ATE62229T1 - Kristallines quinapril und ein verfahren zu seiner herstellung. - Google Patents

Kristallines quinapril und ein verfahren zu seiner herstellung.

Info

Publication number
ATE62229T1
ATE62229T1 AT88105131T AT88105131T ATE62229T1 AT E62229 T1 ATE62229 T1 AT E62229T1 AT 88105131 T AT88105131 T AT 88105131T AT 88105131 T AT88105131 T AT 88105131T AT E62229 T1 ATE62229 T1 AT E62229T1
Authority
AT
Austria
Prior art keywords
quinapril
production
novel
crystalline quinapril
crystalline
Prior art date
Application number
AT88105131T
Other languages
English (en)
Inventor
Om Prakash Goel
Uldis Krolls
Original Assignee
Warner Lambert Co
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Warner Lambert Co filed Critical Warner Lambert Co
Application granted granted Critical
Publication of ATE62229T1 publication Critical patent/ATE62229T1/de

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D217/00—Heterocyclic compounds containing isoquinoline or hydrogenated isoquinoline ring systems
    • C07D217/22—Heterocyclic compounds containing isoquinoline or hydrogenated isoquinoline ring systems with hetero atoms or with carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals, directly attached to carbon atoms of the nitrogen-containing ring
    • C07D217/26—Carbon atoms having three bonds to hetero atoms with at the most one bond to halogen
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P43/00—Drugs for specific purposes, not provided for in groups A61P1/00-A61P41/00
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P9/00—Drugs for disorders of the cardiovascular system
    • A61P9/12—Antihypertensives

Landscapes

  • Organic Chemistry (AREA)
  • Chemical & Material Sciences (AREA)
  • Health & Medical Sciences (AREA)
  • Veterinary Medicine (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • General Chemical & Material Sciences (AREA)
  • Medicinal Chemistry (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Engineering & Computer Science (AREA)
  • Public Health (AREA)
  • Animal Behavior & Ethology (AREA)
  • General Health & Medical Sciences (AREA)
  • Heart & Thoracic Surgery (AREA)
  • Cardiology (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Nitrogen Condensed Heterocyclic Rings (AREA)
  • Peptides Or Proteins (AREA)
  • Other In-Based Heterocyclic Compounds (AREA)
  • Steroid Compounds (AREA)
  • Plural Heterocyclic Compounds (AREA)
AT88105131T 1987-03-30 1988-03-29 Kristallines quinapril und ein verfahren zu seiner herstellung. ATE62229T1 (de)

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
US07/032,209 US4761479A (en) 1987-03-30 1987-03-30 Crystalline quinapril and a process for producing the same
EP88105131A EP0285992B1 (de) 1987-03-30 1988-03-29 Kristallines Quinapril und ein Verfahren zu seiner Herstellung

Publications (1)

Publication Number Publication Date
ATE62229T1 true ATE62229T1 (de) 1991-04-15

Family

ID=21863696

Family Applications (1)

Application Number Title Priority Date Filing Date
AT88105131T ATE62229T1 (de) 1987-03-30 1988-03-29 Kristallines quinapril und ein verfahren zu seiner herstellung.

Country Status (13)

Country Link
US (1) US4761479A (de)
EP (1) EP0285992B1 (de)
JP (1) JP2659990B2 (de)
KR (1) KR960007087B1 (de)
AT (1) ATE62229T1 (de)
AU (1) AU605555B2 (de)
CA (1) CA1291999C (de)
DE (1) DE3862227D1 (de)
ES (1) ES2021778B3 (de)
GR (1) GR3001736T3 (de)
NZ (1) NZ223671A (de)
PH (1) PH24986A (de)
ZA (1) ZA881426B (de)

Families Citing this family (7)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
ES2122941B1 (es) 1997-05-29 1999-07-01 Esteve Quimica Sa Procedimiento para la obtencion de quinapril clorhidrato y solvatos utiles para el aislamiento y purificacion de quinapril clorhidrato.
NZ333206A (en) * 1998-12-08 2000-07-28 Bernard Charles Sherman Solid pharmaceutical compositions comprising a stable magnesium salt of quinapril that acts as a ACE (Angiotensin Converting Enzyme) inhibitor
US20030225124A1 (en) * 1999-08-31 2003-12-04 Spiridon Spireas Stable formulations of ACE inhibitors, and methods for preparation thereof
SI1572661T1 (sl) * 2002-12-16 2007-10-31 Lupin Ltd Kristalna oblika kvinapril hidroklorida in postopek njene priprave
CL2004000541A1 (es) * 2003-03-31 2005-02-04 Warner Lambert Co Procedimiento de preparacion de clorhidrato de quinapril por reaccion entre una 2,5-dioxo-oxazolidina y un ester terbutilico de una tetrahidro isoquinolina, util como principio activo para tratar la hipertension y la insuficiencia cardiaca congestiva
WO2007069268A2 (en) * 2005-10-14 2007-06-21 Sun Pharmaceutical Industries Limited A process for the preparation of substantially pure 1,2,3,4-tetrahydroisoquinoline-3-carboxylic acid derivatives
WO2009113081A1 (en) * 2008-03-10 2009-09-17 Lupin Limited Tris (hydroxymethyl ) amino methane salt of quinapril and ramipril

Family Cites Families (2)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US4294832A (en) * 1979-04-28 1981-10-13 Tanabe Seiyaku Co., Ltd. Tetrahydroisoquinoline compounds and a pharmaceutical composition thereof
US4344949A (en) * 1980-10-03 1982-08-17 Warner-Lambert Company Substituted acyl derivatives of 1,2,3,4-tetrahydroisoquinoline-3-carboxylic acids

Also Published As

Publication number Publication date
DE3862227D1 (de) 1991-05-08
ZA881426B (en) 1989-10-25
ES2021778B3 (es) 1991-11-16
AU1238388A (en) 1988-09-29
JP2659990B2 (ja) 1997-09-30
CA1291999C (en) 1991-11-12
GR3001736T3 (en) 1992-11-23
NZ223671A (en) 1990-10-26
EP0285992B1 (de) 1991-04-03
KR960007087B1 (ko) 1996-05-27
JPS63258459A (ja) 1988-10-25
AU605555B2 (en) 1991-01-17
US4761479A (en) 1988-08-02
EP0285992A1 (de) 1988-10-12
PH24986A (en) 1990-12-26
KR880011110A (ko) 1988-10-26

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Legal Events

Date Code Title Description
UEP Publication of translation of european patent specification
EELA Cancelled due to lapse of time