ATE6201T1 - Verfahren zur lyophilisierung lebender viruszusammensetzungen. - Google Patents

Verfahren zur lyophilisierung lebender viruszusammensetzungen.

Info

Publication number
ATE6201T1
ATE6201T1 AT80401727T AT80401727T ATE6201T1 AT E6201 T1 ATE6201 T1 AT E6201T1 AT 80401727 T AT80401727 T AT 80401727T AT 80401727 T AT80401727 T AT 80401727T AT E6201 T1 ATE6201 T1 AT E6201T1
Authority
AT
Austria
Prior art keywords
lyophilization
methods
live virus
virus compositions
compositions
Prior art date
Application number
AT80401727T
Other languages
English (en)
Inventor
William J. Mcaleer
Henry Z. Markus
Original Assignee
Merck & Co. Inc.
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Merck & Co. Inc. filed Critical Merck & Co. Inc.
Application granted granted Critical
Publication of ATE6201T1 publication Critical patent/ATE6201T1/de

Links

Classifications

    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K39/00—Medicinal preparations containing antigens or antibodies
    • A61K39/12—Viral antigens
    • A61K39/155—Paramyxoviridae, e.g. parainfluenza virus
    • A61K39/165—Mumps or measles virus
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K39/00—Medicinal preparations containing antigens or antibodies
    • A61K39/12—Viral antigens
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K39/00—Medicinal preparations containing antigens or antibodies
    • A61K2039/51—Medicinal preparations containing antigens or antibodies comprising whole cells, viruses or DNA/RNA
    • A61K2039/525—Virus
    • A61K2039/5254—Virus avirulent or attenuated
    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
    • C12N2760/00—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA ssRNA viruses negative-sense
    • C12N2760/00011—Details
    • C12N2760/18011—Paramyxoviridae
    • C12N2760/18411—Morbillivirus, e.g. Measles virus, canine distemper
    • C12N2760/18434—Use of virus or viral component as vaccine, e.g. live-attenuated or inactivated virus, VLP, viral protein

Landscapes

  • Health & Medical Sciences (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Virology (AREA)
  • Animal Behavior & Ethology (AREA)
  • Public Health (AREA)
  • Medicinal Chemistry (AREA)
  • Microbiology (AREA)
  • Mycology (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Epidemiology (AREA)
  • Chemical & Material Sciences (AREA)
  • General Health & Medical Sciences (AREA)
  • Immunology (AREA)
  • Veterinary Medicine (AREA)
  • Communicable Diseases (AREA)
  • Pulmonology (AREA)
  • Medicines Containing Material From Animals Or Micro-Organisms (AREA)
  • Medicines Containing Antibodies Or Antigens For Use As Internal Diagnostic Agents (AREA)
  • Micro-Organisms Or Cultivation Processes Thereof (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
AT80401727T 1979-12-03 1980-12-02 Verfahren zur lyophilisierung lebender viruszusammensetzungen. ATE6201T1 (de)

Applications Claiming Priority (1)

Application Number Priority Date Filing Date Title
US06/099,772 US4273762A (en) 1979-12-03 1979-12-03 Lyophilization process for live viral compositions

Publications (1)

Publication Number Publication Date
ATE6201T1 true ATE6201T1 (de) 1984-03-15

Family

ID=22276548

Family Applications (1)

Application Number Title Priority Date Filing Date
AT80401727T ATE6201T1 (de) 1979-12-03 1980-12-02 Verfahren zur lyophilisierung lebender viruszusammensetzungen.

Country Status (10)

Country Link
US (1) US4273762A (de)
EP (1) EP0030199B1 (de)
JP (1) JPS5692822A (de)
AT (1) ATE6201T1 (de)
CA (1) CA1146861A (de)
DE (1) DE3066651D1 (de)
DK (1) DK512780A (de)
ES (1) ES8205306A1 (de)
GR (1) GR71638B (de)
PT (1) PT72105B (de)

Families Citing this family (22)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US4337242A (en) * 1980-02-05 1982-06-29 Merck & Co., Inc. Vaccine stabilizer containing L-glutamic acid and L-arginine
US4338335A (en) * 1980-02-05 1982-07-06 Merck & Co., Inc. Vaccine stabilizer containing L-glutamic acid and L-arginine
US4537769A (en) * 1982-04-06 1985-08-27 American Cyanamid Company Stabilization of influenza virus vaccine
HU188847B (en) * 1983-02-22 1986-05-28 Human Oltoanyagtermeloe Es Kutato Intezet,Hu Process for producing liophylized combined vaccines
FR2561916B1 (fr) * 1984-03-30 1987-12-11 Lafon Labor Forme galenique pour administration orale et son procede de preparation par lyophilisation d'une emission huile dans eau
US5024836A (en) * 1987-05-04 1991-06-18 Merck & Co., Inc. Stable lyophilized live herpes virus vaccine
IL86180A (en) * 1987-05-04 1992-08-18 Merck & Co Inc Stable lyophilized live herpes virus vaccine and such a vaccine combined with other virus vaccines
GB8802174D0 (en) * 1988-02-01 1988-03-02 Quadrant Bioresources Ltd Method of drying macromolecules
US5169834A (en) * 1990-11-30 1992-12-08 American Cyanamid Company Compositions and method for reducing vial breakage during lyophilization
RU2126269C1 (ru) * 1992-06-04 1999-02-20 Мерк Энд Ко., Инк. Способ получения вакцины, способ получения свободной от клеток вакцины, способ культивирования клеток, питательная среда
US5360736A (en) * 1992-06-04 1994-11-01 Merck & Co., Inc. Process for attenuated varicella zoster virus vaccine production
DE122006000063I1 (de) 1992-07-17 2007-05-10 Merck & Co Inc Methode zur Verhinderung von Zoster und Linderung der mit Varicellea verbundenen Postherpetischen Neuralgie
AU7971194A (en) * 1993-10-12 1995-05-04 Chiron Corporation Methods for preserving recombinant viruses
US5728386A (en) * 1993-12-21 1998-03-17 Merck & Co., Inc. Thermostable varicella zoster virus
US6290967B1 (en) * 1996-12-20 2001-09-18 Merck & Co., Inc. Stabilizers for lyophilized vaccines
EP0946193A1 (de) * 1996-12-20 1999-10-06 Merck & Co., Inc. Stabilisatoren fpr lyophilisierte impfstoffe
US6051238A (en) * 1996-12-20 2000-04-18 Merck & Co., Inc. Stabilizers for lyophilized mumps vaccines
US6210683B1 (en) 1997-09-05 2001-04-03 Merck & Co., Inc. Stabilizers containing recombinant human serum albumin for live virus vaccines
RU2144369C1 (ru) * 1998-12-28 2000-01-20 Трифонов Валерий Дмитриевич Живая культуральная коревая вакцина
US6465207B1 (en) 2000-11-03 2002-10-15 Cytologix Corporation Silver-based staining processes employing non-gelling gelatin
ES2536322T3 (es) * 2003-12-17 2015-05-22 Wyeth Llc Procedimiento para producir composiciones de VSR estables en almacenamiento
US20080294361A1 (en) * 2007-05-24 2008-11-27 Popp Shane M Intelligent execution system for the monitoring and execution of vaccine manufacturing

Family Cites Families (20)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US3197374A (en) * 1962-10-11 1965-07-27 Behringwerke Ag Process for the disaggregation and purification of viruses
NL285236A (de) *
BE622212A (de) *
US3183161A (en) * 1955-05-02 1965-05-11 Parke Davis & Co Aqueous resuspension vaccine product of aluminum phosphate-adsorbed poliomyelitis virus antigen, and production process
US3078215A (en) * 1959-12-22 1963-02-19 Glaxo Group Ltd Process for the purification and concentration of poliomyelitis vaccine
GB960642A (en) * 1961-04-06 1964-06-10 Pfizer & Co C Measles vaccine
US3133861A (en) * 1961-11-08 1964-05-19 Dow Chemical Co Attenuated live measles virus vaccine and method of production
US3132073A (en) * 1962-03-14 1964-05-05 Lilly Co Eli Measles vaccine
US3478145A (en) * 1964-09-15 1969-11-11 American Home Prod Chromatographic purification of virus with brushite modified by autoclaving
US3316153A (en) * 1965-03-29 1967-04-25 Lilly Co Eli Virus purification
US3629399A (en) * 1967-09-05 1971-12-21 Behringwerke Ag Stable poliomyelitis vaccines
FR1604134A (de) * 1967-09-26 1971-07-12
US3509070A (en) * 1968-06-13 1970-04-28 American Home Prod Adsorbent for chromatographic purification of virus
US3555149A (en) * 1968-07-05 1971-01-12 Merck & Co Inc Mumps vaccine and its preparation
US3783098A (en) * 1971-08-10 1974-01-01 Cornell Res Foundation Inc Highly potent,viable and stable cellfree virus preparations from cells infected with cell-associated viruses and method for obtaining the same
US3933585A (en) * 1972-06-14 1976-01-20 Merck & Co., Inc. Process for production of vaccines
IL44143A0 (en) * 1973-02-07 1974-05-16 Wellcome Found Method of inactivating viruses and vaccines prepared thereby
US3915794A (en) * 1973-02-09 1975-10-28 Rit Rech Ind Therapeut Stabilizing compositions for cell-free viruses and cell-free virus preparations containing them
US3961046A (en) * 1974-12-02 1976-06-01 American Cyanamid Company Mumps vaccine and preparation thereof
US4147772A (en) * 1976-02-03 1979-04-03 Merck & Co., Inc. Vaccine stabilizer

Also Published As

Publication number Publication date
ES497361A0 (es) 1982-06-01
ES8205306A1 (es) 1982-06-01
GR71638B (de) 1980-11-29
DK512780A (da) 1981-06-04
JPS5692822A (en) 1981-07-27
EP0030199B1 (de) 1984-02-15
DE3066651D1 (en) 1984-03-22
PT72105B (en) 1982-06-25
EP0030199A3 (en) 1982-06-09
EP0030199A2 (de) 1981-06-10
US4273762A (en) 1981-06-16
CA1146861A (en) 1983-05-24
PT72105A (en) 1980-12-01

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Legal Events

Date Code Title Description
UEP Publication of translation of european patent specification
REN Ceased due to non-payment of the annual fee