ATE556596T1 - Regulierte attenuierung von lebendimpfstoffen zur verbesserung der kreuzimmunitätsschutzfunktion - Google Patents
Regulierte attenuierung von lebendimpfstoffen zur verbesserung der kreuzimmunitätsschutzfunktionInfo
- Publication number
- ATE556596T1 ATE556596T1 AT03721711T AT03721711T ATE556596T1 AT E556596 T1 ATE556596 T1 AT E556596T1 AT 03721711 T AT03721711 T AT 03721711T AT 03721711 T AT03721711 T AT 03721711T AT E556596 T1 ATE556596 T1 AT E556596T1
- Authority
- AT
- Austria
- Prior art keywords
- immmunity
- protective function
- live vaccines
- improve cross
- regulated attenuation
- Prior art date
Links
Classifications
-
- C—CHEMISTRY; METALLURGY
- C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
- C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
- C12N1/00—Microorganisms, e.g. protozoa; Compositions thereof; Processes of propagating, maintaining or preserving microorganisms or compositions thereof; Processes of preparing or isolating a composition containing a microorganism; Culture media therefor
- C12N1/36—Adaptation or attenuation of cells
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K39/00—Medicinal preparations containing antigens or antibodies
- A61K39/02—Bacterial antigens
- A61K39/025—Enterobacteriales, e.g. Enterobacter
- A61K39/0258—Escherichia
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K39/00—Medicinal preparations containing antigens or antibodies
- A61K39/02—Bacterial antigens
- A61K39/025—Enterobacteriales, e.g. Enterobacter
- A61K39/0275—Salmonella
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K14/00—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof
- C07K14/195—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from bacteria
- C07K14/24—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from bacteria from Enterobacteriaceae (F), e.g. Citrobacter, Serratia, Proteus, Providencia, Morganella, Yersinia
- C07K14/255—Salmonella (G)
-
- C—CHEMISTRY; METALLURGY
- C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
- C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
- C12N15/00—Mutation or genetic engineering; DNA or RNA concerning genetic engineering, vectors, e.g. plasmids, or their isolation, preparation or purification; Use of hosts therefor
- C12N15/09—Recombinant DNA-technology
- C12N15/63—Introduction of foreign genetic material using vectors; Vectors; Use of hosts therefor; Regulation of expression
- C12N15/74—Vectors or expression systems specially adapted for prokaryotic hosts other than E. coli, e.g. Lactobacillus, Micromonospora
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K39/00—Medicinal preparations containing antigens or antibodies
- A61K2039/51—Medicinal preparations containing antigens or antibodies comprising whole cells, viruses or DNA/RNA
- A61K2039/52—Bacterial cells; Fungal cells; Protozoal cells
- A61K2039/522—Bacterial cells; Fungal cells; Protozoal cells avirulent or attenuated
-
- Y—GENERAL TAGGING OF NEW TECHNOLOGICAL DEVELOPMENTS; GENERAL TAGGING OF CROSS-SECTIONAL TECHNOLOGIES SPANNING OVER SEVERAL SECTIONS OF THE IPC; TECHNICAL SUBJECTS COVERED BY FORMER USPC CROSS-REFERENCE ART COLLECTIONS [XRACs] AND DIGESTS
- Y02—TECHNOLOGIES OR APPLICATIONS FOR MITIGATION OR ADAPTATION AGAINST CLIMATE CHANGE
- Y02A—TECHNOLOGIES FOR ADAPTATION TO CLIMATE CHANGE
- Y02A50/00—TECHNOLOGIES FOR ADAPTATION TO CLIMATE CHANGE in human health protection, e.g. against extreme weather
- Y02A50/30—Against vector-borne diseases, e.g. mosquito-borne, fly-borne, tick-borne or waterborne diseases whose impact is exacerbated by climate change
Landscapes
- Health & Medical Sciences (AREA)
- Life Sciences & Earth Sciences (AREA)
- Chemical & Material Sciences (AREA)
- Genetics & Genomics (AREA)
- Organic Chemistry (AREA)
- Engineering & Computer Science (AREA)
- General Health & Medical Sciences (AREA)
- Medicinal Chemistry (AREA)
- Bioinformatics & Cheminformatics (AREA)
- Biotechnology (AREA)
- Microbiology (AREA)
- Wood Science & Technology (AREA)
- Zoology (AREA)
- General Engineering & Computer Science (AREA)
- Biomedical Technology (AREA)
- Biochemistry (AREA)
- Public Health (AREA)
- Veterinary Medicine (AREA)
- Molecular Biology (AREA)
- Immunology (AREA)
- Mycology (AREA)
- Pharmacology & Pharmacy (AREA)
- Epidemiology (AREA)
- Animal Behavior & Ethology (AREA)
- Biophysics (AREA)
- Virology (AREA)
- Physics & Mathematics (AREA)
- Cell Biology (AREA)
- Tropical Medicine & Parasitology (AREA)
- Plant Pathology (AREA)
- Gastroenterology & Hepatology (AREA)
- Proteomics, Peptides & Aminoacids (AREA)
- Medicines Containing Antibodies Or Antigens For Use As Internal Diagnostic Agents (AREA)
- Micro-Organisms Or Cultivation Processes Thereof (AREA)
Applications Claiming Priority (3)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| US37261602P | 2002-04-15 | 2002-04-15 | |
| US37362602P | 2002-04-18 | 2002-04-18 | |
| PCT/US2003/011802 WO2003096812A1 (en) | 2002-04-15 | 2003-04-15 | Regulated attenuation of live vaccines to enhance cross protective immunogenicity |
Publications (1)
| Publication Number | Publication Date |
|---|---|
| ATE556596T1 true ATE556596T1 (de) | 2012-05-15 |
Family
ID=29553427
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| AT03721711T ATE556596T1 (de) | 2002-04-15 | 2003-04-15 | Regulierte attenuierung von lebendimpfstoffen zur verbesserung der kreuzimmunitätsschutzfunktion |
Country Status (5)
| Country | Link |
|---|---|
| US (1) | US8133493B2 (de) |
| EP (2) | EP1499191B1 (de) |
| AT (1) | ATE556596T1 (de) |
| CA (1) | CA2526895A1 (de) |
| WO (1) | WO2003096812A1 (de) |
Families Citing this family (41)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| AU2004204751A1 (en) * | 2003-01-09 | 2004-07-29 | The Trustees Of The University Of Pennsylvania | Compositions, methods and kits for enhancing the immunogenicity of a bacterial vaccine vector |
| EP1616029A2 (de) * | 2003-04-18 | 2006-01-18 | Warnex Research Inc. | Oligonukleotide zum nachweis von salmonella-spezies |
| CN101522210B (zh) | 2006-09-18 | 2017-03-22 | 阿肯色大学评议会 | 增强免疫应答的组合物和方法 |
| US20080124355A1 (en) | 2006-09-22 | 2008-05-29 | David Gordon Bermudes | Live bacterial vaccines for viral infection prophylaxis or treatment |
| WO2009025888A2 (en) * | 2007-05-10 | 2009-02-26 | The Arizona Board Of Regents For And On Behalf Of Arizona State University | Regulated synthesis of antigen and/or regulated attentuation to enhance vaccine immunogenics and/or safety |
| WO2008141226A2 (en) * | 2007-05-10 | 2008-11-20 | The Arizona Board Of Regents For And On Behalf Of Arizona State University | Recombinant bacteria comprising vectors for expression of nucleic acid sequences encoding antigens |
| PL2164862T3 (pl) * | 2007-06-08 | 2015-12-31 | Australian Poultry Crc Pty Ltd | Toksyna netb z clostridium |
| US20090035815A1 (en) * | 2007-06-29 | 2009-02-05 | Laxmi Srinivas Rao | Synthetic Gene for Enhanced Expression in E. Coli |
| WO2009046449A1 (en) * | 2007-10-05 | 2009-04-09 | The Arizona Board Of Regents For And On Behalf Of Arizona State University | Recombinant bacterium capable of eliciting an immune response against enteric pathogens |
| NZ585776A (en) * | 2007-10-30 | 2012-07-27 | Univ Arkansas | Compositions and methods of enhancing immune responses to flagellated bacterium |
| PL2214701T3 (pl) * | 2007-11-01 | 2017-01-31 | The Board Of Trustees Of The University Of Arkansas | Kompozycje i sposoby wzmacniania odpowiedzi odpornościowych na Eimeria |
| WO2010045620A1 (en) | 2008-10-17 | 2010-04-22 | The Arizona Board Of Regents For And On Behalf Of Arizona State University | Recombinant bacterium capable of eliciting an immune response against streptococcus pneumoniae |
| WO2010094699A1 (en) * | 2009-02-19 | 2010-08-26 | Creatogen Laboratories Gmbh | Attenuated salmonella enteritidis strain |
| US9163219B2 (en) * | 2009-04-14 | 2015-10-20 | Arizona Board Of Regents On Behalf Of Arizona State University | Single expression vector for generation of a virus with a segmented genome |
| US8709444B2 (en) | 2009-05-14 | 2014-04-29 | Northwestern University | Live-attenuated compositions for bacterial infections |
| WO2010135563A1 (en) | 2009-05-22 | 2010-11-25 | The Arizona Board Of Regents For And On Behalf Of Arizona State University | Recombinant bacterium and methods of antigen and nucleic acid delivery |
| US9045742B2 (en) | 2009-05-29 | 2015-06-02 | The Arizona Board Of Regents For And On Behalf Of Arizona State University | Recombinant Edwardsiella bacterium |
| US9062297B2 (en) | 2010-01-13 | 2015-06-23 | The Arizona Board Of Regents For And On Behalf Of Arizona State University | Yersinia pestis vaccine |
| UA110024C2 (uk) | 2010-01-21 | 2015-11-10 | Вакцинний вектор і спосіб посилення імунної відповіді | |
| WO2011091291A1 (en) | 2010-01-22 | 2011-07-28 | The Arizona Board Of Regents For And On Behalf Of Arizona State University | BACTERIUM COMPRISING A REGULATED rfaH NUCLEIC ACID |
| WO2011150421A2 (en) | 2010-05-28 | 2011-12-01 | The Arizona Board Of Regents For And On Behalf Of Arizona State University | Recombinant bacterium to decrease tumor growth |
| KR102007132B1 (ko) | 2010-06-09 | 2019-08-05 | 더 보드 오브 트러스티스 오브 더 유니버시티 오브 아칸소 | 캄필로박터 감염을 감소시키기 위한 백신 및 방법 |
| WO2012003460A2 (en) | 2010-07-02 | 2012-01-05 | The Arizona Board Of Regents For And On Behalf Of Arizona State University | Compositions and methods for bacterial lysis and neutral lipid production |
| US9328148B2 (en) | 2012-02-01 | 2016-05-03 | The Arizona Board Of Regents On Behalf Of The University Of Arizona | Campylobacter immunogenic compositions and uses thereof |
| US9303264B2 (en) | 2012-05-18 | 2016-04-05 | The Arizona Board Of Regents For And On Behalf Of Arizona State University | Photosynthetic microorganisms expressing thermostable lipase |
| NZ711019A (en) | 2013-02-14 | 2019-07-26 | Univ Arkansas | Compositions and methods of enhancing immune responses to eimeria or limiting eimeria infection |
| EP2968423A4 (de) | 2013-03-15 | 2016-11-09 | Univ Arkansas | Zusammensetzungen und verfahren zur verstärkung der immunreaktionen gegen enterale pathogene |
| US9580718B2 (en) | 2013-06-17 | 2017-02-28 | Arizona Board Of Regents On Behalf Of Arizona State University | Attenuated live bacteria with increased acid resistance and methods of use thereof |
| WO2015103104A1 (en) * | 2014-01-06 | 2015-07-09 | The United States Of America, As Represented By The Secretary Of Agriculture | Attenuated salmonella enterica |
| NZ725349A (en) * | 2014-03-27 | 2024-05-31 | Sambuddha Ghosh | Expression of a single chain antibody against salmonella in lactobacillus |
| BR112018072592A2 (pt) | 2016-05-03 | 2019-04-16 | The Board Of Trustees Of The University Of Arkansas | vetor de vacina de levedura que inclui polipeptídeos imunoestimulantes e antigênicos, e métodos de uso dos mesmos |
| US11129906B1 (en) | 2016-12-07 | 2021-09-28 | David Gordon Bermudes | Chimeric protein toxins for expression by therapeutic bacteria |
| US11180535B1 (en) | 2016-12-07 | 2021-11-23 | David Gordon Bermudes | Saccharide binding, tumor penetration, and cytotoxic antitumor chimeric peptides from therapeutic bacteria |
| WO2019014398A1 (en) | 2017-07-11 | 2019-01-17 | Actym Therapeutics, Inc. | MODIFIED IMMUNOSTIMULATORY BACTERIAL STRAINS AND USES THEREOF |
| WO2020014543A2 (en) * | 2018-07-11 | 2020-01-16 | Actym Therapeutics, Inc. | Engineered immunostimulatory bacterial strains and uses thereof |
| EP3844276A2 (de) | 2018-08-28 | 2021-07-07 | Actym Therapeutics, Inc. | Manipulierte immunstimulierende bakterienstämme und verwendungen davon |
| US12024709B2 (en) | 2019-02-27 | 2024-07-02 | Actym Therapeutics, Inc. | Immunostimulatory bacteria engineered to colonize tumors, tumor-resident immune cells, and the tumor microenvironment |
| EP4142781A4 (de) * | 2020-04-30 | 2024-09-04 | Univ Florida | Lebende selbstzerstörende bakterielle adjuvantien zur erhöhung der immunitätsinduktion |
| US10973908B1 (en) | 2020-05-14 | 2021-04-13 | David Gordon Bermudes | Expression of SARS-CoV-2 spike protein receptor binding domain in attenuated salmonella as a vaccine |
| CN112695004A (zh) * | 2020-12-28 | 2021-04-23 | 南通大学 | APEC双基因rpoS和arcA缺失菌株及弱毒疫苗 |
| WO2022271976A1 (en) * | 2021-06-24 | 2022-12-29 | Elanco Us Inc. | Attenuated salmonella, vaccines, and delivery platform |
Family Cites Families (15)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| US4888170A (en) | 1981-10-22 | 1989-12-19 | Research Corporation | Vaccines obtained from antigenic gene products of recombinant genes |
| IL86583A0 (en) * | 1987-06-04 | 1988-11-15 | Molecular Eng Ass | Vaccine containing a derivative of a microbe and method for the production thereof |
| US5294441A (en) * | 1987-06-04 | 1994-03-15 | Washington University | Avirulent microbes and uses therefor: salmonella typhi |
| JPH04501351A (ja) | 1987-10-07 | 1992-03-12 | ワシントン ユニバーシティ | 細胞の遺伝的集団において所望の組換え遺伝子を維持する方法 |
| AU645489B2 (en) | 1989-03-31 | 1994-01-20 | Washington University | Vaccines containing avirulent phoP-type microorganisms |
| GB8912330D0 (en) * | 1989-05-30 | 1989-07-12 | Wellcome Found | Live vaccines |
| WO1991006317A1 (en) | 1989-11-03 | 1991-05-16 | Washington University | Cross-protective salmonella vaccines |
| DE69322092T2 (de) * | 1992-09-04 | 1999-07-15 | University Of Saskatchewan, Saskatoon | Neue bakterielle impfstoffe unter verwendung von impfstämmen von pathogenen bakterien |
| GB9711964D0 (en) * | 1997-06-09 | 1997-08-06 | Medical Res Council | Live attenuated vaccines |
| US6024961A (en) | 1997-11-14 | 2000-02-15 | Washington University | Recombinant avirulent immunogenic S typhi having rpos positive phenotype |
| US6521441B1 (en) * | 1998-03-20 | 2003-02-18 | Human Genome Sciences, Inc. | Staphylococcus aureus genes and polypeptides |
| US6248329B1 (en) * | 1998-06-01 | 2001-06-19 | Ramaswamy Chandrashekar | Parasitic helminth cuticlin nucleic acid molecules and uses thereof |
| US6399074B1 (en) * | 1998-07-24 | 2002-06-04 | Megan Health, Inc. | Live attenuated salmonella vaccines to control avian pathogens |
| US6713073B1 (en) | 1998-07-24 | 2004-03-30 | Megan Health, Inc. | Method of vaccination of newly hatched poultry |
| US6780405B1 (en) * | 2000-04-28 | 2004-08-24 | Avant Immunotherapeutics, Inc. | Regulated antigen delivery system (RADS) |
-
2003
- 2003-04-15 EP EP03721711A patent/EP1499191B1/de not_active Expired - Lifetime
- 2003-04-15 CA CA002526895A patent/CA2526895A1/en not_active Abandoned
- 2003-04-15 AT AT03721711T patent/ATE556596T1/de active
- 2003-04-15 US US10/511,616 patent/US8133493B2/en active Active
- 2003-04-15 EP EP10181350.9A patent/EP2380440B1/de not_active Expired - Lifetime
- 2003-04-15 WO PCT/US2003/011802 patent/WO2003096812A1/en not_active Application Discontinuation
Also Published As
| Publication number | Publication date |
|---|---|
| CA2526895A1 (en) | 2003-11-27 |
| EP1499191A1 (de) | 2005-01-26 |
| US8133493B2 (en) | 2012-03-13 |
| WO2003096812A1 (en) | 2003-11-27 |
| EP2380440A1 (de) | 2011-10-26 |
| US20060233829A1 (en) | 2006-10-19 |
| EP1499191A4 (de) | 2006-06-21 |
| EP2380440B1 (de) | 2016-03-09 |
| AU2003235457A1 (en) | 2003-12-02 |
| EP1499191B1 (de) | 2012-05-09 |
Similar Documents
| Publication | Publication Date | Title |
|---|---|---|
| ATE556596T1 (de) | Regulierte attenuierung von lebendimpfstoffen zur verbesserung der kreuzimmunitätsschutzfunktion | |
| ATE549032T1 (de) | Adjuvanzverbindungen zur verbesserung von immunreaktionen auf polynukleotid-basierten impfstoffen | |
| ECSP11010975A (es) | Método de uso de una cepa de bacillus subtilis para mejorar la salud de animales | |
| ATE451119T1 (de) | Untereinheit-impfstoff gegen das respiratorische synzytialvirus | |
| ATE426412T1 (de) | Adjuvante influenza-vakzine | |
| MY149604A (en) | C.perfringens alpha toxoid vaccine | |
| ATE419008T1 (de) | Adjuvante zusammensetzung und anwendungsverfahren dafür | |
| RS52188B (en) | A PSYCHI VACCINE FOR THE PROTECTION OF ERLIHIOSIS | |
| ECSP077179A (es) | Co-cultivos manejados de organismos que tienen efectos profilacticos y promotores de la salud | |
| ATE521621T1 (de) | Cpg-einzelstrang-desoxynukleotide zur verwendung als adjuvans | |
| HUP0301634A2 (hu) | Hőmérséklet-érzékeny, élő vakcina Mycoplasma hyopneumoniaera | |
| GB2386072A (en) | Novel vaccine | |
| BR0316346A (pt) | Vacina para vìrus do nilo ocidental | |
| ME01140B (me) | Virus goveđe virusne dijareje s modifikovanim erns proteinom | |
| MA28268A1 (fr) | Composes et techniques de traitement de la dyslipidemie | |
| MX2010000864A (es) | Vacuna de celulas enteras estafilococcicas inactivadas. | |
| PT1112747E (pt) | Vacina de salmonella que nao induz anticorpos contra flagelina ou flagelos | |
| CY1112575T1 (el) | Βελτιωμενα αδρανοποιημενα εμβολια fcv | |
| DK1395283T3 (da) | Heterolog beskyttelse induceret ved immunisering med Invaplex-vaccine | |
| DE69824794D1 (de) | Streptococcus equi Impfstoff | |
| DE602004006026D1 (de) | Streptococcus-phocae-vakzine | |
| SG147465A1 (en) | Vaccine | |
| AR041090A1 (es) | Uso de toxina labil al calor de esterichia coli como adyuvante en pajaros y aves de corral | |
| ATE347905T1 (de) | Lebende attenuierte bakterien zur verwendung als impfstoff | |
| HUP9700975A2 (hu) | Élő, legyengített, Pasteurellaceae családba tartozó, RTX-termelő baktériumok |