICATIONS CONTAINING THESE COMPOUNDS.

Country Status (13)

Country Link
US (2) US4330549A (en)
EP (1) EP0013894B1 (en)
JP (1) JPS5598179A (en)
AT (1) ATE645T1 (en)
AU (1) AU529663B2 (en)
CA (1) CA1141385A (en)
CS (1) CS226405B2 (en)
DD (1) DD148634A5 (en)
DE (2) DE2901336A1 (en)
ES (1) ES487677A1 (en)
HU (1) HU182084B (en)
SU (1) SU997606A3 (en)
YU (1) YU6880A (en)

Families Citing this family (21)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
DE2901336A1 (en) 1979-01-15 1980-07-24 Boehringer Mannheim Gmbh NEW ARYLETHERS, METHOD FOR THE PRODUCTION THEREOF AND MEDICINAL PRODUCTS CONTAINING THESE COMPOUNDS
DE3034237A1 (en) * 1979-09-18 1981-04-16 Otsuka Pharmaceutical Co. Ltd., Tokyo CARBOSTYRIL DERIVATIVES, METHOD FOR THE PRODUCTION THEREOF AND ANTIHISTAMINICALLY ACTIVE AGENTS CONTAINING THESE COMPOUNDS
DE3025385A1 (en) * 1980-07-04 1982-01-28 Boehringer Mannheim Gmbh, 6800 Mannheim NEW TRICYCLIC ARYL ETHERS, METHOD FOR THE PRODUCTION THEREOF AND MEDICINAL PRODUCTS CONTAINING THESE COMPOUNDS
US4390541A (en) * 1980-12-19 1983-06-28 Lilly Industries Limited Quinolone derivatives and their use in a method of controlling an immediate hypersensitivity disease
DE3117389A1 (en) 1981-05-02 1982-11-18 Boehringer Mannheim Gmbh, 6800 Mannheim BENZOPYRANYLETHER, METHOD FOR PRODUCING THE SAME AND MEDICINAL PRODUCTS CONTAINING THESE COMPOUNDS
DE3209271A1 (en) * 1982-03-13 1983-09-15 Boehringer Mannheim Gmbh, 6800 Mannheim BICYCLIC PHENOLETHERS, METHOD FOR THE PRODUCTION THEREOF AND MEDICINAL PRODUCTS CONTAINING THESE COMPOUNDS
JPS6013788A (en) * 1983-07-05 1985-01-24 Yamanouchi Pharmaceut Co Ltd Novel coumarin derivative
US4808619A (en) * 1983-07-27 1989-02-28 Beecham Group P.L.C. Di/tetra-hydroquinolines
DE3431004A1 (en) * 1984-08-23 1986-03-06 Hoechst Ag, 6230 Frankfurt NEW 3-PYRIDYL COMPOUNDS AND METHOD FOR THEIR PRODUCTION
US4701456A (en) * 1984-09-19 1987-10-20 Warner-Lambert Company Aminoalkoxybenzopyranones as antipsychotic and anxiolytic agents
DE3520718A1 (en) * 1985-06-10 1986-12-11 Herbert 7853 Steinen Hüttlin FLUID BED APPARATUS
US4704390A (en) * 1986-02-13 1987-11-03 Warner-Lambert Company Phenyl and heterocyclic tetrahydropyridyl alkoxy-benzheterocyclic compounds as antipsychotic agents
GB9018134D0 (en) * 1989-09-29 1990-10-03 Ici Plc Heterocyclic derivatives
US5082847A (en) * 1990-07-18 1992-01-21 Syntex (U.S.A.) Inc. Carbostyril compounds connected via an oxyalkyl group with a piperidine ring and having pharmaceutical utility
TR200000272T2 (en) * 1997-07-31 2000-09-21 F. Hoffmann -La Roche Ag O-substituted hydrocycumaranone derivatives as antitumor and antimetastatic agents.
DE10316081A1 (en) * 2003-04-08 2004-10-21 Morphochem AG Aktiengesellschaft für kombinatorische Chemie New compounds with antibacterial activity
CN100393716C (en) * 2006-05-18 2008-06-11 中国药科大学 Coumarin derivatives, and their preparing method and use as alpha, receptor agonist
US8716280B2 (en) 2009-01-21 2014-05-06 Basilea Pharmaceutica Ag Bicyclic antibiotics
US10633336B2 (en) 2014-12-19 2020-04-28 The Broad Institute, Inc. Dopamine D2 receptor ligands
US10752588B2 (en) * 2014-12-19 2020-08-25 The Broad Institute, Inc. Dopamine D2 receptor ligands
CN113816944B (en) * 2020-06-20 2023-06-27 中山大学 Anti-filovirus compounds and uses thereof

Family Cites Families (19)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US3275658A (en) * 1963-05-23 1966-09-27 Upjohn Co Tertiary-aminoalkoxy-substituted 3, 4-diphenylcoumarins
GB1058822A (en) 1963-07-30 1967-02-15 Ici Ltd 3-amino-2-hydroxypropoxy heterocyclic derivatives
DE1932384U (en) 1965-11-30 1966-02-10 Wilhelm Klein & Soehne Spezial MILLING DEVICE FOR KNIFE BLOCKS.
CH529746A (en) * 1968-08-01 1972-10-31 Spofa Vereinigte Pharma Werke Process for the production of chroman derivatives
US4029801A (en) 1970-09-03 1977-06-14 John Wyeth & Brother Limited Pharmaceutical compositions and methods of treating hypertension
DE2162721A1 (en) * 1970-12-19 1972-06-22 Dr L Zambeletti SpA, Mailand (Italien) Substituted coumarins and processes for their preparation
BE884459Q (en) 1971-05-14 1981-01-26 Boehringer Mannheim Gmbh 4- (OMEGA- (COUMARINE-7-YL-OXY) -ALKYL) -PIPERAZINE DERIVATIVES AND PREPARATION METHOD
GB1410783A (en) * 1972-01-20 1975-10-22 Wyeth John & Brother Ltd N-substituted 4-amidopyridines tetrahydropyridines and piperidines
US4153617A (en) * 1974-07-30 1979-05-08 Beecham Group Limited Anorexic chromans
GB1493998A (en) * 1975-06-03 1977-12-07 Beecham Group Ltd Propanolamine derivatives
US4210753A (en) * 1976-03-17 1980-07-01 Otsuka Pharmaceutical Co., Ltd. Carbostyril compounds
CH619453A5 (en) * 1976-03-17 1980-09-30 Otsuka Pharma Co Ltd
LU75688A1 (en) * 1976-08-31 1978-04-13
GB1524260A (en) 1976-11-23 1978-09-06 Beecham Group Ltd Aminoalkyloneoxyd substituted 4-hydroxy-3 nitrocoumarins
FI782133A7 (en) * 1977-07-08 1979-01-09 Ciba Geigy Ag PIPERIDINO-PROPANOLER OCH FOERFARANDE FOER DERAS FRAMSTAELLNING
US4281132A (en) * 1977-10-29 1981-07-28 John Wyeth & Brother Limited Piperidino ureas and thioureas
DE2901336A1 (en) 1979-01-15 1980-07-24 Boehringer Mannheim Gmbh NEW ARYLETHERS, METHOD FOR THE PRODUCTION THEREOF AND MEDICINAL PRODUCTS CONTAINING THESE COMPOUNDS
DE2905876A1 (en) * 1979-02-16 1980-08-28 Boehringer Mannheim Gmbh NEW PIPERIDINOPROPYL DERIVATIVES, METHOD FOR THE PRODUCTION THEREOF AND MEDICINAL PRODUCTS CONTAINING THESE COMPOUNDS
DE3034237A1 (en) 1979-09-18 1981-04-16 Otsuka Pharmaceutical Co. Ltd., Tokyo CARBOSTYRIL DERIVATIVES, METHOD FOR THE PRODUCTION THEREOF AND ANTIHISTAMINICALLY ACTIVE AGENTS CONTAINING THESE COMPOUNDS

Also Published As

Publication number Publication date
US4330549A (en) 1982-05-18
DE2901336A1 (en) 1980-07-24
CS226405B2 (en) 1984-03-19
SU997606A3 (en) 1983-02-15
DE3060160D1 (en) 1982-03-11
ES487677A1 (en) 1980-06-16
EP0013894A1 (en) 1980-08-06
HU182084B (en) 1983-12-28
AU529663B2 (en) 1983-06-16
EP0013894B1 (en) 1982-02-03
DD148634A5 (en) 1981-06-03
JPS5598179A (en) 1980-07-25
US4427680A (en) 1984-01-24
AU5435880A (en) 1980-07-24
CA1141385A (en) 1983-02-15
YU6880A (en) 1983-01-21

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