ATE62229T1 - Kristallines quinapril und ein verfahren zu seiner herstellung. - Google Patents
Kristallines quinapril und ein verfahren zu seiner herstellung.Info
- Publication number
- ATE62229T1 ATE62229T1 AT88105131T AT88105131T ATE62229T1 AT E62229 T1 ATE62229 T1 AT E62229T1 AT 88105131 T AT88105131 T AT 88105131T AT 88105131 T AT88105131 T AT 88105131T AT E62229 T1 ATE62229 T1 AT E62229T1
- Authority
- AT
- Austria
- Prior art keywords
- quinapril
- production
- novel
- crystalline quinapril
- crystalline
- Prior art date
Links
- 238000000034 method Methods 0.000 title abstract 3
- JSDRRTOADPPCHY-HSQYWUDLSA-N quinapril Chemical compound C([C@@H](C(=O)OCC)N[C@@H](C)C(=O)N1[C@@H](CC2=CC=CC=C2C1)C(O)=O)CC1=CC=CC=C1 JSDRRTOADPPCHY-HSQYWUDLSA-N 0.000 title abstract 3
- 229960001455 quinapril Drugs 0.000 title abstract 3
- QTBSBXVTEAMEQO-UHFFFAOYSA-N Acetic acid Chemical compound CC(O)=O QTBSBXVTEAMEQO-UHFFFAOYSA-N 0.000 abstract 2
- 239000005541 ACE inhibitor Substances 0.000 abstract 1
- 229960000583 acetic acid Drugs 0.000 abstract 1
- 229940044094 angiotensin-converting-enzyme inhibitor Drugs 0.000 abstract 1
- 239000002775 capsule Substances 0.000 abstract 1
- 238000009472 formulation Methods 0.000 abstract 1
- 239000012362 glacial acetic acid Substances 0.000 abstract 1
- 239000000203 mixture Substances 0.000 abstract 1
- 239000000126 substance Substances 0.000 abstract 1
Classifications
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D217/00—Heterocyclic compounds containing isoquinoline or hydrogenated isoquinoline ring systems
- C07D217/22—Heterocyclic compounds containing isoquinoline or hydrogenated isoquinoline ring systems with hetero atoms or with carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals, directly attached to carbon atoms of the nitrogen-containing ring
- C07D217/26—Carbon atoms having three bonds to hetero atoms with at the most one bond to halogen
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P43/00—Drugs for specific purposes, not provided for in groups A61P1/00-A61P41/00
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P9/00—Drugs for disorders of the cardiovascular system
- A61P9/12—Antihypertensives
Landscapes
- Organic Chemistry (AREA)
- Chemical & Material Sciences (AREA)
- Health & Medical Sciences (AREA)
- Medicinal Chemistry (AREA)
- General Chemical & Material Sciences (AREA)
- Veterinary Medicine (AREA)
- Chemical Kinetics & Catalysis (AREA)
- Life Sciences & Earth Sciences (AREA)
- Pharmacology & Pharmacy (AREA)
- Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
- Engineering & Computer Science (AREA)
- Bioinformatics & Cheminformatics (AREA)
- Public Health (AREA)
- Animal Behavior & Ethology (AREA)
- General Health & Medical Sciences (AREA)
- Heart & Thoracic Surgery (AREA)
- Cardiology (AREA)
- Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
- Nitrogen Condensed Heterocyclic Rings (AREA)
- Other In-Based Heterocyclic Compounds (AREA)
- Peptides Or Proteins (AREA)
- Plural Heterocyclic Compounds (AREA)
- Steroid Compounds (AREA)
Applications Claiming Priority (2)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| US07/032,209 US4761479A (en) | 1987-03-30 | 1987-03-30 | Crystalline quinapril and a process for producing the same |
| EP88105131A EP0285992B1 (de) | 1987-03-30 | 1988-03-29 | Kristallines Quinapril und ein Verfahren zu seiner Herstellung |
Publications (1)
| Publication Number | Publication Date |
|---|---|
| ATE62229T1 true ATE62229T1 (de) | 1991-04-15 |
Family
ID=21863696
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| AT88105131T ATE62229T1 (de) | 1987-03-30 | 1988-03-29 | Kristallines quinapril und ein verfahren zu seiner herstellung. |
Country Status (13)
| Country | Link |
|---|---|
| US (1) | US4761479A (de) |
| EP (1) | EP0285992B1 (de) |
| JP (1) | JP2659990B2 (de) |
| KR (1) | KR960007087B1 (de) |
| AT (1) | ATE62229T1 (de) |
| AU (1) | AU605555B2 (de) |
| CA (1) | CA1291999C (de) |
| DE (1) | DE3862227D1 (de) |
| ES (1) | ES2021778B3 (de) |
| GR (1) | GR3001736T3 (de) |
| NZ (1) | NZ223671A (de) |
| PH (1) | PH24986A (de) |
| ZA (1) | ZA881426B (de) |
Families Citing this family (7)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| ES2122941B1 (es) | 1997-05-29 | 1999-07-01 | Esteve Quimica Sa | Procedimiento para la obtencion de quinapril clorhidrato y solvatos utiles para el aislamiento y purificacion de quinapril clorhidrato. |
| NZ333206A (en) * | 1998-12-08 | 2000-07-28 | Bernard Charles Sherman | Solid pharmaceutical compositions comprising a stable magnesium salt of quinapril that acts as a ACE (Angiotensin Converting Enzyme) inhibitor |
| US20030225124A1 (en) * | 1999-08-31 | 2003-12-04 | Spiridon Spireas | Stable formulations of ACE inhibitors, and methods for preparation thereof |
| ATE360616T1 (de) * | 2002-12-16 | 2007-05-15 | Lupin Ltd | Kristalline form von quinapril hydrochlorid und verfahren zu dessen herstellung |
| CL2004000541A1 (es) * | 2003-03-31 | 2005-02-04 | Warner Lambert Co | Procedimiento de preparacion de clorhidrato de quinapril por reaccion entre una 2,5-dioxo-oxazolidina y un ester terbutilico de una tetrahidro isoquinolina, util como principio activo para tratar la hipertension y la insuficiencia cardiaca congestiva |
| WO2007069268A2 (en) * | 2005-10-14 | 2007-06-21 | Sun Pharmaceutical Industries Limited | A process for the preparation of substantially pure 1,2,3,4-tetrahydroisoquinoline-3-carboxylic acid derivatives |
| WO2009113081A1 (en) * | 2008-03-10 | 2009-09-17 | Lupin Limited | Tris (hydroxymethyl ) amino methane salt of quinapril and ramipril |
Family Cites Families (2)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| US4294832A (en) * | 1979-04-28 | 1981-10-13 | Tanabe Seiyaku Co., Ltd. | Tetrahydroisoquinoline compounds and a pharmaceutical composition thereof |
| US4344949A (en) * | 1980-10-03 | 1982-08-17 | Warner-Lambert Company | Substituted acyl derivatives of 1,2,3,4-tetrahydroisoquinoline-3-carboxylic acids |
-
1987
- 1987-03-30 US US07/032,209 patent/US4761479A/en not_active Expired - Lifetime
-
1988
- 1988-02-26 NZ NZ223671A patent/NZ223671A/xx unknown
- 1988-02-29 AU AU12383/88A patent/AU605555B2/en not_active Ceased
- 1988-02-29 ZA ZA881426A patent/ZA881426B/xx unknown
- 1988-03-04 CA CA000560594A patent/CA1291999C/en not_active Expired - Lifetime
- 1988-03-25 PH PH36687A patent/PH24986A/en unknown
- 1988-03-29 ES ES88105131T patent/ES2021778B3/es not_active Expired - Lifetime
- 1988-03-29 JP JP63073492A patent/JP2659990B2/ja not_active Expired - Lifetime
- 1988-03-29 DE DE8888105131T patent/DE3862227D1/de not_active Expired - Lifetime
- 1988-03-29 EP EP88105131A patent/EP0285992B1/de not_active Expired - Lifetime
- 1988-03-29 AT AT88105131T patent/ATE62229T1/de not_active IP Right Cessation
- 1988-03-30 KR KR1019880003494A patent/KR960007087B1/ko not_active Expired - Fee Related
-
1991
- 1991-04-04 GR GR91400309T patent/GR3001736T3/el unknown
Also Published As
| Publication number | Publication date |
|---|---|
| AU605555B2 (en) | 1991-01-17 |
| AU1238388A (en) | 1988-09-29 |
| KR960007087B1 (ko) | 1996-05-27 |
| PH24986A (en) | 1990-12-26 |
| DE3862227D1 (de) | 1991-05-08 |
| KR880011110A (ko) | 1988-10-26 |
| EP0285992A1 (de) | 1988-10-12 |
| CA1291999C (en) | 1991-11-12 |
| US4761479A (en) | 1988-08-02 |
| ZA881426B (en) | 1989-10-25 |
| EP0285992B1 (de) | 1991-04-03 |
| JP2659990B2 (ja) | 1997-09-30 |
| ES2021778B3 (es) | 1991-11-16 |
| JPS63258459A (ja) | 1988-10-25 |
| GR3001736T3 (en) | 1992-11-23 |
| NZ223671A (en) | 1990-10-26 |
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Legal Events
| Date | Code | Title | Description |
|---|---|---|---|
| UEP | Publication of translation of european patent specification | ||
| EELA | Cancelled due to lapse of time |