ATE554800T1 - Medizinische vorrichtungen mit porösen regionen zur kontrollierten aussetzung oder verabreichung therapeutischer wirkstoffe - Google Patents

Medizinische vorrichtungen mit porösen regionen zur kontrollierten aussetzung oder verabreichung therapeutischer wirkstoffe

Info

Publication number
ATE554800T1
ATE554800T1 AT07839083T AT07839083T ATE554800T1 AT E554800 T1 ATE554800 T1 AT E554800T1 AT 07839083 T AT07839083 T AT 07839083T AT 07839083 T AT07839083 T AT 07839083T AT E554800 T1 ATE554800 T1 AT E554800T1
Authority
AT
Austria
Prior art keywords
porous regions
medical devices
administration
active ingredients
therapeutic active
Prior art date
Application number
AT07839083T
Other languages
German (de)
English (en)
Inventor
Barron Tenney
Michael Helmus
Yixin Xu
Original Assignee
Boston Scient Ltd
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Boston Scient Ltd filed Critical Boston Scient Ltd
Application granted granted Critical
Publication of ATE554800T1 publication Critical patent/ATE554800T1/de

Links

Classifications

    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61M—DEVICES FOR INTRODUCING MEDIA INTO, OR ONTO, THE BODY; DEVICES FOR TRANSDUCING BODY MEDIA OR FOR TAKING MEDIA FROM THE BODY; DEVICES FOR PRODUCING OR ENDING SLEEP OR STUPOR
    • A61M25/00—Catheters; Hollow probes
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61L—METHODS OR APPARATUS FOR STERILISING MATERIALS OR OBJECTS IN GENERAL; DISINFECTION, STERILISATION OR DEODORISATION OF AIR; CHEMICAL ASPECTS OF BANDAGES, DRESSINGS, ABSORBENT PADS OR SURGICAL ARTICLES; MATERIALS FOR BANDAGES, DRESSINGS, ABSORBENT PADS OR SURGICAL ARTICLES
    • A61L27/00—Materials for grafts or prostheses or for coating grafts or prostheses
    • A61L27/50—Materials characterised by their function or physical properties, e.g. injectable or lubricating compositions, shape-memory materials, surface modified materials
    • A61L27/54—Biologically active materials, e.g. therapeutic substances
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61L—METHODS OR APPARATUS FOR STERILISING MATERIALS OR OBJECTS IN GENERAL; DISINFECTION, STERILISATION OR DEODORISATION OF AIR; CHEMICAL ASPECTS OF BANDAGES, DRESSINGS, ABSORBENT PADS OR SURGICAL ARTICLES; MATERIALS FOR BANDAGES, DRESSINGS, ABSORBENT PADS OR SURGICAL ARTICLES
    • A61L27/00—Materials for grafts or prostheses or for coating grafts or prostheses
    • A61L27/50—Materials characterised by their function or physical properties, e.g. injectable or lubricating compositions, shape-memory materials, surface modified materials
    • A61L27/56—Porous materials, e.g. foams or sponges
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61L—METHODS OR APPARATUS FOR STERILISING MATERIALS OR OBJECTS IN GENERAL; DISINFECTION, STERILISATION OR DEODORISATION OF AIR; CHEMICAL ASPECTS OF BANDAGES, DRESSINGS, ABSORBENT PADS OR SURGICAL ARTICLES; MATERIALS FOR BANDAGES, DRESSINGS, ABSORBENT PADS OR SURGICAL ARTICLES
    • A61L29/00—Materials for catheters, medical tubing, cannulae, or endoscopes or for coating catheters
    • A61L29/14—Materials characterised by their function or physical properties, e.g. lubricating compositions
    • A61L29/146—Porous materials, e.g. foams or sponges
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61L—METHODS OR APPARATUS FOR STERILISING MATERIALS OR OBJECTS IN GENERAL; DISINFECTION, STERILISATION OR DEODORISATION OF AIR; CHEMICAL ASPECTS OF BANDAGES, DRESSINGS, ABSORBENT PADS OR SURGICAL ARTICLES; MATERIALS FOR BANDAGES, DRESSINGS, ABSORBENT PADS OR SURGICAL ARTICLES
    • A61L29/00—Materials for catheters, medical tubing, cannulae, or endoscopes or for coating catheters
    • A61L29/14—Materials characterised by their function or physical properties, e.g. lubricating compositions
    • A61L29/16—Biologically active materials, e.g. therapeutic substances
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61L—METHODS OR APPARATUS FOR STERILISING MATERIALS OR OBJECTS IN GENERAL; DISINFECTION, STERILISATION OR DEODORISATION OF AIR; CHEMICAL ASPECTS OF BANDAGES, DRESSINGS, ABSORBENT PADS OR SURGICAL ARTICLES; MATERIALS FOR BANDAGES, DRESSINGS, ABSORBENT PADS OR SURGICAL ARTICLES
    • A61L31/00—Materials for other surgical articles, e.g. stents, stent-grafts, shunts, surgical drapes, guide wires, materials for adhesion prevention, occluding devices, surgical gloves, tissue fixation devices
    • A61L31/14—Materials characterised by their function or physical properties, e.g. injectable or lubricating compositions, shape-memory materials, surface modified materials
    • A61L31/146—Porous materials, e.g. foams or sponges
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61L—METHODS OR APPARATUS FOR STERILISING MATERIALS OR OBJECTS IN GENERAL; DISINFECTION, STERILISATION OR DEODORISATION OF AIR; CHEMICAL ASPECTS OF BANDAGES, DRESSINGS, ABSORBENT PADS OR SURGICAL ARTICLES; MATERIALS FOR BANDAGES, DRESSINGS, ABSORBENT PADS OR SURGICAL ARTICLES
    • A61L31/00—Materials for other surgical articles, e.g. stents, stent-grafts, shunts, surgical drapes, guide wires, materials for adhesion prevention, occluding devices, surgical gloves, tissue fixation devices
    • A61L31/14—Materials characterised by their function or physical properties, e.g. injectable or lubricating compositions, shape-memory materials, surface modified materials
    • A61L31/16—Biologically active materials, e.g. therapeutic substances
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61M—DEVICES FOR INTRODUCING MEDIA INTO, OR ONTO, THE BODY; DEVICES FOR TRANSDUCING BODY MEDIA OR FOR TAKING MEDIA FROM THE BODY; DEVICES FOR PRODUCING OR ENDING SLEEP OR STUPOR
    • A61M31/00—Devices for introducing or retaining media, e.g. remedies, in cavities of the body
    • A61M31/002—Devices for releasing a drug at a continuous and controlled rate for a prolonged period of time
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61M—DEVICES FOR INTRODUCING MEDIA INTO, OR ONTO, THE BODY; DEVICES FOR TRANSDUCING BODY MEDIA OR FOR TAKING MEDIA FROM THE BODY; DEVICES FOR PRODUCING OR ENDING SLEEP OR STUPOR
    • A61M37/00—Other apparatus for introducing media into the body; Percutany, i.e. introducing medicines into the body by diffusion through the skin
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61F—FILTERS IMPLANTABLE INTO BLOOD VESSELS; PROSTHESES; DEVICES PROVIDING PATENCY TO, OR PREVENTING COLLAPSING OF, TUBULAR STRUCTURES OF THE BODY, e.g. STENTS; ORTHOPAEDIC, NURSING OR CONTRACEPTIVE DEVICES; FOMENTATION; TREATMENT OR PROTECTION OF EYES OR EARS; BANDAGES, DRESSINGS OR ABSORBENT PADS; FIRST-AID KITS
    • A61F2250/00—Special features of prostheses classified in groups A61F2/00 - A61F2/26 or A61F2/82 or A61F9/00 or A61F11/00 or subgroups thereof
    • A61F2250/0058—Additional features; Implant or prostheses properties not otherwise provided for
    • A61F2250/0067—Means for introducing or releasing pharmaceutical products into the body
    • A61F2250/0068—Means for introducing or releasing pharmaceutical products into the body the pharmaceutical product being in a reservoir
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61L—METHODS OR APPARATUS FOR STERILISING MATERIALS OR OBJECTS IN GENERAL; DISINFECTION, STERILISATION OR DEODORISATION OF AIR; CHEMICAL ASPECTS OF BANDAGES, DRESSINGS, ABSORBENT PADS OR SURGICAL ARTICLES; MATERIALS FOR BANDAGES, DRESSINGS, ABSORBENT PADS OR SURGICAL ARTICLES
    • A61L2300/00—Biologically active materials used in bandages, wound dressings, absorbent pads or medical devices
    • A61L2300/60—Biologically active materials used in bandages, wound dressings, absorbent pads or medical devices characterised by a special physical form
    • A61L2300/602—Type of release, e.g. controlled, sustained, slow
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61M—DEVICES FOR INTRODUCING MEDIA INTO, OR ONTO, THE BODY; DEVICES FOR TRANSDUCING BODY MEDIA OR FOR TAKING MEDIA FROM THE BODY; DEVICES FOR PRODUCING OR ENDING SLEEP OR STUPOR
    • A61M25/00—Catheters; Hollow probes
    • A61M25/0043—Catheters; Hollow probes characterised by structural features
    • A61M2025/0057—Catheters delivering medicament other than through a conventional lumen, e.g. porous walls or hydrogel coatings

Landscapes

  • Health & Medical Sciences (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Veterinary Medicine (AREA)
  • Public Health (AREA)
  • Chemical & Material Sciences (AREA)
  • Animal Behavior & Ethology (AREA)
  • General Health & Medical Sciences (AREA)
  • Engineering & Computer Science (AREA)
  • Epidemiology (AREA)
  • Biomedical Technology (AREA)
  • Medicinal Chemistry (AREA)
  • Heart & Thoracic Surgery (AREA)
  • Anesthesiology (AREA)
  • Molecular Biology (AREA)
  • Dispersion Chemistry (AREA)
  • Dermatology (AREA)
  • Hematology (AREA)
  • Surgery (AREA)
  • Vascular Medicine (AREA)
  • Oral & Maxillofacial Surgery (AREA)
  • Transplantation (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Medical Informatics (AREA)
  • Biophysics (AREA)
  • Pulmonology (AREA)
  • Materials For Medical Uses (AREA)
  • Prostheses (AREA)
  • Medicines Containing Material From Animals Or Micro-Organisms (AREA)
  • Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
  • Medicinal Preparation (AREA)
AT07839083T 2006-10-10 2007-10-01 Medizinische vorrichtungen mit porösen regionen zur kontrollierten aussetzung oder verabreichung therapeutischer wirkstoffe ATE554800T1 (de)

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
US11/545,439 US7666179B2 (en) 2006-10-10 2006-10-10 Medical devices having porous regions for controlled therapeutic agent exposure or delivery
PCT/US2007/021055 WO2008045228A2 (en) 2006-10-10 2007-10-01 Medical devices having porous regions for controlled therapeutic agent exposure or delivery

Publications (1)

Publication Number Publication Date
ATE554800T1 true ATE554800T1 (de) 2012-05-15

Family

ID=39091787

Family Applications (1)

Application Number Title Priority Date Filing Date
AT07839083T ATE554800T1 (de) 2006-10-10 2007-10-01 Medizinische vorrichtungen mit porösen regionen zur kontrollierten aussetzung oder verabreichung therapeutischer wirkstoffe

Country Status (6)

Country Link
US (1) US7666179B2 (enExample)
EP (1) EP2089070B1 (enExample)
JP (1) JP2010505591A (enExample)
AT (1) ATE554800T1 (enExample)
CA (1) CA2669075A1 (enExample)
WO (1) WO2008045228A2 (enExample)

Families Citing this family (43)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US7445616B2 (en) * 2001-03-23 2008-11-04 Petrakis Dennis N Temperature responsive systems
US8172458B2 (en) * 2001-03-23 2012-05-08 Petrakis Dennis N Temperature responsive systems
US20050182443A1 (en) 2004-02-18 2005-08-18 Closure Medical Corporation Adhesive-containing wound closure device and method
US20060009099A1 (en) 2004-07-12 2006-01-12 Closure Medical Corporation Adhesive-containing wound closure device and method
NZ588816A (en) 2007-01-21 2011-11-25 Hemoteq Ag Medical device for the treatment of stenoses of corporal lumina and for the prevention of impending restenoses
US8187255B2 (en) * 2007-02-02 2012-05-29 Boston Scientific Scimed, Inc. Medical devices having nanoporous coatings for controlled therapeutic agent delivery
WO2009006390A2 (en) 2007-07-03 2009-01-08 Charles Stark Draper Laboratory, Inc. Drug-eluting staples prosthesis
US9192697B2 (en) 2007-07-03 2015-11-24 Hemoteq Ag Balloon catheter for treating stenosis of body passages and for preventing threatening restenosis
US7833266B2 (en) * 2007-11-28 2010-11-16 Boston Scientific Scimed, Inc. Bifurcated stent with drug wells for specific ostial, carina, and side branch treatment
GB0811874D0 (en) * 2008-06-30 2008-07-30 Nemaura Pharma Ltd Patches for reverse iontophoresis
US20110159070A1 (en) * 2008-07-03 2011-06-30 The Regents Of The University Of California Biomaterials and implants for enhanced cartilage formation, and methods for making and using them
US7951193B2 (en) * 2008-07-23 2011-05-31 Boston Scientific Scimed, Inc. Drug-eluting stent
US7727450B1 (en) * 2009-01-20 2010-06-01 Gm Global Technology Operations, Inc. Method of using shape memory polymers
US10369256B2 (en) 2009-07-10 2019-08-06 Boston Scientific Scimed, Inc. Use of nanocrystals for drug delivery from a balloon
EP2453938B1 (en) 2009-07-17 2015-08-19 Boston Scientific Scimed, Inc. Nucleation of drug delivery balloons to provide improved crystal size and density
CN102065372B (zh) * 2009-11-16 2014-10-08 中国移动通信集团公司 以广播方式传输数据的方法及相关装置
US8992411B2 (en) 2010-02-16 2015-03-31 Ams Research Corporation Bioabsorbable mesh for surgical implants
US8889211B2 (en) 2010-09-02 2014-11-18 Boston Scientific Scimed, Inc. Coating process for drug delivery balloons using heat-induced rewrap memory
JP5696279B2 (ja) * 2010-12-01 2015-04-08 学校法人自治医科大学 長期徐放型薬剤硬膜外腔留置システム
AU2012220537A1 (en) * 2011-02-23 2013-08-29 Ams Research Corporation Pelvic implant and therapeutic agent system and method
US8669360B2 (en) 2011-08-05 2014-03-11 Boston Scientific Scimed, Inc. Methods of converting amorphous drug substance into crystalline form
WO2013028208A1 (en) 2011-08-25 2013-02-28 Boston Scientific Scimed, Inc. Medical device with crystalline drug coating
FR2986156B1 (fr) * 2012-01-30 2014-07-04 Rhenovia Pharma Dispositif transdermique pour l'administration controlee a un patient d'au moins un principe actif
US11013835B2 (en) 2012-02-03 2021-05-25 Board Of Regents, The University Of Texas System Processability of polymeric substrates and related methods
US9526640B2 (en) 2013-08-18 2016-12-27 Boston Scientific Scimed, Inc. Anti-migration micropatterned stent coating
DE102012025143A1 (de) * 2012-11-07 2014-05-08 Heraeus Medical Gmbh Verfahren zur Wirkstofffreisetzung und Wirkstofffreisetzungssysteme
US20150336058A1 (en) * 2013-01-31 2015-11-26 Regents Of The University Of Minnesota Nanoporous filtration membranes
EP2849212B1 (en) * 2013-09-17 2018-05-23 IMEC vzw Protection of porous substrates before treatment
US20150342760A1 (en) * 2014-06-02 2015-12-03 Boston Scientific Scimed Inc. Anti-migration stent
CN104803348A (zh) * 2015-04-20 2015-07-29 中国科学院光电技术研究所 一种牺牲模板制备高深宽比聚合物纳米柱阵列的方法
US10232154B2 (en) * 2015-07-28 2019-03-19 Boston Scientific Scimed, Inc. Implantable medical devices and related methods of use
EP3481571A4 (en) * 2016-07-05 2020-07-22 Porosteon Development LLC POROUS METAL DEVICES
US10792024B2 (en) 2016-09-28 2020-10-06 Ethicon, Inc. Scaffolds with channels for joining layers of tissue at discrete points
USD848624S1 (en) 2016-09-29 2019-05-14 Ethicon, Inc. Release paper for wound treatment devices
US10687986B2 (en) 2016-09-29 2020-06-23 Ethicon, Inc. Methods and devices for skin closure
US10470935B2 (en) 2017-03-23 2019-11-12 Ethicon, Inc. Skin closure systems and devices of improved flexibility and stretchability for bendable joints
US20180271505A1 (en) * 2017-03-23 2018-09-27 Ethicon, Inc. Scaffolds for Joining Layers of Tissue at Discrete Points
US11504446B2 (en) 2017-04-25 2022-11-22 Ethicon, Inc. Skin closure devices with self-forming exudate drainage channels
US10993708B2 (en) 2018-07-31 2021-05-04 Ethicon, Inc. Skin closure devices with interrupted closure
WO2020207793A1 (en) * 2019-04-08 2020-10-15 Universite De Lille Cutaneous device for storing and releasing molecules, and corresponding method
WO2020226983A1 (en) * 2019-05-03 2020-11-12 Monroe Mary Beth Shape memory polymer hydrogels for wound healing
US11707351B2 (en) 2019-08-19 2023-07-25 Encompass Technologies, Inc. Embolic protection and access system
JP7508551B2 (ja) 2019-10-29 2024-07-01 ボストン サイエンティフィック サイムド，インコーポレイテッド ずれ防止機能を有するステント

Family Cites Families (19)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
GB8527369D0 (en) * 1985-11-06 1985-12-11 Smiths Industries Plc Catheters
JPH01285274A (ja) * 1988-05-12 1989-11-16 Olympus Optical Co Ltd 薬剤徐放装置
JPH0723572B2 (ja) 1988-10-17 1995-03-15 三菱重工業株式会社 形状記憶性ポリマーによる織布
US5811447A (en) 1993-01-28 1998-09-22 Neorx Corporation Therapeutic inhibitor of vascular smooth muscle cells
US6106642A (en) 1998-02-19 2000-08-22 Boston Scientific Limited Process for the improved ductility of nitinol
IL144948A0 (en) * 1999-02-18 2002-06-30 Biovalve Technologies Inc Electroactive pore
US6491061B1 (en) 2000-02-25 2002-12-10 University Of New Mexico Stimuli responsive hybrid materials containing molecular actuators and their applications
US6682521B2 (en) 2000-03-23 2004-01-27 Dennis N. Petrakis Temperature activated systems
EP1372602B1 (en) * 2001-01-09 2007-04-18 Microchips, Inc. Flexible microchip devices for ophthalmic and other applications
US20030109824A1 (en) 2001-11-07 2003-06-12 Microvena Corporation Distal protection device with local drug delivery to maintain patency
US7108685B2 (en) * 2002-04-15 2006-09-19 Boston Scientific Scimed, Inc. Patch stabilization of rods for treatment of cardiac muscle
US20040193262A1 (en) * 2003-03-29 2004-09-30 Shadduck John H. Implants for treating ocular hypertension, methods of use and methods of fabrication
US20050013988A1 (en) 2003-04-16 2005-01-20 Qiang Fu Stimuli responsive mesoporous materials for control of molecular transport
US7356368B2 (en) * 2004-07-21 2008-04-08 Boston Scientific Scimed, Inc. Light-activated anti-infective coatings and devices made thereof
JP2005139183A (ja) * 2004-11-04 2005-06-02 Cellseed Inc 刺激応答性材料の利用方法
US20060127442A1 (en) 2004-12-09 2006-06-15 Helmus Michael N Use of supercritical fluids to incorporate biologically active agents into nanoporous medical articles
US20060129215A1 (en) * 2004-12-09 2006-06-15 Helmus Michael N Medical devices having nanostructured regions for controlled tissue biocompatibility and drug delivery
US20070148251A1 (en) * 2005-12-22 2007-06-28 Hossainy Syed F A Nanoparticle releasing medical devices
US20070224235A1 (en) 2006-03-24 2007-09-27 Barron Tenney Medical devices having nanoporous coatings for controlled therapeutic agent delivery

Also Published As

Publication number Publication date
CA2669075A1 (en) 2008-04-17
EP2089070B1 (en) 2012-04-25
US20080086113A1 (en) 2008-04-10
US7666179B2 (en) 2010-02-23
WO2008045228A3 (en) 2009-02-12
JP2010505591A (ja) 2010-02-25
EP2089070A2 (en) 2009-08-19
WO2008045228A2 (en) 2008-04-17

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